S. Cowell

发表

Plasmon resonance studies of agonist/antagonist binding to the human delta-opioid receptor: new structural insights into receptor-ligand interactions.

Z. Salamon, G. Tollin, V. Hruby, 2000, Biophysical journal.

Binding of agonists, antagonists and inverse agonists to the human delta-opioid receptor produces distinctly different conformational states distinguishable by plasmon-waveguide resonance spectroscopy.

Z. Salamon, G. Tollin, V. Hruby, 2002, The journal of peptide research : official journal of the American Peptide Society.

Use of plasmon waveguide resonance (PWR) spectroscopy for examining binding, signaling and lipid domain partitioning of membrane proteins.

I. Alves, Z. Salamon, G. Tollin, 2010, Life sciences.

Intelligent design in combinatorial chemistry: use of designed peptide libraries to explore secondary and tertiary structures in peptides and proteins.

V. Hruby, J. Vagner, S. Cowell, 2003, Methods in enzymology.

Design and synthesis of peptide antagonists and inverse agonists for G protein-coupled receptors.

V. Hruby, Jung-Mo Ahn, S. Cowell, 2002, Methods in enzymology.

A novel strategy toward [6,5]-bicyclic β-turn dipeptide

Jinfa Ying, V. Hruby, S. Cowell, 2002 .

Synthesis of β-phenyl-δ,ε-unsaturated amino acids and stereoselective introduction of side chain groups into [4,3,0]-bicyclic β-turn dipeptides

Jinfa Ying, V. Hruby, S. Cowell, 2003 .

New paradigms and tools in drug design for pain and addiction

I. Alves, Z. Salamon, G. Tollin, 2006, The AAPS Journal.

Plasmon-waveguide resonance spectroscopy: a new tool for investigating signal transduction by G-protein coupled receptors.

Z. Salamon, G. Tollin, V. Hruby, 2003, Life sciences.

Coupled Plasmon Waveguide Resonance Studies of Agonist/Antagonist Binding to the Human δ-Opioid Receptor Provide New Structural Insights Into the Three-State Model for Receptor-Ligand Interactions

I. Alves, Z. Salamon, G. Tollin, 2001 .

Differential down-regulation of the human δ-opioid receptor by SNC80 and [d-Pen2,d-Pen5]enkephalin

V. Hruby, H. Yamamura, S. Cowell, 2000 .

Differential down-regulation of the human delta-opioid receptor by SNC80 and [D-Pen(2),D-Pen(5)]enkephalin.

V. Hruby, H. Yamamura, S. Cowell, 2000, European journal of pharmacology.

De novo antimicrobial peptides with low mammalian cell toxicity.

S. Bishop, M. Javadpour, S. Cowell, 1996, Journal of medicinal chemistry.

Exploring Ramachandran and chi space: conformationally constrained amino acids and peptides in the design of bioactive polypeptide ligands.

James P. Cain, V. Hruby, S. Cowell, 2004, Current medicinal chemistry.

A novel 3-step enantioselective synthesis of pyrenylalanine with subsequent incorporation into opioid, CCK, and melanotropin ligands.

I. Alves, V. Hruby, F. Porreca, 2004, Biochemical and biophysical research communications.

The delta-opioid receptor: molecular pharmacology, signal transduction, and the determination of drug efficacy.

R. Quock, H. Yamamura, S. Cowell, 1999, Pharmacological reviews.

The efficacy of δ-opioid receptor-selective drugs

R. Quock, V. Hruby, H. Yamamura, 1998 .

Lipid bilayers on polyacrylamide brushes for inclusion of membrane proteins.

Emily A. Smith, V. Hruby, M. Wirth, 2005, Langmuir : the ACS journal of surfaces and colloids.

Biphalin: The Foundation of Bivalent Ligands.

S. Cowell, Y. Lee, 2016, Current medicinal chemistry.

Agonist-specific down-regulation of the human δ-opioid receptor

V. Hruby, E. Navratilova, K. Rice, 2003 .

Development of potent μ and δ opioid agonists with high lipophilicity.

V. Hruby, T. Vanderah, F. Porreca, 2011, Journal of medicinal chemistry.

Different structural states of the proteolipid membrane are produced by ligand binding to the human delta-opioid receptor as shown by plasmon-waveguide resonance spectroscopy.

I. Alves, Z. Salamon, G. Tollin, 2004, Molecular pharmacology.

Agonist-specific down-regulation of the human delta-opioid receptor.

V. Hruby, E. Navratilova, H. Yamamura, 2003, European journal of pharmacology.

Truncation of the peptide sequence in bifunctional ligands with mu and delta opioid receptor agonist and neurokinin 1 receptor antagonist activities.

V. Hruby, E. Navratilova, T. Vanderah, 2013, Bioorganic & medicinal chemistry letters.