Jeffrey M. Casavant

发表

Development of a Scaleable Route for the Production of cis-N-Benzyl-3-methylamino-4-methylpiperidine

Glenn E Wilcox, D. Ripin, Stefan Abele, 2003 .

Novel PIKK inhibitor antibody-drug conjugates: Synthesis and anti-tumor activity.

F. Loganzo, C. J. O’Donnell, E. Graziani, 2019, Bioorganic & medicinal chemistry letters.

Targeting and pharmacology of an anti-IL13Rα2 antibody and antibody-drug conjugate in a melanoma xenograft model

Parul Gupta, E. Rosfjord, Z. Jiang, 2021, mAbs.

Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3 Inhibitor

J. O’Shea, A. Milici, B. Reitz, 2003, Science.

PF-06804103, A Site-specific Anti-HER2 Antibody–Drug Conjugate for the Treatment of HER2-expressing Breast, Gastric, and Lung Cancers

F. Loganzo, C. J. O’Donnell, J. Lucas, 2020, Molecular Cancer Therapeutics.

Optimization of Tubulysin Antibody–Drug Conjugates: A Case Study in Addressing ADC Metabolism

S. C. K. Sukuru, F. Loganzo, C. J. O’Donnell, 2016, ACS medicinal chemistry letters.

Novel monobactams utilizing a siderophore uptake mechanism for the treatment of gram-negative infections.

V. Shanmugasundaram, M. Huband, T. Harris, 2012, Bioorganic & medicinal chemistry letters.

Preparation, gram-negative antibacterial activity, and hydrolytic stability of novel siderophore-conjugated monocarbam diols.

T. Gootz, M. Huband, S. J. Brickner, 2011, ACS medicinal chemistry letters.

Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases.

Mark J. Mitton-Fry, J. D. Clark, M. Hegen, 2018, Journal of medicinal chemistry.

Cross-Coupling Methods for the Large-Scale Preparation of an Imidazole−Thienopyridine: Synthesis of [2-(3-Methyl-3H-imidazol-4-yl)- thieno[3,2-b]pyridin-7-yl]-(2-methyl-1H-indol-5-yl)-amine

Brian P. Jones, Ruth E. McDermott, M. Munchhof, 2003 .

Pyridone-conjugated monobactam antibiotics with gram-negative activity.

V. Shanmugasundaram, M. Huband, T. Harris, 2013, Journal of medicinal chemistry.

Novel quinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV.

M. Huband, A. Marfat, J. Driscoll, 2013, Bioorganic & medicinal chemistry letters.

Structure-activity relationships and hepatic safety risks of thiazole agonists of the thrombopoietin receptor.

M. Munchhof, T. Harris, J. Driscoll, 2010, Bioorganic & medicinal chemistry letters.

The identification of orally bioavailable thrombopoietin agonists.

A. Marfat, M. Munchhof, T. Harris, 2009, Bioorganic & medicinal chemistry letters.

Synthesis and activity of a novel class of tribasic macrocyclic antibiotics: the triamilides.

Jeffrey M. Casavant, Hengmiao Cheng, M. Letavic, 2002, Bioorganic & medicinal chemistry letters.

Discovery of CP-690,550: a potent and selective Janus kinase (JAK) inhibitor for the treatment of autoimmune diseases and organ transplant rejection.

M. Hines, M. Munchhof, P. Changelian, 2010, Journal of medicinal chemistry.

Site Selection: a Case Study in the Identification of Optimal Cysteine Engineered Antibody Drug Conjugates

F. Loganzo, C. J. O’Donnell, E. Graziani, 2017, The AAPS Journal.

Novel 3-fluoro-6-methoxyquinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV.

Mark J. Mitton-Fry, M. Huband, A. Marfat, 2017, Bioorganic & medicinal chemistry letters.

Mild method for succinimide hydrolysis on ADCs: impact on ADC potency, stability, exposure, and efficacy.

Frank Loganzo, Tracey Clark, Judy Lucas, 2014, Bioconjugate chemistry.

Novel quinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV.

Mark J. Mitton-Fry, M. Huband, A. Marfat, 2013, Bioorganic & medicinal chemistry letters.