K. Takeuchi

发表

Poisson-gap sampling and forward maximum entropy reconstruction for enhancing the resolution and sensitivity of protein NMR data.

S. Hyberts, G. Wagner, K. Takeuchi, 2010, Journal of the American Chemical Society.

Mutation-induced change in chignolin stability from π-turn to α-turn

A. Mitsutake, Y. Maruyama, Misaki Imai, 2020, RSC advances.

HNCA-TOCSY-CANH experiments with alternate 13C-12C labeling: a set of 3D experiment with unique supra-sequential information for mainchain resonance assignment

G. Wagner, I. Shimada, Hideo Takahashi, 2011, Journal of biomolecular NMR.

NMR studies of protein interactions.

Koh Takeuchi, Gerhard Wagner, G. Wagner, 2006, Current opinion in structural biology.

Structural basis of the KcsA K(+) channel and agitoxin2 pore-blocking toxin interaction by using the transferred cross-saturation method.

Haruki Nakamura, I. Shimada, Hideo Takahashi, 2003, Structure.

Targeting the cryptic sites: NMR-based strategy to improve protein druggability by controlling the conformational equilibrium

I. Shimada, H. Hanzawa, Misaki Imai, 2020, Science Advances.

The role of NMR in leveraging dynamics and entropy in drug design

M. Reibarkh, H. Arthanari, K. Takeuchi, 2020, Journal of Biomolecular NMR.

Direct determination of a membrane-peptide interface using the nuclear magnetic resonance cross-saturation method.

I. Shimada, Hideo Takahashi, T. Kohno, 2005, Biophysical journal.

Bead-linked proteoliposomes: a reconstitution method for nmr analyses of membrane protein-ligand interactions.

I. Shimada, K. Takeuchi, M. Yokogawa, 2005, Journal of the American Chemical Society.

Prediction of Passive Membrane Permeability by Semi‐Empirical Method Considering Viscous and Inertial Resistances and Different Rates of Conformational Change and Diffusion

Hironori K. Nakamura, Y. Fukunishi, T. Mashimo, 2019, Molecular informatics.

1-13C amino acid selective labeling in a 2H15N background for NMR studies of large proteins

G. Wagner, T. Malia, K. Takeuchi, 2007, Journal of biomolecular NMR.

Allosteric enhancement of MAP kinase p38α's activity and substrate selectivity by docking interactions

I. Shimada, Hideo Takahashi, K. Takeuchi, 2014, Nature Structural &Molecular Biology.

Emerging solution NMR methods to illuminate the structural and dynamic properties of proteins.

G. Wagner, H. Arthanari, K. Takeuchi, 2019, Current opinion in structural biology.

Nitrogen-detected TROSY yields comparable sensitivity to proton-detected TROSY for non-deuterated, large proteins under physiological salt conditions

G. Wagner, I. Shimada, H. Arthanari, 2016, Journal of biomolecular NMR.

Nitrogen detected TROSY at high field yields high resolution and sensitivity for protein NMR

G. Wagner, I. Shimada, H. Arthanari, 2015, Journal of biomolecular NMR.

CACA-TOCSY with alternate 13C–12C labeling: a 13Cα direct detection experiment for mainchain resonance assignment, dihedral angle information, and amino acid type identification

G. Wagner, D. Frueh, Zhen-Yu J Sun, 2010, Journal of biomolecular NMR.

High-resolution 3D CANCA NMR experiments for complete mainchain assignments using C(alpha) direct detection.

S. Hyberts, G. Wagner, D. Frueh, 2010, Journal of the American Chemical Society.

Structure determination using solution NMR: Is it worth the effort?

Koh Takeuchi, Haribabu Arthanari, Kumaran Baskaran, 2019, Journal of magnetic resonance.

Alternate 13C-12C labeling for complete mainchain resonance assignments using C alpha direct-detection with applicability toward fast relaxing protein systems.

G. Wagner, Zhen-Yu J Sun, K. Takeuchi, 2008, Journal of the American Chemical Society.

Auto-inhibitory interaction in the multidomain adaptor protein Nck: possible roles in improving specificity and functional diversity

G. Wagner, Zhen-Yu J Sun, K. Takeuchi, 2011 .

3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents.

C. Müller, M. Gütschow, A. Kawaguchi, 2021, Journal of medicinal chemistry.

Distinctive CD3 Heterodimeric Ectodomain Topologies Maximize Antigen-Triggered Activation of αβ T Cell Receptors

E. Reinherz, G. Wagner, Zhen-Yu J Sun, 2010, The Journal of Immunology.

Rapid identification of ligand-binding sites by using an assignment-free NMR approach.

Yuya Kodama, N. Shimba, E. Suzuki, 2013, Journal of medicinal chemistry.

The GTP responsiveness of PI5P4Kβ evolved from a compromised trade-off between activity and specificity.

Kaori Fukuzawa, A. Sasaki, A. Harada, 2022, Structure.

Role of the Orphan Transporter SLC35E1 in the Nuclear Egress of Herpes Simplex Virus 1

M. Oyama, S. Miyano, S. Imoto, 2022, Journal of virology.

NMR resonance assignments of the catalytic domain of human serine/threonine phosphatase calcineurin in unligated and PVIVIT-peptide-bound states

G. Wagner, K. Takeuchi, Zhen-Yu J. Sun, 2015, Biomolecular NMR assignments.

Molecular Basis of the High-Affinity Activation of Skeletal Ryanodine Receptor Ca^ -Release Channel by Imperatoxin A

I. Shimada, Hideo Takahashi, Kazuki Sato, 2005 .

A Homogeneous, High-Throughput Assay for Phosphatidylinositol 5-Phosphate 4-Kinase with a Novel, Rapid Substrate Preparation

Mindy I. Davis, L. Cantley, A. Simeonov, 2013, PloS one.

Conformational equilibrium defines the variable induction of the multidrug-binding transcriptional repressor QacR

I. Shimada, Misaki Imai, K. Takeuchi, 2019, Proceedings of the National Academy of Sciences.

The crystal structure of a new O‐demethylase from Sphingobium sp. strain SYK‐6

N. Kamimura, E. Masai, A. Harada, 2017, The FEBS journal.

Quantitative Structure‐activity Relationship (QSAR) Models for Docking Score Correction

Y. Fukunishi, Haruki Nakamura, S. Yamasaki, 2016, Molecular informatics.

A BRET-based assay reveals collagen–Hsp47 interaction dynamics in the endoplasmic reticulum and small-molecule inhibition of this interaction

T. Doi, Masahito Yoshida, S. Ito, 2019, The Journal of Biological Chemistry.

A small-molecule compound inhibits a collagen-specific molecular chaperone and could represent a potential remedy for fibrosis

K. Shin‐ya, T. Hirokawa, I. Shimada, 2017, The Journal of Biological Chemistry.

Structure-Based Development of a Protein-Protein Interaction Inhibitor Targeting Tumor Necrosis Factor Receptor-Associated Factor 6.

Y. Fukunishi, I. Shimada, A. Inoue, 2015, Journal of medicinal chemistry.

Autoinhibitory interaction in the multidomain adaptor protein Nck: possible roles in improving specificity and functional diversity.

G. Wagner, K. Takeuchi, Zhen-Yu J. Sun, 2010, Biochemistry.

Ubiquitination of K-Ras Enhances Activation and Facilitates Binding to Select Downstream Effectors

P. Pandolfi, L. Cantley, J. Asara, 2011, Science Signaling.

Nitrogen detected TROSY at high field yields high resolution and sensitivity for protein NMR

G. Wagner, I. Shimada, H. Arthanari, 2015, Journal of Biomolecular NMR.

Increased resolution of aromatic cross peaks using alternate 13C labeling and TROSY

G. Wagner, A. Boeszoermenyi, H. Arthanari, 2015, Journal of Biomolecular NMR.

The LxVP and PxIxIT NFAT Motifs Bind Simultaneously to Overlapping Epitopes in Calcineurin’s Catalytic Domain CnA Distant to the Regulatory Domain CnB

R. E. Luna, Gerhard Wagner, K. Takeuchi, 2014 .

Design, synthesis, and structural characterization of helix-forming aliphatic homo-δ-peptides based on conformational restriction due to the structural characteristics of cyclopropane

S. Shuto, T. Kameda, K. Takeuchi, 2021 .

Channel-forming Membrane Permeabilization by an Antibacterial Protein, Sapecin

Koh Takeuchi, Hideo Takahashi, Toshiyuki Kohno, 2004, Journal of Biological Chemistry.

Flexibility and Cell Permeability of Cyclic Ras-Inhibitor Peptides Revealed by the Coupled Nosé-Hoover Equation

Y. Fukunishi, K. Moritsugu, J. Higo, 2021, J. Chem. Inf. Model..

Aromatic 19F-13C TROSY: A background-free approach to probe biomolecular structure, function and dynamics

C. Anklin, G. Wagner, I. Kuprov, 2019, Nature Methods.

Increased resolution of aromatic cross peaks using alternate 13C labeling and TROSY

G. Wagner, A. Boeszoermenyi, H. Arthanari, 2015, Journal of biomolecular NMR.

Mixed pyruvate labeling enables backbone resonance assignment of large proteins using a single experiment

Paul W. Coote, S. Hyberts, G. Wagner, 2018, Nature Communications.

Role of NMR in High Ordered Structure Characterization of Monoclonal Antibodies

K. Takeuchi, Yuji Tokunaga, 2020, International journal of molecular sciences.

Structural Fingerprints of an Intact Monoclonal Antibody Acquired under Formulated Storage Conditions via 15N Direct Detection Nuclear Magnetic Resonance.

T. Torizawa, I. Shimada, K. Takeuchi, 2020, Journal of medicinal chemistry.

Spotlight on the Ballet of Proteins: The Structural Dynamic Properties of Proteins Illuminated by Solution NMR

H. Arthanari, Thibault Viennet, K. Takeuchi, 2020, International journal of molecular sciences.

Anti-Tumor Potential of IMP Dehydrogenase Inhibitors: A Century-Long Story

Eric P. Smith, A. Sasaki, Kara Wolfe, 2019, Cancers.

Perspective: revisiting the field dependence of TROSY sensitivity

G. Wagner, H. Arthanari, K. Takeuchi, 2016, Journal of Biomolecular NMR.

Perspective: revisiting the field dependence of TROSY sensitivity

Koh Takeuchi, Gerhard Wagner, Haribabu Arthanari, 2016, Journal of biomolecular NMR.

Functional dynamics of proteins revealed by solution NMR.

I. Shimada, N. Nishida, K. Takeuchi, 2012, Current opinion in structural biology.

Nitrogen-detected TROSY yields comparable sensitivity to proton-detected TROSY for non-deuterated, large proteins under physiological salt conditions

Gerhard Wagner, I. Shimada, H. Arthanari, 2016, Journal of Biomolecular NMR.

Nitrogen-detected CAN and CON experiments as alternative experiments for main chain NMR resonance assignments

G. Wagner, D. Frueh, G. Heffron, 2010, Journal of biomolecular NMR.

Transcription Factor Binding in Embryonic Stem Cells Is Constrained by DNA Sequence Repeat Symmetry.

Oren Ram, E. Meshorer, M. Imashimizu, 2020, Biophysical journal.

Divergent Mechanisms Activating RAS and Small GTPases Through Post-translational Modification

Ryouko Kamata, A. Sasaki, S. Campbell, 2021, Frontiers in Molecular Biosciences.

Cross-saturation and transferred cross-saturation experiments

I. Shimada, N. Nishida, K. Takeuchi, 2009, Quarterly Reviews of Biophysics.

Degradation of Activated K-Ras Orthologue via K-Ras-specific Lysine Residues Is Required for Cytokinesis*

Pascale G. Charest, R. Firtel, J. Asara, 2013, The Journal of Biological Chemistry.

The LxVP and PxIxIT NFAT motifs bind jointly to overlapping epitopes on calcineurin's catalytic domain distant to the regulatory domain.

R. E. Luna, G. Wagner, K. Takeuchi, 2014, Structure.

Screening for inhibitor of episomal DNA identified dicumarol as a hepatitis B virus inhibitor

K. Chayama, T. Fujita, Y. Iwasawa, 2019, PloS one.

15N detection harnesses the slow relaxation property of nitrogen: Delivering enhanced resolution for intrinsically disordered proteins

Norman E. Davey, N. Davey, G. Wagner, 2018, Proceedings of the National Academy of Sciences.

Structure of the VP16 Transactivator Target in ARC/Mediator

R. E. Luna, G. Wagner, A. Näär, 2010, Nature Structural &Molecular Biology.

Structural and functional evidence that Nck interaction with CD3epsilon regulates T-cell receptor activity.

E. Reinherz, G. Wagner, K. Takeuchi, 2008, Journal of molecular biology.

Activity-specificity trade-off gives PI5P4Kβ a nucleotide preference to function as a GTP-sensing kinase

Kaori Fukuzawa, A. Sasaki, A. Harada, 2020, bioRxiv.

The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis.

J. Asara, J. Locasale, T. Yokota, 2016, Molecular cell.

Dynamic equilibrium on DNA defines transcriptional regulation of a multidrug binding transcriptional repressor, LmrR

I. Shimada, Misaki Imai, K. Takeuchi, 2017, Scientific Reports.

Dynamic multidrug recognition by multidrug transcriptional repressor LmrR

I. Shimada, Hideo Takahashi, Misaki Imai, 2014, Scientific Reports.

Structural reverse genetics study of the PI5P4Kβ–nucleotide complexes reveals the presence of the GTP bioenergetic system in mammalian cells

A. Sasaki, K. Takeuchi, Satoshi Kofuji, 2016, The FEBS journal.

The Lipid Kinase PI 5 P 4 K b Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis Graphical

J. Asara, J. Locasale, T. Yokota, 2016 .

P 2 : phosphatidylinositol 4 , 5-diphosphate PTEN : phosphatase and tensin homolog TNFAIP 3 / A 20 : tumor necrosis factor alpha-induced protein 3 PVP : polyvinylpyrrolidone K 15 WT :

A. Sasaki, K. Takeuchi, Satoshi Kofuji, 2016 .

Dynamic equilibrium on DNA defines transcriptional regulation of a multidrug binding transcriptional repressor, LmrR

I. Shimada, Misaki Imai, K. Takeuchi, 2017, Scientific Reports.

Forbidden Coherence Transfer of 19F Nuclei to Quantitatively Measure the Dynamics of a CF3-Containing Ligand in Receptor-Bound States

I. Shimada, K. Takeuchi, Yuji Tokunaga, 2017, Molecules.

Improvement of Ligand Affinity and Thermodynamic Properties by NMR-Based Evaluation of Local Dynamics and Surface Complementarity in the Receptor-Bound State.

I. Shimada, H. Hanzawa, K. Takeuchi, 2016, Angewandte Chemie.

Perdeuteration and methyl-selective 1H, 13C-labeling by using a Kluyveromyces lactis expression system

I. Shimada, Hideo Takahashi, T. Sugiki, 2013, Journal of Biomolecular NMR.

Functional Equilibrium of the KcsA Structure Revealed by NMR*

S. Oiki, I. Shimada, K. Takeuchi, 2012, The Journal of Biological Chemistry.

Use of Multiple Cryoprotectants to Improve Diffraction Quality from Protein Crystals

A. Sasaki, M. Hatakeyama, K. Takeuchi, 2016 .

Functional dynamics of cell surface membrane proteins.

I. Shimada, N. Nishida, K. Takeuchi, 2014, Journal of magnetic resonance.

Structural Basis for the Golgi Association by the Pleckstrin Homology Domain of the Ceramide Trafficking Protein (CERT)*

I. Shimada, Hideo Takahashi, T. Sugiki, 2012, The Journal of Biological Chemistry.

Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau

D. Agard, Miguel Betegon, J. Gestwicki, 2018, Nature Communications.

The αβ T Cell Receptor Is an Anisotropic Mechanosensor*

E. Reinherz, G. Wagner, C. Castro, 2009, The Journal of Biological Chemistry.

Phosphoinositide binding by the PH domain in ceramide transfer protein (CERT) is inhibited by hyperphosphorylation of an adjacent serine-repeat motif

T. Fujiwara, C. Kojima, I. Shimada, 2018, The Journal of Biological Chemistry.

Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau

D. Agard, Miguel Betegon, J. Gestwicki, 2018, Nature Communications.

Suppression of Problematic Compound Oligomerization by Cosolubilization of Nondetergent Sulfobetaines

I. Shimada, Hideo Takahashi, H. Hanzawa, 2015, ChemMedChem.

Protein-ligand docking guided by ligand pharmacophore-mapping experiment by NMR.

Haruki Nakamura, Koh Takeuchi, Hideo Takahashi, 2011, Journal of molecular graphics & modelling.

Solution Structure of ω-Grammotoxin SIA, A Gating Modifier of P/Q and N-type Ca2+ Channel

I. Shimada, Hideo Takahashi, J. Kim, 2002 .

Speeding up direct 15N detection: hCaN 2D NMR experiment

G. Wagner, K. Takeuchi, M. Gal, 2011, Journal of biomolecular NMR.

Solution Structure of the First Src Homology 3 Domain of Human Nck2

G. Wagner, K. Takeuchi, Sunghyouk Park, 2006, Journal of biomolecular NMR.

NMR Analyses of the Gβγ Binding and Conformational Rearrangements of the Cytoplasmic Pore of G Protein-activated Inwardly Rectifying Potassium Channel 1 (GIRK1)*

I. Shimada, K. Takeuchi, M. Osawa, 2010, The Journal of Biological Chemistry.

Molecular basis of the high-affinity activation of type 1 ryanodine receptors by imperatoxin A.

D. H. Kim, I. Shimada, Hideo Takahashi, 2004, The Biochemical journal.

I. Shimada, K. Takeuchi, Takumi Ueda, 2021, Membranes.

Backbone resonance assignments for the cytoplasmic regions of G protein-activated inwardly rectifying potassium channel 1 (GIRK1)

I. Shimada, T. Muramatsu, K. Takeuchi, 2009, Biomolecular NMR assignments.

Development of a method for reconstruction of crowded NMR spectra from undersampled time-domain data

I. Shimada, K. Takeuchi, Takumi Ueda, 2015, Journal of biomolecular NMR.

Aromatic 19F-13C TROSY: A background-free approach to probe biomolecular structure, function and dynamics

C. Anklin, G. Wagner, I. Kuprov, 2019, Nature Methods.

Structural basis underlying the dual gate properties of KcsA

I. Shimada, K. Takeuchi, M. Osawa, 2010, Proceedings of the National Academy of Sciences.

Structure-based approach to improve a small-molecule inhibitor by the use of a competitive peptide ligand.

K. Ono, I. Shimada, Hideo Takahashi, 2014, Angewandte Chemie.

NMR resonance assignments of the catalytic domain of human serine/threonine phosphatase calcineurin in unligated and PVIVIT-peptide-bound states

K. Takeuchi, Zhen-Yu J. Sun, M. Gal, 2014, Biomolecular NMR Assignments.

Structure of the calcineurin-NFAT complex: defining a T cell activation switch using solution NMR and crystal coordinates.

G. Wagner, M. Roehrl, K. Takeuchi, 2007, Structure.

Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells.

Mindy I. Davis, A. Simeonov, R. Pragani, 2023, Biochemical and biophysical research communications.

Functional molecular evolution of a GTP sensing kinase: PI5P4Kβ

Kaori Fukuzawa, A. Sasaki, S. Nakagawa, 2023, The FEBS journal.

Degradation of Activated K-Ras Orthologue via K-Ras-specific Lysine Residues Is Required for Cytokinesis*

Pascale G. Charest, R. Firtel, J. Asara, 2013, The Journal of Biological Chemistry.

Identification and Characterization of the Slowly Exchanging pH-dependent Conformational Rearrangement in KcsA*

I. Shimada, K. Takeuchi, S. Kawano, 2007, Journal of Biological Chemistry.

I. Shimada, K. Takeuchi, Takumi Ueda, 2022, Nihon Kessho Gakkaishi.

Nonthermal excitation effects mediated by sub-terahertz radiation on hydrogen exchange in ubiquitin

Masahito Tanaka, H. Iida, M. Kinoshita, 2021, Biophysical journal.

Solution Structure of v-Grammotoxin SIA , A Gating Modifier of P / Q and N-type Ca 2 1 Channel

I. Shimada, J. Kim, C. Lee, 2002 .

HNCA-TOCSY-CANH experiments with alternate 13C-12C labeling: a set of 3D experiment with unique supra-sequential information for mainchain resonance assignment

G. Wagner, I. Shimada, K. Takeuchi, 2011, Journal of biomolecular NMR.

Residue-based program of a β-peptoid twisted strand shape via a cyclopentane constraint.

K. Tsumoto, K. Umezawa, S. Sando, 2022, Organic & biomolecular chemistry.

Oligo(N-methylalanine) as a Peptide-Based Molecular Scaffold with a Minimal Structure and High Density of Functionalizable Sites.

K. Tsumoto, S. Sando, K. Takeuchi, 2022, Angewandte Chemie.

Application of C-Terminal 7-Azabicyclo[2.2.1]heptane to Stabilize β-Strand-like Extended Conformation of a Neighboring α-Amino Acid.

I. Shimada, T. Ohwada, K. Takeuchi, 2018, The Journal of organic chemistry.

Structure of the calcineurin-NFAT complex

G. Wagner, M. Roehrl, K. Takeuchi, 2007 .

Perdeuteration and methyl-selective 1H, 13C-labeling by using a Kluyveromyces lactis expression system

I. Shimada, T. Sugiki, K. Takeuchi, 2013, Journal of Biomolecular NMR.