D. Freed

发表

A Decrease in Hypoxic Pulmonary Vasoconstriction Correlates With Increased Inflammation During Extended Normothermic Ex Vivo Lung Perfusion

M. Mengel, S. Himmat, A. Alzamil, 2018, Artificial organs.

Differential impact of mechanical unloading on structural and nonstructural components of the extracellular matrix in advanced human heart failure.

C. Sergi, G. Oudit, Z. Kassiri, 2016, Translational research : the journal of laboratory and clinical medicine.

Quantitative assessment of cardiac output and left ventricular function by noninvasive phase‐contrast and cine MRI: Validation study with invasive pressure‐volume loop analysis in a swine model

B. Tomanek, B. Xiang, R. Arora, 2011, Journal of magnetic resonance imaging : JMRI.

Bivalirudin Experience in a Heterogeneous Ventricular Assist Device Population

J. Conway, D. Freed, H. Buchholz, 2019, ASAIO journal.

Driveline Site Is Not a Predictor of Infection After Ventricular Assist Device Implantation

B. Martin, J. Conway, J. Luc, 2017, ASAIO journal.

Can long-term ventricular assist devices be safely implanted in low-volume, non-heart transplant centres?

A. Menkis, C. White, D. Freed, 2011, The Canadian journal of cardiology.

Laparoscopic nephroureterectomy in a patient with a left ventricular assist device.

H. Grocott, Jasmir G. Nayak, C. White, 2013, Canadian Urological Association journal = Journal de l'Association des urologues du Canada.

The Donation after Circulatory Death Donor can be a Source of Organs for Cardiac Transplantation

D. Freed, Ayyaz A. Ali, S. Large, 2012 .

Functional and haemodynamic outcome 1 year after pulmonary thromboendarterectomy.

D. Freed, J. Pepke-Żaba, S. Tsui, 2008, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

Cardiotrophin-1: Expression in experimental myocardial infarction and potential role in post-MI wound healing

Stephen C. Jones, I. Dixon, P. Zahradka, 2003, Molecular and Cellular Biochemistry.

Adipose-derived stem cells are an effective cell candidate for treatment of heart failure: an MR imaging study of rat hearts.

B. Tomanek, M. Glogowski, J. Rendell, 2009, American journal of physiology. Heart and circulatory physiology.

Avoiding initial hypothermia does not improve liver graft quality in a porcine donation after circulatory death (DCD) model of normothermic perfusion

Sunita Ghosh, A. M. Shapiro, T. Churchill, 2019, PloS one.

Normothermic Ex Vivo Machine Perfusion for Liver Grafts Recovered from Donors after Circulatory Death: A Systematic Review and Meta-Analysis

A. M. Shapiro, D. Bigam, D. Freed, 2018, HPB surgery : a world journal of hepatic, pancreatic and biliary surgery.

Successful ablation of idiopathic left ventricular tachycardia in an adult patient during extracorporeal membrane oxygenation treatment.

J. Rizkallah, D. Freed, A. Tischenko, 2013, The Canadian journal of cardiology.

Functional mitral regurgitation: current understanding and approach to management.

R. Ducas, C. White, D. Freed, 2014, The Canadian journal of cardiology.

Autophagy is a regulator of TGF-β1-induced fibrogenesis in primary human atrial myofibroblasts

I. Dixon, S. Ghavami, A. Halayko, 2015, Cell Death and Disease.

Machine Perfusion of Donor Heart: State of the Art

S. Hatami, D. Freed, 2019, Current Transplantation Reports.

Transplantation of Hearts Donated after Circulatory Death

J. Conway, C. White, D. Freed, 2018, Front. Cardiovasc. Med..

Steroids Limit Myocardial Edema During Ex Vivo Perfusion of Hearts Donated After Circulatory Death.

I. Dixon, R. Arora, L. Hryshko, 2018, The Annals of thoracic surgery.

A whole blood-based perfusate provides superior preservation of myocardial function during ex vivo heart perfusion.

B. Xiang, R. Arora, L. Hryshko, 2015, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Assessment of donor heart viability during ex vivo heart perfusion.

I. Dixon, B. Hiebert, R. Arora, 2015, Canadian journal of physiology and pharmacology.

A cardioprotective preservation strategy employing ex vivo heart perfusion facilitates successful transplant of donor hearts after cardiocirculatory death.

B. Xiang, R. Arora, L. Hryshko, 2013, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Management of the neurologically deceased organ donor: A Canadian clinical practice guideline

M. Meade, S. Keenan, L. Hornby, 2020, Canadian Medical Association Journal.

Activation of proteolytic enzymes and depression of the sarcolemmal Na+/K+-ATPase in ischemia-reperfused heart may be mediated through oxidative stress.

N. Dhalla, L. Hryshko, D. Freed, 2012, Canadian journal of physiology and pharmacology.

Clinical and angiographic outcomes associated with surgical revascularization of angiographically borderline 50-69% coronary artery stenoses.

J. Afilalo, C. Norris, M. Graham, 2016, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

QUANTIFYING THE IMMUNE RESPONSE TO TISSUE ENGINEERED EXTRACELLULAR MATRIX

D. Freed, J. Nagendran, J. Nagendran, 2020 .

Comparing Scaffold Design and Recellularization Techniques for Development of Tissue Engineered Heart Valves

A. Mathew, D. Freed, J. Nagendran, 2020, Regenerative Engineering and Translational Medicine.

Current techniques and the future of lung preservation.

J. Acker, D. Freed, J. Nagendran, 2020, Cryobiology.

Growth and positioning of adipose-derived stem cells in microfluidic devices.

Francis Lin, Sivakumar Gajjeraman, Jing Li, 2012, Lab on a chip.

Preoperative Predictors of Mortality in Short-Term Continuous-Flow Ventricular Assist Devices.

J. Conway, D. Freed, H. Buchholz, 2019, ASAIO journal.

Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients

Richard B. Thompson, D. O’Regan, Lan Zhao, 2017, Science Translational Medicine.

Resuscitative extracorporeal membrane oxygenation for in hospital cardiac arrest: a Canadian observational experience.

B. Hiebert, R. Manji, R. Singal, 2014, Resuscitation.

Clinical transplantation using negative pressure ventilation ex situ lung perfusion with extended criteria donor lungs

D. Freed, J. Nagendran, A. Hirji, 2020, Nature Communications.

Ex-Vivo Lung Perfusion: From Bench to Bedside

S. Himmat, N. Aboelnazar, D. Freed, 2016 .

Negative pressure ventilation decreases inflammation and lung edema during normothermic ex-vivo lung perfusion.

J. Dyck, M. Mengel, S. Himmat, 2017, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Type A Aortic Dissection Complicated by an Aorto‐Right Atrial Fistula

R. Arora, C. White, D. Freed, 2015, Journal of cardiac surgery.

Preclinical models of acute liver failure: a comprehensive review

R. Pawlick, D. Bigam, B. Marfil-Garza, 2021, PeerJ.

FIASCO II failure to achieve a satisfactory cardiac outcome study: the elimination of system errors.

S. Nashef, D. Freed, D. Jenkins, 2013, Interactive cardiovascular and thoracic surgery.

Death in low-risk cardiac surgery: the failure to achieve a satisfactory cardiac outcome (FIASCO) study.

S. Nashef, D. Freed, M. Jones, 2009, Interactive cardiovascular and thoracic surgery.

Nineteen-millimeter prosthetic aortic valves allow normalization of left ventricular mass in elderly women.

Gregory E. J. Harding, D. Freed, J. Tam, 2002, The Annals of thoracic surgery.

Preservation of Myocardial Perfusion and Function by Keeping Hypertrophied Heart Empty and Beating for Valve Surgery: An In Vivo MR Study of Pig Hearts

B. Xiang, R. Arora, D. Freed, 2017, BioMed research international.

Apoptosis, autophagy and ER stress in mevalonate cascade inhibition-induced cell death of human atrial fibroblasts

I. Dixon, S. Ghavami, A. Halayko, 2012, Cell Death and Disease.

The effects of body mass index on long-term outcomes and cardiac remodeling following mitral valve repair surgery

R. Gill, D. Freed, J. Nagendran, 2021, International Journal of Obesity.

Impact of sex on cardiac remodeling and long‐term outcomes, following mitral valve replacement

D. Freed, J. Nagendran, J. Nagendran, 2020, Journal of cardiac surgery.

Short-term mechanical circulatory support for recovery from acute right ventricular failure: clinical outcomes.

A. Cheung, C. White, D. Freed, 2014, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

TCT-371 First Clinical Evaluation of a Novel Percutaneous Right Ventricular Assist Device: The Impella RP

P. Leprince, A. Cheung, P. Hunziker, 2012 .

Is stress cardiomyopathy the underlying cause of ventricular dysfunction associated with brain death?

E. Ashley, K. Clarke, J. Parameshwar, 2010, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Resveratrol attenuates stimulated T-cell activation and proliferation: potential therapy against cellular rejection in organ transplantation.

D. Al-Adra, D. Freed, J. Nagendran, 2020, American journal of clinical and experimental immunology.

Coronary Artery Revascularization in Heart Transplant Patients: A Systematic Review and Meta-Analysis

D. Freed, J. Nagendran, S. Meyer, 2022, Cardiology.

Outcomes following bioprosthetic valve replacement in prior non‐cardiac transplant recipients

D. Al-Adra, D. Freed, J. Nagendran, 2019, Clinical transplantation.

Lung Transplantation, Pulmonary Endothelial Inflammation, and Ex-Situ Lung Perfusion: A Review

D. Freed, J. Nagendran, N. Fialka, 2021, Cells.

Chronic exogenous ketone supplementation blunts the decline of cardiac function in the failing heart

J. Dyck, M. Ferdaoussi, Zaid H Maayah, 2021, ESC heart failure.

Immunity and Stress Responses Are Induced During Ex Situ Heart Perfusion

C. Sergi, S. Himmat, S. Hatami, 2020, Circulation. Heart failure.

Impact of Reperfusion Calcium and pH on the Resuscitation of Hearts Donated After Circulatory Death.

I. Dixon, R. Arora, L. Hryshko, 2017, The Annals of thoracic surgery.

Impact of sex on long-term outcomes following mitral valve repair

D. Freed, J. Nagendran, J. Nagendran, 2021 .

Hypoxia enhances the therapeutic potential of superparamagnetic iron oxide-labeled adipose-derived stem cells for myocardial infarction

B. Xiang, R. Arora, D. Freed, 2017, Journal of Huazhong University of Science and Technology [Medical Sciences].

Differential MR Delayed Enhancement Patterns of Chronic Myocardial Infarction between Extracellular and Intravascular Contrast Media

B. Xiang, R. Arora, Hong-yu Liu, 2015, PloS one.

Recellularization of xenograft heart valves reduces the xenoreactive immune response in an in vivo rat model.

D. Freed, J. Nagendran, J. Nagendran, 2020, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

Survival after pulmonary thromboendarterectomy: effect of residual pulmonary hypertension.

D. Freed, S. Tsui, M. Berman, 2011, The Journal of thoracic and cardiovascular surgery.

High Spinal Anesthesia Enhances Anti-Inflammatory Responses in Patients Undergoing Coronary Artery Bypass Graft Surgery and Aortic Valve Replacement: Randomized Pilot Study

D. Freed, Trevor W. R. Lee, K. HayGlass, 2016, PloS one.

Decreasing driveline infections in patients supported on ventricular assist devices: a care pathway approach

J. Conway, D. Freed, H. Buchholz, 2021, BMJ open quality.

The evaluation of constant coronary artery flow versus constant coronary perfusion pressure during normothermic ex situ heart perfusion.

J. Acker, D. Nobes, S. Himmat, 2022, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Myocardial Functional Decline During Prolonged Ex Situ Heart Perfusion.

E. Michelakis, S. Himmat, S. Hatami, 2019, The Annals of thoracic surgery.

Heart Transplantation With Donation After Circulatory Death: What Have We Learned From Preclinical Studies?

P. Macdonald, T. Carrel, Mathieu Raillard, 2019, Circulation. Heart failure.

Steroids Limit Myocardial Edema During Ex Vivo Perf usion Of Hearts Donated After Circulatory Death Running Head : Steroids minimize edema during EVHP

Avery, I. Dixon, R. Arora, 2018 .

Canadian Guidelines for Controlled Pediatric Donation After Circulatory Determination of Death—Summary Report*

L. Hornby, B. Rochwerg, Daniel Z. Buchman, 2017, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

Functional assessment and transplantation of the donor heart after circulatory death.

E. Ashley, M. Goddard, P. White, 2016, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Physiologic Changes in the Heart Following Cessation of Mechanical Ventilation in a Porcine Model of Donation After Circulatory Death: Implications for Cardiac Transplantation

B. Xiang, I. Dixon, R. Arora, 2016, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Disparate Remodeling of the Extracellular Matrix and Proteoglycans in Failing Pediatric Versus Adult Hearts

H. Zhang, C. Sergi, G. Lopaschuk, 2018, Journal of the American Heart Association.

Recellularized bovine pericardium with autologous mesenchymal stem cells reduces immune activation

D. Freed, J. Nagendran, J. Nagendran, 2022, Xenotransplantation.

A Low-Cost Perfusate Alternative for Ex Vivo Lung Perfusion.

B. Adam, S. Himmat, N. Aboelnazar, 2020, Transplantation proceedings.

Total parenteral nutrition in ex vivo lung perfusion: Addressing metabolism improves both inflammation and oxygenation

S. Himmat, S. Hatami, D. Freed, 2019, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Ex vivo perfusion induces a time‐ and perfusate‐dependent molecular repair response in explanted porcine lungs

M. Mengel, B. Adam, J. Luc, 2018, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Feasibility of Lung Transplantation From Donation After Circulatory Death Donors Following Portable Ex Vivo Lung Perfusion: A Pilot Study.

J. Luc, D. Freed, J. Nagendran, 2017, Transplantation proceedings.

Superparamagnetic iron oxide does not affect the viability and function of adipose-derived stem cells, and superparamagnetic iron oxide-enhanced magnetic resonance imaging identifies viable cells.

G. Dai, B. Tomanek, M. Glogowski, 2009, Magnetic resonance imaging.

Interprovincial spoke-to-hub transport using the Impella Recover LP 5.0 left ventricular assist device as a bridge to long-term circulatory support.

A. Menkis, D. Freed, R. Philipp, 2010, The Canadian journal of cardiology.

The acutely occluded left main coronary artery culprit in cardiogenic shock and initial percutaneous coronary intervention: a substudy of the Manitoba "no option" left main PCI registry.

A. Menkis, D. Jassal, M. Kass, 2012, Canadian journal of physiology and pharmacology.

Inhibition of Viability, Proliferation, Cytokines Secretion, Surface Antigen Expression, and Adipogenic and Osteogenic Differentiation of Adipose-Derived Stem Cells by Seven-Day Exposure to 0.5 T Static Magnetic Fields

B. Xiang, R. Arora, D. Freed, 2016, Stem cells international.

Medium to long-term clinical outcome following stentless aortic valve replacement: comparison between allograft and xenograft valves.

J. Pepper, T. Athanasiou, Z. Ali, 2010, Interactive cardiovascular and thoracic surgery.

Cryopreservation timing is a critical process parameter in a thymic regulatory T-cell therapy manufacturing protocol.

J. Piret, M. Levings, I. Rebeyka, 2019, Cytotherapy.

Ventricular assist device support following pediatric heart transplantation

J. Conway, D. Freed, S. Urschel, 2022, Pediatric transplantation.

Sternal Bone Marrow Harvesting and Culturing Techniques from Patients Undergoing Cardiac Surgery

D. Freed, J. Nagendran, J. Nagendran, 2021, Micromachines.

Externally Applied Static Magnetic Field Enhances Cardiac Retention and Functional Benefit of Magnetically Iron‐Labeled Adipose‐Derived Stem Cells in Infarcted Hearts

B. Xiang, R. Arora, D. Freed, 2016, Stem cells translational medicine.

Adipose tissue houses different subtypes of stem cells.

B. Xiang, R. Arora, Hong-yu Liu, 2012, Canadian journal of physiology and pharmacology.

A Leukocyte Filter Does Not Provide Further Benefit During Ex Vivo Lung Perfusion

M. Mengel, J. Luc, S. Himmat, 2017, ASAIO journal.

Lung transplantation from donors after circulatory death using portable ex vivo lung perfusion.

J. Luc, D. Freed, J. Nagendran, 2015, Canadian respiratory journal.

2-Methoxyestradiol: A Hormonal Metabolite Modulates Stimulated T-Cells Function and proliferation.

J. Y. Zhao, E. Michelakis, J. Luc, 2015, Transplantation proceedings.

Ventricular septal defect as a result of direct trauma from mechanical mitral valve prosthesis.

D. Jassal, D. Freed, J. Tam, 2011, The Canadian journal of cardiology.

Clearance of transaminases during normothermic ex situ liver perfusion

A. M. Shapiro, A. Thiesen, D. Bigam, 2019, PloS one.

Donor heart preservation: straight up, or on the rocks?

C. White, D. Freed, 2015, The Lancet.

Valve Sparing Aortic Root Replacement Three Decades After Repair of Aortico-Left Ventricular Tunnel.

D. Freed, I. V. Muhll, Şafak Alpat, 2019, The Annals of thoracic surgery.

Evaluating the Prevalence and Factors Associated With an Optimal Neurodevelopmental Outcome in 4- to 6-Year-Old Children With Fontan Circulation.

C. Robertson, A. Joffe, I. Dinu, 2022, The Canadian journal of cardiology.

Addressing organ shortages: progress in donation after circulatory death for liver transplantation

J. Shapiro, D. Bigam, D. Freed, 2020, Canadian journal of surgery. Journal canadien de chirurgie.

New Answers to Old Conundrums: What Antibodies, Exosomes and Inflammasomes Bring to the Conversation. Canadian National Transplant Research Program International Summit Report

T. Mohanakumar, R. Fairchild, C. Cairo, 2017, Transplantation.

Minimally invasive left-heart decompression during venoarterial extracorporeal membrane oxygenation: an alternative to a percutaneous approach.

A. Menkis, D. Freed, Kanwal K Kumar, 2010, Interactive cardiovascular and thoracic surgery.

Experimental Investigation Of The Effect Of Compliance Properties On The Flow In An Analogous Ex-Vivo Heart Perfusion System

Hyun‐Joong Chung, D. Nobes, D. Freed, 2021, Progress in Canadian Mechanical Engineering. Volume 4.

End-Stage Liver Disease Models and Outcomes in Pediatric Patients Supported With Short-Term Continuous-Flow Ventricular Assist Devices.

J. Conway, D. Freed, H. Buchholz, 2019, ASAIO journal.

Rat model of veno-arterial extracorporeal membrane oxygenation

E. Ashley, A. Kirtane, Z. Ali, 2014, Journal of Translational Medicine.

Extracorporeal membrane oxygenation for blastomycosis-related acute respiratory distress syndrome: a case series

Anand Kumar, B. Light, R. Singal, 2015, Canadian Journal of Anesthesia/Journal canadien d'anesthésie.

Inflammation and Oxidative Stress in the Context of Extracorporeal Cardiac and Pulmonary Support

Joshua Hefler, S. Hatami, D. Freed, 2022, Frontiers in Immunology.

Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease.

M. Post, S. Ghavami, E. Wiechec, 2014, Pharmacology & therapeutics.

Thoracic organ donation after circulatory determination of death

J. Conway, S. Hatami, D. Freed, 2022, Transplantation Reports.

Coronary Artery Bypass Surgery Improves Outcomes in Patients With Diabetes and Left Ventricular Dysfunction.

F. McAlister, C. Norris, D. Freed, 2018, Journal of the American College of Cardiology.

HMG-COA Reductase Inhibitors Do not Attenuate the Inflammatory Response Associated With Glutaraldehyde-Fixed Bioprosthetic Heart Valve Conduits

D. Jassal, R. Manji, R. Arora, 2013 .

Autophagy regulates trans fatty acid-mediated apoptosis in primary cardiac myofibroblasts.

I. Dixon, S. Ghavami, M. Los, 2012, Biochimica et biophysica acta.

Smad Cofactors/Corepressors in the Fibrosed Post-MI Heart: Possible Therapeutic Targets

I. Dixon, D. Freed, Baiqiu Wang, 2004 .

Model of Acute Liver Failure in an Isolated Perfused Porcine Liver—Challenges and Lessons Learned

A. M. Shapiro, J. Acker, A. Thiesen, 2022, Biomedicines.

Ex situ liver perfusion: Organ preservation into the future.

A. Shapiro, D. Bigam, B. Gala-Lopez, 2018, Transplantation reviews.

High Molecular Weight Fibroblast Growth Factor-2 in the Human Heart Is a Potential Target for Prevention of Cardiac Remodeling

R. Fandrich, E. Kardami, R. Arora, 2014, PloS one.

Cardiac fibroblast to myofibroblast differentiation in vivo and in vitro: Expression of focal adhesion components in neonatal and adult rat ventricular myofibroblasts

E. Kardami, I. Dixon, D. Freed, 2010, Developmental dynamics : an official publication of the American Association of Anatomists.

Ethicality of Heart Transplantation from Donation after Circulatory Death Donors

Z. Ali, C. White, D. Freed, 2013 .

A review of the immune response stimulated by xenogenic tissue heart valves

D. Al-Adra, D. Freed, J. Nagendran, 2020, Scandinavian journal of immunology.

Human mesenchymal stem cells express a myofibroblastic phenotype in vitro: comparison to human cardiac myofibroblasts

I. Dixon, R. Arora, D. Freed, 2014, Molecular and Cellular Biochemistry.

Intermediate-term outcomes of the arterial switch operation for transposition of great arteries in neonates: alive but well?

R. Sauve, C. Robertson, A. Joffe, 2006, The Journal of thoracic and cardiovascular surgery.

K+ currents regulate the resting membrane potential, proliferation, and contractile responses in ventricular fibroblasts and myofibroblasts.

W. Giles, I. Dixon, Y. Imaizumi, 2005, American journal of physiology. Heart and circulatory physiology.

Temporal dystrophic remodeling within the intrinsic cardiac nervous system of the streptozotocin-induced diabetic rat model

G. Glazner, R. Arora, P. Fernyhough, 2014, Acta neuropathologica communications.

Discharge and Readmission to the Pediatric Cardiac ICU in Pediatric Patients With Durable Ventricular Assist Devices

J. Conway, D. Freed, H. Buchholz, 2020, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

Maintaining the permanence principle for death during in situ normothermic regional perfusion for donation after circulatory death organ recovery: A United Kingdom and Canadian proposal

L. Hornby, J. Teitelbaum, G. Oniscu, 2020, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Emerging evidence for the role of cardiotrophin-1 in cardiac repair in the infarcted heart.

I. Dixon, D. Freed, R. Cunnington, 2005, Cardiovascular research.

Induction of protein synthesis in cardiac fibroblasts by cardiotrophin-1: integration of multiple signaling pathways.

I. Dixon, A. Borowiec, D. Freed, 2003, Cardiovascular research.

Unanticipated intra-operative finding of pulmonary artery tumour thromboembolism during radical nephrectomy and caval thrombectomy: Case report and management.

D. Freed, R. Sharda, D. Horne, 2013, Canadian Urological Association journal = Journal de l'Association des urologues du Canada.

Adult presentation with a bilobed membranous ventricular septal aneurysm.

G. Mackenzie, C. White, D. Freed, 2013, The Canadian journal of cardiology.

Percutaneous Treatment of Ascending Aortic Obstruction in a Young Child After Orthotopic Heart Transplantation.

J. Conway, D. Freed, K. Averin, 2023, Pediatric cardiology.

The Human Explanted Heart Program: A translational bridge for cardiovascular medicine

C. Sergi, Hao Zhang, A. Viveiros, 2020, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.

Bone Marrow-Derived Progenitor Cells, micro-RNA, and Fibrosis

D. Freed, A. Müller, 2015 .

Endovascular stenting for treatment of a left internal mammary artery pseudoaneurysm following redo‐sternotomy: A case report

D. Freed, P. Cheung, R. Philipp, 2013, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.

Subcellular Remodeling and Cardiac Dysfunction Due to Ischemia–Reperfusion Injury

N. Dhalla, L. Hryshko, D. Freed, 2013 .

Human mesenchymal stem cells express a myofibroblastic phenotype in vitro: comparison to human cardiac myofibroblasts

R. Arora, D. Freed, G. Tian, 2014, Molecular and Cellular Biochemistry.

The participation of the Na+–Ca2+ exchanger in primary cardiac myofibroblast migration, contraction, and proliferation

I. Dixon, D. Freed, J. Raizman, 2007, Journal of cellular physiology.

Successful repair of donation after circulatory death lungs with large pulmonary embolus using the lung organ care system for ex vivo thrombolysis and subsequent clinical transplantation.

J. Luc, D. Freed, J. Nagendran, 2015, Transplantation.

Dynamic Compression of the Left Main Coronary Artery by the Left Atrium

D. Jassal, R. Ducas, D. Freed, 2009, Journal of thoracic imaging.

Quantifying the immune response to a tissue-engineered porcine extracellular matrix.

D. Al-Adra, J. Kang, D. Freed, 2020, Regenerative medicine.

Control of the Mesenchymal-Derived Cell Phenotype by Ski and Meox2: A Putative Mechanism for Postdevelopmental Phenoconversion

I. Dixon, A. Halayko, J. Wigle, 2011 .

Hibernating myocardium: pathophysiology, diagnosis, and treatment.

P. Singal, D. Freed, N. Tribulova, 2009, Canadian journal of physiology and pharmacology.

Pathological Mechanism for Delayed Hyperenhancement of Chronic Scarred Myocardium in Contrast Agent Enhanced Magnetic Resonance Imaging

B. Xiang, R. Arora, Hong-yu Liu, 2014, PloS one.

Collateral circulation formation determines the characteristic profiles of contrast-enhanced MRI in the infarcted myocardium of pigs

B. Xiang, R. Arora, Hong-yu Liu, 2015, Acta Pharmacologica Sinica.

Role of myosin light chain kinase in cardiotrophin-1-induced cardiac myofibroblast cell migration.

I. Dixon, L. Hryshko, L. Chilton, 2011, American journal of physiology. Heart and circulatory physiology.

Statins Impair Survival of Primary Human Mesenchymal Progenitor Cells via Mevalonate Depletion, NF-κB Signaling, and Bnip3

L. Kirshenbaum, R. Arora, D. Freed, 2015, Journal of Cardiovascular Translational Research.

Structural Valve Deterioration Is Linked to Increased Immune Infiltrate and Chemokine Expression

J. Dyck, G. Oudit, B. Adam, 2020, Journal of Cardiovascular Translational Research.

Oxidative stress and related metabolic alterations are induced in ex situ perfusion of donated hearts regardless of the ventricular load or leukocyte depletion.

S. Himmat, S. Hatami, D. Freed, 2023, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

The effect of total spinal anesthesia on cardiac function in a large animal model of brain death.

R. Arora, D. Freed, Trevor W. R. Lee, 2012, Canadian journal of physiology and pharmacology.

fibroblasts and myofibroblasts proliferation, and contractile responses in ventricular currents regulate the resting membrane potential, +

W. Giles, I. Dixon, L. Chilton, 2016 .

The effects of body mass index on outcomes for patients undergoing surgical aortic valve replacement

R. Gill, C. Norris, A. Ishaque, 2020, BMC Cardiovascular Disorders.

Activation of proteases and changes in Na+‐K+ ATPase subunits in hearts subjected to ischemia‐reperfusion

N. Dhalla, D. Freed, A. Müller, 2013, Journal of applied physiology.

Thoracic organ machine perfusion: A review of concepts with a focus on reconditioning therapies

Mitchell J. Wagner, S. Hatami, D. Freed, 2023, Frontiers in Transplantation.

The Impact of Ex Situ Heart Perfusion in Pediatric Transplantation: An Analysis of the United Network for Organ Sharing Registry

J. Conway, D. Freed, T. Pidborochynski, 2022, ASAIO journal.

Normothermic Ex Situ Heart Perfusion in Working Mode: Assessment of Cardiac Function and Metabolism.

Hyun‐Joong Chung, D. Nobes, S. Himmat, 2019, Journal of visualized experiments : JoVE.

Influenza myocarditis and myositis: case presentation and review of the literature.

A. Menkis, Evelyn Lo, R. Arora, 2011, The Canadian journal of cardiology.

The utility of cardiac biomarkers and echocardiography for the early detection of bevacizumab- and sunitinib-mediated cardiotoxicity.

M. Kohli, D. Jassal, P. Singal, 2015, American journal of physiology. Heart and circulatory physiology.

Multicentre Canadian experience with the HeartWare ventricular assist device: concerns about adverse neurological outcomes.

V. Rao, A. Cheung, J. Légaré, 2014, The Canadian journal of cardiology.

The varying effects of obesity and morbid obesity on outcomes following cardiac transplantation

C. Norris, M. Graham, D. Freed, 2016, International Journal of Obesity.

Enhanced myocardial protection in cardiac donation after circulatory death using Intralipid® postconditioning in a porcine model

E. Lucchinetti, Phing-How Lou, M. Zaugg, 2019, Canadian Journal of Anesthesia/Journal canadien d'anesthésie.

What are the predictors that affect the excellent long-term benefits of redo coronary artery bypass grafting?

H. Ashrafian, T. Athanasiou, Z. Ali, 2010, Heart, lung & circulation.

The benefits of 24/7 in-house intensivist coverage for prolonged-stay cardiac surgery patients.

R. Manji, R. Singal, R. Arora, 2014, The Journal of thoracic and cardiovascular surgery.

Autophagy and heart disease: implications for cardiac ischemia-reperfusion damage.

I. Dixon, S. Ghavami, S. Gupta, 2014, Current molecular medicine.

Corrigendum to “Preservation of Myocardial Perfusion and Function by Keeping Hypertrophied Heart Empty and Beating for Valve Surgery: An In Vivo MR Study of Pig Hearts”

B. Xiang, R. Arora, D. Freed, 2017, BioMed research international.

Impact of Obesity on Heart and Lung Transplantation: Does Pre-Transplant Obesity Affect Outcomes?

R. Gill, D. Freed, J. Nagendran, 2017, Transplantation proceedings.

Successful transplantation of extended criteria lungs after prolonged ex vivo lung perfusion performed on a portable device

D. Freed, J. Nagendran, S. Bozso, 2015, Transplant international : official journal of the European Society for Organ Transplantation.

Viability and proliferation potential of adipose-derived stem cells following labeling with a positron-emitting radiotracer

Andrew L. Goertzen, Esmat Elhami, Chris Stillwell, 2011, European Journal of Nuclear Medicine and Molecular Imaging.

Continuous Hemodialysis Does Not Improve Graft Function During Ex Vivo Lung Perfusion Over 24 Hours.

B. Adam, S. Himmat, S. Hatami, 2019, Transplantation proceedings.

Mimicking "J-Shaped" and Anisotropic Stress-Strain Behavior of Human and Porcine Aorta by Fabric-Reinforced Elastomer Composites.

Hyun‐Joong Chung, A. Adesida, Thanh‐Giang La, 2019, ACS applied materials & interfaces.

Adipose-Derived Stem Cells from Both Visceral and Subcutaneous Fat Deposits Significantly Improve Contractile Function of Infarcted Rat Hearts

B. Xiang, R. Arora, F. Lin, 2015, Cell transplantation.

The influence of renal disease on outcomes and cardiac remodeling following surgical mitral valve replacement

D. Freed, J. Nagendran, J. Nagendran, 2023, Clinical Research in Cardiology.

Left Ventricular Outflow Tract Obstruction by a Bioprosthetic Mitral Valve: Diagnosis by Cardiac Computed Tomography

Darren H Freed, Davinder S Jassal, D. Jassal, 2009, Journal of thoracic imaging.

Effect of red blood cell storage time in pediatric cardiac surgical patients: a subgroup analysis of a randomized controlled trial

N. Poirier, D. Fergusson, P. Spinella, 2023, JTCVS Open.

Basic and Clinical Observations of Mevalonate Depletion on the Mevalonate Signaling Pathway.

D. Freed, Alison L Muller, 2017, Current Molecular Pharmacology.

Multimodality cardiac imaging of infective endocarditis.

D. Jassal, D. Freed, C. Seifer, 2017, Journal of cardiovascular medicine.

Stentless aortic valve replacement in patients with bicuspid aortic valve disease: clinical outcome and aortic diameter changes during follow-up.

J. Pepper, T. Athanasiou, Z. Ali, 2010, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

Assessment of three techniques for delivering stem cells to the heart using PET and MR imaging

B. Xiang, A. Goertzen, R. Arora, 2013, EJNMMI Research.

Barriers and misconceptions of ex situ heart perfusion in pediatric donation

J. Conway, D. Freed, T. Pidborochynski, 2022, Pediatric Transplantation.

Canadian Cardiovascular Society focused position statement update on assessment of the cardiac patient for fitness to drive: fitness following left ventricular assist device implantation.

N. Giannetti, D. Freed, C. Simpson, 2012, The Canadian journal of cardiology.

Multimodality imaging of a right atrial myxoma with pulmonary embolization.

D. Jassal, D. Freed, D. Horne, 2012, Canadian Journal of Cardiology.

hearts subjected to ischemia-reperfusion

N. Dhalla, D. Freed, A. Müller, 2012 .

Extracorporeal lung support for patients who had severe respiratory failure secondary to influenza A (H1N1) 2009 infection in Canada

Anand Kumar, R. Fowler, A. Guerguerian, 2010, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

Inadvertent cannulation of the azygos vein during eCPR

N. Yanchar, D. Freed, D. Fruitman, 2021 .

Heart donation and transplantation after circulatory determination of death: expert guidance from a Canadian consensus building process

L. Hornby, J. Teitelbaum, S. Shemie, 2021, Canadian Journal of Anesthesia/Journal canadien d'anesthésie.

Implications of protease activation in cardiac dysfunction and development of genetic cardiomyopathy in hamsters.

N. Dhalla, L. Hryshko, D. Freed, 2012, Canadian journal of physiology and pharmacology.

Experimental investigation into the effect of compliance of a mock aorta on cardiac performance

David S Nobes, Katie Cameron, Mouhammad El Hassan, 2020, PloS one.

The Position of the Heart During Normothermic Ex Situ Heart Perfusion is an Important Factor in Preservation and Recovery of Myocardial Function

Hyun‐Joong Chung, C. Sergi, D. Nobes, 2021, ASAIO journal (1992).

Rat model of veno-arterial extracorporeal membrane oxygenation

E. Ashley, A. Kirtane, Z. Ali, 2014, Journal of Translational Medicine.

Successful cardiac resuscitation with extracorporeal membrane oxygenation in the setting of persistent ventricular fibrillation: a case report

D. Jassal, A. Ravandi, D. Freed, 2014, BMC Research Notes.

Canada's longest experience with extracorporeal membrane oxygenation as a bridge to lung transplantation: a case report.

D. Freed, J. Nagendran, S. Bozso, 2015, Transplantation proceedings.

Effect of red blood cell storage time in pediatric cardiac surgery patients: A subgroup analysis of a randomized controlled trial

N. Poirier, D. Fergusson, P. Spinella, 2023 .

Cardiac fibroblast to myofibroblast differentiation in vivo and in vitro: Expression of focal adhesion components in neonatal and adult rat ventricular myofibroblasts

E. Kardami, I. Dixon, D. Freed, 2010, Developmental dynamics : an official publication of the American Association of Anatomists.

mass in elderly women Nineteen-millimeter prosthetic aortic valves allow normalization of left ventricular

Edward Pascoe, Darren H. Freed, James W. Tam, 2013 .

Selection of chemotactic adipose-derived stem cells using a microfluidic gradient generator

B. Xiang, R. Arora, F. Lin, 2015 .

Is stress cardiomyopathy the underlying cause of ventricular dysfunction associated with brain death?

E. Ashley, K. Clarke, J. Parameshwar, 2010, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.