P. Hiestand

发表

FK 506-binding protein proline rotamase is a target for the immunosuppressive agent FK 506 in Saccharomyces cerevisiae.

J. Heitman, M. Hall, N. Movva, 1991, Proceedings of the National Academy of Sciences of the United States of America.

The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors*

Michael D. Davis, M. Zollinger, C. A. Foster, 2002, The Journal of Biological Chemistry.

Inhibition of human immunodeficiency virus type 1 replication by SDZ NIM 811, a nonimmunosuppressive cyclosporine analog

B. Rosenwirth, P. Hiestand, A. Billich, 1994, Antimicrobial Agents and Chemotherapy.

Ascomycete derivative to MS therapeutic: S1P receptor modulator FTY720.

M. Rausch, C. A. Foster, P. Hiestand, 2008, Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques.

New Derivatives of Ascomycin with Modifications in the Amino Acid Region – Synthesis and Biological Activities, and X‐Ray Crystal Structure of 5,6‐Dehydroascomycin

P. Hiestand, T. Wagner, C. Rochais, 2009 .

Immunomodulation: particular perspectives.

P. Hiestand, J. Borel, J. Borel, 1999, Transplantation proceedings.

Angiogenesis is present in experimental autoimmune encephalomyelitis and pro-angiogenic factors are increased in multiple sclerosis lesions

C. Schnell, V. Brinkmann, P. Hiestand, 2010, Journal of Neuroinflammation.

FTY720 sustains and restores neuronal function in the DA rat model of MOG-induced experimental autoimmune encephalomyelitis

C. A. Foster, G. Lambrou, P. Hiestand, 2007, Brain Research Bulletin.

SDZ PSC 833, A non‐immunosuppressive cyclosporine: Its potency in overcoming P‐glycoprotein‐mediated multidrug resistance of murine leukemia

J. Laissue, H. Altermatt, P. Hiestand, 1992, International journal of cancer.

Pharmacologic interactions between the resistance‐modifying cyclosporine sdz psc 833 and etoposide (VP 16–213) enhance In Vivo cytostatic activity and toxicity

J. Laissue, H. Altermatt, H. Altermatt, 1992, International journal of cancer.

Overcoming multidrug resistance in Chinese hamster ovary cells in vitro by cyclosporin A (Sandimmune) and non-immunosuppressive derivatives.

P. Hiestand, R. Traber, M. Eberle, 1989, British Journal of Cancer.

Effects of potassium channel toxins from Leiurus quinquestriatus hebraeus venom on responses to cromakalim in rabbit blood vessels

P. Hiestand, P. Strong, D. Beech, 1989, British journal of pharmacology.

Molecular Mechanisms of Immunosuppression by Cyclosporins

M. Schreier, P. Hiestand, V. Quesniaux, 1993, Annals of the New York Academy of Sciences.

MOLECULAR CHARACTERISTICS OF CYCLOPHILIN‐CYCLOSPORINE INTERACTION

M. V. Regenmortel, M. Schreier, M. Harding, 1988, Transplantation.

Adenosine 3':5'-monophosphate-dependent protein kinase and the stimulation of ovarian nuclear ribonucleic acid polymerase activities.

P. Hiestand, J. S. Schweppe, R. Jungmann, 1974, Journal of Biological Chemistry.

Brain Penetration of the Oral Immunomodulatory Drug FTY720 and Its Phosphorylation in the Central Nervous System during Experimental Autoimmune Encephalomyelitis: Consequences for Mode of Action in Multiple Sclerosis

E. Persohn, C. A. Foster, C. Beerli, 2007, Journal of Pharmacology and Experimental Therapeutics.

Prolactin as a modulator of lymphocyte responsiveness provides a possible mechanism of action for cyclosporine.

P. Hiestand, R. Nordmann, A. Grieder, 1986, Proceedings of the National Academy of Sciences of the United States of America.

A COMPARISON OF CYCLOSPORINE BINDING BY CYCLOPHILIN AND CALMODULIN AND THE IDENTIFICATION OF A NOVEL 45 KD CYCLOSPORINE‐BINDING PHOSPHOPROTEIN IN JURKAT CELLS

B. Ryffel, B. Foxwell, P. Hiestand, 1988, Transplantation.

Molecular mechanisms of immunosuppression.

M. Schreier, P. Hiestand, V. Quesniaux, 1992, Journal of autoimmunity.

Interleukin-6 exacerbates glomerulonephritis in (NZB x NZW)F1 mice.

B. Ryffel, M. Mihatsch, B. Car, 1994, The American journal of pathology.

Identification of cyclophilin as the erythrocyte ciclosporin-binding protein.

B. Ryffel, B. Foxwell, P. Hiestand, 1988, Biochimica et biophysica acta.

Cyclosporin A (Sandimmun®) modulates the Ca2+ uptake of mitogen-stimulated lymphocytes

P. Hiestand, 1984, Agents and Actions.

Yeast cyclophilin: isolation and characterization of the protein, cDNA and gene.

H P Kocher, B. Haendler, N. Movva, 1989, Gene.

Identification of several cyclosporine binding proteins in lymphoid and non-lymphoid cells in vivo.

H. Husi, B. Ryffel, B. Foxwell, 1992, Biochimica et biophysica acta.

The effects of fractions (Chalones) obtained from lymphoid organs on lymphocyte proliferation in vitro

Z. Kis, P. Hiestand, J. Borel, 1977, Agents and Actions.

Dispholidus typus (bommslang) snake venom: purification and properties of the coagulant principle.

P. Hiestand, R. Hiestand, 1979, Toxicon : official journal of the International Society on Toxinology.

Preparation and in vitro activities of ethers of [D-serine]8-cyclosporin.

P. Hiestand, M. Eberle, A. Jutzi-Eme, 1995, Journal of medicinal chemistry.

Mechanism of action: ciclosporin- and prolactin-mediated control of immunity.

P. Hiestand, P. Mekler, 1986, Progress in allergy.

Cyclophilin binds to the region of cyclosporine involved in its immunosuppressive activity

M. Schreier, M. Harding, P. Hiestand, 1987, European journal of immunology.

Overcoming hERG issues for brain-penetrating cathepsin S inhibitors: 2-cyanopyrimidines. Part 2.

S. Bevan, T. Kanazawa, M. Malcangio, 2008, Bioorganic & medicinal chemistry letters.

SAR of 2,6-diamino-3,5-difluoropyridinyl substituted heterocycles as novel p38MAP kinase inhibitors.

R. Wolf, F. D. Di Padova, H. Gram, 2002, Bioorganic & medicinal chemistry letters.

Pyrazoloheteroaryls: novel p38alpha MAP kinase inhibiting scaffolds with oral activity.

F. D. Di Padova, H. Gram, P. Hiestand, 2006, Bioorganic & medicinal chemistry letters.

Isolation and synthesis of a novel immunosuppressive 17alpha-substituted dammarane from the flour of the Palmyrah palm (Borassus flabellifer).

H. Naegeli, H. Roth, R. Naef, 1999, Bioorganic & medicinal chemistry letters.

In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors. Part I.

W. Jahnke, M. Kroemer, P. Hiestand, 2010, Bioorganic & medicinal chemistry letters.

SAR of 4-hydroxypiperidine and hydroxyalkyl substituted heterocycles as novel p38 map kinase inhibitors.

F. D. Di Padova, H. Gram, P. Hiestand, 2000, Bioorganic & medicinal chemistry letters.

Mechanism of action of gonadotropin. IV. Cyclic adenosine monophosphate-dependent translocation of ovarian cytoplasmic cyclic adenosine monophosphate-binding protein and protein kinase to nuclear acceptor sites.

P. Hiestand, J. S. Schweppe, R. Jungmann, 1974, Endocrinology.

Mechanism of action of gonadotropin. 3. Binding of adenosine 3',5'-monophosphate by the 105,000 X g supernatant fraction from homogenates of calf ovaries.

U. Eppenberger, P. Hiestand, R. Jungmann, 1973, Endocrinology.

Immunostimulatory properties of ethylene-2,2' -bis(dithio)bis(ethanol) and related compounds in vivo.

P. Hiestand, M. Strasser, 1985, International journal of immunopharmacology.

Immunomodulating activities of ethylene-2,2'-bis(dithio)bis(ethanol) and related compounds. Effects on murine lymphocyte proliferation and functions in vitro.

P. Hiestand, M. Strasser, 1985, International journal of immunopharmacology.

Phosphorylation of myelin basic proteins: an age-dependent process affected by divalent cations and Co-Dergocrine (dihydroergotoxine).

G. Poschmann, P. Hiestand, H. Zihlmann, 1983, Experimental aging research.

SAR of 2,6‐Diamino‐3,5‐difluoropyridinyl Substituted Heterocycles as Novel p38 MAP Kinase Inhibitors

R. Wolf, H. Gram, F. Padova, 2002 .

SDZ 281‐977: A modified partial structure of lavendustin A that exerts potent and selective antiproliferative activities in vitro and in vivo

P. Nussbaumer, A. Winiski, S. Cammisuli, 1996, International journal of cancer.

Studies on the biologic activities of Sandimmun metabolites in humans and in animal models: review and original experiments.

B. Ryffel, A. Fahr, P. Hiestand, 1990, Transplantation proceedings.

Immunosuppressive Agents (II)

T. Ochiai, P. Hiestand, 1989 .

New cyclosporine derivative SDZ IMM 125: in vitro and in vivo pharmacologic effects and toxicologic evaluation.

B. Ryffel, S. Cammisuli, U. Hurtenbach, 1993, Transplantation proceedings.

The new cyclosporine derivative, SDZ IMM 125: in vitro and in vivo pharmacologic effects.

S. Cammisuli, U. Hurtenbach, P. Hiestand, 1992, Transplantation proceedings.

What Can the NZB/W Mice Teach us about the Treatment of SLE with Ciclosporin?

B. Ryffel, P. Hiestand, J. Borel, 1985 .

SAR of benzoylpyridines and benzophenones as p38alpha MAP kinase inhibitors with oral activity.

F. D. Di Padova, H. Gram, P. Hiestand, 2004, Bioorganic & medicinal chemistry letters.

EVIDENCE THAT RAPAMYCIN HAS DIFFERENTIAL EFFECTS ON IL‐4 FUNCTION: MULTIPLE IL‐4 SIGNALING PATHWAYS AND IMPLICATIONS FOR IN VIVO USE

B. Foxwell, M. Ritter, P. Hiestand, 1993, Transplantation.

beta-RTX. A receptor-active protein from Russell's viper (Vipera russelli russelli) venom.

P. Hiestand, P. Bevan, 1983, The Journal of biological chemistry.

Predictability of FTY720 efficacy in experimental autoimmune encephalomyelitis by in vivo macrophage tracking: Clinical implications for ultrasmall superparamagnetic iron oxide‐enhanced magnetic resonance imaging

M. Rausch, M. Rudin, D. Baumann, 2004, Journal of magnetic resonance imaging : JMRI.

Analysis of lesion development during acute inflammation and remission in a rat model of experimental autoimmune encephalomyelitis by visualization of macrophage infiltration, demyelination and blood‐brain barrier damage

Markus Rudin, Peter Hiestand, M. Rausch, 2006, NMR in biomedicine.

The effects of fractions (chalones) obtained from lymphoid organs on the immune response in vivo

P. Hiestand, J. Borel, C. Feurer, 1978, Agents and Actions.

In vivo monitoring the fate of Cy5.5-Tat labeled T lymphocytes by quantitative near-infrared fluorescence imaging during acute brain inflammation in a rat model of experimental autoimmune encephalomyelitis.

M. Rausch, M. Rudin, H. Gremlich, 2007, Journal of immunological methods.

Novel antiproliferative agents derived from lavendustin A.

P. Nussbaumer, A. Winiski, S. Cammisuli, 1994, Journal of medicinal chemistry.

MRI‐based monitoring of inflammation and tissue damage in acute and chronic relapsing EAE

M. Rausch, M. Rudin, D. Baumann, 2003, Magnetic resonance in medicine.

Nephrotoxic and immunosuppressive potentials of cyclosporine metabolites in rats.

B. Ryffel, M. Mihatsch, B. Foxwell, 1986, Transplantation proceedings.

Novel p38 inhibitors with potent oral efficacy in several models of rheumatoid arthritis.

F. D. Di Padova, H. Gram, P. Hiestand, 2004, Bioorganic & medicinal chemistry letters.

O1-06-01 Immunization with Aβ1-6 coupled to the virus-like particle Qβ (CAD106) efficiently removes β-amyloid without inducing Aβ-reactive T-cells

M. Stoeckli, M. Staufenbiel, A. Tissot, 2006, Alzheimer's & Dementia.

A novel anti‐inflammatory drug, SDZ ASM 981, for the treatment of skin diseases: in vitro pharmacology

A. Winiski, F. Kalthoff, P. Hiestand, 1999, The British journal of dermatology.

Mechanism of action: ciclosporin- and prolactin-mediated control of immunity.

P. Hiestand, P. Mekler, 1986, Progress in allergy.

SAR of Benzoylpyridines and Benzophenones as p38α MAP Kinase Inhibitors with Oral Activity.

H. Gram, F. Padova, P. Hiestand, 2004 .

Cyclosporins: Immunopharmacologic Properties of Natural Cyclosporins

P. Hiestand, H. Gubler, 1988 .

Vascular transplantation of Syrian hamster heart into Lewis rat: effect of brequinar, cyclosporine, cobra venom factor, and splenectomy.

T. Meerloo, M. Schreier, H. Schuurman, 1994, Transplantation proceedings.

Bridged Piperazines and Piperidines as CCR1 Antagonists with Oral Activity in Models of Arthritis and Multiple Sclerosis

P. Loetscher, P. Hiestand, A. Schlapbach, 2006 .

Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis.

P. Loetscher, P. Hiestand, A. Schlapbach, 2005, Bioorganic & medicinal chemistry letters.