Victoria A. Assimon

发表

Predicting protein targets for drug-like compounds using transcriptomics

Nicolas A. Pabon, Z. Bar-Joseph, C. Camacho, 2018, bioRxiv.

A Novel Glucose 6-Phosphate Isomerase from Listeria monocytogenes

Pan-Fen Wang, R. Woodard, Victoria A. Assimon, 2014, The Protein Journal.

Mapping Interactions with the Chaperone Network Reveals Factors that Protect Against Tau Aggregation

J. Gestwicki, Mark R. Wilson, M. Zweckstetter, 2018, Nature Structural & Molecular Biology.

Proteome-scale detection of drug-target interactions using correlations in transcriptomic perturbations

Nicolas A. Pabon, Z. Bar-Joseph, C. Camacho, 2018 .

Specific Binding of Tetratricopeptide Repeat Proteins to Heat Shock Protein 70 (Hsp70) and Heat Shock Protein 90 (Hsp90) Is Regulated by Affinity and Phosphorylation.

J. Gestwicki, Victoria A. Assimon, D. Southworth, 2015, Biochemistry.

Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement*

E. Zuiderweg, J. Gestwicki, S. Stevens, 2015, The Journal of Biological Chemistry.

Protein cross-linking capillary electrophoresis at increased throughput for a range of protein-protein interactions.

James P. Grinias, R. Kennedy, A. Mapp, 2018, The Analyst.

Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of Tauopathy.

G. Carlson, E. Zuiderweg, J. Gestwicki, 2016, Cell chemical biology.

Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys

Adam P. Silverman, Jennifer A. Getz, T. Miyamoto, 2020, Science Translational Medicine.

Hsp70 protein complexes as drug targets.

J. Gestwicki, Victoria A. Assimon, J. Rauch, 2012, Current pharmaceutical design.

Binding The Molecular Chaperone Hsp 70 Activates Protein Structure and Folding :

Southworth, E. Zuiderweg, Duxin Sun, 2014 .

The Molecular Chaperone Hsp70 Activates Protein Phosphatase 5 (PP5) by Binding the Tetratricopeptide Repeat (TPR) Domain*

E. Zuiderweg, J. Gestwicki, Duxin Sun, 2013, The Journal of Biological Chemistry.

Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases

L. Grinberg, C. Craik, M. Arkin, 2019, Nature Chemical Biology.

The E3 ubiquitin ligase CHIP and the molecular chaperone Hsc70 form a dynamic, tethered complex.

H. Paulson, E. Zuiderweg, J. Gestwicki, 2013, Biochemistry.

Predicting protein targets for drug-like compounds using transcriptomics

Yan Xia, Ziv Bar-Joseph, Jeffrey L Brodsky, 2018, bioRxiv.

CB-6644 Is a Selective Inhibitor of the RUVBL1/2 Complex with Anticancer Activity.

Yangzhong Tang, Daniel J. Anderson, M. Rolfe, 2019, ACS chemical biology.

High-throughput screen for inhibitors of protein–protein interactions in a reconstituted heat shock protein 70 (Hsp70) complex

T. Komiyama, M. Jacobson, C. Kalyanaraman, 2018, The Journal of Biological Chemistry.

A Local Allosteric Network in Heat Shock Protein 70 (Hsp70) Links Inhibitor Binding to Enzyme Activity and Distal Protein-Protein Interactions.

G. Colombo, G. Morra, S. Rinaldi, 2018, ACS chemical biology.

Concise Synthesis of Spergualin-Inspired Molecules With Broad-Spectrum Antibiotic Activity.

J. Gestwicki, S. Garneau‐Tsodikova, Victoria A. Assimon, 2015, MedChemComm.

Conformational Stability of Mammalian Prion Protein Amyloid Fibrils Is Dictated by a Packing Polymorphism within the Core Region

Southworth, E. Zuiderweg, J. Gestwicki, 2014 .

The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics.

J. Gestwicki, S. Borysov, M. Zweckstetter, 2015, Human molecular genetics.

Tryptophan scanning mutagenesis as a way to mimic the compound-bound state and probe the selectivity of allosteric inhibitors in cells†

G. Colombo, G. Morra, S. Rinaldi, 2020, Chemical science.

The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics.

J. Gestwicki, S. Borysov, M. Zweckstetter, 2015, Human molecular genetics.