M. Lolli

发表

A novel SWCNT platform bearing DOTA and β-cyclodextrin units. "One shot" multidecoration under microwave irradiation.

E. Terreno, E. Calcio Gaudino, G. Cravotto, 2014, Organic & biomolecular chemistry.

Refining the chemical toolbox to be fit for educational and practical purpose for drug discovery in the 21st Century.

C. Fishwick, M. Lolli, K. Pors, 2015, Drug discovery today.

Androgen-AR axis in primary and metastatic prostate cancer: chasing steroidogenic enzymes for therapeutic intervention

S. Oliaro-Bosso, D. Boschi, M. Lolli, 2017 .

Dihydroorotate dehydrogenase inhibitors in anti-infective drug research.

D. Boschi, M. Lolli, A. Pippione, 2019, European journal of medicinal chemistry.

Recent advances in the synthesis of analogues of phytohormones strigolactones with ring-closing metathesis as a key step.

F. Spyrakis, C. Prandi, M. Lolli, 2017, Organic & biomolecular chemistry.

A New NF-κB Inhibitor, MEDS-23, Reduces the Severity of Adverse Post-Ischemic Stroke Outcomes in Rats

J. Kaplanski, C. Cifani, D. Boschi, 2021, Brain sciences.

Searching for new NO-donor aspirin-like molecules: Furoxanylacyl derivatives of salicylic acid and related furazans.

E. Guaita, G. Coruzzi, Elisabetta Marini, 2011, Bioorganic & medicinal chemistry.

Use of the 4-Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands.

J. Kastrup, K. Hansen, D. Boschi, 2019, Journal of medicinal chemistry.

The Synergism between DHODH Inhibitors and Dipyridamole Leads to Metabolic Lethality in Acute Myeloid Leukemia

P. Circosta, D. Cilloni, G. Saglio, 2020, bioRxiv.

Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and pharmacological characterization of gamma-aminobutyric acid (GABA) related compounds.

U. Kristiansen, B. Rolando, R. Fruttero, 2006, Journal of medicinal chemistry.

The New Generation hDHODH Inhibitor MEDS433 Hinders the In Vitro Replication of SARS-CoV-2 and Other Human Coronaviruses

N. Montserrat, A. Luganini, G. Gribaudo, 2021, Microorganisms.

Urinary excretion of O6-butylguanine after the administration of N-nitroso-N-butylurea in rats.

R. Fanelli, L. Airoldi, R. Bagnati, 1992, Cancer research.

Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Aryloxyaryl Moiety

P. Circosta, B. Rolando, S. Al-Karadaghi, 2022, Journal of medicinal chemistry.

Exploring the intramolecular catalysis of the proton exchange process to modulate the relaxivity of Gd(iii)-complexes of HP-DO3A-like ligands.

S. Aime, M. Lolli, L. Lattuada, 2018, Chemical communications.

Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia

F. Orso, P. Circosta, D. Taverna, 2022, Cell Death & Disease.

Identification of Human Dihydroorotate Dehydrogenase Inhibitor by a Pharmacophore-Based Virtual Screening Study

D. Boschi, T. Tuccinardi, M. Giorgis, 2022, Molecules.

Hydroxyazoles as acid isosteres and their drug design applications—Part 2: Bicyclic systems

D. Boschi, M. Lolli, A. Pippione, 2021, Advances in Heterocyclic Chemistry.

A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action

A. Rosato, P. Carloni, E. Baloglu, 2017, Nature Communications.

Structure–activity relationships of strigolactones via a novel, quantitative in planta bioassay

F. Spyrakis, F. Cardinale, C. Prandi, 2018, Journal of Experimental Botany.

Michael addition of Grignard reagents to tetraethyl ethenylidenebisphosphonate

L. Lazzarato, R. Fruttero, A. Gasco, 2002 .

Heterocyclic ring cleavage upon collision-induced dissociation of deprotonated 3-hydroxy-1,2,5-oxadiazoles (3-hydroxyfurazans).

Robert L. White, D. Boschi, M. Lolli, 2015, Journal of mass spectrometry : JMS.

N-Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK.

M. Kubbutat, J. Contreras, S. Al-Karadaghi, 2018, MedChemComm.

Antiinflammatory, gastrosparing, and antiplatelet properties of new NO-donor esters of aspirin.

E. Guaita, G. Coruzzi, L. Lazzarato, 2003, Journal of Medicinal Chemistry.

Hydroxyazoles as acid isosteres and their drug design applications—Part 1: Monocyclic systems

D. Boschi, M. Lolli, A. Pippione, 2021, Advances in Heterocyclic Chemistry.

Regioselective N‐Alkylation of Ethyl 4‐Benzyloxy‐1,2,3‐triazolecarboxylate: A Useful Tool for the Synthesis of Carboxylic Acid Bioisosteres

Robert L. White, B. Rolando, K. Martina, 2018, Journal of Heterocyclic Chemistry.

Substituted 4-hydroxy-1,2,3-triazoles: synthesis, characterization and first drug design applications through bioisosteric modulation and scaffold hopping approaches

K. Janda, K. Martina, F. Dosio, 2015 .

Synthesis and preliminary pharmacological characterisation of a new class of nitrogen-containing bisphosphonates (N-BPs).

P. Tosco, B. Rolando, L. Lazzarato, 2010, Bioorganic & medicinal chemistry.

Synthesis of NO-donor bisphosphonates and their in-vitro action on bone resorption.

B. Rolando, L. Lazzarato, R. Fruttero, 2005, Journal of medicinal chemistry.

One-Pot Alkoxymercuriation-Bromodemercuriation: A Versatile Access to 3-Alkoxy-2-bromopropanoic Esters

P. Anelli, M. Lolli, F. Uggeri, 1993 .

Five-membered N-heterocyclic Scaffolds as Novel Amino Bioisosteres at -Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters.

D. Gloriam, B. Rolando, D. Boschi, 2019, Journal of medicinal chemistry.

4-Hydroxy-1,2,3-triazole moiety as bioisostere of the carboxylic acid function: a novel scaffold to probe the orthosteric γ-aminobutyric acid receptor binding site.

B. Rolando, D. Boschi, B. Frølund, 2018, European journal of medicinal chemistry.

A new class of ibuprofen derivatives with reduced gastrotoxicity.

G. Coruzzi, L. Lazzarato, C. Cena, 2001, Journal of medicinal chemistry.

Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid.

W. Y. Wahlgren, Elisabetta Marini, S. Oliaro-Bosso, 2018, European journal of medicinal chemistry.

Studies on Agents with Mixed NO-Dependent Vasodilating and β-Blocking Activities

C. Cena, R. Fruttero, A. Gasco, 1997, Pharmaceutical Research.

The Novel hDHODH Inhibitor MEDS433 Prevents Influenza Virus Replication by Blocking Pyrimidine Biosynthesis

A. Luganini, G. Gribaudo, D. Boschi, 2022, Viruses.

Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Biphenyl Moiety

P. Circosta, B. Rolando, S. Al-Karadaghi, 2021, Journal of medicinal chemistry.

Effective deploying of a novel DHODH inhibitor against herpes simplex type 1 and type 2 replication.

A. Luganini, G. Gribaudo, D. Boschi, 2021, Antiviral research.

Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors.

P. Circosta, B. Rolando, S. Al-Karadaghi, 2018, Journal of medicinal chemistry.

Synthesis of labelled [15N3]‐6‐bromopurine, a useful precursor of 15N‐labelled O6‐alkylguanines, to be used as internal standards for quantitative GC‐MS analyses

R. Fanelli, C. Medana, L. Airoldi, 1998 .

Unsymmetrically substituted furoxans. XVII. Structural investigations in benzenesulfonylfuroxan derivatives and related compounds

R. Fruttero, A. Gasco, G. Ermondi, 1997 .

Targeting Human Onchocerciasis: Recent Advances Beyond Ivermectin

F. Dosio, D. Boschi, M. Lolli, 2018 .

MDP, a database linking drug response data to genomic information, identifies dasatinib and statins as a combinatorial strategy to inhibit YAP/TAZ in cancer cells

Domenico Beneventano, Laura Anderlucci, Jimmy Caroli, 2015, Oncotarget.

Multiple catalytic activities of human 17β-hydroxysteroid dehydrogenase type 7 respond differently to inhibitors.

F. Spyrakis, S. Oliaro-Bosso, D. Poirier, 2019, Biochimie.

Bioisosteres of Indomethacin as Inhibitors of Aldo-Keto Reductase 1C3.

W. Y. Wahlgren, Elisabetta Marini, B. Rolando, 2019, ACS medicinal chemistry letters.

Detection of O6-butyl- and O6-(4-hydroxybutyl)guanine in urothelial and hepatic DNA of rats given the bladder carcinogen N-nitrosobutyl(4-hydroxybutyl)amine.

R. Fanelli, M. Bonfanti, C. Medana, 1994, Carcinogenesis.

Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds.

C. Andrade, M. Piccinini, R. Friemann, 2017, European journal of medicinal chemistry.

New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffold.

P. Tosco, R. Fruttero, A. Gasco, 2012, European journal of medicinal chemistry.

1,2,5-Oxadiazole analogues of leflunomide and related compounds.

P. Tosco, B. Rolando, R. Fruttero, 2011, European journal of medicinal chemistry.

SAR studies on H2 antagonists containing alkylamino substituted 1,2, 5-thiadiazole 1-oxide moieties.

G. Coruzzi, M. Adami, C. Cena, 1998, Farmaco.

4-hydroxy-1,2,5-oxadiazol-3-yl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and molecular pharmacological characterization at ionotropic glutamate receptors of compounds related to glutamate and its homologues.

B. Rolando, R. Fruttero, A. Gasco, 2010, Journal of medicinal chemistry.

Molecular Pharmacological Characterization at Ionotropic Glutamate Receptors of Compounds Related to Glutamate and Its Homologues /

B. Rolando, R. Fruttero, A. Gasco, 2022 .

Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity.

S. Oliaro-Bosso, D. Boschi, M. Lolli, 2019, MedChemComm.

2 1 , 2 , 5-Oxadiazole analogues of leflunomide and related compounds

P. Tosco, B. Rolando, R. Fruttero, 2022 .

Use of human Dihydroorotate Dehydrogenase (hDHODH) Inhibitors in Autoimmune Diseases and New Perspectives in Cancer Therapy.

F. Dosio, D. Boschi, M. Giorgis, 2018, Recent patents on anti-cancer drug discovery.

Hydroxyazole scaffold-based Plasmodium falciparum dihydroorotate dehydrogenase inhibitors: Synthesis, biological evaluation and X-ray structural studies.

C. Andrade, B. Rolando, S. Al-Karadaghi, 2019, European journal of medicinal chemistry.

4-Hydroxy-N-[3,5-bis(trifluoromethyl)phenyl]-1,2,5-thiadiazole-3-carboxamide: a novel inhibitor of the canonical NF-κB cascade.

M. Kubbutat, J. Contreras, S. Al-Karadaghi, 2017, MedChemComm.

New aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the hydroxytriazole scaffold.

F. Spyrakis, B. Rolando, D. Boschi, 2022, European journal of medicinal chemistry.

Biochemical characterization of Mycobacterium tuberculosis dihydroorotate dehydrogenase and identification of a selective inhibitor

R. Miggiano, M. Rizzi, D. Boschi, 2023, FEBS letters.

Phenothiazines as anti-cancer agents: SAR overview and synthetic strategies.

D. Boschi, M. Lolli, Deepak Kumar, 2023, European journal of medicinal chemistry.

Hydroxytriazole derivatives as potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors discovered by bioisosteric scaffold hopping approach.

Elisabetta Marini, C. Cena, D. Boschi, 2017, European journal of medicinal chemistry.

Computational Method for Structure-Based Analysis of SAR Transfer.

J. Bajorath, M. Lolli, D. Bonanni, 2020, Journal of medicinal chemistry.

Exploring the Potential of Sulfur Moieties in Compounds Inhibiting Steroidogenesis

D. Boschi, M. Lolli, Tomasz M. Wróbel, 2023, Biomolecules.

Hydroxytriazole derivatives as potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors discovered by bioisosteric scaffold hopping approach.

Elisabetta Marini, C. Cena, D. Boschi, 2017, European journal of medicinal chemistry.

The University of Bradford Institutional Repository

C. Cena, D. Boschi, Annalisa Costale, 2022 .

Synthesis and preliminary pharmacological characterisation of a new class of nitrogen-containing bisphosphonates (N-BPs).

P. Tosco, B. Rolando, L. Lazzarato, 2010, Bioorganic & medicinal chemistry.

The role of fluorine in stabilizing the bioactive conformation of dihydroorotate dehydrogenase inhibitors

P. Tosco, R. Fruttero, M. Giorgis, 2013, Journal of Molecular Modeling.

A novel SWCNT platform bearing DOTA and β-cyclodextrin units. "One shot" multidecoration under microwave irradiation.

E. Terreno, K. Martina, A. Barge, 2014, Organic & biomolecular chemistry.

AI is a viable alternative to high throughput screening: a 318-target study

Eva M García-Cuesta, Frederick S. Vizeacoumar, Stephen J. Capuzzi, 2024, Scientific reports.

Mechanisms of antiviral activity of the new hDHODH inhibitor MEDS433 against respiratory syncytial virus replication.

A. Luganini, D. Boschi, M. Lolli, 2023, Antiviral research.

A comprehensive review of synthetic strategies and SAR studies for the discovery of PfDHODH inhibitors as antimalarial agents. Part 1: triazolopyrimidine, isoxazolopyrimidine and pyrrole-based (DSM) compounds.

V. Vyas, T. Tuccinardi, M. Lolli, 2024, Bioorganic chemistry.

The new generation hDHODH inhibitor MEDS433 hinders the in vitro replication of SARS-CoV-2

A. Luganini, G. Gribaudo, D. Boschi, 2020, bioRxiv.