H. Locher

发表

Chimeric peptidomimetic antibiotics against Gram-negative bacteria

John A. Robinson, P. Zbinden, T. Sharpe, 2019, Nature.

Dimers of Nostocarboline with Potent Antibacterial Activity

K. Gademann, D. Ritz, S. Schroeder, 2010, Chemotherapy.

Potent algicides based on the cyanobacterial alkaloid nostocarboline.

K. Gademann, J. F. Blom, H. Locher, 2006, Organic letters.

Different Resistance Mechanisms for Cadazolid and Linezolid in Clostridium difficile Found by Whole-Genome Sequencing Analysis

P. Caspers, D. Ritz, H. Locher, 2017, Antimicrobial Agents and Chemotherapy.

Structural basis of translation inhibition by cadazolid, a novel quinoxolidinone antibiotic

P. Caspers, D. Boehringer, M. Leibundgut, 2019, Scientific Reports.

In Vitro and In Vivo Antibacterial Evaluation of Cadazolid, a New Antibiotic for Treatment of Clostridium difﬁcile Infections

D. Ritz, A. Klenk, C. Kelly, 2014 .

4-Sulphobenzoate 3,4-dioxygenase. Purification and properties of a desulphonative two-component enzyme system from Comamonas testosteroni T-2.

T. Leisinger, H. Locher, A. M. Cook, 1991, The Biochemical journal.

Biomimetic total synthesis and antimicrobial evaluation of anachelin H.

K. Gademann, H. Locher, C. Hubschwerlen, 2007, The Journal of organic chemistry.

Synthesis and Characterization of Tetrahydropyran-Based Bacterial Topoisomerase Inhibitors with Antibacterial Activity against Gram-Negative Bacteria.

D. Ritz, H. Locher, P. Seiler, 2017, Journal of medicinal chemistry.

Optimization of LpxC inhibitor lead compounds focusing on efficacy and formulation for high dose intravenous administration.

D. Ritz, R. Lange, S. Diethelm, 2019, Journal of medicinal chemistry.

Degradation of p-toluic acid (p-toluenecarboxylic acid) and p-toluenesulphonic acid via oxygenation of the methyl sidechain is initiated by the same set of enzymes in Comamonas testosteroni T-2

T. Vorherr, S. Hooper, T. Leisinger, 1991 .

Investigations of the Mode of Action and Resistance Development of Cadazolid, a New Antibiotic for Treatment of Clostridium difficile Infections

P. Caspers, D. Ritz, S. Schroeder, 2013, Antimicrobial Agents and Chemotherapy.

Cadazolid , a New Antibiotic for the Treatment of Clostridium difficile Infections : 1 Investigations on the Mode of Action and Resistance Development

P. Caspers, D. Ritz, S. Schroeder, 2013 .

Antimicrobial activity of POL7306 tested against clinical isolates of Gram-negative bacteria collected worldwide.

G. Dale, P. Rhomberg, H. Locher, 2020, The Journal of antimicrobial chemotherapy.

2-(2-Oxo-1,4-dihydro-2H-quinazolin-3-yl)- and 2-(2,2-dioxo-1,4-dihydro-2H-2lambda6-benzo[1,2,6]thiadiazin-3-yl)-N-hydroxy-acetamides as potent and selective peptide deformylase inhibitors.

D. Banner, H. Locher, F. Marlin, 2001, Journal of medicinal chemistry.

Hydroxamic acid derivatives as potent peptide deformylase inhibitors and antibacterial agents.

M. Page, D. Banner, G. Rosse, 2000, Journal of medicinal chemistry.

Structure-activity relationship in the oxazolidinone-quinolone hybrid series: influence of the central spacer on the antibacterial activity and the mode of action.

S. Schroeder, H. Locher, C. Hubschwerlen, 2003, Bioorganic & medicinal chemistry letters.

Design, synthesis and biological evaluation of oxazolidinone-quinolone hybrids.

S. Schroeder, H. Locher, C. Hubschwerlen, 2003, Bioorganic & medicinal chemistry.

Design, synthesis, and characterization of novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram-positive activity.

Wolfgang Keck, Christopher Kohl, Daniel Ritz, 2013, Journal of medicinal chemistry.

4-Toluene sulfonate methyl-monooxygenase from Comamonas testosteroni T-2: purification and some properties of the oxygenase component

T. Leisinger, H. Locher, A. M. Cook, 1991, Journal of bacteriology.

Structural basis of translation inhibition by cadazolid, a novel quinoxolidinone antibiotic

P. Caspers, D. Boehringer, M. Leibundgut, 2019, Scientific reports.

Biomimetic total synthesis and antimicrobial evaluation of anachelin H.

K. Gademann, H. Locher, C. Hubschwerlen, 2007, The Journal of organic chemistry.

Peptide Deformylase as an Antibacterial Drug Target: Target Validation and Resistance Development

M. Page, H. Locher, B. Takács, 2001, Antimicrobial Agents and Chemotherapy.

Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity.

L. Prade, D. Ritz, R. Lange, 2012, Bioorganic & medicinal chemistry letters.

The targets of currently used antibacterial agents: lessons for drug discovery.

R. Lange, H. Locher, R. Then, 2007, Current pharmaceutical design.

Chimeric peptidomimetic antibiotics against Gram-negative bacteria

John A. Robinson, P. Zbinden, T. Sharpe, 2019, Nature.

Time‐kill kinetics of cadazolid and comparator antibacterial agents against different ribotypes of Clostridium difficile

H. Locher, D. Corbett, Kirsty Skinner, 2018, Journal of medical microbiology.

Infections: In Vitro and in Vivo Antibacterial Evaluation

D. Ritz, A. Klenk, C. Kelly, 2013 .

Degradation of p-toluenesulphonic acid via sidechain oxidation, desulphonation and meta ring cleavage in Pseudomonas (Comamonas) testosteroni T-2.

T. Leisinger, H. Locher, A. M. Cook, 1989, Journal of general microbiology.

3-Nitrobenzenesulfonate, 3-Aminobenzenesulfonate, and 4-Aminobenzenesulfonate as Sole Carbon Sources for Bacteria

T. Thurnheer, T. Leisinger, H. Locher, 1989, Applied and environmental microbiology.

Uptake of 4-toluene sulfonate by Comamonas testosteroni T-2

B. Poolman, W. Konings, H. Locher, 1993, Journal of Bacteriology.

Novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram positive activity and improved safety profile.

D. Ritz, H. Locher, P. Seiler, 2015, Journal of medicinal chemistry.

In Vitro and In Vivo Antibacterial Evaluation of Cadazolid, a New Antibiotic for Treatment of Clostridium difficile Infections

D. Ritz, A. Klenk, C. Kelly, 2013, Antimicrobial Agents and Chemotherapy.

Cadazolid Does Not Promote Intestinal Colonization of Vancomycin-Resistant Enterococci in Mice

D. Ritz, H. Locher, P. Seiler, 2015, Antimicrobial Agents and Chemotherapy.

Identification of Genes Required for Resistance to Peptidomimetic Antibiotics by Transposon Sequencing

John A. Robinson, G. Pessi, L. Eberl, 2020, Frontiers in Microbiology.

Novel dihydrofolate reductase inhibitors. Structure-based versus diversity-based library design and high-throughput synthesis and screening.

Martin Stahl, P. Gerber, M. Stahl, 2003, Journal of medicinal chemistry.

A single amino acid substitution in Staphylococcus aureus dihydrofolate reductase determines trimethoprim resistance.

M. Page, A. D'arcy, C. Oefner, 1997, Journal of molecular biology.

Time‐kill kinetics of cadazolid and comparator antibacterial agents against different ribotypes of Clostridium difficile

H. Locher, D. Corbett, Kirsty Skinner, 2018, Journal of medical microbiology.

Investigations of the Mode of Action and Resistance Development of Cadazolid, a New Antibiotic for Treatment of Clostridium difficile Infections

P. Caspers, D. Ritz, S. Schroeder, 2013, Antimicrobial Agents and Chemotherapy.