A. Kontrogianni-Konstantopoulos

发表

Competition through Dimerization between Antiapoptotic and Proapoptotic HS-1-associated Protein X-1 (Hax-1)*

Jason M Koontz, A. Kontrogianni-Konstantopoulos, Jason M. Koontz, 2013, The Journal of Biological Chemistry.

HAX‐1: A family of apoptotic regulators in health and disease

Jason M Koontz, A. Kontrogianni-Konstantopoulos, S. Yap, 2011, Journal of cellular physiology.

transcriptome of cardiomyopathies Array lessons from the heart: focus on the genome and

D. Sanoudou, D. Arvanitis, A. Kontrogianni-Konstantopoulos, 2005 .

Prostaglandin (PG)D2 and 15-deoxy-Δ12,14-PGJ2, but not PGE2, Mediate Shear-Induced Chondrocyte Apoptosis via Protein Kinase A-dependent Regulation of Polo-like Kinases

K. Konstantopoulos, Pu Wang, A. Kontrogianni-Konstantopoulos, 2010, Cell Death and Differentiation.

Loss of actomyosin regulation in distal arthrogryposis myopathy due to mutant myosin binding protein‐C slow

E. Homsher, J. Sellers, Y. Takagi, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Intercellular Connections in the Heart: The Intercalated Disc

A. Kontrogianni-Konstantopoulos, Maegen A. Ackermann, Lingyu Hu, 2012 .

De novo myofibrillogenesis in C2C12 cells: evidence for the independent assembly of M bands and Z disks.

R. Bloch, A. Kontrogianni-Konstantopoulos, D. Catino, 2006, American journal of physiology. Cell physiology.

Muscle giants: molecular scaffolds in sarcomerogenesis.

R. Bloch, A. Kontrogianni-Konstantopoulos, Aikaterini Kontrogianni-Konstantopoulos, 2009, Physiological reviews.

Double the trouble: giant proteins with dual kinase activity in the heart

A. Kontrogianni-Konstantopoulos, Panagiotis Tsakiroglou, A. Grogan, 2020, Biophysical Reviews.

Deletion of obscurin immunoglobulin domains Ig58/59 leads to age-dependent cardiac remodeling and arrhythmia

C. Ward, H. Granzier, A. Kontrogianni-Konstantopoulos, 2020, Basic Research in Cardiology.

Sarcomeric myopathies associated with tremor: new insights and perspectives

A. Kontrogianni-Konstantopoulos, J. Stavusis, J. Geist, 2019, Journal of Muscle Research and Cell Motility.

Correction: Obscurins: Goliaths and Davids Take over Non-Muscle Tissues

A. Kontrogianni-Konstantopoulos, N. Perry, M. Shriver, 2018, PloS one.

Novel obscurins mediate cardiomyocyte adhesion and size via the PI3K/AKT/mTOR signaling pathway.

Christopher E. Berndsen, P. Hecker, A. Kontrogianni-Konstantopoulos, 2017, Journal of molecular and cellular cardiology.

Giant obscurins regulate the PI3K cascade in breast epithelial cells via direct binding to the PI3K/p85 regulatory subunit

K. Konstantopoulos, C. Paul, Saravanakumar Marimuthu, 2016, Oncotarget.

Obscurins: Goliaths and Davids Take over Non-Muscle Tissues

A. Kontrogianni-Konstantopoulos, N. Perry, M. Shriver, 2014, PloS one.

The kinase domains of obscurin interact with intercellular adhesion proteins

A. Kontrogianni-Konstantopoulos, Li-Yen R. Hu, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Cardiomyopathies: When the Goliaths of Heart Muscle Hurt

A. Kontrogianni-Konstantopoulos, Maegen A. Ackermann, 2013 .

Myosin Binding Protein-C Slow: An Intricate Subfamily of Phosphoproteins

A. Kontrogianni-Konstantopoulos, Maegen A. Ackermann, Jane Valenti, 2012 .

Myosin Binding Protein-C Slow: An Intricate Subfamily of Proteins

A. Kontrogianni-Konstantopoulos, Maegen A. Ackermann, 2010, Journal of biomedicine & biotechnology.

Rapid response of cardiac obscurin gene cluster to aortic stenosis: differential activation of Rho-GEF and MLCK and involvement in hypertrophic growth.

M. Russell, D. Kurnit, R. Bloch, 2003, Biochemical and biophysical research communications.

Dynamics of Obscurin Localization During Differentiation and Remodeling of Cardiac Myocytes: Obscurin as an Integrator of Myofibrillar Structure

M. Russell, R. Bloch, A. Kontrogianni-Konstantopoulos, 2004, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Obscurin regulates the organization of myosin into A bands.

R. Bloch, A. Kontrogianni-Konstantopoulos, W. Randall, 2004, American journal of physiology. Cell physiology.

Obscurin: a multitasking muscle giant

R. Bloch, A. Kontrogianni-Konstantopoulos, 2006, Journal of Muscle Research & Cell Motility.

Essential role of obscurin in cardiac myofibrillogenesis and hypertrophic response: evidence from small interfering RNA-mediated gene silencing

M. Russell, R. Bloch, A. Kontrogianni-Konstantopoulos, 2006, Histochemistry and Cell Biology.

Different obscurin isoforms localize to distinct sites at sarcomeres

M. Russell, R. Bloch, A. Kontrogianni-Konstantopoulos, 2007, FEBS letters.

Fluid shear promotes chondrosarcoma cell invasion by activating matrix metalloproteinase 12 via IGF-2 and VEGF signaling pathways

K. Konstantopoulos, P. Wang, Peipei Guan, 2014, Oncogene.

The Phosphorylation Profile of Myosin Binding Protein-C Slow is Dynamically Regulated in Slow-Twitch Muscles in Health and Disease

A. Kontrogianni-Konstantopoulos, Maegen A. Ackermann, Brendan King, 2015, Scientific Reports.

Resisting resistin; it's good for the heart.

A. Kontrogianni-Konstantopoulos, 2011, Journal of molecular and cellular cardiology.

A Nonerythroid Isoform of Protein 4.1r Interacts with Components of the Contractile Apparatus in Skeletal Myofibers

A. Kontrogianni-Konstantopoulos, E. Benz, S. Huang, 1999 .

Regulation of myofilament force and loaded shortening by skeletal myosin binding protein C

K. McDonald, A. Kontrogianni-Konstantopoulos, Laurin M Hanft, 2019, The Journal of general physiology.

Phospholamban interacts with HAX-1, a mitochondrial protein with anti-apoptotic function.

D. Sanoudou, E. Kranias, D. Arvanitis, 2007, Journal of molecular biology.

The anti-apoptotic protein HAX-1 is a regulator of cardiac function

P. Schroder, J. Qian, Zhiguo Zhang, 2009, Proceedings of the National Academy of Sciences.

NEB mutations disrupt the super-relaxed state of myosin and remodel the muscle metabolic proteome in nemaline myopathy

K. Claeys, C. Wallgren‐Pettersson, H. Granzier, 2022, Acta neuropathologica communications.

The Sarcomeric M-Region: A Molecular Command Center for Diverse Cellular Processes

A. Kontrogianni-Konstantopoulos, Maegen A. Ackermann, Li-Yen R. Hu, 2015, BioMed research international.

The rho-guanine nucleotide exchange factor domain of obscurin regulates assembly of titin at the Z-disk through interactions with Ran binding protein 9.

R. Bloch, A. Kontrogianni-Konstantopoulos, W. Randall, 2008, Molecular biology of the cell.

A microfluidic assay for the quantification of the metastatic propensity of breast-cancer specimens

K. Konstantopoulos, N. Varadarajan, P. Mistriotis, 2019, Nature Biomedical Engineering.

Obscurin: A multitasking giant in the fight against cancer.

M. Eason, A. Kontrogianni-Konstantopoulos, Talia Guardia, 2021, Biochimica et biophysica acta. Reviews on cancer.

Array lessons from the heart: focus on the genome and transcriptome of cardiomyopathies.

Despina Sanoudou, D. Sanoudou, E. Kranias, 2005, Physiological genomics.

Loss of the obscurin-RhoGEF downregulates RhoA signaling and increases microtentacle formation and attachment of breast epithelial cells

M. Vitolo, A. Kontrogianni-Konstantopoulos, N. Perry, 2014, Oncotarget.

Heterozygous variants in MYBPC1 are associated with an expanded neuromuscular phenotype beyond arthrogryposis

Murim Choi, V. Shashi, K. Schoch, 2019, Human mutation.

Thick Filament Protein Network, Functions, and Disease Association.

A. Kontrogianni-Konstantopoulos, Li-Yen R. Hu, Janelle Geist, 2018, Comprehensive Physiology.

MYBPC1, an Emerging Myopathic Gene: What We Know and What We Need to Learn

A. Kontrogianni-Konstantopoulos, Janelle Geist, 2016, Front. Physiol..

Myosin binding protein-C slow is a novel substrate for protein kinase A (PKA) and C (PKC) in skeletal muscle.

A. Kontrogianni-Konstantopoulos, Maegen A. Ackermann, 2011, Journal of proteome research.

Advances in Muscle Physiology and Pathophysiology

H. Granzier, G. Benian, A. Kontrogianni-Konstantopoulos, 2010, Journal of biomedicine & biotechnology.

Myosin Binding Protein-C: A Regulator of Actomyosin Interaction in Striated Muscle

A. Kontrogianni-Konstantopoulos, Maegen A. Ackermann, 2011, Journal of biomedicine & biotechnology.

Structure before function: myosin binding protein‐C slow is a structural protein with regulatory properties

C. Ward, A. Kontrogianni-Konstantopoulos, Janelle Geist, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Integrity of the network sarcoplasmic reticulum in skeletal muscle requires small ankyrin 1

C. Ward, R. Bloch, A. Kontrogianni-Konstantopoulos, 2011, Journal of Cell Science.

Loss of giant obscurins from breast epithelium promotes epithelial-to-mesenchymal transition, tumorigenicity and metastasis

K Konstantopoulos, K. Stroka, S. Martin, 2014, Oncogene.

Loss of giant obscurins alters breast epithelial cell mechanosensing of matrix stiffness

K. Stroka, J. Phillip, K. Konstantopoulos, 2016, Oncotarget.

Obscurins: Unassuming giants enter the spotlight

A. Kontrogianni-Konstantopoulos, N. Perry, M. Shriver, 2013, IUBMB life.

Obscurin interacts with a novel isoform of MyBP-C slow at the periphery of the sarcomeric M-band and regulates thick filament assembly.

R. Bloch, A. Kontrogianni-Konstantopoulos, Amber L. Bowman, 2009, Molecular biology of the cell.

Obscurin is a ligand for small ankyrin 1 in skeletal muscle.

D. V. van Rossum, R. Bloch, A. Kontrogianni-Konstantopoulos, 2003, Molecular biology of the cell.

Loss of giant obscurins alters breast epithelial cell mechanosensing of matrix stiffness.

Denis Wirtz, Konstantinos Konstantopoulos, K. Stroka, 2017, Oncotarget.

The anti-apoptotic protein HAX-1 interacts with SERCA2 and regulates its protein levels to promote cell survival.

D. Sanoudou, E. Kranias, D. Arvanitis, 2009, Molecular biology of the cell.

Characterization and comparison of two binding sites on obscurin for small ankyrin 1.

Ben Busby, R. Bloch, A. Kontrogianni-Konstantopoulos, 2010, Biochemistry.

Myosin Binding Protein-C Slow Phosphorylation is Altered in Duchenne Dystrophy and Arthrogryposis Myopathy in Fast-Twitch Skeletal Muscles

C. Ward, A. Kontrogianni-Konstantopoulos, C. Gurnett, 2015, Scientific Reports.

Embryonic and post-embryonic utilization and subcellular localization of the nuclear receptor SpSHR2 in the sea urchin.

P. Leahy, C. Flytzanis, A. Kontrogianni-Konstantopoulos, 1998, Journal of cell science.

A microfluidic assay for the quantification of the metastatic propensity of breast-cancer specimens

Navin Varadarajan, Stuart S Martin, Konstantinos Konstantopoulos, 2019, Nature Biomedical Engineering.

Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase.

D. Sanoudou, F. del Monte, G. Fan, 2007, American journal of physiology. Heart and circulatory physiology.

Giant obscurin regulates migration and metastasis via RhoA-dependent cytoskeletal remodeling in pancreatic cancer.

K. Konstantopoulos, Daniel J. Shea, A. Kontrogianni-Konstantopoulos, 2021, Cancer letters.

The Ser96Ala variant in histidine-rich calcium-binding protein is associated with life-threatening ventricular arrhythmias in idiopathic dilated cardiomyopathy

G. Dorn, D. Sanoudou, E. Kranias, 2008, European heart journal.

HAX-1: a multifaceted antiapoptotic protein localizing in the mitochondria and the sarcoplasmic reticulum of striated muscle cells.

A. Kontrogianni-Konstantopoulos, E. Vafiadaki, J. Strong, 2010, Journal of molecular and cellular cardiology.

The Prototypical 4.1R-10-kDa Domain and the 4.1G-10-kDa Paralog Mediate Fodrin-Actin Complex Formation*

A. Kontrogianni-Konstantopoulos, E. Benz, C. Frye, 2001, The Journal of Biological Chemistry.

Differential cellular compartmentalization of the nuclear receptor SpSHR2 splicing variants in early sea urchin embryos

C. Flytzanis, A. Kontrogianni-Konstantopoulos, 2001, Molecular reproduction and development.

Obscurin modulates the assembly and organization of sarcomeres and the sarcoplasmic reticulum

M. Russell, R. Bloch, A. Kontrogianni-Konstantopoulos, 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Mapping the Binding Site on Small Ankyrin 1 for Obscurin*

Maegen A. Borzok, R. Bloch, A. Kontrogianni-Konstantopoulos, 2007, Journal of Biological Chemistry.

Proteomic Analysis of Myocardia Containing the Obscurin R4344Q Mutation Linked to Hypertrophic Cardiomyopathy

A. Kontrogianni-Konstantopoulos, Li-Yen R. Hu, 2020, Frontiers in Physiology.

The Hydrophilic Domain of Small Ankyrin-1 Interacts with the Two N-terminal Immunoglobulin Domains of Titin*

R. Bloch, A. Kontrogianni-Konstantopoulos, Aikaterini Kontrogianni-Konstantopoulos, 2003, The Journal of Biological Chemistry.

Myosin binding protein-C slow: a multifaceted family of proteins with a complex expression profile in fast and slow twitch skeletal muscles

A. Kontrogianni-Konstantopoulos, Maegen A. Ackermann, 2013, Front. Physiol..

Regulation of myo ﬁ lament force and loaded shortening by skeletal myosin binding protein C

K. McDonald, A. Kontrogianni-Konstantopoulos, Laurin M Hanft, 2019 .

Obscurin is required for the lateral alignment of striated myofibrils in zebrafish

M. Russell, Fengyun Su, A. Kontrogianni-Konstantopoulos, 2006, Developmental dynamics : an official publication of the American Association of Anatomists.

Novel mutations in MYBPC1 are associated with myogenic tremor and mild myopathy

C. Bönnemann, S. Pajusalu, D. Haubenberger, 2019, Annals of neurology.

Corrigendum: The Phosphorylation Profile of Myosin Binding Protein-C Slow is Dynamically Regulated in Slow-Twitch Muscles in Health and Disease

C. Ward, A. Kontrogianni-Konstantopoulos, Maegen A. Ackermann, 2018, Scientific Reports.

OBSCN restoration via OBSCN-AS1 long-noncoding RNA CRISPR-targeting suppresses metastasis in triple-negative breast cancer

K. Konstantopoulos, A. Kontrogianni-Konstantopoulos, Talia Guardia, 2023, Proceedings of the National Academy of Sciences of the United States of America.

Unraveling obscurins in heart disease

A. Kontrogianni-Konstantopoulos, Alyssa Grogan, 2018, Pflügers Archiv - European Journal of Physiology.

Loss of giant obscurins promotes breast epithelial cell survival through apoptotic resistance

E. Balzer, A. Kontrogianni-Konstantopoulos, N. Perry, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Deregulated Ca2+ cycling underlies the development of arrhythmia and heart disease due to mutant obscurin

Christopher E. Berndsen, P. Hecker, A. Kontrogianni-Konstantopoulos, 2017, Science Advances.

Electrostatic interactions mediate binding of obscurin to small ankyrin 1: biochemical and molecular modeling studies.

Alexander D. MacKerell, Ben Busby, R. Bloch, 2011, Journal of molecular biology.

Double the trouble: giant proteins with dual kinase activity in the heart

A. Kontrogianni-Konstantopoulos, Panagiotis Tsakiroglou, Alyssa Grogan, 2020, Biophysical Reviews.

Alterations in cytoskeletal and Ca2+ cycling regulators in atria lacking the obscurin Ig58/59 module

Weiliang Huang, A. Kontrogianni-Konstantopoulos, Alyssa Grogan, 2023, Frontiers in Cardiovascular Medicine.

Sarcomeric deficits underlie MYBPC1-associated myopathy with myogenic tremor

K. McDonald, K. Konstantopoulos, J. Stains, 2021, JCI insight.

Advances in Muscle Physiology and Pathophysiology 2011

H. Granzier, G. Benian, A. Kontrogianni-Konstantopoulos, 2012, Journal of biomedicine & biotechnology.

Unraveling obscurins in heart disease

A. Kontrogianni-Konstantopoulos, Alyssa Grogan, 2018, Pflügers Archiv - European Journal of Physiology.

The anti-apoptotic protein HAX-1 interacts with SERCA2 and regulates its protein levels to promote cell survival.

D. Sanoudou, E. Kranias, D. Arvanitis, 2009, Molecular biology of the cell.

Fluid shear promotes chondrosarcoma cell invasion by activating matrix metalloproteinase 12 via IGF-2 and VEGF signaling pathways

A. Kontrogianni-Konstantopoulos, Fei Zhu, Pu Wang, 2014, Oncogene.

A nonerythroid isoform of protein 4.1R interacts with components of the contractile apparatus in skeletal myofibers.

A. Kontrogianni-Konstantopoulos, Shu‐Ching Huang, Edward J. Benz, 2000, Molecular biology of the cell.

A novel sea urchin nuclear receptor encoded by alternatively spliced maternal RNAs.

A. Vlahou, C. Flytzanis, A. Kontrogianni-Konstantopoulos, 1996, Developmental biology.