J. Gonçalves

发表

Modulation of Bax mitochondrial insertion and induced cell death in yeast by mammalian protein kinase Cα.

L. Saraíva, M. Côrte-Real, S. Manon, 2011, Experimental cell research.

The importance of humanized yeast to better understand the role of bcl-2 family in apoptosis: finding of novel therapeutic opportunities.

L. Saraíva, M. Côrte-Real, S. Manon, 2011, Current pharmaceutical design.

Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule

Maria M. M. Santos, A. Inga, L. Saraíva, 2015, OncoTarget.

Distinct regulation of p53-mediated apoptosis by protein kinase Cα, δ, ε and ζ: Evidence in yeast for transcription-dependent and -independent p53 apoptotic mechanisms.

L. Saraíva, M. Côrte-Real, J. Gonçalves, 2011, Experimental cell research.

Isoform-selectivity of PKC Inhibitors Acting at the Regulatory and Catalytic Domain of Mammalian PKC-α, -βI, -δ, -η and -ζ

L. Saraíva, J. Gonçalves, P. Fresco, 2003 .

Specific modulation of apoptosis and Bcl-xL phosphorylation in yeast by distinct mammalian protein kinase C isoforms

L. Saraíva, M. Côrte-Real, Rui D. Silva, 2006, Journal of Cell Science.

Involvement of G-protein βγ subunits on the influence of inhibitory α2-autoreceptors on the angiotensin AT1-receptor modulation of noradrenaline release in the rat vas deferens

D. Moura, J. Gonçalves, G. Queiróz, 2006, Neurochemistry International.

Selective activation of protein kinase C-δ and-ɛ by 6 , 11 , 12 , 14-tetrahydroxy-abieta-5 , 8 , 11 , 13-tetraene-7-one ( coleon U )

L. Saraíva, M. Côrte-Real, J. Gonçalves, 2018 .

Nuclear G-protein-coupled receptors as putative novel pharmacological targets.

Martin Vojtek, S. Gonçalves-Monteiro, C. Diniz, 2019, Drug discovery today.

Vancomycin therapeutic drug monitoring and population pharmacokinetic models in special patient subpopulations

J. Gonçalves, P. Fresco, J. Monteiro, 2018, Pharmacology research & perspectives.

Immunohistochemical characterization of adenosine receptors in rat aorta and tail arteries

C. Diniz, J. Gonçalves, P. Fresco, 2008, Microscopy research and technique.

Adenosine receptors involved in modulation of noradrenaline release in isolated rat tail artery.

C. Diniz, J. Gonçalves, P. Fresco, 2004, European journal of pharmacology.

Coupling to protein kinases A and C of adenosine A2B receptors involved in the facilitation of noradrenaline release in the prostatic portion of rat vas deferens

J. Gonçalves, G. Queiróz, Carlos Talaia, 2004, Neuropharmacology.

Regional differences in the adenosine A(2) receptor-mediated modulation of contractions in rat vas deferens.

C. Diniz, J. Gonçalves, Sandra Leal, 2003, European journal of pharmacology.

Loss of selectivity of so-called selective α1-adrenoceptor agonists after phenoxybenzamine

J. Gonçalves, J. Nunes, S. Guimarães, 1988, Naunyn-Schmiedeberg's Archives of Pharmacology.

Microglia P2Y13 Receptors Prevent Astrocyte Proliferation Mediated by P2Y1 Receptors

N. Vale, J. Gonçalves, G. Queiróz, 2018, Front. Pharmacol..

Ligands and therapeutic perspectives of adenosine A(2A) receptors.

L. Santana, E. Uriarte, C. Diniz, 2008, Current pharmaceutical design.

Centaurium Erythraea Extracts Exert Vascular Effects through Endothelium- and Fibroblast-dependent Pathways

P. Andrade, P. Valentão, J. Gonçalves, 2019, Planta Medica.

ATP Modulates Noradrenaline Release by Activation of Inhibitory P2Y Receptors and Facilitatory P2X Receptors in the Rat Vas Deferens

J. Gonçalves, G. Queiróz, Carlos Talaia, 2003, Journal of Pharmacology and Experimental Therapeutics.

Facilitatory and inhibitory modulation by endogenous adenosine of noradrenaline release in the epididymal portion of rat vas deferens

J. Gonçalves, G. Queiróz, G. Queiroz, 1993, Naunyn-Schmiedeberg's Archives of Pharmacology.

Intracellular adenosine released from THP-1 differentiated human macrophages is involved in an autocrine control of Leishmania parasitic burden, mediated by adenosine A2A and A2B receptors.

J. Gonçalves, Dany Silva, A. Cordeiro-da-Silva, 2020, European journal of pharmacology.

Opposite modulation of noradrenaline and ATP release in guinea-pig vas deferens through prejunctional β-adrenoceptors: evidence for the β2 subtype

K. Starke, B. Driessen, J. Gonçalves, 1996, Naunyn-Schmiedeberg's Archives of Pharmacology.

Opposite modulation of cotransmitter release in guinea-pig vas deferens: increase of noradrenaline and decrease of ATP release by activation of prejunctional β-adrenoceptors

B. Driessen, J. Gonçalves, R. Bültmann, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

Facilitation of noradrenaline release by adenosine A(2A) receptors in the epididymal portion and adenosine A(2B) receptors in the prostatic portion of the rat vas deferens.

C. Diniz, J. Gonçalves, G. Queiróz, 2002, European journal of pharmacology.

Release inhibitory receptors activation favours the A2A‐adenosine receptor‐mediated facilitation of noradrenaline release in isolated rat tail artery

C. Diniz, J. Gonçalves, G. Queiróz, 2002, British journal of pharmacology.

Influence of neuronal uptake on pre- and postjunctional effects of α-adrenoceptor agonists in tissues with noradrenaline — ATP cotransmission

J. Gonçalves, S. Guimarães, 1991, Naunyn-Schmiedeberg's Archives of Pharmacology.

P2Y receptors on astrocytes and microglia mediate opposite effects in astroglial proliferation

J. Gonçalves, S. Fraga, G. Queiróz, 2011, Purinergic Signalling.

Comparison of corelease of noradrenaline and ATP evoked by hypogastric nerve stimulation and field stimulation in guinea-pig vas deferens

K. Starke, B. Driessen, J. Gonçalves, 1995, Naunyn-Schmiedeberg's Archives of Pharmacology.

Synthesis and in vivo modulatory activity of protein kinase C of xanthone derivatives.

E. Sousa, M. Pinto, L. Saraíva, 2002, Bioorganic & medicinal chemistry.

Inhibition of protein kinase C by synthetic xanthone derivatives.

E. Sousa, M. Pinto, L. Saraíva, 2003, Bioorganic & medicinal chemistry.

Electrically-evoked release of taurine in the rat vas deferens: evidence for a purinoceptor-mediated effect

J. Gonçalves, P. Vale, G. Queiroz, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

Functional consequences of inhibition of nucleotide breakdown in rat vas deferens: a study with Evans blue

K. Starke, B. Driessen, J. Gonçalves, 1995, Naunyn-Schmiedeberg's Archives of Pharmacology.

Differential inhibition of noradrenaline release mediated by inhibitory A1-adenosine receptors in the mesenteric vein and artery from normotensive and hypertensive rats

C. Diniz, J. Gonçalves, P. Fresco, 2013, Neurochemistry International.

Contribution of adrenergic mechanisms for the stress‐induced breast cancer carcinogenesis

J. Gonçalves, Dany Silva, P. Fresco, 2022, Journal of cellular physiology.

Selective activation of protein kinase C-delta and -epsilon by 6,11,12,14-tetrahydroxy-abieta-5,8,11,13-tetraene-7-one (coleon U).

L. Saraíva, M. Côrte-Real, J. Gonçalves, 2009, Biochemical pharmacology.

Differential Activation by Daphnetoxin and Mezerein of PKC-Isotypes α, βI, δ and ζ

L. Saraíva, J. Gonçalves, P. Fresco, 2001 .

Inhibition of α, βI, δ, η and ζ Protein Kinase C Isoforms by Xanthonolignoids

E. Sousa, M. Pinto, L. Saraíva, 2003, Journal of enzyme inhibition and medicinal chemistry.

Functional crosstalk of prejunctional receptors on the modulation of noradrenaline release in mesenteric vessels: A differential study of artery and vein.

M. Morato, J. Gonçalves, Carlos Talaia, 2011, European journal of pharmacology.

Semiautomated computer-assisted image analysis to quantify 3,3'-diaminobenzidine tetrahydrochloride-immunostained small tissues.

Carlos Sá, Paula Fresco, C. Diniz, 2006, Analytical biochemistry.

β-Adrenoceptor Activation in Breast MCF-10A Cells Induces a Pattern of Catecholamine Production Similar to that of Tumorigenic MCF-7 Cells

N. Vale, J. Gonçalves, H. Reguengo, 2020, International journal of molecular sciences.

Presynaptic adenosine and P2Y receptors.

J. Gonçalves, G. Queiroz, 2008, Handbook of experimental pharmacology.

Taurine release in the rat vas deferens is modulated by Ca2+ and is independent of contractions.

C. Diniz, J. Gonçalves, P. da Cruz Fresco, 1999, European journal of pharmacology.

Potential use of renin-angiotensin-aldosterone system inhibitors to reduce COVID-19 severity

F. Fernandez‐Llimos, J. Gonçalves, P. Fresco, 2023, Revista Portuguesa de Cardiologia.

The P2Y1 and P2Y12 receptors mediate autoinhibition of transmitter release in sympathetic innervated tissues

J. Gonçalves, S. Fraga, C. Quintas, 2009, Neurochemistry International.

Adenosine Receptor Ligands on Cancer Therapy: A Review of Patent Literature.

C. Diniz, J. Gonçalves, P. Fresco, 2018, Recent Patents on Anti-Cancer Drug Discovery.

Using yeast to uncover the regulation of protein kinase Cδ by ceramide.

L. Saraíva, Mariana Leão, M. Côrte-Real, 2013, FEMS yeast research.

Skin temperature response to thermal stimulus in patients with hyperhidrosis: A comparative study.

F. Fernandez‐Llimos, J. Gonçalves, Fátima Carvalho, 2022, Journal of thermal biology.

Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay.

L. Saraíva, J. Gonçalves, P. Fresco, 2004, European journal of pharmacology.

Differential regulation of p53 function by protein kinase C isoforms revealed by a yeast cell system

L. Saraíva, Mariana Leão, M. Côrte-Real, 2009, FEBS Letters.

In Situ Mitochondrial Ca2+ Buffering Differences of Intact Neurons and Astrocytes from Cortex and Striatum*

J. Gonçalves, J. Oliveira, 2009, Journal of Biological Chemistry.

Discovery of a small-molecule protein kinase Cδ-selective activator with promising application in colon cancer therapy

L. Saraíva, J. Loureiro, J. Soares, 2018, Cell Death & Disease.

Hypothermia induces supersensitivity of mouse vas deferens to adrenergic agonists: evidence for postjunctional α2‐adrenoceptors

J. Gonçalves, M. Q. Paiva, J. Proença, 1989, The Journal of pharmacy and pharmacology.

Uptake inhibitors do not change the effect of imidazoline α2-adrenoceptor agonists on transmitter release evoked by single pulse stimulation in mouse vas deferens

J. Gonçalves, S. Guimarães, F. Carvalho, 1989, Naunyn-Schmiedeberg's Archives of Pharmacology.

REGIONAL DIFFERENCES IN EXTRACELLULAR PURINE DEGRADATION IN THE PROSTATIC AND EPIDIDYMAL PORTIONS OF THE RAT VAS DEFERENS

C. Diniz, J. Gonçalves, P. Fresco, 2005, Clinical and experimental pharmacology & physiology.

Impaired inhibitory function of presynaptic A1-adenosine receptors in SHR mesenteric arteries.

C. Diniz, J. Gonçalves, S. Arribas, 2013, Journal of pharmacological sciences.

Discovery of a small-molecule protein kinase Cδ-selective activator with promising application in colon cancer therapy

L. Saraíva, J. Loureiro, J. Soares, 2018, Cell Death & Disease.

Opposite modulation of astroglial proliferation by adenosine 5′-O-(2-thio)-diphosphate and 2-methylthioadenosine-5′-diphosphate: mechanisms involved

J. Gonçalves, S. Fraga, C. Quintas, 2011, Neuroscience.

A2A adenosine-receptor-mediated facilitation of noradrenaline release in rat tail artery involves protein kinase C activation and βγ subunits formed after α2-adrenoceptor activation

C. Diniz, J. Gonçalves, J. Oliveira, 2007, Neurochemistry International.

Adenosine A2A receptor‐mediated facilitation of noradrenaline release involves protein kinase C activation and attenuation of presynaptic inhibitory receptor‐mediated effects in the rat vas deferens

J. Gonçalves, Carlos Talaia, G. Queiroz, 2003, Journal of neurochemistry.

Facilitation of noradrenaline release by activation of adenosine A(2A) receptors triggers both phospholipase C and adenylate cyclase pathways in rat tail artery.

C. Diniz, J. Gonçalves, P. Fresco, 2004, Cardiovascular research.

Purinoceptor modulation of noradrenaline release in rat tail artery: tonic modulation mediated by inhibitory P2Y‐ and facilitatory A2A‐purinoceptors

J. Gonçalves, G. Queiroz, 1996, British journal of pharmacology.

Activation of β-Adrenoceptors Promotes Lipid Droplet Accumulation in MCF-7 Breast Cancer Cells via cAMP/PKA/EPAC Pathways

J. Gonçalves, Dany Silva, P. Fresco, 2023, International journal of molecular sciences.

Immunohistochemical localization of angiotensin II receptor types 1 and 2 in the mesenteric artery from spontaneously hypertensive rats

C. Diniz, J. Gonçalves, P. Fresco, 2007, Microscopy research and technique.

Microglia P2Y6 receptors mediate nitric oxide release and astrocyte apoptosis

L. Saraíva, D. Pinho, J. Gonçalves, 2014, Journal of Neuroinflammation.

Inhibition of neural ATP release by atrial natriuretic peptide in guinea-pig vas deferens.

B. Driessen, J. Gonçalves, 1996, European journal of pharmacology.

Mitochondrial dysfunction in Huntington’s disease: the bioenergetics of isolated and in situ mitochondria from transgenic mice

L. Ellerby, D. Nicholls, Sylvia F. Chen, 2007, Journal of neurochemistry.

Mitochondrial-Dependent Ca2+ Handling in Huntington's Disease Striatal Cells: Effect of Histone Deacetylase Inhibitors

M. Hayden, L. Ellerby, C. Oliveira, 2006, The Journal of Neuroscience.

Challenges in Pharmacological Intervention in Perilipins (PLINs) to Modulate Lipid Droplet Dynamics in Obesity and Cancer

J. Gonçalves, Dany Silva, P. Fresco, 2023, Cancers.

Long-term 1,2-dimethylhydrazine triggers pathological remodeling of colon mucosa through repression of sestrin2, nuclear factor (erythroid-derived 2)-like 2, and sirtuin4 stimulating mitochondrial stress and metabolic reprogramming

J. Gonçalves, Dany Silva, B. Djerdjouri, 2023, Naunyn-Schmiedeberg's Archives of Pharmacology.

Potential use of renin-angiotensin-aldosterone system inhibitors to reduce COVID-19 severity

F. Fernandez‐Llimos, J. Gonçalves, P. Fresco, 2023, Revista Portuguesa de Cardiologia.

Yeast as a powerful model system for the study of apoptosis regulation by protein kinase C isoforms.

L. Saraíva, M. Côrte-Real, J. Gonçalves, 2012, Current pharmaceutical design.

Involvement of P2Y1, P2Y6, A1 and A2A Receptors in the Purinergic Inhibition of NMDA-Evoked Noradrenaline Release in the Rat Brain Cortex

J. Gonçalves, C. Quintas, G. Queiroz, 2023, Cells.

Interaction between adenosine A2B-receptors and α2-adrenoceptors on the modulation of noradrenaline release in the rat vas deferens: Possible involvement of a group 2 adenylyl cyclase isoform

J. Gonçalves, Carlos Talaia, C. Quintas, 2005, Neurochemistry International.

Vancomycin therapeutic drug monitoring and population pharmacokinetic models in special patient subpopulations

J. Gonçalves, P. Fresco, J. Monteiro, 2018, Pharmacology research & perspectives.