P. Leff

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Operational models of pharmacological agonism

J. Black, P. Leff, 1983, Proceedings of the Royal Society of London. Series B. Biological Sciences.

ADP can induce aggregation of human platelets via both P2Y1 and P2T receptors

M. J. Robertson, P. Leff, G. Jarvis, 2000, British journal of pharmacology.

Ligand bias prevents class equality among beta-blockers.

M. Bouvier, R. Bond, P. Leff, 2014, Current opinion in pharmacology.

Painful connection for ATP

P. Leff, C. Kennedy, 1995, Nature.

Pharmacological and biochemical analysis of FPL 67156, a novel, selective inhibitor of ecto‐ATPase

A. IJzerman, M. Beukers, C. Pollard, 1995, British journal of pharmacology.

β‐Blockers have differential effects on the murine asthma phenotype

B. J. Knoll, M. Bouvier, R. Bond, 2015, British journal of pharmacology.

Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the β2-adrenoceptor

T. Kenakin, R. Lefkowitz, L. F. Allen, 1995, Nature.

Comparative analysis of two types of 5-hydroxytryptamine receptor mediating vasorelaxation: differential classification using tryptamines

G. Martin, P. Leff, V. Barrett, 1987, Naunyn-Schmiedeberg's Archives of Pharmacology.

The classification of 5‐hydroxytryptamine receptors

G. Martin, P. Leff, 1988, Medicinal research reviews.

Differential classification of vascular smooth muscle and endothelial cell 5‐HT receptors by use of tryptamine analogues

G. Martin, P. Leff, J. M. Morse, 1987, British journal of pharmacology.

Peripheral 5‐HT2‐like receptors. Can they be classified with the available antagonists?

G. Martin, P. Leff, 1986, British journal of pharmacology.

Antagonists of the platelet P2T receptor: a novel approach to antithrombotic therapy.

A. Bailey, David Cox, P. Leff, 1999, Journal of medicinal chemistry.

Errors in agonist affinity estimation: do they and should they occur in isolated tissue experiments?

P. Leff, I. Dainty, I. Dougall, 1990, Trends in pharmacological sciences.

Potential errors in agonist dissociation constant estimation caused by desensitization.

P. Leff, 1986, Journal of theoretical biology.

Inverse agonism: theory and practice.

P. Leff, 1995, TIPS - Trends in Pharmacological Sciences.

Further subclassification of ATP receptors based on agonist studies.

P. Leff, I. Dainty, S. O'Connor, 1991, Trends in pharmacological sciences.

Pharmacological profile of the novel P2T‐purinoceptor antagonist, FPL 67085 in vitro and in the anaesthetized rat in vivo

P. Leff, R. G. Humphries, N. Kindon, 1995, British journal of pharmacology.

The biology and pharmacology of PGD2.

P. Leff, H. Giles, 1988, Prostaglandins.

From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis.

P. Leeson, B. Springthorpe, P. Barton, 2007, Bioorganic & medicinal chemistry letters.

Interaction of BW A868C, a prostanoid DP-receptor antagonist, with two receptor subtypes in the rabbit isolated saphenous vein.

P. Leff, K. McKechnie, S. Lydford, 1996, Prostaglandins.

Differences in asthma study models and the effectiveness of β2‐adrenoceptor ligands: response to Lipworth et al.

R. Bond, P. Leff, S. Parra, 2016, British journal of pharmacology.

Suramin is a Competitive But Slowly-Equilibrating Antagonist at P2x-Receptors in the Rabbit Ear Artery

P. Leff, B. E. Wood, S. O'Connor, 1991 .

P2x-Receptor Characterisation in Rabbit Isolated Ear Artery

P. Leff, B. E. Wood, S. O'Connor, 1991 .

Pharmacological analysis of ecto‐ATPase inhibition: evidence for combined enzyme inhibition and receptor antagonism in P2X‐purinoceptor ligands

A. IJzerman, M. Beukers, P. Leff, 1994, British journal of pharmacology.

FPL 66096: a novel, highly potent and selective antagonist at human platelet P2T‐purinoceptors

P. Leff, R. G. Humphries, A. Ingall, 1994, British journal of pharmacology.

P2Y1‐receptors in human platelets which are pharmacologically distinct from P2YADP‐receptors

M. J. Robertson, P. Leff, R. G. Humphries, 1998, British journal of pharmacology.

Synthesis of Hexahydrocyclopentimidazol-2-(1H)-one derivatives displaying selective DP-receptor agonist properties.

A. Robertson, C. Harris, P. Leff, 1996, Bioorganic & medicinal chemistry.

Suramin is a slowly‐equilibrating but competitive antagonist at P2x‐receptors in the rabbit isolated ear artery

P. Leff, B. E. Wood, S. O'Connor, 1990, British journal of pharmacology.

Estimation of the efficacy and affinity of the β2‐adrenoceptor agonist salmeterol in guinea‐pig trachea

P. Leff, I. Dougall, D. Harper, 1991, British journal of pharmacology.

Theoretical implications of receptor coupling to multiple G proteins based on analysis of a three-state model.

P. Leff, C. Scaramellini, 2002, Methods in enzymology.

A Three‐State Receptor Model: Predictions of Multiple Agonist Pharmacology for the Same Receptor Type a

P. Leff, C. Caramellini, 1998, Annals of the New York Academy of Sciences.

Quantification of H2-agonism by clonidine and dimaprit in an adenylate cyclase assay

P. Leff, D. Trist, 1985, Agents and Actions.

Is pharmacological analysis of agonist action useful in medicinal chemistry

P. Leff, I. Dougall, 1992 .

Pharmacological estimation of agonist affinity: detection of errors that may be caused by the operation of receptor isomerisation or ternary complex mechanisms

P. Leff, I. Dainty, I. Dougall, 1990, British journal of pharmacology.

Do pharmacological methods for the quantification of agonists work when the ternary complex mechanism operates?

P. Leff, D. Harper, 1989, Journal of theoretical biology.

Pharmacological analysis of β‐adrenoceptor‐mediated agonism in the guinea‐pig, isolated, right atrium

J. Black, N. Shankley, P. Leff, 1985, British journal of pharmacology.

An operational model of pharmacological agonism: the effect of E/[A] curve shape on agonist dissociation constant estimation

P. Leff, J. Wood, J. Black, 2010, British journal of pharmacology.

Partial agonist effects of BW A868C, a selective DP receptor antagonist, on Cl- secretion in dog tracheal epithelium.

P. Leff, D. Jackson, Y. J. Liu, 1996, European journal of pharmacology.

Quantitative analysis of the agonist and antagonist actions of some ATP analogues at P2X‐purinoceptors in the rabbit ear artery

P. Leff, B. E. Wood, K. McKechnie, 1993, British journal of pharmacology.

Classification of platelet and vascular prostaglandin D2 (DP) receptors: estimation of affinities and relative efficacies for a series of novel bicylic ligands With an Appendix on Goodness‐of‐fit analyses

P. Leff, H. Giles, 1992, British journal of pharmacology.

Estimation oftheefficacy andaffinity ofthefl2-adrenoceptor agonist salmeterol inguinea-pig trachea

P. Leff, D. Jackson, I. Dougall, 1991 .

Estimation of affinities and efficacies for κ‐receptor agonists in guinea‐pig ileum

P. Leff, I. Dougall, 1989 .

Estimation ofaffinities andefficacies forK-receptor agonists inguinea-plg ileum

P. Leff, 1989 .

Differences in agonist dissociation constant estimates for 5‐HT at 5‐HT2‐receptors: a problem of acute desensitization?

G. Martin, P. Leff, 1988, British journal of pharmacology.

Estimation of opioid receptor agonist dissociation constants with β‐chlornaltrexamine, an irreversible ligand which also displays agonism

P. Leff, I. Dougall, 1988, British journal of pharmacology.

Pharmacological analysis of the calcium‐dependence of μ‐receptor agonism

P. Leff, I. Dougall, 1987, British journal of pharmacology.

The classification of peripheral 5‐HT2‐like receptors using tryptamine agonist and antagonist analogues

G. Martin, P. Leff, J. M. Morse, 1986, British journal of pharmacology.

Application of the operational model of agonism to establish conditions when functional antagonism may be used to estimate agonist dissociation constants

G. Martin, P. Leff, J. M. Morse, 1985, British journal of pharmacology.

VI. Nomenclature and Classification of Purinoceptors *

B. Fredholm, G. Burnstock, K. Jacobson, 2016 .

International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. IX. Recommendations on terms and symbols in quantitative pharmacology.

D. Jenkinson, D. Hoyer, E. Barnard, 1995, Pharmacological reviews.

Steady-state kinetic studies on benzylamine oxidase from pig plasma.

K. Yadav, P. Knowles, P. Leff, 2005, European journal of biochemistry.

Nomenclature and Classification of Purinoceptors*

G Burnstock, B B Fredholm, B. Fredholm, 2005 .

Pharmacological analysis of the interaction between Bay K 8644 and 5‐HT in rabbit aorta

G. Martin, P. Richardson, P. Leff, 1986, British journal of pharmacology.

Deviations from Michaelis-Menten kinetics. The possibility of complicated curves for simple kinetic schemes and the computer fitting of experimental data for acetylcholinesterase, acid phosphatase, adenosine deaminase, arylsulphatase, benzylamine oxidase, chymotrypsin, fumarase, galactose dehydrogen

P. Leff, W. Bardsley, J. Kavanagh, 1980, The Biochemical journal.

Steady-state kinetic studies of the negative co-operativity and flip-flop mechanism for Escherichia coli alkaline phosphatase.

W G Bardsley, P. Leff, W. Bardsley, 1977, The Biochemical journal.

A three-state receptor model of agonist action.

P. Leff, P Leff, K McKechnie, 1997, Trends in pharmacological sciences.

Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: evidence for agonist-directed trafficking of receptor stimulus.

P. Leff, S. Maayani, K A Berg, 1998, Molecular pharmacology.

Characterization of P2x‐receptors in rabbit isolated ear artery

P. Leff, B. E. Wood, S. O'Connor, 1990, British journal of pharmacology.

How should P2X purinoceptors be classified pharmacologically?

P. Leff, C. Kennedy, P Leff, 1995, Trends in pharmacological sciences.

Adenosine 5'-(2-fluorodiphosphate) is not a selective P2Y purinoceptor agonist in the rabbit jugular vein.

P. Leff, B. E. Wood, S. O'Connor, 1992, The Journal of pharmacology and experimental therapeutics.

Pharmacokinetics of chlorambucil in ovarian carcinoma using a new HPLC assay.

P. Leff, W. Bardsley, 1979, Biochemical pharmacology.

The classification of prostaglandin DP‐receptors in platelets and vasculature using BW A868C, a novel, selective and potent competitive antagonist

A. Robertson, P. Leff, H. Giles, 1989, British journal of pharmacology.

An operational model of pharmacological agonism: the effect of E/[A] curve shape on agonist dissociation constant estimation

J. Black, N. Shankley, P. Leff, 1985, British journal of pharmacology.

Deviations from receptor theory?

P. Leff, I. Dougall, D. Harper, 1992, Trends in pharmacological sciences.

Further concerns over Cheng-Prusoff analysis.

P. Leff, I. Dougall, I. Dougall, 1993, Trends in pharmacological sciences.

A novel series of P2T purinoceptor antagonists: definition of the role of ADP in arterial thrombosis.

M. J. Robertson, P. Leff, R. G. Humphries, 1995, Trends in pharmacological sciences.

Resultant pharmacological actions of verapamil: quantification of competitive 5-hydroxytryptamine antagonism in combination with calcium antagonism.

P. Leff, J. M. Morse, 1987, The Journal of pharmacology and experimental therapeutics.

Further analysis of anomalous pKB values for histamine H2‐receptor antagonists on the mouse isolated stomach assay

J. Black, N. Shankley, P. Leff, 1985, British journal of pharmacology.

The two-state model of receptor activation.

P. Leff, P Leff, 1995, Trends in pharmacological sciences.

Agonist-antagonist interactions at angiotensin receptors: application of a two-state receptor model.

M. J. Robertson, P. Leff, I. Dougall, 1994, Trends in pharmacological sciences.

An analysis of amplifying and potentiating interactions between agonists.

P. Leff, 1987, The Journal of pharmacology and experimental therapeutics.

Estimation of agonist affinity and efficacy by direct, operational model-fitting.

G. Martin, P. Leff, P Leff, 1990, Journal of pharmacological methods.

Estimation of partial agonist affinity by interaction with a full agonist: a direct operational model‐fitting approach

P. Leff, I. Dougall, D. Harper, 1993, British journal of pharmacology.

Analysis of agonist-agonist interactions: the crucial influence of curve shape.

P. Leff, C. Scaramellini, G. Bennett, 1997, Journal of pharmacological and toxicological methods.

Analysis of agonist action using the operational model.

P. Leff, 1988, Trends in pharmacological sciences.

Receptor-based drug design

P. Leff, 1998 .

Adventures in the pharmacological analysis of P2 receptors.

P. Leff, G. Jarvis, I. Dougall, 2000, Journal of the autonomic nervous system.

Tryptamine fingerprints in the classification of 5-hydroxytryptamine receptors

G. Martin, P. Leff, S. Maclennan, 1990 .

The Classification of 5-HT Receptors Using Tryptamine Analogues

G. Martin, P. Leff, 1989 .

Pharmacological analysis of the pentagastrin‐tiotidine interaction in the mouse isolated stomach

J. Black, P. Leff, N.P. Shankley, 1985, British journal of pharmacology.

Chapter One – Reflections on the Classification of Histamine Receptors

James Black, P. Leff, J. Black, 1982 .

Inhibition of Collagen‐ and ADP‐Induced Platelet Aggregation by Substance P In Vivo: Involvement of Endothelium‐Derived Relaxing Factor

P. Leff, R. G. Humphries, W. Tomlinson, 1990, Journal of cardiovascular pharmacology.

Endothelium-Derived Relaxing Factor-Mediated Inhibition of Collagen-Induced Platelet Aggregation in vivo

P. Leff, R. G. Humphries, W. Tomlinson, 1990 .