L. Beljaars

发表

M. Harmsen, G. Molema, D. Meijer, 2001, Antiviral research.

Osteoprotegerin Expression in Liver is Induced by IL13 through TGFβ.

P. Olinga, D. Schuppan, L. Beljaars, 2022, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.

Osteoprotegerin expression in liver is induced by IL-13 through TGF-β

P. Olinga, D. Schuppan, L. Beljaars, 2020, bioRxiv.

Local inhibition of liver fi brosis by specifi c delivery of a PDGF kinase inhibitor to hepatic stellate cells

G. Kéri, D. Meijer, M. V. D. Bovenkamp, 2006 .

Homing of negatively charged albumins to the lymphatic system: general implications for drug targeting to peripheral tissues and viral reservoirs.

D. Meijer, M. Kuipers, P. J. Swart, 1999, Biochemical pharmacology.

Characterization of the anti-HIV effects of native lactoferrin and other milk proteins and protein-derived peptides.

B. Berkhout, D. Meijer, L. Beljaars, 2002, Antiviral research.

Reduction of advanced liver fi brosis by targeted delivery of the angiotensin II receptor antagonist losartan to hepatic stellate cells

R. Bataller, R. Kok, D. Meijer, 2006 .

Mannose-6-Phosphate/Insulin-Like Growth Factor-II Receptors may Represent a Target for the Selective Delivery of Mycophenolic Acid to Fibrogenic Cells

H. Bakker, H. Goor, R. Greupink, 2006, Pharmaceutical Research.

RESEARCH Liver and Biliary Tract Physiology/Pathophysiology WNT-5A regulates TGF- (cid:2) -related activities in liver ﬁbrosis

L. Beljaars, R. Gosens, K. Poelstra, 2017 .

In vivo evaluation of RGD-albumin constructs as carriers for small molecule drugs

G. Molema, R. Kok, L. Beljaars, 2007 .

Pharmacokinetics of a hepatic stellate cell-targeted doxorubicin construct in bile duct-ligated rats.

J. Proost, R. Greupink, L. Beljaars, 2007, Biochemical pharmacology.

The preferential homing of a platelet derived growth factor receptor-recognizing macromolecule to fibroblast-like cells in fibrotic tissue.

D. Meijer, L. Beljaars, K. Poelstra, 2003, Biochemical pharmacology.

Interferon gamma peptidomimetic targeted to interstitial myofibroblasts attenuates renal fibrosis after unilateral ureteral obstruction in mice

J. van den Born, H. van Goor, J. Hillebrands, 2016, Oncotarget.

iFnγ peptidomimetic targeted to interstitial myofibroblasts attenuates renal fibrosis in unilateral ureteral obstruction in mice

J. Hillebrands, M. Borst, H. Goor, 2015 .

Chemical Modification of Interleukin-10 with Mannose 6-Phosphate Groups Yields a Liver-Selective Cytokine

H. Rachmawati, M. L. Lub-de Hooge, L. Beljaars, 2007, Drug Metabolism and Disposition.

Osteoprotegerin Is more than a Possible Serum Marker in Liver Fibrosis: A Study into Its Function in Human and Murine Liver

P. Olinga, L. Beljaars, C. Reker-Smit, 2020, Pharmaceutics.

Pharmacokinetic and Biodistribution Profile of Recombinant Human Interleukin-10 Following Intravenous Administration in Rats with Extensive Liver Fibrosis

D. Meijer, H. Rachmawati, W. Hagens, 2004, Pharmaceutical Research.

Increased Liver Uptake and Reduced Hepatic Stellate Cell Activation with a Cell-Specific Conjugate of the Rho-kinase Inhibitor Y27632

J. Prakash, L. Beljaars, C. Reker-Smit, 2011, Pharmaceutical Research.

Phosphate Groups in the Lipid A Moiety Determine the Effects of LPS on Hepatic Stellate Cells: A Role for LPS-Dephosphorylating Activity in Liver Fibrosis

D. Schuppan, J. Millán, R. Hodin, 2020, Cells.

PEGylation of interleukin-10 improves the pharmacokinetic profile and enhances the antifibrotic effectivity in CCl₄-induced fibrogenesis in mice.

L. Beljaars, A. de Jager‐Krikken, K. Poelstra, 2012, Journal of controlled release : official journal of the Controlled Release Society.

Synthesis of radiotracer for liver fibrosis

S. Friedman, J. Machac, L. Beljaars, 2001 .

Intravenous administration of recombinant human IL-10 suppresses the development of anti-thy 1-induced glomerulosclerosis in rats.

H. Bakker, H. Rachmawati, M. L. Lub-de Hooge, 2011, PDA journal of pharmaceutical science and technology.

Rho-kinase inhibitor coupled to peptide-modified albumin carrier reduces portal pressure and increases renal perfusion in cirrhotic rats

P. Boor, J. Trebicka, D. Fürst, 2019, Scientific Reports.

Peptide-modified albumin carrier explored as a novel strategy for a cell-specific delivery of interferon gamma to treat liver fibrosis.

Ruchi Bansal, J. Prakash, L. Beljaars, 2011, Molecular pharmaceutics.

Inhibition of cytomegalovirus infection by lactoferrin in vitro and in vivo.

M. Harmsen, G. Molema, D. Meijer, 2004, Antiviral research.

Conditions influencing the in vitro antifungal activity of lactoferrin combined with antimycotics against clinical isolates of Candida

D. Meijer, J. J. van den Berg, M. Kuipers, 2002, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

Liver and Biliary Tract Physiology / Pathophysiology WNT-5 A regulates TGF-- related activities in liver fibrosis

L. Beljaars, R. Gosens, K. Poelstra, 2017 .

Selective targeting of pentoxifylline to hepatic stellate cells using a novel platinum-based linker technology.

G. Molema, R. Kok, D. Meijer, 2006, Journal of controlled release : official journal of the Controlled Release Society.

A Study on the Effects of IL-10 in Anti-Thy 1-Induced Glomerulonephritis in Rats

H. Bakker, H. Rachmawati, L. Beljaars, 2009 .

Targeting tumor stromal cells through a PDGF-beta receptor binding carrier.

J. Prakash, L. Beljaars, K. Poelstra, 2010, Journal of controlled release : official journal of the Controlled Release Society.

Prediction of the pharmacokinetics of succinylated human serum albumin in man from in vivo disposition data in animals and in vitro liver slice incubations.

P. Olinga, J. Proost, G. Groothuis, 2006, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Reprint of: Targeting fibrosis with selective drug carriers

R. Greupink, L. Beljaars, K. Poelstra, 2010 .

Targeting fibrosis with selective drug carriers

R. Greupink, L. Beljaars, K. Poelstra, 2010 .

Studies on the targeted delivery of the antifibrogenic compound mycophenolic acid to the hepatic stellate cell.

R. Kok, D. Meijer, H. Bakker, 2005, Journal of hepatology.

Albumin modified with mannose 6‐phosphate: A potential carrier for selective delivery of antifibrotic drugs to rat and human hepatic stellate cells

P. Olinga, G. Groothuis, G. Molema, 1999, Hepatology.

Targeting of sugar- and charge-modified albumins to fibrotic rat livers: the accessibility of hepatic cells after chronic bile duct ligation.

G. Molema, D. Meijer, L. Beljaars, 1998, Journal of hepatology.

The influence of charge clustering on the anti-HIV-1 activity and in vivo distribution of negatively charged albumins.

B. Berkhout, G. Molema, D. Meijer, 2002, Biochemical pharmacology.

The Metabolic Fate of the Anti-HIV Active Drug Carrier Succinylated Human Serum Albumin after Intravenous Administration in Rats

D. Meijer, M. Kuipers, P. J. Swart, 2001, Journal of drug targeting.

Dissemination of Rat Cytomegalovirus through Infected Granulocytes and Monocytes In Vitro and In Vivo

M. Harmsen, G. Molema, D. Meijer, 2003, Journal of Virology.

The Elusive Antifibrotic Macrophage

L. Beljaars, B. Melgert, A. Adhyatmika, 2015, Front. Med..

The Elusive Antifibrotic Macrophage

L. Beljaars, B. Melgert, A. Adhyatmika, 2015, Front. Med..

Targeted imaging of integrins in cancer tissues using photocleavable Ru(ii) polypyridine complexes as mass-tags.

A. Casini, G. Groothuis, R. Bischoff, 2020, Chemical communications.

Neoglyco- and Neopeptide Albumins for Cell-Specific Delivery of Drugs to Chronically Diseased Livers

L. Beljaars, 2001 .

Drug targeting to the diseased liver.

J. Prakash, L. Beljaars, K. Poelstra, 2012, Journal of controlled release : official journal of the Controlled Release Society.

Targeting 15d-Prostaglandin J2 to Hepatic Stellate Cells: Two Options Evaluated

A. Gouw, W. Hagens, R. Greupink, 2007, Pharmaceutical Research.

Characteristics of the hepatic stellate cell-selective carrier mannose 6-phosphate modified albumin (M6P(28)-HSA).

P. Olinga, G. Groothuis, P. de Bleser, 2001, Liver.

Current Concepts of Biliary Atresia and Matrix Metalloproteinase-7: A Review of Literature

P. Olinga, H. Verkade, L. Beljaars, 2020, Frontiers in Medicine.

Targeted Therapies in Liver Fibrosis: Combining the Best Parts of Platelet-Derived Growth Factor BB and Interferon Gamma

P. Olinga, L. Beljaars, K. Poelstra, 2015, Front. Med..

HSC-specific inhibition of Rho-kinase reduces portal pressure in cirrhotic rats without major systemic effects.

T. Sauerbruch, J. Trebicka, R. Schierwagen, 2012, Journal of hepatology.

Reduction of advanced liver fibrosis by short‐term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats

R. Bataller, R. Kok, C. Fondevila, 2010, Hepatology.

A novel approach to deliver anticancer drugs to key cell types in tumors using a PDGF receptor-binding cyclic peptide containing carrier.

A. Gouw, J. Prakash, L. Beljaars, 2010, Journal of controlled release : official journal of the Controlled Release Society.

Targeting hepatic stellate cells for cell-specific treatment of liver fibrosis.

Klaas Poelstra, Leonie Beljaars, D. Meijer, 2002, Frontiers in bioscience : a journal and virtual library.

Enhanced Effectivity of an ALK5-Inhibitor after Cell-Specific Delivery to Hepatic Stellate Cells in Mice with Liver Injury

J. Prakash, L. Beljaars, C. Reker-Smit, 2013, PloS one.

Tumor‐targeted intracellular delivery of anticancer drugs through the mannose‐6‐phosphate/insulin‐like growth factor II receptor

J. Prakash, L. Beljaars, A. de Jager‐Krikken, 2010, International journal of cancer.

PDGF-receptor beta-targeted adenovirus redirects gene transfer from hepatocytes to activated stellate cells.

M. Rots, P. Jansen, H. Haisma, 2008, Molecular pharmaceutics.

Hepatic Localization of Macrophage Phenotypes during Fibrogenesis and Resolution of Fibrosis in Mice and Humans

F. Martínez, L. Helming, L. Beljaars, 2014, Front. Immunol..

Cell-specific delivery of biologicals: problems, pitfalls and possibilities of antifibrotic compounds in the liver.

L. Beljaars, B. Melgert, K. Poelstra, 2013, Drug discovery today.

Exacerbation of liver fibrosis after selective inhibition of cyclooxygenase-2 in Hepatic Stellate Cells

D. Meijer, A. Mallat, S. Lotersztajn, 2022 .

Successful Targeting to Rat Hepatic Stellate Cells Using Albumin Modified with Cyclic Peptides That Recognize the Collagen Type VI Receptor*

D. Schuppan, P. de Bleser, G. Molema, 2000, The Journal of Biological Chemistry.

Targeting of superoxide dismutase to the liver results in anti-inflammatory effects in rats with fibrotic livers.

D. Meijer, M. Nishikawa, T. Hirano, 1999, Journal of hepatology.

Cell-specific delivery of interferon alpha: IN VIVO EVALUATION

L. Beljaars, Amirah Adlia, 2017 .

THE effects of vegf-a on fibrosis-associated angiogenesis

G. Groothuis, L. Beljaars, K. Poelstra, 2017 .

A Phase I/IIa Study with Succinylated Human Serum Albumin (Suc-HSA), a candidate HIV-1 Fusion Inhibitor

J. Proost, F. Wit, D. Meijer, 2007, Antiviral Therapy.

Rho-kinase inhibitor coupled to peptide-modified albumin carrier reduces portal pressure and increases renal perfusion in cirrhotic rats

P. Boor, J. Trebicka, R. Schierwagen, 2019, Scientific Reports.

The Antiproliferative Drug Doxorubicin Inhibits Liver Fibrosis in Bile Duct-Ligated Rats and Can Be Selectively Delivered to Hepatic Stellate Cells in Vivo

D. Meijer, H. Bakker, R. Greupink, 2006, Journal of Pharmacology and Experimental Therapeutics.

Novel engineered targeted interferon‐gamma blocks hepatic fibrogenesis in mice

D. Schuppan, Ruchi Bansal, J. Prakash, 2011, Hepatology.

Local Inhibition of Liver Fibrosis by Specific Delivery of a Platelet-Derived Growth Factor Kinase Inhibitor to Hepatic Stellate Cells

G. Kéri, R. Kok, D. Meijer, 2007, Journal of Pharmacology and Experimental Therapeutics.

Upregulation of Epac-1 in Hepatic Stellate Cells by Prostaglandin E2 in Liver Fibrosis Is Associated with Reduced Fibrogenesis

B. Han, S. Lotersztajn, L. Beljaars, 2017, The Journal of Pharmacology and Experimental Therapeutics.

143 Redirection of PDGF-receptor targeted adenovirus from hepatocytes to activated stellate cells

M. Rots, P. Jansen, H. Haisma, 2003 .

Modification of Interleukin-10 with Mannose-6-Phosphate Groups Yields a Liver-Specific Cytokine with Antifibrotic Activity in Rats

H. Rachmawati, L. Beljaars, C. Reker-Smit, 2012 .

Disease-induced drug targeting using novel peptide-ligand albumins.

G. Molema, D. Meijer, L. Beljaars, 2001, Journal of controlled release : official journal of the Controlled Release Society.

Cellular Targeting of the Apoptosis-Inducing Compound Gliotoxin to Fibrotic Rat Livers

S. Lotersztajn, W. Hagens, M. Wright, 2008, Journal of Pharmacology and Experimental Therapeutics.

Design of a Gene Panel to Expose the Versatile Role of Hepatic Stellate Cells in Human Liver Fibrosis

P. Olinga, K. Rombouts, L. Beljaars, 2020, Pharmaceutics.

The antifibrotic potential of a sustained release formulation of a PDGF&bgr;‐receptor targeted rho kinase inhibitor

P. Olinga, W. Hinrichs, H. Frijlink, 2019, Journal of controlled release : official journal of the Controlled Release Society.

Distinct responses between healthy and cirrhotic human livers upon LPS challenge: possible implications for ACLF.

P. Olinga, K. D. de Jong, D. Oosterhuis, 2022, American Journal of Physiology - Gastrointestinal and Liver Physiology.

Gliotoxin non‐selectively induces apoptosis in fibrotic and normal livers

P. Olinga, G. Groothuis, D. Meijer, 2006, Liver international : official journal of the International Association for the Study of the Liver.

Reduction of advanced liver fibrosis by short‐term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats

R. Bataller, R. Kok, C. Fondevila, 2010, Hepatology.

The Antiviral Protein Human Lactoferrin Is Distributed in the Body to Cytomegalovirus (CMV) Infection-Prone Cells and Tissues

G. Molema, D. Meijer, H. Bakker, 2004, Pharmaceutical Research.

Targeting of superoxide dismutase to the liver results in anti-inflammatory effects in rats with fibrotic livers.

M. Nishikawa, L. Beljaars, K. Poelstra, 1999, Journal of hepatology.

The antifibrotic potential of a sustained release formulation of a PDGF&bgr;‐receptor targeted rho kinase inhibitor

H. Frijlink, L. Beljaars, K. Poelstra, 2019, Journal of controlled release : official journal of the Controlled Release Society.

Reduction of Fibrogenesis by Selective Delivery of a Rho Kinase Inhibitor to Hepatic Stellate Cells in Mice

J. Prakash, L. Beljaars, R. Gosens, 2011, Journal of Pharmacology and Experimental Therapeutics.

The antifibrotic potential of a sustained release formulation of a PDGF beta-receptor targeted rho kinase inhibitor

H. Frijlink, L. Beljaars, K. Poelstra, 2019 .

Pharmacokinetics of a sustained release formulation of PDGF&bgr;‐receptor directed carrier proteins to target the fibrotic liver

P. Olinga, W. Hinrichs, H. Frijlink, 2018, Journal of controlled release : official journal of the Controlled Release Society.