T. Ritchie

发表

The impact of aromatic ring count on compound developability--are too many aromatic rings a liability in drug design?

T. Ritchie, S. Macdonald, 2009, Drug discovery today.

Physicochemical descriptors of aromatic character and their use in drug discovery.

T. Ritchie, S. Macdonald, 2014, Journal of medicinal chemistry.

The developability of heteroaromatic and heteroaliphatic rings – do some have a better pedigree as potential drug molecules than others?

Stephen D. Pickett, Simon J. F. Macdonald, Christopher N. Luscombe, 2012 .

Increasing small molecule drug developability in sub-optimal chemical space

S. Pickett, T. Ritchie, S. Macdonald, 2013 .

Sulfonamido-aryl ethers as bradykinin B1 receptor antagonists.

S. Bevan, H. Gstach, Viral Patel, 2009, Bioorganic & medicinal chemistry letters.

Bradyzide, a potent non‐peptide B2 bradykinin receptor antagonist with long‐lasting oral activity in animal models of inflammatory hyperalgesia

P. McIntyre, R. Wrigglesworth, C. Snell, 2000, British journal of pharmacology.

Heterocyclic replacements for benzene: Maximising ADME benefits by considering individual ring isomers.

T. Ritchie, S. Macdonald, 2016, European journal of medicinal chemistry.

Antihyperalgesic activity of a novel nonpeptide bradykinin B1 receptor antagonist in transgenic mice expressing the human B1 receptor

P. McIntyre, I. Dragoni, S. Bevan, 2005, British journal of pharmacology.

Some Studies on Carbonyl Radical Cyclizations and on the Synthesis of 2-Deoxy-β-D-Glycosides by Stereoselective Radical Reactions

T. Ritchie, D. Crich, S. Fortt, 1989 .

Preparation of 2-deoxy-β-d-lyxo-hexosides (2-deoxy-β-d-galactosides)

T. Ritchie, D. Crich, 1989 .

Diastereoselective free-radical reactions. Part 1. Preparation of 2-deoxy-β-glycosides by synthesis and reductive decarboxylation of 3-deoxyulosonic acid glycosides

T. Ritchie, D. Crich, 1990 .

Silyl migration and formation of an anhydro derivative on attempted benzylation of 3-O-tert-butyldimethylsilyl-6-O-tosyl-d-glucal

T. Ritchie, D. Crich, 1990 .

Stereoselective free radical reactions in the preparation of 2-deoxy-β-D-glucosides

T. Ritchie, D. Crich, 1988 .

The graphical representation of ADME-related molecule properties for medicinal chemists.

Peter Ertl, Richard Lewis, Timothy J Ritchie, 2011, Drug discovery today.

The impact of aromatic ring count on compound developability: further insights by examining carbo- and hetero-aromatic and -aliphatic ring types.

Stephen D Pickett, Simon J F Macdonald, Timothy J Ritchie, 2011, Drug discovery today.

Preparation and reactions of some cyclic orthoester derivatives

T. Ritchie, D. Crich, 1988 .

Chemoinformatics: manipulating chemical information to facilitate decision-making in drug discovery.

T J. Ritchie, T. Ritchie, 2001, Drug discovery today.

Analysis of the Calculated Physicochemical Properties of Respiratory Drugs: Can We Design for Inhaled Drugs Yet?

Simon J. F. Macdonald, Timothy J. Ritchie, Christopher N. Luscombe, 2009, J. Chem. Inf. Model..

Potent and orally bioavailable non-peptide antagonists at the human bradykinin B(1) receptor based on a 2-alkylamino-5-sulfamoylbenzamide core.

P. McIntyre, S. Bevan, T. Ritchie, 2004, Journal of medicinal chemistry.

Mining, Environmental, Petroleum, and Engineering Industry Applications of Electromagnetic Techniques in Geophysics

T. Ritchie, S. N. Sheard, T. J. Ritchie, 2005 .

How drug-like are 'ugly' drugs: do drug-likeness metrics predict ADME behaviour in humans?

Simon J F Macdonald, Timothy J Ritchie, T. Ritchie, 2014, Drug discovery today.

Insights into the impact of N- and O-methylation on aqueous solubility and lipophilicity using matched molecular pair analysis

S. Pickett, T. Ritchie, S. Macdonald, 2015 .

How drug-like are 'ugly' drugs: do drug-likeness metrics predict ADME behaviour in humans?

T. Ritchie, S. Macdonald, 2014, Drug Discovery Today.