B. Grubb

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Evidence for Periciliary Liquid Layer Depletion, Not Abnormal Ion Composition, in the Pathogenesis of Cystic Fibrosis Airways Disease

S. Randell, J. Gatzy, R. Tarran, 1998, Cell.

The Relative Roles of Passive Surface Forces and Active Ion Transport in the Modulation of Airway Surface Liquid Volume and Composition

J. Gatzy, R. Tarran, R. Boucher, 2001, The Journal of general physiology.

Mucociliary transport determined by in vivo microdialysis in the airways of normal and CF mice.

R. Boucher, B. Grubb, J. H. Jones, 2004, American journal of physiology. Lung cellular and molecular physiology.

Conditional deletion of dnaic1 in a murine model of primary ciliary dyskinesia causes chronic rhinosinusitis.

L. Ostrowski, W. O'Neal, T. Rogers, 2010, American journal of respiratory cell and molecular biology.

Transmembrane Protein 16A (TMEM16A) Is a Ca2+-regulated Cl– Secretory Channel in Mouse Airways*

B. Harfe, S. Randell, W. O'Neal, 2009, Journal of Biological Chemistry.

Identification of trans Protein QTL for Secreted Airway Mucins in Mice and a Causal Role for Bpifb1

W. O'Neal, R. Boucher, L. Donoghue, 2017, Genetics.

Inefficient gene transfer by adenovirus vector to cystic fibrosis airway epithelia of mice and humans

James M. Wilson, H. Ye, J. Yankaskas, 1994, Nature.

Salt restriction induces pseudohypoaldosteronism type 1 in mice expressing low levels of the beta-subunit of the amiloride-sensitive epithelial sodium channel.

M. Burnier, S. Pradervand, J. Gatzy, 1999, Proceedings of the National Academy of Sciences of the United States of America.

In vivo microdialysis for determination of nasal liquid ion composition.

R. Boucher, B. Grubb, James L Chadburn, 2002, American journal of physiology. Cell physiology.

Nucleotide Release Provides a Mechanism for Airway Surface Liquid Homeostasis*

Seiko F. Okada, R. Tarran, R. Boucher, 2004, Journal of Biological Chemistry.

Restoring ciliary function to differentiated Primary Ciliary Dyskinesia cells with a lentiviral vector

L. Ostrowski, J. Olsen, T. Rogers, 2014, Gene Therapy.

Reduced Three-Dimensional Motility in Dehydrated Airway Mucus Prevents Neutrophil Capture and Killing Bacteria on Airway Epithelial Surfaces1

S. Randell, R. Boucher, J. Sheehan, 2005, The Journal of Immunology.

Exchanges of lead in vitro by the rabbit crystalline lens.

B. Grubb, P. Bentley, S. Driscoll, 1986, Experimental eye research.

Animal models of cystic fibrosis in the era of highly effective modulator therapies.

B. Grubb, A. Livraghi-Butrico, 2022, Current opinion in pharmacology.

An Improved Inhaled Mucolytic to Treat Airway Muco‐obstructive Diseases

Boya Wang, S. Donaldson, D. Hill, 2019, American journal of respiratory and critical care medicine.

Regional differences in rat conjunctival ion transport activities.

S. Randell, R. Boucher, W. Thelin, 2012, American journal of physiology. Cell physiology.

Extracellular nucleotides block bone mineralization in vitro: evidence for dual inhibitory mechanisms involving both P2Y2 receptors and pyrophosphate.

G. Burnstock, T. Arnett, I. Orriss, 2007, Endocrinology.

Calcium in the toad (Bufo marinus) cornea: binding by the stroma.

B. Grubb, P. Bentley, 1987, Comparative biochemistry and physiology. A, Comparative physiology.

Enhanced in vivo airway gene transfer via transient modification of host barrier properties with a surface-active agent.

L. G. Johnson, R. Boucher, B. Grubb, 1998, Human gene therapy.

Tissue distribution of subcutaneously administered aluminum chloride in weanling rabbits.

B. Grubb, P. Bentley, G. Du Val, 1986, Journal of toxicology and environmental health.

Inactivation of Chibby affects function of motile airway cilia

R. Moon, P. Treuting, K. Takemaru, 2009, The Journal of cell biology.

Role of Spdef in the Regulation of Muc5b Expression in the Airways of Naive and Mucoobstructed Mice

R. Boucher, X. Bustamante-Marin, B. Grubb, 2018, American journal of respiratory cell and molecular biology.

Mucociliary Clearance in Mice Measured by Tracking Trans-tracheal Fluorescence of Nasally Aerosolized Beads

L. Ostrowski, T. Rogers, B. Grubb, 2018, Scientific Reports.

Reduced mucociliary clearance in old mice is associated with a decrease in Muc5b mucin.

L. Ostrowski, T. Rogers, W. Yin, 2016, American journal of physiology. Lung cellular and molecular physiology.

Anomalies in ion transport in CF mouse tracheal epithelium.

R. Boucher, A. M. Paradiso, B. Grubb, 1994, The American journal of physiology.

Effect of in vivo corticosteroids on Na+ transport across airway epithelia.

R. Boucher, B. Grubb, Richard C. Boucher, 1998, American journal of physiology. Cell physiology.

Airway Surface Liquid Volume Regulation Determines Different Airway Phenotypes in Liddle Compared with βENaC-overexpressing Mice*

S. Pradervand, C. Schultz, A. Livraghi, 2010, The Journal of Biological Chemistry.

Human Alveolar Type II Cells Secrete and Absorb Liquid in Response to Local Nucleotide Signaling*

Seiko F. Okada, S. Randell, R. Boucher, 2010, The Journal of Biological Chemistry.

between C3H/HeJ and C57BL/6J mice Comparison of postnatal lung growth and development

J. Curtis, W. Mitzner, S. Randell, 2015 .

Hyperabsorption of Na+ and raised Ca(2+)-mediated Cl- secretion in nasal epithelia of CF mice.

R. Boucher, B. Grubb, R. Vick, 1994, The American journal of physiology.

Relationship of a non-cystic fibrosis transmembrane conductance regulator-mediated chloride conductance to organ-level disease in Cftr(-/-) mice.

C. Cotton, A. McKenzie, J. Yankaskas, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Expression of the amino acid transporter ATB 0+ in lung: possible role in luminal protein removal.

S. Mager, B. Grubb, J. Sloan, 2003, American Journal of Physiology - Lung cellular and Molecular Physiology.

Culture of murine nasal epithelia: model for cystic fibrosis.

L. Ostrowski, R. Boucher, T. Rogers, 2006, American journal of physiology. Lung cellular and molecular physiology.

Effect of Loss of P2Y2 Receptor Gene Expression on Nucleotide Regulation of Murine Epithelial Cl−Transport*

V. Cressman, B. Koller, R. Boucher, 1999, The Journal of Biological Chemistry.

Airway Epithelial Nucleotide Release Contributes to Mucociliary Clearance

E. Lazarowski, B. Grubb, B. Button, 2021, Life.

The Cystic Fibrosis Transmembrane Conductance Regulator Is Regulated by a Direct Interaction with the Protein Phosphatase 2A*

R. Tarran, W. Thelin, J. Sheehan, 2005, Journal of Biological Chemistry.

Mice with a Deletion of Rsph1 Exhibit a Low Level of Mucociliary Clearance and Develop a PCD Phenotype.

P. Sears, L. Ostrowski, T. Rogers, 2019, American journal of respiratory cell and molecular biology.

Mice with a Deletion of Rsph1 Exhibit a Low Level of Mucociliary Clearance and Develop a Primary Ciliary Dyskinesia Phenotype

P. Sears, L. Ostrowski, T. Rogers, 2019 .

Role of gammaENaC subunit in lung liquid clearance and electrolyte balance in newborn mice. Insights into perinatal adaptation and pseudohypoaldosteronism.

J. Gatzy, R. Boucher, B. Rossier, 1998, The Journal of clinical investigation.

A mouse model for the renal salt-wasting syndrome pseudohypoaldosteronism.

M. Burnier, J. Gatzy, R. Boucher, 1997, Proceedings of the National Academy of Sciences of the United States of America.

SERCA Pump Inhibitors Do Not Correct Biosynthetic Arrest of (cid:1) F508 CFTR in Cystic Fibrosis

J. Riordan, M. Drumm, S. Randell, 2006 .

Loss of Cftr function exacerbates the phenotype of Na(+) hyperabsorption in murine airways.

S. Randell, R. Boucher, T. Rogers, 2013, American journal of physiology. Lung cellular and molecular physiology.

Alterations in airway ion transport in NKCC1-deficient mice.

R. Boucher, B. Grubb, A. Pace, 2001, American journal of physiology. Cell physiology.

Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs

J. Sallenave, R. Boucher, C. Ehre, 2012, Proceedings of the National Academy of Sciences.

Regional Differences in Mucociliary Clearance in the Upper and Lower Airways

L. Ostrowski, T. Rogers, B. Grubb, 2022, Frontiers in Physiology.

Isolation and culture of airway epithelial cells from chronically infected human lungs

S. Randell, J. Yankaskas, B. Grubb, 2001, In Vitro Cellular & Developmental Biology - Animal.

and ciliated epithelium Ion transport across CF and normal murine olfactory

Seiko F. Okada, P. Lebecque, L. Ostrowski, 2011 .

Ion transport across CF and normal murine olfactory and ciliated epithelium.

L. Ostrowski, R. Boucher, T. Rogers, 2009, American journal of physiology. Cell physiology.

Intestinal ion transport in NKCC1-deficient mice.

R. Boucher, B. Grubb, A. Pace, 2000, American journal of physiology. Gastrointestinal and liver physiology.

The biology of strontium: interactions with the mammalian crystalline lens.

B. Grubb, P. Bentley, 1984, Experimental eye research.

Electrical PD, short-circuit current and fluxes of Na and Cl across avian intestine

B. Grubb, P. Bentley, S. Driscoll, 2004, Journal of Comparative Physiology B.

Abnormal surface liquid pH regulation by cultured cystic fibrosis bronchial epithelium

Richard C Boucher, J. Gatzy, L. G. Johnson, 2003, Proceedings of the National Academy of Sciences of the United States of America.

In Vivo Airway Surface Liquid Cl− Analysis with Solid-State Electrodes

M. Knowles, R. Tarran, R. Boucher, 2002, The Journal of general physiology.

Allometric relations of cardiovascular function in birds.

B. Grubb, 1983, The American journal of physiology.

Enamel Mineral Composition of Normal and Cystic Fibrosis Transgenic Mice

B. Grubb, K. Hall, J.T. Wright, 1996, Advances in dental research.

Abnormal Enamel Development in a Cystic Fibrosis Transgenic Mouse Model

J. T. Wright, B. Grubb, K. Hall, 1996, Journal of dental research.

Aldosterone-induced, amiloride-inhibitable short-circuit current in the avian ileum.

B. Grubb, P. Bentley, 1987, The American journal of physiology.

Muc5b is required for airway defence

Ivana V. Yang, Richard C. Boucher, Joseph H. Sisson, 2013, Nature.

Airway and Lung Pathology Due to Mucosal Surface Dehydration in β-Epithelial Na+ Channel-Overexpressing Mice: Role of TNF-α and IL-4Rα Signaling, Influence of Neonatal Development, and Limited Efficacy of Glucocorticoid Treatment1

S. Randell, A. Livraghi, R. Boucher, 2009, The Journal of Immunology.

Lack of GAS2L2 Causes PCD by Impairing Cilia Orientation and Mucociliary Clearance.

Laura E. Herring, P. Sears, L. Ostrowski, 2019, American journal of human genetics.

Pathophysiology of gene-targeted mouse models for cystic fibrosis.

R. Boucher, B. Grubb, R C Boucher, 1999, Physiological reviews.

Intestinal physiology and pathology in gene-targeted mouse models of cystic fibrosis.

B. Grubb, S. Gabriel, Sherif E. Gabriel, 1997, The American journal of physiology.

Bioelectric measurement of CFTR function in mice.

B. Grubb, 2002, Methods in molecular medicine.

Cloning and functional characterization of two murine uridine nucleotide receptors reveal a potential target for correcting ion transport deficiency in cystic fibrosis gallbladder.

L. Rochelle, R. Boucher, E. Lazarowski, 2001, The Journal of pharmacology and experimental therapeutics.

Ion transport across the normal and CF neonatal murine intestine.

B. Grubb, 1999, American journal of physiology. Gastrointestinal and liver physiology.

Ion transport across the normal and CF neonatal murine intestine.

B. Grubb, 1999, The American journal of physiology.

Cardiac output and stroke volume in exercising ducks and pigeons.

B. Grubb, 1982, Journal of applied physiology: respiratory, environmental and exercise physiology.

Secretory Cells Dominate Airway CFTR Expression and Function in Human Airway Superficial Epithelia.

L. Ostrowski, B. Stripp, S. Randell, 2020, American journal of respiratory and critical care medicine.

SERCA pump inhibitors do not correct biosynthetic arrest of deltaF508 CFTR in cystic fibrosis.

J. Riordan, M. Drumm, S. Randell, 2006, American journal of respiratory cell and molecular biology.

Transgenic hCFTR expression fails to correct β-ENaC mouse lung disease.

L. Ostrowski, R. Boucher, B. Grubb, 2012, American journal of physiology. Lung cellular and molecular physiology.

Expression of CFTR from a ciliated cell-specific promoter is ineffective at correcting nasal potential difference in CF mice

L. Ostrowski, T. Rogers, W. Yin, 2007, Gene Therapy.

Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of muco-obstructive lung disease

Richard C. Boucher, Wanda K. O'Neal, R. Boucher, 2016, Mucosal Immunology.

Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice

Richard C Boucher, Jack R Harkema, R. Boucher, 2004, Nature Medicine.

Ion transport across the murine intestine in the absence and presence of CFTR.

B. Grubb, 1997, Comparative biochemistry and physiology. Part A, Physiology.

Phenotypes of CF rabbits generated by CRISPR/Cas9-mediated disruption of the CFTR gene.

Y. E. Chen, M. Gentzsch, Jifeng Zhang, 2020, JCI insight.

Tissue accumulation of cadmium as a function of blood concentration

B. Grubb, G. Duval, 1986, Biological Trace Element Research.

Potassium transport across the intestines of the fowl Gallus domesticus

B. Grubb, P. Bentley, 1990, Journal of Comparative Physiology B.

Defective Epithelial Chloride Transport in a Gene-Targeted Mouse Model of Cystic Fibrosis

Richard C. Boucher, Beverly H. Koller, B. Koller, 1992, Science.

Olfactory epithelia exhibit progressive functional and morphological defects in CF mice.

L. Ostrowski, R. Reed, T. Rogers, 2007, American journal of physiology. Cell physiology.

Mucociliary Clearance in Mice Measured by Tracking Trans-tracheal Fluorescence of Nasally Aerosolized Beads

L. Ostrowski, T. Rogers, B. Grubb, 2018, Scientific Reports.

Genetically determined heterogeneity of lung disease in a mouse model of airway mucus obstruction.

S. Randell, M. Geiser, R. Boucher, 2012, Physiological genomics.

Lung disease phenotypes caused by overexpression of combinations of α-, β-, and γ-subunits of the epithelial sodium channel in mouse airways.

R. Boucher, T. Rogers, B. Grubb, 2017, American journal of physiology. Lung cellular and molecular physiology.

Effects of corticosteroids on short-circuit current across the cecum of the domestic fowl, Gallus domesticus

B. Grubb, P. Bentley, 1992, Journal of Comparative Physiology B.

Avian cecum: role of glucose and volatile fatty acids in transepithelial ion transport.

B. Grubb, 1991, The American journal of physiology.

ANOMALOUS BEHAVIOUR OF 86 Rb AS A TRACER FOR TRANSINTESTINAL POTASSIUM TRANSPORT IN THE FOWL , GALLUS DOMESTICUS

B. Grubb, P. Bentley, H. V. Brown, 2005 .

Ion transport across the jejunum in normal and cystic fibrosis mice.

B. Grubb, Barbara R. Grubb, 1995, The American journal of physiology.

Enhanced colonic Na+ absorption in cystic fibrosis mice versus normal mice.

R. Boucher, B. Grubb, 1997, The American journal of physiology.

Isobutylmethylxanthine fails to stimulate chloride secretion in cystic fibrosis airway epithelia.

M. Knowles, R. Boucher, E. Lazarowski, 1993, American journal of respiratory cell and molecular biology.

Accumulation of cadmium by the eye with special reference to the lens.

B. Grubb, J. Morris, P. Bentley, 1985, Toxicology and applied pharmacology.

structuretranscript profiling and predicted protein Candidate genes controlling pulmonary function in

C. Tomlinson, H. Schulz, M. Medvedovic, 2014 .

Experimental dietary hyperzincemia tissue disposition of excess zinc in rabbits

B. Grubb, P. Bentley, 1991 .

BPIFB1 loss alters airway mucus properties and diminishes mucociliary clearance

D. Hill, T. Rogers, C. Ehre, 2020, bioRxiv.

Mercury accumulation in the eye following administration of methylmercury.

B. Grubb, P. Bentley, G. Duval, 1987, Experimental eye research.

Chronic airway epithelial hypoxia exacerbates injury in muco-obstructive lung disease through mucus hyperconcentration

S. Randell, P. Kota, M. Gentzsch, 2023, Science Translational Medicine.

The CF salt controversy: in vivo observations and therapeutic approaches.

R. Tarran, R. Boucher, C. W. Davis, 2001, Molecular cell.

Blood flow and oxygen consumption in avian skeletal muscle during hypoxia.

B. Grubb, 1981, Journal of applied physiology: respiratory, environmental and exercise physiology.

Reuse of Cell Culture Inserts for in vitro Human Primary Airway Epithelial Cell Studies.

P. Sears, L. Ostrowski, S. Randell, 2021, American journal of respiratory cell and molecular biology.

Volume transport across tracheal and bronchial airway epithelia in a tubular culture system.

R. Boucher, B. Grubb, F. R. Schiretz, 1997, American Journal of Physiology.

Genetically determined heterogeneity of lung disease in a mouse model of airway mucus obstruction.

S. Randell, M. Geiser, R. Boucher, 2012, Physiological genomics.

In Vivo Airway Surface Liquid Cl− Analysis with Solid-State Electrodes

M. Knowles, R. Tarran, R. Boucher, 2002, The Journal of general physiology.

Relationship of a non-cystic fibrosis transmembrane conductance regulator-mediated chloride conductance to organ-level disease in Cftr(-/-) mice.

C. Cotton, J. Yankaskas, R. Boucher, 1994, Proceedings of the National Academy of Sciences of the United States of America.