S. Sabatini

发表

Ligand Promiscuity between the Efflux Pumps Human P-Glycoprotein and S. aureus NorA.

G. Cruciani, E. Carosati, M. Frosini, 2012, ACS medicinal chemistry letters.

Effects of KATPopeners on the QT prolongation induced by HERG-blocking drugs in guinea-pigs: KATPopeners and drug-induced QT prolongation

M. Breschi, V. Calderone, S. Sabatini, 2010 .

Effects of K openers on the QT prolongation induced by HERG-blocking drugs in guinea-pigs.

M. Breschi, V. Calderone, S. Sabatini, 2010, The Journal of pharmacy and pharmacology.

Synthesis and characterization of 1,2,4-triazolo[1,5-a]pyrimidine-2-carboxamide-based compounds targeting the PA-PB1 interface of influenza A virus polymerase

M. Loza, J. Brea, L. Goracci, 2020, European Journal of Medicinal Chemistry.

Synthesis and anti-BVDV activity of acridones as new potential antiviral agents.

E. De Clercq, J. Rozenski, J. Neyts, 2006, Journal of medicinal chemistry.

A comparative study of adduct formation between the anticancer ruthenium(III) compound HInd trans-[RuCl4(Ind)2] and serum proteins.

B. Keppler, L. Messori, S. Sabatini, 2004, Journal of inorganic biochemistry.

Pleiotropic effect of Lactoferrin in the prevention and treatment of COVID-19 infection: randomized clinical trial, in vitro and in silico preliminary evidences

F. Iacovelli, M. Falconi, A. Terrinoni, 2020, bioRxiv.

6‐Hydrogen‐8‐Methylquinolones Active Against Replicating and Non‐replicating Mycobacterium tuberculosis

S. Franzblau, Marco Pieroni, S. Sabatini, 2012, Chemical biology & drug design.

Natural isoflavone biochanin A as a template for the design of new and potent 3-phenylquinolone efflux inhibitors against Mycobacterium avium.

M. Viveiros, I. Couto, S. Sabatini, 2017, European journal of medicinal chemistry.

Modifications on C6 and C7 Positions of 3-Phenylquinolone Efflux Pump Inhibitors Led to Potent and Safe Antimycobacterial Treatment Adjuvants.

M. Viveiros, S. Sabatini, G. Manfroni, 2019, ACS infectious diseases.

Mode of action of the 2-phenylquinoline efflux inhibitor PQQ4R against Escherichia coli

M. Viveiros, I. Couto, S. Sabatini, 2017, PeerJ.

Effects of KATP openers on the QT prolongation induced by HERG‐blocking drugs in guinea‐pigs

M. Breschi, V. Calderone, S. Sabatini, 2010 .

Deciphering the Molecular Recognition Mechanism of Multidrug Resistance Staphylococcus aureus NorA Efflux Pump Using a Supervised Molecular Dynamics Approach

Maicol Bissaro, M. Sturlese, S. Moro, 2019, International journal of molecular sciences.

Re-evolution of the 2-phenylquinolines: ligand-based design, synthesis, and biological evaluation of a potent new class of Staphylococcus aureus NorA efflux pump inhibitors to combat antimicrobial resistance.

G. Kaatz, S. Sabatini, G. Manfroni, 2013, Journal of medicinal chemistry.

Searching for innovative quinolone-like scaffolds: synthesis and biological evaluation of 2,1-benzothiazine 2,2-dioxide derivatives

G. Kaatz, Marco Pieroni, S. Sabatini, 2012 .

Pyrazolo[4,3-c][1,2]benzothiazines 5,5-dioxide: a promising new class of Staphylococcus aureus NorA efflux pump inhibitors.

E. Carosati, G. Kaatz, M. Villarini, 2012, Journal of medicinal chemistry.

Evolution from a natural flavones nucleus to obtain 2-(4-Propoxyphenyl)quinoline derivatives as potent inhibitors of the S. aureus NorA efflux pump.

G. Kaatz, S. Sabatini, D. Patel, 2011, Journal of medicinal chemistry.

New Pyrazolobenzothiazine Derivatives as Hepatitis C Virus NS5B Polymerase Palm Site I Inhibitors

C. Zamperini, E. Dreassi, Neerja Kaushik-Basu, 2014, Journal of medicinal chemistry.

Impact of conventional/non-conventional extraction methods on the untargeted phenolic profile of Moringa oleifera leaves.

G. Rocchetti, L. Lucini, D. Montesano, 2019, Food research international.

Discovery of 2-Phenylquinolines with Broad-Spectrum Anti-coronavirus Activity

J. Neyts, D. Schols, E. Tramontano, 2022, ACS medicinal chemistry letters.

C-2 phenyl replacements to obtain potent quinoline-based Staphylococcus aureus NorA inhibitors

D. Pietrella, S. Sabatini, G. Manfroni, 2020, Journal of enzyme inhibition and medicinal chemistry.

1,4-Benzothiazine ATP-sensitive potassium channel openers: modifications at the C-2 and C-6 positions.

V. Calderone, M. Novelli, P. Masiello, 2013, Journal of medicinal chemistry.

Investigation of targeted pyrrolizidine alkaloids in traditional Chinese medicines and selected herbal teas sourced in Ireland using LC-ESI-MS/MS

A. Furey, M. Danaher, S. Sabatini, 2014, Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.

Efficient and regioselective one-step synthesis of 7-aryl-5-methyl- and 5-aryl-7-methyl-2-amino-[1,2,4]triazolo[1,5-a]pyrimidine derivatives.

L. Goracci, A. Loregian, Giulio Nannetti, 2017, Organic & biomolecular chemistry.

Pharmacophore-Based Repositioning of Approved Drugs as Novel Staphylococcus aureus NorA Efflux Pump Inhibitors.

G. Kaatz, D. Pietrella, S. Sabatini, 2017, Journal of medicinal chemistry.

A Broad Anti-influenza Hybrid Small Molecule That Potently Disrupts the Interaction of Polymerase Acidic Protein-Basic Protein 1 (PA-PB1) Subunits.

L. Goracci, G. Cruciani, G. Palù, 2015, Journal of medicinal chemistry.

Efficient microwave assisted synthesis of metal-organic framework UiO-66: optimization and scale up.

Seth M. Cohen, J. V. van Bokhoven, R. Vivani, 2015, Dalton transactions.

From phenothiazine to 3-phenyl-1,4-benzothiazine derivatives as inhibitors of the Staphylococcus aureus NorA multidrug efflux pump.

G. Kaatz, G. Rossolini, S. Sabatini, 2008, Journal of medicinal chemistry.

From Quinoline to Quinazoline‐Based S. aureus NorA Efflux Pump Inhibitors by Coupling a Focused Scaffold Hopping Approach and a Pharmacophore Search

S. Sabatini, G. Manfroni, Serena Massari, 2021, ChemMedChem.

Structural Modifications of the Quinolin-4-yloxy Core to Obtain New Staphylococcus aureus NorA Inhibitors

S. Sabatini, G. Manfroni, Serena Massari, 2020, International journal of molecular sciences.

Novel 1,4-benzothiazine derivatives as large conductance Ca2+-activated potassium channel openers.

Roberto Spogli, V. Calderone, S. Sabatini, 2008, Journal of medicinal chemistry.

p38α MAPK and Type I Inhibitors: Binding Site Analysis and Use of Target Ensembles in Virtual Screening

S. Sabatini, V. Cecchetti, M. Barreca, 2015, Molecules.

The use of a rigid tritopic phosphonic ligand for the synthesis of a robust honeycomb-like layered zirconium phosphonate framework.

Seth M. Cohen, R. Vivani, F. Costantino, 2014, Chemical communications.

Sustainable, three-component, one-pot procedure to obtain active anti-flavivirus agents.

S. Vasudevan, S. Alonso, S. Sabatini, 2020, European journal of medicinal chemistry.

Discovery of novel inhibitors of the NorA multidrug transporter of Staphylococcus aureus.

Stefano Sabatini, Gabriele Cruciani, Emanuele Carosati, 2011, Journal of medicinal chemistry.

Structural Investigation of the Naphthyridone Scaffold: Identification of a 1,6‐Naphthyridone Derivative with Potent and Selective Anti‐HIV Activity

C. Pannecouque, D. Daelemans, S. Sabatini, 2011, ChemMedChem.

Structure modifications of 6-aminoquinolones with potent anti-HIV activity.

E. De Clercq, C. Pannecouque, M. Palumbo, 2004, Journal of medicinal chemistry.

The versatile nature of the 6-aminoquinolone scaffold: identification of submicromolar hepatitis C virus NS5B inhibitors.

Neerja Kaushik-Basu, J. Neyts, P. Leyssen, 2014, Journal of medicinal chemistry.

Design, Synthesis, and Evaluation of WC5 Analogues as Inhibitors of Human Cytomegalovirus Immediate‐Early 2 Protein, a Promising Target for Anti‐HCMV Treatment

C. Pannecouque, G. Palù, A. Loregian, 2013, ChemMedChem.

Pyridobenzothiazole derivatives as new chemotype targeting the HCV NS5B polymerase.

G. Maga, J. Neyts, P. Leyssen, 2012, Bioorganic & medicinal chemistry.

Dibenzo[1,6]naphthyridindiones as modified quinolone antibacterials

S. Sabatini, O. Tabarrini, V. Cecchetti, 1998 .

Interionic Solution Structure of Acetyl RuII Complexes Bearing Diimine and Diamine Ligands by 1H‐NOESY and 19F{1H}‐HOESY NMR: Still More Specific Anion−Cation Interactions

G. Bellachioma, G. Cardaci, A. Macchioni, 2001 .

2‐Phenylquinolones as Inhibitors of the HIV‐1 Tat–TAR Interaction

B. Gatto, M. Palumbo, S. Sabatini, 2009, ChemMedChem.

A 1,8-naphthyridone derivative targets the HIV-1 Tat-mediated transcription and potently inhibits the HIV-1 replication.

C. Pannecouque, A. Knezevich, A. Marcello, 2010, Journal of medicinal chemistry.

Towards the sustainable discovery and development of new antibiotics

H. Petković, I. Gilbert, M. Lindvall, 2021, Nature Reviews Chemistry.

Computer‐Aided Design, Synthesis and Validation of 2‐Phenylquinazolinone Fragments as CDK9 Inhibitors with Anti‐HIV‐1 Tat‐Mediated Transcription Activity

C. Pannecouque, A. Marcello, S. Sabatini, 2013, ChemMedChem.

Solution structure investigations of olefin Pd(II) and Pt(II) complex ion pairs bearing α-diimine ligands by 19F, 1H-HOESY NMR

G. Bellachioma, G. Cardaci, A. Macchioni, 2002 .

PGSE and NOE NMR evidence for higher order aggregation in some cationic ruthenium complexes in both protic and aprotic solvents.

G. Bellachioma, G. Cardaci, A. Macchioni, 2003, Inorganic chemistry.

Structure-activity relationship study on anti-HIV 6-desfluoroquinolones.

C. Pannecouque, J. Balzarini, D. Daelemans, 2008, Journal of medicinal chemistry.

Searching for Novel Inhibitors of the S. aureus NorA Efflux Pump: Synthesis and Biological Evaluation of the 3‐Phenyl‐1,4‐benzothiazine Analogues

G. Kaatz, B. Schindler, S. Sabatini, 2017, ChemMedChem.

1,2,4-Triazolo[1,5-a]pyrimidines as a Novel Class of Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity

C. Pannecouque, E. Tramontano, S. Sabatini, 2020, Molecules.

Design and synthesis of modified quinolones as antitumoral acridones.

S. Sabatini, H. Miao, O. Tabarrini, 1999, Journal of medicinal chemistry.

Broad spectrum anti-flavivirus pyridobenzothiazolones leading to less infective virions.

A. Marcello, G. Quérat, S. Sabatini, 2019, Antiviral research.

Studies on 6-aminoquinolones: synthesis and antibacterial evaluation of 6-amino-8-ethyl- and 6-amino-8-methoxyquinolones.

S. Sabatini, H. Miao, O. Tabarrini, 1999, Bioorganic & medicinal chemistry.

Dibenzo[1,6]naphthyridinediones as Modified Quinolone Antibacterials.

S. Sabatini, O. Tabarrini, V. Cecchetti, 1999 .

Binding studies and GRIND/ALMOND-based 3D QSAR analysis of benzothiazine type K(ATP)-channel openers.

Stefano Sabatini, Raimund Mannhold, Emanuele Carosati, 2005, Bioorganic & medicinal chemistry.

From 6-aminoquinolone antibacterials to 6-amino-7-thiopyranopyridinylquinolone ethyl esters as inhibitors of Staphylococcus aureus multidrug efflux pumps.

E. Carosati, G. Kaatz, Marco Pieroni, 2010, Journal of medicinal chemistry.

Synthesis of 2‐(Arylamino)ethanethiols via Lewis Acid Catalyzed Aminolysis of 2,2‐Dimethylthiirane as Precursors of the 1,4‐Benzothiazine Nucleus.

Roberto Spogli, S. Sabatini, G. Manfroni, 2009 .

The Pyrazolobenzothiazine Core as a New Chemotype of p38 Alpha Mitogen‐Activated Protein Kinase Inhibitors

M. Loza, J. Brea, S. Laufer, 2015, Chemical biology & drug design.

Synthesis and biological evaluation of 2-phenylquinolones targeted at Tat/TAR recognition.

B. Gatto, M. Palumbo, C. Del Vecchio, 2009, Bioorganic & medicinal chemistry letters.

Highly potent 1,4-benzothiazine derivatives as K(ATP)-channel openers.

Roberto Spogli, V. Calderone, S. Sabatini, 2003, Journal of medicinal chemistry.

Antitubercular polyhalogenated phenothiazines and phenoselenazine with reduced binding to CNS receptors.

J. Handzlik, A. Bojarski, G. Satała, 2020, European journal of medicinal chemistry.

Studies on anti-HIV quinolones: new insights on the C-6 position.

C. Pannecouque, D. Daelemans, S. Sabatini, 2009, Bioorganic & medicinal chemistry.

Blocking HIV-1 replication by targeting the Tat-hijacked transcriptional machinery.

S. Sabatini, Serena Massari, O. Tabarrini, 2013, Current pharmaceutical design.

Microbial Efflux Pump Inhibitors: A Journey around Quinoline and Indole Derivatives

S. Sabatini, T. Felicetti, Giada Cernicchi, 2021, Molecules.

From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors

C. Pannecouque, E. Tramontano, S. Sabatini, 2018, Journal of enzyme inhibition and medicinal chemistry.

Studies on Cycloheptathiophene‐3‐carboxamide Derivatives as Allosteric HIV‐1 Ribonuclease H Inhibitors

C. Pannecouque, E. Tramontano, S. Sabatini, 2016, ChemMedChem.

Structural investigation of cycloheptathiophene-3-carboxamide derivatives targeting influenza virus polymerase assembly.

L. Goracci, G. Cruciani, G. Palù, 2013, Journal of medicinal chemistry.

Investigation on the effect of known potent S. aureus NorA efflux pump inhibitors on the staphylococcal biofilm formation

M. Nocchetti, D. Pietrella, R. Pagiotti, 2017 .

Lactoferrin as Antiviral Treatment in COVID-19 Management: Preliminary Evidence

E. Squillaci, F. Iacovelli, M. Falconi, 2021, International journal of environmental research and public health.

Pyridobenzothiazolones Exert Potent Anti-Dengue Activity by Hampering Multiple Functions of NS5 Polymerase.

S. Vasudevan, S. Sabatini, G. Manfroni, 2020, ACS medicinal chemistry letters.

Lactoferrin Against SARS-CoV-2: In Vitro and In Silico Evidences

F. Iacovelli, M. Falconi, A. Terrinoni, 2021, Frontiers in Pharmacology.

Accounting for Target Flexibility and Water Molecules by Docking to Ensembles of Target Structures: The HCV NS5B Palm Site I Inhibitors Case Study

Stefano Sabatini, M. Letizia Barreca, Nunzio Iraci, 2014, Journal of Chemical Information and Modeling.

Q-raKtion: A Semiautomated KNIME Workflow for Bioactivity Data Points Curation

S. Sabatini, Serena Massari, M. Barreca, 2022, J. Chem. Inf. Model..

19F, (1)H-HOESY and PGSE NMR studies of neutral trinuclear complexes of Au(I) and Hg(II): evidence for acid-base stacking in solution.

R. Galassi, A. Macchioni, M. Omary, 2002, Journal of the American Chemical Society.

Drug efflux transporters in Staphylococcus pseudintermedius: in silico prediction and characterization of resistance.

D. Pietrella, S. Sabatini, F. Passamonti, 2022, The Journal of antimicrobial chemotherapy.

Studies on 2-phenylquinoline Staphylococcus aureus NorA efflux pump inhibitors: New insights on the C-6 position.

G. Kaatz, B. Schindler, S. Sabatini, 2018, European journal of medicinal chemistry.

The "racemic approach" in the evaluation of the enantiomeric NorA efflux pump inhibition activity of 2-phenylquinoline derivatives.

G. Kaatz, W. Lindner, B. Natalini, 2016, Journal of pharmaceutical and biomedical analysis.

Discovery of potent p38α MAPK inhibitors through a funnel like workflow combining in silico screening and in vitro validation.

M. Loza, J. Brea, S. Laufer, 2019, European journal of medicinal chemistry.

Ethyl 1,8-naphthyridone-3-carboxylates downregulate human papillomavirus-16 E6 and E7 oncogene expression.

A. Loregian, R. Cavalli, D. Lembo, 2014, Journal of medicinal chemistry.

Alternate NF-κB-Independent Signaling Reactivation of Latent HIV-1 Provirus

J. Hiscott, A. Borsetti, R. Lin, 2019, Journal of Virology.

Functionalized sulfonyl anthranilic acid derivatives inhibit replication of all the four dengue serotypes.

S. Vasudevan, S. Alonso, S. Sabatini, 2023, European journal of medicinal chemistry.

2-Phenylquinoline S. aureus NorA Efflux Pump Inhibitors: Evaluation of the Importance of Methoxy Group Introduction.

K. Kieć‐Kononowicz, G. Kaatz, D. Pietrella, 2018, Journal of medicinal chemistry.

Functionalized 2,1-benzothiazine 2,2-dioxides as new inhibitors of Dengue NS5 RNA-dependent RNA polymerase.

G. Quérat, S. Sabatini, G. Manfroni, 2018, European journal of medicinal chemistry.

Biofunctionalization of Poly(lactide-co-glycolic acid) Using Potent NorA Efflux Pump Inhibitors Immobilized on Nanometric Alpha-Zirconium Phosphate to Reduce Biofilm Formation

M. Nocchetti, M. Pica, D. Pietrella, 2021, Materials.

Ethidium bromide exposure unmasks an antibiotic efflux system in Rhodococcus equi.

D. Pietrella, S. Sabatini, S. Giovagnoli, 2021, The Journal of antimicrobial chemotherapy.

Unconventional Extraction of Total Non-Polar Carotenoids from Pumpkin Pulp and Their Nanoencapsulation

N. Pinna, S. Sabatini, F. Ianni, 2022, Molecules.

New C-6 functionalized quinoline NorA inhibitors strongly synergize with ciprofloxacin against planktonic and biofilm growing resistant Staphylococcus aureus strains.

S. Sabatini, G. Manfroni, Serena Massari, 2022, European journal of medicinal chemistry.

Structure-based discovery of pyrazolobenzothiazine derivatives as inhibitors of hepatitis C virus replication.

Neerja Kaushik-Basu, Stefano Sabatini, Jan Paeshuyse, 2013, Journal of medicinal chemistry.

Identification of Anti-Influenza A Compounds Inhibiting the Viral Non-Structural Protein 1 (NS1) Using a Type I Interferon-Driven Screening Strategy

L. Nencioni, J. Hiscott, Mariangela Agamennone, 2023, International journal of molecular sciences.

Fighting Antimicrobial Resistance: Insights on How the Staphylococcus aureus NorA Efflux Pump Recognizes 2-Phenylquinoline Inhibitors by Supervised Molecular Dynamics (SuMD) and Molecular Docking Simulations

M. Sturlese, S. Moro, S. Sabatini, 2023, J. Chem. Inf. Model..

A Broad Anti-influenza Hybrid Small Molecule That Potently Disrupts the Interaction of Polymerase Acidic Protein-Basic Protein 1 (PA-PB1) Subunits.

G. Cruciani, G. Palù, A. Loregian, 2015, Journal of medicinal chemistry.

Computer‐Aided Design, Synthesis and Validation of 2‐Phenylquinazolinone Fragments as CDK9 Inhibitors with Anti‐HIV‐1 Tat‐Mediated Transcription Activity

C. Pannecouque, A. Marcello, S. Sabatini, 2013, ChemMedChem.

Inhibition of Staphylococcus pseudintermedius Efflux Pumps by Using Staphylococcus aureus NorA Efflux Pump Inhibitors

S. Sabatini, F. Passamonti, V. Stefanetti, 2023, Antibiotics.

Searching for Novel Inhibitors of the S. aureus NorA Efflux Pump: Synthesis and Biological Evaluation of the 3‐Phenyl‐1,4‐benzothiazine Analogues

G. Kaatz, B. Schindler, S. Sabatini, 2017, ChemMedChem.

Discovery of novel inhibitors of the NorA multidrug transporter of Staphylococcus aureus.

G. Cruciani, E. Carosati, G. Kaatz, 2011, Journal of medicinal chemistry.