T. Erker

发表

The third-generation P-glycoprotein inhibitor tariquidar may overcome bacterial multidrug resistance by increasing intracellular drug concentration.

M. Zeitlinger, O. Langer, J. Nemeth, 2011, The Journal of antimicrobial chemotherapy.

Trapping and dissociation of propafenone derivatives in HERG channels

T. Erker, E. Timin, S. Hering, 2011, British journal of pharmacology.

Identification and characterization of diarylimidazoles as hybrid inhibitors of butyrylcholinesterase and amyloid beta fibril formation.

U. Holzgrabe, A. Fallarero, P. Vuorela, 2012, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Resveratrol blocks Akt activation in angiotensin II- or EGF-stimulated vascular smooth muscle cells in a redox-independent manner

A. Atanasov, E. Heiss, V. Dirsch, 2010, Cardiovascular research.

PET and SPECT radiotracers to assess function and expression of ABC transporters in vivo.

O. Langer, T. Erker, S. Mairinger, 2011, Current drug metabolism.

Role of NKCC1 Activity in Glioma K+ Homeostasis and Cell Growth: New Insights With the Bumetanide-Derivative STS66

Md Nabiul Hasan, Shih-Hua Lin, S. Yang, 2020, Frontiers in Physiology.

The role of oxidative stress in 63 T-induced cytotoxicity against human lung cancer and normal lung fibroblast cell lines

H. Piotrowska-Kempisty, T. Erker, M. Kucińska, 2018, Investigational New Drugs.

Synthesis of 1,2-Disubstituted Imidazoles via Cross-Coupling and Substitution Reactions

T. Erker, I. Langhammer, 2005 .

Novel Promising Estrogenic Receptor Modulators: Cytotoxic and Estrogenic Activity of Benzanilides and Dithiobenzanilides

H. Piotrowska, N. Lisiak, R. Salto, 2016, PloS one.

Foam Cell Specific LXRα Ligand

S. Sauer, T. Erker, Radmila Feldmann, 2013, PloS one.

Multiple blood-brain barrier transport mechanisms limit bumetanide accumulation, and therapeutic potential, in the mammalian brain

W. Löscher, M. Fedrowitz, T. Erker, 2017, Neuropharmacology.

Interaction of HM30181 with P-glycoprotein at the murine blood-brain barrier assessed with positron emission tomography.

C. Kuntner, P. Chiba, Z. Parveen, 2012, European journal of pharmacology.

A Novel PET Protocol for Visualization of Breast Cancer Resistance Protein Function at the Blood–Brain Barrier

W. Löscher, C. Kuntner, O. Langer, 2012, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Selective anticancer activity of the novel thiobenzanilide 63T against human lung adenocarcinoma cells.

M. Zehl, W. Jäger, H. Piotrowska-Kempisty, 2016, Toxicology in vitro : an international journal published in association with BIBRA.

Cyclooxygenase‐1 and Cyclooxygenase‐2 Inhibition of Novel 1,2‐Disubtituted Imidazoles

W. Jaeger, T. Erker, N. Handler, 2005, Archiv der Pharmazie.

Antitumor effects of KITC, a new resveratrol derivative, in AsPC-1 and BxPC-3 human pancreatic carcinoma cells

T. Szekeres, W. Jaeger, M. Grusch, 2009, Investigational New Drugs.

Cytotoxic and biochemical effects of 3,3',4,4',5,5'-hexahydroxystilbene, a novel resveratrol analog in HL-60 human promyelocytic leukemia cells.

T. Szekeres, W. Jaeger, M. Grusch, 2006, Experimental hematology.

The exploration of thienothiazines as selective butyrylcholinesterase inhibitors.

C. G. Mohan, A. Fallarero, P. Vuorela, 2012, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Synthesis and in vivo evaluation of [11C]tariquidar, a positron emission tomography radiotracer based on a third-generation P-glycoprotein inhibitor.

W. Löscher, C. Kuntner, O. Langer, 2010, Bioorganic & medicinal chemistry.

Synthesis and small-animal positron emission tomography evaluation of [11C]-elacridar as a radiotracer to assess the distribution of P-glycoprotein at the blood-brain barrier.

W. Löscher, C. Kuntner, O. Langer, 2009, Journal of medicinal chemistry.

Radiosynthesis and in vivo evaluation of 1-[18F]fluoroelacridar as a positron emission tomography tracer for P-glycoprotein and breast cancer resistance protein.

Donald W. Miller, W. Löscher, C. Kuntner, 2011, Bioorganic & medicinal chemistry.

Synthesis and Calcium Antagonistic Activity of 8‐[N‐[2‐(3,4‐Dimethoxyphenyl)ethyl]‐β‐alanyl]‐5,6,7,8‐tetrahydrothieno[3,2‐b][1,4]thiazepine Fumarate

T. Erker, S. Boehm, S. Huck, 1996, Archiv der Pharmazie.

Synthesis and in vivo evaluation of the putative breast cancer resistance protein inhibitor [11C]methyl 4-((4-(2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl)phenyl)amino-carbonyl)-2-(quinoline-2-carbonylamino)benzoate.

W. Löscher, C. Baumgartner, C. Kuntner, 2010, Nuclear medicine and biology.

No evidence for modulation of endothelial nitric oxide synthase by the olive oil polyphenol hydroxytyrosol in human endothelial cells.

E. Heiss, V. Dirsch, T. Erker, 2007, Atherosclerosis.

Novel resveratrol analogs induce apoptosis and cause cell cycle arrest in HT29 human colon cancer cells: inhibition of ribonucleotide reductase activity.

T. Szekeres, W. Jaeger, M. Grusch, 2008, Oncology reports.

Antioxidant activity of resveratrol, piceatannol and 3,3',4,4',5,5'-hexahydroxy-trans-stilbene in three leukemia cell lines.

T. Szekeres, T. Erker, N. Handler, 2006, Oncology reports.

Tariquidar and elacridar are dose-dependently transported by P-glycoprotein and Bcrp at the blood-brain barrier: a small-animal PET and in-vitro study

W. Löscher, A. Windhorst, C. Kuntner, 2013 .

Title page Tariquidar and elacridar are dose-dependently transported by P-glycoprotein and Bcrp at the blood-brain barrier: a small-animal PET and in-vitro study

W. Löscher, A. Windhorst, C. Kuntner, 2013 .

Tariquidar and Elacridar Are Dose-Dependently Transported by P-Glycoprotein and Bcrp at the Blood-Brain Barrier: A Small-Animal Positron Emission Tomography and In Vitro Study

Claudia Kuntner, Albert D. Windhorst, Wolfgang Löscher, 2013, Drug Metabolism and Disposition.

A comparative small-animal PET evaluation of [11C]tariquidar, [11C]elacridar and (R)-[11C]verapamil for detection of P-glycoprotein-expressing murine breast cancer

W. Löscher, C. Kuntner, O. Langer, 2011, European Journal of Nuclear Medicine and Molecular Imaging.

Synthesis of novel curcumin analogues and their evaluation as selective cyclooxygenase-1 (COX-1) inhibitors.

W. Jaeger, T. Erker, N. Handler, 2007, Chemical & pharmaceutical bulletin.

Studies on the chemistry of thienoanellated O,N- and S,N-containing heterocycles. Part 30: synthesis and pharmacological properties of thieno[2,3-b][1,4]thiazines with potential vasopressin receptor antagonistic activity.

R. Lemmens‐Gruber, M. Kamyar, T. Erker, 2006, Bioorganic & medicinal chemistry.

Synthesis and pharmacological profile of non-peptide vasopressin antagonists.

R. Lemmens‐Gruber, M. Kamyar, T. Erker, 2005, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Discovery of small molecules with vasodilating characteristics and adjustable hydrolytic behavior.

T. Erker, C. Studenik, Mario Gabriel, 2015, Bioorganic & medicinal chemistry.

Valerenic acid derivatives as novel subunit‐selective GABAA receptor ligands –in vitro and in vivo characterization

G. Ecker, C. Schwarzer, J. Mulzer, 2010, British journal of pharmacology.

Functional characterization of novel bumetanide derivatives for epilepsy treatment

C. Schwarzer, T. Erker, Philipp Schreppel, 2019, Neuropharmacology.

Effects of novel synthesized pyridothiazines on various guinea pig heart muscle preparations.

T. Erker, Manuela Weber, C. Studenik, 2004, Biological & pharmaceutical bulletin.

Structure–activity relationships of bumetanide derivatives: correlation between diuretic activity in dogs and inhibition of the human NKCC2A transporter

W. Löscher, N. MacAulay, T. Erker, 2015, British journal of pharmacology.

Ketene Addition on Thienoanellated Thiazines and Thiazepines with Subsequent Ring Enlargement Reaction to Thieno[2,3-b][1,4]thiazocines and Thieno[2,3-b][1,4]thiazonines

T. Erker, 1994 .

Resveratrol, an Ingredient of Wine, Acts Synergistically with Ara-C and Tiazofurin in HL-60 Human Promyelocytic Leukemia Cells

T. Szekeres, W. Jaeger, W. Bauer, 2006, Nucleosides, nucleotides & nucleic acids.

Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity

O. Werz, U. Förstermann, V. Dirsch, 2014, Nucleic acids research.

The search for NKCC1-selective drugs for the treatment of epilepsy: Structure–function relationship of bumetanide and various bumetanide derivatives in inhibiting the human cation-chloride cotransporter NKCC1A

W. Löscher, N. MacAulay, T. Erker, 2016, Epilepsy & Behavior.

Impaired chloride homeostasis in epilepsy: Molecular basis, impact on treatment, and current treatment approaches.

C. Schwarzer, T. Erker, Philipp Schreppel, 2019, Pharmacology & therapeutics.

The bumetanide prodrug BUM5, but not bumetanide, potentiates the antiseizure effect of phenobarbital in adult epileptic mice

W. Löscher, C. Brandt, T. Erker, 2016, Epilepsia.

Efficient Modulation of γ-Aminobutyric Acid Type A Receptors by Piperine Derivatives

G. Ecker, I. Baburin, M. Mihovilovic, 2014, Journal of medicinal chemistry.

The antiepileptic drug mephobarbital is not transported by P-glycoprotein or multidrug resistance protein 1 at the blood–brain barrier: A positron emission tomography study

W. Löscher, C. Kuntner, O. Langer, 2012, Epilepsy Research.

Studies on the chemistry of O,N- and S,N-containing heterocycles. 16. Investigations on the synthesis of new tricyclic β-lactams via [2+2]cycloaddition reaction†‡

T. Erker, H. Bartsch, S. Pippich, 1997 .

Studies on the chemistry of O,N- and S,N-containing heterocycles. 3. Synthesis of 1,5-benzothiazepines with potential CNS activity†

T. Erker, H. Bartsch, 1988 .

The 1,3-dipolar cycloaddition as an approach to novel tricyclic O,N- and S,N-heterocycles

T. Erker, H. Bartsch, 1988 .

Synthesis of tricyclic pyrido[2,3-b][1,4]-thiazines via nucleophilic substitution of activated precursors

W. Jäger, T. Erker, Manuela Weber, 2003 .

Studies on the chemistry of thienoannelated O,N- and S,N-containing heterocycles. 24 [1]. Synthesis of imidazo[1,5-d]thieno[2,3-b][1,4]-thiazine derivatives as potential receptor ligands

T. Erker, N. Handler, 2002 .

Chemistry of O,N‐ and S,N‐Containing Heterocycles. Part 13. Investigations on the Ring Contraction of 1,5‐Benzothiazepines to 1,4‐ Benzothiazines.

T. Erker, H. Bartsch, 1992 .

Studies on the chemistry of O,N- and S,N-containing heterocycles. 12 [1]. Investigations on the synthesis of tricyclic 1,5-benzoxazepines

T. Erker, Thomas Erker, Herbert Bartsch, 1990 .

Synthesis of fluorine‐18‐labelled 5‐ and 6‐fluoro‐2‐pyridinamine

P. Angelberger, O. Langer, Markus Müller, 2006 .

Synthesis, biological evaluation and 3D-QSAR studies of new chalcone derivatives as inhibitors of human P-glycoprotein.

G. Ecker, P. Chiba, Z. Parveen, 2014, Bioorganic & medicinal chemistry.

Benzanilides with spasmolytic activity: chemistry, pharmacology, and SAR.

T. Erker, Gerda Brunhofer, N. Handler, 2008, Bioorganic & medicinal chemistry.

Synthesis, spasmolytic activity and structure-activity relationship study of a series of polypharmacological thiobenzanilides.

G. Ecker, T. Erker, Gerda Brunhofer, 2011, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Synthesis of new acridone derivatives, inhibitors of NS3 helicase, which efficiently and specifically inhibit subgenomic HCV replication.

T. Erker, B. Dörner, Anna Stankiewicz-Drogoń, 2010, Journal of medicinal chemistry.

The Lawesson reagent as selective reducing agent for sulfoxides

T. Erker, H. Bartsch, 1992 .

Stilbene analogues affect cell cycle progression and apoptosis independently of each other in an MCF-7 array of clones with distinct genetic and chemoresistant backgrounds.

T. Szekeres, W. Jäger, I. Tentes, 2008, Oncology reports.

The Lawesson Reagent as Selective Reducing Agent for Sulfoxides.

T. Erker, H. Bartsch, 1992 .

Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship.

G. Ecker, T. Szekeres, W. Jäger, 2004, Bioorganic & medicinal chemistry.

GABAA receptor modulation by piperine and a non-TRPV1 activating derivative☆

C. Schwarzer, I. Baburin, M. Hamburger, 2013, Biochemical pharmacology.

Novel resveratrol derivatives induce apoptosis and cause cell cycle arrest in prostate cancer cell lines.

T. Szekeres, W. Jaeger, B. Djavan, 2007, Anticancer research.

'Bridged' stilbene derivatives as selective cyclooxygenase-1 inhibitors.

Walter Jaeger, Norbert Handler, W. Jaeger, 2007, Bioorganic & medicinal chemistry.

Antioxidant, prooxidant and cytotoxic activity of hydroxylated resveratrol analogues: structure-activity relationship.

T. Szekeres, W. Jäger, L. Gille, 2005, Biochemical pharmacology.

Synthesis of a New Series of Imidazo-[1,5-a]pyrido[2,3-e]pyrazines as Potential Ligands for the GABA Receptor Complex

T. Erker, Manuela Weber, H. Bartsch, 2002 .

Synthesis of 1,2,4-Oxadiazolylimidazo[1,5-a]thieno[2,3-e]pyrazines as Ligands for the g-Aminobutyric Acid A/Benzodiazepine Receptor Complex

T. Erker, K. Trinkl, 2001 .

Synergistic action of resveratrol, an ingredient of wine, with Ara-C and tiazofurin in HL-60 human promyelocytic leukemia cells.

Walter Jaeger, T. Szekeres, W. Jaeger, 2005, Experimental hematology.

Studies on the Chemistry of Thienoanellated O,N‐ and S,N‐Containing Heterocycles. Part 22. Synthesis of 1,2,4‐Oxadiazolylimidazo[1,5‐a]thieno[2,3‐e]pyrazines as Ligands for the γ‐Aminobutyric Acid A/Benzodiazepine Receptor Complex.

T. Erker, K. Trinkl, 2002 .

Synthesis of a New Series of Imidazo[1,5-d]pyrido[2,3-b][1,4]thiazines as Potential Ligands for the GABA Receptor Complex.

T. Erker, Manuela Weber, 2003 .

Nucleophilic Substitution Reactions on Chlorinated Thiophene Derivatives as Basis for the Synthesis of Thienoanellated O,N- and S,N-Heterocycles

T. Erker, I. Puschmann, 1993 .

Studies on the chemistry of thienoannelated O,N- and S,N-containing heterocycles. 17. Preparation of 1H-thieno[2,3-b][1,4]thiazine-1-carboxarnides as smooth muscle relaxants

T. Erker, M. E. Schreder, 2000 .

Studies on the Chemistry of Thienoanellated O,N- and S,N-Containing Heterocycles. Part 1. Nucleophilic Substitution Reactions on Chlorinated Thiophene Derivatives as Basis for the Synthesis of Thienoanellated O,N- and S,N-Heterocycles

T. Erker, I. Puschmann, 1993 .

Studies on the chemistry of thienoanellated O,N- and S,N-containing heterocycles. 3. Synthesis of tricyclic thieno[2,3-b][1,4]thiazines via nucleophilic substitution of activated precursors†

T. Erker, 1993 .

Synthesis of Nitrated Thienylphosphonates via Michaelis-Arbuzov-Type Rearrangement

T. Erker, N. Handler, 2004 .

Studies on the Chemistry of Thieno‐Anellated O,N‐ and S,N‐Containing Heterocycles. Part 9. Synthesis and Ca2+ Antagonistic Activity of a Thieno‐KT‐362 Analogue.

T. Erker, 1995 .

Studies on the Chemistry of Thienoanellated O,N‐ and S,N‐Containing Heterocycles. Part 5. An Access to the Thieno(2,3‐b) (1,4)oxazine Ring System.

T. Erker, I. Puschmann, 1995 .

Chemistry of Thienoanellated O,N- and S,N-Containing Heterocycles. Part 17. Preparation of 1H-Thieno[2,3-b][1,4]thiazine-1-carboxamides as Smooth Muscle Relaxants.

T. Erker, M. E. Schreder, 2010 .

Chemistry of Thienoanellated O,N‐ and S,N‐Containing Heterocycles. Part 10. Synthesis of 2‐Substituted Thieno‐Diltiazem Derivatives.

T. Erker, I. Puschmann, 1995 .

Studies on the Chemistry of Thienoanellated O,N- and S,N-Containing Heterocycles. Part 3. Synthesis of Tricyclic Thieno(2,3-b)(1,4) thiazines via Nucleophilic Substitution of Activated Precursors.

T. Erker, 1994 .

Pros and cons of using resazurin staining for quantification of viable Staphylococcus aureus biofilms in a screening assay.

A. Fallarero, P. Vuorela, T. Erker, 2009, Journal of microbiological methods.

A novel prodrug‐based strategy to increase effects of bumetanide in epilepsy

W. Löscher, K. Kaila, C. Brandt, 2014, Annals of neurology.

Synthesis of thieno[2,3-b]pyrazines via an acylation-deacylation process of 3,4-dihydro precursors

T. Erker, F. Pertlik, K. Trinkl, 2003 .

Studies on the Chemistry of Thienoanellated O,N‐ and S,N‐Containing Heterocycles. Part 27. Synthesis of Thieno[2,3‐b]pyrazines via an Acylation‐Deacylation Process of 3,4‐Dihydro Precursors.

T. Erker, F. Pertlik, K. Trinkl, 2003 .

Gene expression profiling of aortic smooth muscle cells treated with a novel H2S-based compound

J. Wojta, M. Bilban, T. Erker, 2015 .

Gene expression profiling of aortic smooth muscle cells treated with a novel H 2 S-based compound

J. Wojta, M. Bilban, T. Erker, 2015 .

Hydrogen sulphide induces HIF-1α and Nrf2 in THP-1 macrophages.

B. Gmeiner, T. Erker, H. Laggner, 2015, Biochimie.

Enhanced Antiproliferative and Pro-apoptotic Activities of a Novel Curcumin-related Compound in Jurkat Leukemia T-Cells.

G. Steiner, T. Erker, K. Goldhahn, 2014, Anticancer research.

Interaction of diltiazem with an intracellularly accessible binding site on CaV1.2

T. Erker, E. Timin, A. Hohaus, 2011, British journal of pharmacology.

Drug trapping in hERG K+ channels: (not) a matter of drug size?† †The authors declare no competing interests.

Steffen Hering, Tobias Linder, Priyanka Saxena, 2015, MedChemComm.

N-hydroxy-N'-(3,4,5-trimethoxyphenyl)-3,4,5-trimethoxy-benzamidine, a novel resveratrol analog, inhibits ribonucleotide reductase in HL-60 human promyelocytic leukemia cells: synergistic antitumor activity with arabinofuranosylcytosine.

T. Szekeres, W. Jaeger, M. Grusch, 2007, International journal of oncology.

Studies on the chemistry of 1,4‐oxazines. 18. Synthesis of tricyclic 1,4‐benzoxazines via nucleophilic substitution of activated precursors

T. Erker, H. Bartsch, G. Neubauer, 1989 .

Chemistry of O,N- and S,N-Containing Heterocycles. Part 7. Synthesis of New Tricyclic Heterocycles from 1,4-Benzoxazin- and 1,4-Benzothiazin-3-oximes.

T. Erker, H. Bartsch, G. Neubauer, 1989 .

Chemistry of 1,4-Oxazines. Part 18. Synthesis of Tricyclic 1,4-Benzoxazines via Nucleophilic Substitution of Activated Precursors.

T. Erker, H. Bartsch, G. Neubauer, 1989 .

A Novel Na+-K+-Cl− Cotransporter 1 Inhibitor STS66* Reduces Brain Damage in Mice After Ischemic Stroke

B. Molyneaux, Shanshan Song, Shih-Hua Lin, 2019, Stroke.

Bumetanide is not capable of terminating status epilepticus but enhances phenobarbital efficacy in different rat models.

W. Löscher, C. Brandt, T. Erker, 2015, European journal of pharmacology.

Small-animal PET evaluation of [11C]MC113 as a PET tracer for P-glycoprotein

F. Berardi, R. Perrone, N. Colabufo, 2010, BMC Pharmacology.

Austrian Pharmacological Society ( APHAR ) Vienna , Austria 25 – 27 November 2010 A 1 The trafficking of GPR 55 is regulated by the G protein-coupled receptor-associated sorting protein 1

F. Berardi, R. Perrone, N. Colabufo, 2010 .

The interplay of excitatory and inhibitory coupling modes is crucial for the regulation of neuronal electrical activities by L-type calcium channels

W. Wadsak, F. Berardi, R. Perrone, 2022 .

Factors Governing P-Glycoprotein-Mediated Drug–Drug Interactions at the Blood–Brain Barrier Measured with Positron Emission Tomography

W. Löscher, C. Kuntner, O. Langer, 2015, Molecular pharmaceutics.

Synthesis and cytotoxic activity of resveratrol-based compounds

T. Szekeres, W. Jaeger, V. Wacheck, 2008 .

Using structural and mechanistic information to design novel inhibitors/substrates of P-glycoprotein.

Markus Müller, Peter Chiba, Thomas Stockner, 2010, Current topics in medicinal chemistry.

SAR-guided development and characterization of a potent antitumor compound toward B-cell neoplasms with no detectable cytotoxicity toward healthy cells.

U. Jäger, T. Erker, K. Vanura, 2015, Journal of medicinal chemistry.

Resveratrol Blocks Akt Activation in Angiotensin Ii- or Egf-stimulated Vascular Smooth Muscle Cells in a Redox-independent Manner

A. Atanasov, E. Heiss, V. Dirsch, 2022 .

A tetracyclic thiophene trimer synthesis and mechanism of formation

T. Erker, K. Wurst, W. Reischl, 2013 .

The exploration of thienothiazines as selective butyrylcholinesterase inhibitors.

C. G. Mohan, A. Fallarero, P. Vuorela, 2012, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Drug trapping in hERG K+ channels: (not) a matter of drug size?

A. Stary-Weinzinger, T. Erker, S. Hering, 2015, MedChemComm.

A Novel Genistein Prodrug: Design, Synthesis and Bioactivity on Mouse RAW264.7 Macrophages

T. Erker, K. Goldhahn, N. Handler, 2016, Natural product communications.

Cyclooxygenase‐1 and Cyclooxygenase‐2 Inhibition of Novel 1,2‐Disubtituted Imidazoles

W. Jaeger, T. Erker, N. Handler, 2005, Archiv der Pharmazie.

Tariquidar and Elacridar Are Dose-Dependently Transported by P-Glycoprotein and Bcrp at the Blood-Brain Barrier: A Small-Animal Positron Emission Tomography and In Vitro Study

W. Löscher, A. Windhorst, C. Kuntner, 2013, Drug Metabolism and Disposition.

Synthesis and small-animal positron emission tomography evaluation of [11C]-elacridar as a radiotracer to assess the distribution of P-glycoprotein at the blood-brain barrier.

W. Löscher, C. Kuntner, O. Langer, 2009, Journal of medicinal chemistry.

SAR-guided development and characterization of a potent antitumor compound toward B-cell neoplasms with no detectable cytotoxicity toward healthy cells.

U. Jäger, T. Erker, K. Vanura, 2015, Journal of medicinal chemistry.

Structure–activity relationships of bumetanide derivatives: correlation between diuretic activity in dogs and inhibition of the human NKCC2A transporter

W. Löscher, N. MacAulay, T. Erker, 2015, British journal of pharmacology.

The bumetanide prodrug BUM5, but not bumetanide, potentiates the antiseizure effect of phenobarbital in adult epileptic mice

W. Löscher, C. Brandt, T. Erker, 2016, Epilepsia.