Richard Z. Chen

发表

Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice

R. Jaenisch, S. Akbarian, M. Tudor, 2001, Nature Genetics.

DNA hypomethylation leads to elevated mutation rates

Rudolf Jaenisch, Laurie Jackson-Grusby, R. Jaenisch, 1998, Nature.

Chronic administration of nalmefene leads to increased food intake and body weight gain in mice.

D. Macneil, Richard Z. Chen, T. Fong, 2004, European journal of pharmacology.

Discovery of N-[(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a novel cannabinoid-1 receptor (CB1R) inverse agonist for the treatment of obesity.

L. Shearman, Richard Z. Chen, R. Ball, 2010, Journal of medicinal chemistry.

DNA methylation study of Huntington’s disease and motor progression in patients and in animal models

S. Horvath, A. Lu, R. Snell, 2020, Nature Communications.

Pharmacological evaluation of LH-21, a newly discovered molecule that binds to cannabinoid CB1 receptor.

A. Frassetto, Richard Z. Chen, T. Fong, 2008, European journal of pharmacology.

Allele-specific silencing of the gain-of-function mutation in Huntington’s disease using CRISPR/Cas9

Eun Pyo Hong, B. Kleinstiver, I. Seong, 2022, JCI insight.

PAM-altering SNP-based allele-specific CRISPR-Cas9 therapeutic strategies for Huntington’s disease

Eun Pyo Hong, Richard Z. Chen, Jong-Min Lee, 2022, Molecular therapy. Methods & clinical development.

Reduced sensitivity to diet-induced obesity in mice carrying a mutant 5-HT6 receptor

J. Metzger, A. Frassetto, Richard Z. Chen, 2008, Brain Research.

Synergistic effects of cannabinoid inverse agonist AM251 and opioid antagonist nalmefene on food intake in mice

D. Macneil, Richard Z. Chen, T. Fong, 2004, Brain Research.

Effects of the CB1 cannabinoid receptor inverse agonist AM251 on food intake and body weight in mice lacking μ-opioid receptors

A. Frassetto, Richard Z. Chen, T. Fong, 2006, Brain Research.

Effects of mutations at conserved TM II residues on ligand binding and activation of mouse 5-HT6 receptor.

B. Francis, Richard Z. Chen, L. Lin, 2006, European journal of pharmacology.

Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain

R. Jaenisch, S. Akbarian, M. Tudor, 2002, Proceedings of the National Academy of Sciences of the United States of America.

The evolutionary history of the polyQ tract in huntingtin sheds light on its functional pro-neural activities

G. Pavesi, A. Møller, T. Vogt, 2022, Cell death and differentiation.

Expression Pattern of the Rett Syndrome Gene MeCP2 in Primate Prefrontal Cortex

R. Jaenisch, S. Akbarian, J. Gribnau, 2001, Neurobiology of Disease.

Generation and characterization of a humanized bradykinin B1 receptor mouse

M. Bock, R. Chang, T. Vogt, 2006, Biological chemistry.

DNA Hypomethylation Perturbs the Function and Survival of CNS Neurons in Postnatal Animals

R. Jaenisch, A. Trumpp, D. Biniszkiewicz, 2001, The Journal of Neuroscience.

A systematic review and meta‐analysis of the mental health symptoms during the Covid‐19 pandemic in Southeast Asia

A. Delios, S. Zhang, Richard Z. Chen, 2021, medRxiv.

The mu-opioid receptor subtype is required for the anorectic effect of an opioid receptor antagonist.

J. Metzger, Sheng-ping Wang, A. Frassetto, 2006, European journal of pharmacology.

The Triple Uptake Inhibitor (1R,5S)-(+)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0] Hexane Hydrochloride (DOV 21947) Reduces Body Weight and Plasma Triglycerides in Rodent Models of Diet-Induced Obesity

M. Tschöp, P. Skolnick, L. Shearman, 2008, Journal of Pharmacology and Experimental Therapeutics.

1-Sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonists for the treatment of obesity.

Donald F Thompson, L. Shearman, A. Frassetto, 2009, Journal of medicinal chemistry.