R. Toita

发表

A protein kinase assay based on FRET between quantum dots and fluorescently-labeled peptides.

T. Niidome, Takeshi Mori, Y. Katayama, 2013, Chemical communications.

Biological evaluation of protein nanocapsules containing doxorubicin

M. Hashizume, K. Ohuchida, J. Piao, 2013, International journal of nanomedicine.

Design of polymeric carriers for cancer-specific gene targeting: utilization of abnormal protein kinase Calpha activation in cancer cells.

T. Niidome, Takeshi Mori, Y. Katayama, 2008, Journal of the American Chemical Society.

Protein kinase C (PKC) isozyme-specific substrates and their design.

Y. Katayama, Chan Woo Kim, Jeong-Hun Kang, 2012, Biotechnology advances.

Modulation of the osteoconductive property and immune response of poly(ether ether ketone) by modification with calcium ions.

Sunarso, K. Ishikawa, R. Toita, 2015, Journal of materials chemistry. B.

Biodistribution of (125)I-labeled polymeric vaccine carriers after subcutaneous injection.

M. Akashi, Seiichi Yamamoto, H. Watabe, 2013, Bioorganic & medicinal chemistry.

Biodistribution of vaccines comprised of hydrophobically-modified poly(γ-glutamic acid) nanoparticles and antigen proteins using fluorescence imaging.

M. Akashi, T. Yamaoka, A. Mahara, 2013, Bioorganic & medicinal chemistry.

Design of substrates and inhibitors of G protein-coupled receptor kinase 2 (GRK2) based on its phosphorylation reaction

T. Kawano, Jeong-Hun Kang, M. Murata, 2020, Amino Acids.

A high-affinity peptide substrate for G protein-coupled receptor kinase 2 (GRK2)

T. Kawano, H. Nakashima, Jeong-Hun Kang, 2019, Amino Acids.

Role of amino acid residues surrounding the phosphorylation site in peptide substrates of G protein-coupled receptor kinase 2 (GRK2)

T. Kawano, H. Nakashima, Jeong-Hun Kang, 2016, Amino Acids.

Monitoring of phosphorylated peptides by radioactive assay and matrix-assisted laser desorption-ionization time-of-flight mass spectrometry

T. Kawano, Jeong-Hun Kang, M. Murata, 2015, Amino Acids.

Liver cell specific targeting by the preS1 domain of hepatitis B virus surface antigen displayed on protein nanocages

M. Hashizume, K. Ohuchida, J. Piao, 2012, International journal of nanomedicine.

Protective and healing effects of apoptotic mimic-induced M2-like macrophage polarization on pressure ulcers in young and middle-aged mice.

Jeong-Hun Kang, M. Murata, R. Toita, 2020, Journal of controlled release : official journal of the Controlled Release Society.

Salinity durable self-healing hydrogels as functional biomimetic systems based on the intercalation of polymer ions into mica

R. Toita, Y. Saito, Shingo Tamesue, 2021, Polymer.

Surface plasma treatment and phosphorylation enhance the biological performance of poly(ether ether ketone).

Sunarso, A. Tsuchiya, K. Ishikawa, 2019, Colloids and surfaces. B, Biointerfaces.

Effect of micro-roughening of poly(ether ether ketone) on bone marrow derived stem cell and macrophage responses, and osseointegration

Sunarso, A. Tsuchiya, K. Ishikawa, 2018, Journal of biomaterials science. Polymer edition.

A superhydrophilic titanium implant functionalized by ozone gas modulates bone marrow cell and macrophage responses

Sunarso, K. Ishikawa, R. Toita, 2016, Journal of Materials Science: Materials in Medicine.

Immobilization of calcium and phosphate ions improves the osteoconductivity of titanium implants.

Sunarso, K. Ishikawa, R. Toita, 2016, Materials science & engineering. C, Materials for biological applications.

Plasma protein kinase C (PKC)alpha as a biomarker for the diagnosis of cancers.

Y. Katayama, Jeong-Hun Kang, R. Toita, 2009, Carcinogenesis.

Peptide substrates for G protein‐coupled receptor kinase 2

Y. Katayama, H. Nakashima, Jeong-Hun Kang, 2014, FEBS letters.

Increased hepatic inflammation in a normal-weight mouse after long-term high-fat diet feeding

S. Fujita, T. Kawano, Jeong-Hun Kang, 2017, Journal of toxicologic pathology.

Stabilization of cancer-specific gene carrier via hydrophobic interaction for a clear-cut response to cancer signaling.

T. Niidome, Takeshi Mori, Y. Katayama, 2013, Journal of controlled release : official journal of the Controlled Release Society.

Effect of Fetal Bovine Serum Concentration on Lysophosphatidylcholine-mediated Proliferation and Apoptosis of Human Aortic Smooth Muscle Cells.

T. Kawano, H. Nakashima, Jeong-Hun Kang, 2020, Journal of oleo science.

Unique cellular interaction of macrophage-targeted liposomes potentiates anti-inflammatory activity.

Jeong-Hun Kang, R. Toita, Eiko Shimizu, 2020, Chemical communications.

Long-term profile of serological biomarkers, hepatic inflammation, and fibrosis in a mouse model of non-alcoholic fatty liver disease.

Jeong-Hun Kang, R. Toita, 2020, Toxicology letters.

Letter: Correlation between Phosphorylation Ratios by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometric Analysis and Enzyme Kinetics

T. Niidome, Takeshi Mori, Y. Katayama, 2008, European journal of mass spectrometry.

A short peptide is a protein kinase C (PKC) α‐specific substrate

T. Niidome, Takeshi Mori, Y. Katayama, 2008, Proteomics.

Suppression of Lysophosphatidylcholine-Induced Human Aortic Smooth Muscle Cell Calcification by Protein Kinase A Inhibition.

T. Kawano, Jeong-Hun Kang, M. Murata, 2019, Lipids.

Phosphatidylserine liposome multilayers mediate the M1-to-M2 macrophage polarization to enhance bone tissue regeneration.

A. Tsuchiya, Jeong-Hun Kang, R. Toita, 2022, Acta biomaterialia.

Protein kinase A (PKA) inhibition reduces human aortic smooth muscle cell calcification stimulated by inflammatory response and inorganic phosphate

S. Fujita, T. Kawano, Jeong-Hun Kang, 2018, Life sciences.

Bioinspired macrophage-targeted anti-inflammatory nanomedicine: A therapeutic option for the treatment of myocarditis.

T. Kawano, Jeong-Hun Kang, M. Murata, 2021, Materials science & engineering. C, Materials for biological applications.

Phosphorylation of Rho-associated kinase (Rho-kinase/ROCK/ROK) substrates by protein kinases A and C.

T. Niidome, Takeshi Mori, Y. Katayama, 2007, Biochimie.

Macrophage Uptake Behavior and Anti-inflammatory Response of Bovine Brain- or Soybean-derived Phosphatidylserine Liposomes.

S. Fujita, Jeong-Hun Kang, R. Toita, 2018, Journal of oleo science.

Effect of Particle Size on Carbonate Apatite Cement Properties Consisting of Calcite (or Vaterite) and Dicalcium Phosphate Anhydrous

Arief Cahyanto, K. Ishikawa, R. Toita, 2014 .

Molecular Mechanism of Caspase-3-Induced Gene Expression of Polyplexes Formed from Polycations Grafted with Cationic Substrate Peptides

T. Niidome, Takeshi Mori, Y. Katayama, 2009, Journal of biomaterials science. Polymer edition.

Protein kinase C alpha-specific peptide substrate graft-type copolymer for cancer cell-specific gene regulation systems.

T. Niidome, Takeshi Mori, Y. Katayama, 2009, Journal of controlled release : official journal of the Controlled Release Society.

Role of plasma as activator and cofactor in phosphorylation catalyzed by protein kinase C

T. Niidome, Takeshi Mori, Y. Katayama, 2008, Cell biochemistry and function.

Monitoring of phosphorylated peptides by radioactive assay and matrix-assisted laser desorption-ionization time-of-flight mass spectrometry

T. Kawano, Jeong-Hun Kang, M. Murata, 2015, Amino Acids.

Effect of the addition of diammonium citrate to α-cyano-4-hydroxycinnamic acid (CHCA) matrix for the detection of phosphorylated peptide in phosphorylation reactions using cell and tissue lysates

T. Niidome, Y. Katayama, Jeong-Hun Kang, 2007, Journal of the American Society for Mass Spectrometry.

Fabrication of porous calcite using chopped nylon fiber and its evaluation using rats

K. Ishikawa, R. Toita, K. Tsuru, 2015, Journal of Materials Science: Materials in Medicine.

Fluorescent nanoparticles consisting of lipopeptides and fluorescein-modified polyanions for monitoring of protein kinase activity.

T. Niidome, Y. Katayama, Jeong-Hun Kang, 2011, Bioconjugate chemistry.

Liver cell-targeted delivery of therapeutic molecules

Jeong-Hun Kang, M. Murata, R. Toita, 2016, Critical reviews in biotechnology.

Applications of human hepatitis B virus preS domain in bio- and nanotechnology.

T. Kawano, Jeong-Hun Kang, M. Murata, 2015, World journal of gastroenterology.

Gene carrier showing all-or-none response to cancer cell signaling.

T. Niidome, Takeshi Mori, Y. Katayama, 2012, Journal of the American Chemical Society.

A gene-delivery system specific for hepatoma cells and an intracellular kinase signal based on human liver-specific bionanocapsules and signal-responsive artificial polymer.

T. Niidome, Takeshi Mori, Y. Katayama, 2010, International journal of pharmaceutics.

Hepatoma-targeted gene delivery using a tumor cell-specific gene regulation system combined with a human liver cell-specific bionanocapsule.

T. Niidome, Takeshi Mori, Y. Katayama, 2010, Nanomedicine : nanotechnology, biology, and medicine.

Liver cell-specific peptides derived from the preS1 domain of human hepatitis B virus.

T. Yamaoka, Jeong-Hun Kang, M. Murata, 2014, Journal of virological methods.

A nanocarrier based on a genetically engineered protein cage to deliver doxorubicin to human hepatocellular carcinoma cells.

M. Hashizume, J. Piao, Jeong-Hun Kang, 2013, Chemical communications.

Development of human hepatocellular carcinoma cell-targeted protein cages.

M. Hashizume, J. Piao, Jeong-Hun Kang, 2012, Bioconjugate chemistry.

Bio and nanotechnological strategies for tumor-targeted gene therapy.

Yoshiki Katayama, Y. Katayama, Jeong-Hun Kang, 2010, Biotechnology advances.

Fluorometric detection of protein kinase Cα activity based on phosphorylation-induced dissociation of a polyion complex.

T. Niidome, Takeshi Mori, Y. Katayama, 2012, Analytical biochemistry.

Protein Kinase C α-Responsive Gene Carrier for Cancer-Specific Transgene Expression and Cancer Therapy.

A. Kishimura, Takeshi Mori, Y. Katayama, 2021, ACS biomaterials science & engineering.

Effective delivery of DNA into tumor cells and tissues by electroporation of polymer-DNA complex.

T. Niidome, Y. Katayama, Jeong-Hun Kang, 2008, Cancer letters.

A novel double-coating carrier produced by solid-in-oil and solid-in-water nanodispersion technology for delivery of genes and proteins into cells.

M. Goto, T. Niidome, Y. Katayama, 2012, Journal of controlled release : official journal of the Controlled Release Society.

A hydrophilic polymer grafted with a histone tail peptide as an artificial gene regulator.

T. Niidome, Takeshi Mori, Y. Katayama, 2011, Bioorganic & medicinal chemistry.

Anti-obesity and anti-inflammatory effects of macrophage-targeted interleukin-10-conjugated liposomes in obese mice.

T. Kawano, Jeong-Hun Kang, M. Murata, 2016, Biomaterials.

Tumor therapy by gene regulation system responding to cellular signal.

T. Niidome, Takeshi Mori, Y. Katayama, 2010, Journal of controlled release : official journal of the Controlled Release Society.

Fluorescent polyion complex nanoparticle that incorporates an internal standard for quantitative analysis of protein kinase activity.

A. Kishimura, T. Niidome, Takeshi Mori, 2014, Bioconjugate chemistry.

Reduction of inorganic phosphate-induced human smooth muscle cells calcification by inhibition of protein kinase A and p38 mitogen-activated protein kinase

T. Yamaoka, Jeong-Hun Kang, M. Murata, 2014, Heart and Vessels.

Simultaneous Analysis of Phosphorylated Peptides by MALDI-TOF-MS

T. Niidome, Y. Katayama, Jeong-Hun Kang, 2006 .

Effect of peptide content on the regulation of transgene expression by protein kinase Cα-responsive linear polyethylenimine-peptide conjugates.

T. Niidome, Takeshi Mori, Y. Katayama, 2014, Colloids and surfaces. B, Biointerfaces.

Enhanced Osseointegration Capability of Poly(ether ether ketone) via Combined Phosphate and Calcium Surface-Functionalization

Sunarso, A. Tsuchiya, K. Ishikawa, 2019, International journal of molecular sciences.

Ozone-gas-mediated surface hydrophilization enhances the cell responses to titanium

Sunarso, K. Ishikawa, R. Toita, 2020, Materials Letters.

Synergistic effect of surface phosphorylation and micro-roughness on enhanced osseointegration ability of poly(ether ether ketone) in the rabbit tibia

Sunarso, A. Tsuchiya, K. Ishikawa, 2018, Scientific Reports.

Protein kinase Cα‐responsive polymeric carrier: its application for gene delivery into human cancers

T. Niidome, Y. Katayama, Jeong-Hun Kang, 2009, Cancer science.

A high-affinity peptide substrate for G protein-coupled receptor kinase 2 (GRK2)

T. Kawano, H. Nakashima, Jeong-Hun Kang, 2019, Amino Acids.

Impact of surface functionalization with phosphate and calcium on the biological performance of Ti-6Al-4V

Sunarso, A. Tsuchiya, K. Ishikawa, 2021 .

Mass-tag technology responding to intracellular signals as a novel assay system for the diagnosis of tumor

T. Niidome, Takeshi Mori, Y. Katayama, 2007, Journal of the American Society for Mass Spectrometry.

Effect of introduction of chondroitin sulfate into polymer-peptide conjugate responding to intracellular signals

T. Niidome, Takeshi Mori, Y. Katayama, 2011 .

Cellular signal-specific peptide substrate is essential for the gene delivery system responding to cellular signals.

T. Niidome, Takeshi Mori, Y. Katayama, 2009, Bioorganic & medicinal chemistry letters.

Increased Pre-Osteoblast Bioactivity on Ca-Modified Titanium

Sunarso, K. Ishikawa, R. Toita, 2016 .

International Journal of Nanomedicine

K. Ohuchida, J. Piao, M. Murata, 2022 .

Immobilization of calcium and phosphate ions improves the osteoconductivity of titanium implants.

Sunarso, K. Ishikawa, R. Toita, 2016, Materials science & engineering. C, Materials for biological applications.

Bisphenol A (BPA) and Cardiovascular or Cardiometabolic Diseases

R. Toita, Jeong-Hun Kang, Daisuke Asai, 2023, Journal of xenobiotics.

Vascular calcification and cellular signaling pathways as potential therapeutic targets.

T. Kawano, M. Murata, R. Toita, 2023, Life sciences.

Synergistic effect of surface phosphorylation and micro-roughness on enhanced osseointegration ability of poly(ether ether ketone) in the rabbit tibia

Sunarso, A. Tsuchiya, K. Ishikawa, 2018, Scientific Reports.

Fluorescent nanoparticles consisting of lipopeptides and fluorescein-modified polyanions for monitoring of protein kinase activity.

T. Niidome, Y. Katayama, Jeong-Hun Kang, 2011, Bioconjugate chemistry.

A short peptide is a protein kinase C (PKC) α‐specific substrate

T. Niidome, Takeshi Mori, Y. Katayama, 2008, Proteomics.

Modulation of the osteoconductive property and immune response of poly(ether ether ketone) by modification with calcium ions.

Sunarso, R. Toita, K. Tsuru, 2015, Journal of materials chemistry. B.

Collagen patches releasing phosphatidylserine liposomes guide M1-to-M2 macrophage polarization and accelerate simultaneous bone and muscle healing.

R. Toita, Eiko Shimizu, Shinjiro Kasahara, 2024, Acta biomaterialia.

Regulation of Transgene Expression in Tumor Cells by Exploiting Endogenous Intracellular Signals

T. Niidome, Y. Katayama, A. Tsuchiya, 2008, Nanoscale research letters.