J. de Leon

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Pharmacogenetic Tests in Psychiatry: From Fear to Failure to Hype.

J. de Leon, 2016, Journal of clinical psychopharmacology.

Short self-reported sleep duration and suicidal behavior: a cross-sectional study.

E. Baca-García, J. López-Castromán, A. Alegria, 2011, Journal of affective disorders.

Using data mining to explore complex clinical decisions: A study of hospitalization after a suicide attempt.

Ricardo Santiago-Mozos, Antonio Artés-Rodríguez, Enrique Baca-García, 2006, The Journal of clinical psychiatry.

Fagerstrom test for nicotine dependence vs heavy smoking index in a general population survey

M. I. Santiago-Pérez, M. Pérez-Ríos, J. de Leon, 2009, BMC public health.

Association between smoking and alcohol use in the general population: stable and unstable odds ratios across two years in two different countries.

E. Baca-García, F. Aizpuru, J. de Leon, 2007, Alcohol and alcoholism.

Evidence-Based Medicine Versus Personalized Medicine: Are They Enemies?

J. de Leon, 2012, Journal of clinical psychopharmacology.

Clinical guidelines for psychiatrists for the use of pharmacogenetic testing for CYP450 2D6 and CYP450 2C19.

Scott C Armstrong, J. de Leon, S. C. Armstrong, 2006, Psychosomatics.

Measuring individual benefits of psychiatric treatment using longitudinal binary outcomes: Application to antipsychotic benefits in non-cannabis and cannabis users

B. Crespo-Facorro, J. de Leon, F. J. Diaz, 2020, Journal of biopharmaceutical statistics.

Teaching Medical Students How To Think: Narrative, Mechanistic and Mathematical Thinking.

J. de Leon, 2018, Actas espanolas de psiquiatria.

Clinically relevant drug interactions between newer antidepressants and oral anticoagulants

E. Spina, A. Bruno, J. de Leon, 2019, Expert opinion on drug metabolism & toxicology.

The effects of antiepileptic inducers in neuropsychopharmacology, a neglected issue. Part I: A summary of the current state for clinicians

J. de Leon, J. Leon, 2015 .

Lack of association between plasma apolipoprotein E and suicide attempts.

E. Baca-García, J. Saiz-ruiz, J. de Leon, 2004, The Journal of clinical psychiatry.

Personalizing dosing of risperidone, paliperidone and clozapine using therapeutic drug monitoring and pharmacogenetics

J. de Leon, 2020, Neuropharmacology.

A comprehensive review of the clinical utility of and a combined analysis of the clozapine/norclozapine ratio in therapeutic drug monitoring for adult patients

J. Kane, E. Spina, C. Hiemke, 2019, Expert review of clinical pharmacology.

A systematic review and combined analysis of therapeutic drug monitoring studies for long-acting risperidone

E. Spina, C. Hiemke, J. de Leon, 2017, Expert review of clinical pharmacology.

Severity of personality disorders and suicide attempt

E. Baca-García, M. Oquendo, M. Pérez-Rodríguez, 2009, Acta psychiatrica Scandinavica.

Effects of platelet glycoprotein IIb/IIIa inhibition with abciximab on thrombin generation and activity during percutaneous coronary intervention.

G. Dangas, J. Badimón, J. Marmur, 1999, American heart journal.

Three Patients Needing High Doses of Valproic Acid to Get Therapeutic Concentrations

J. de Leon, F. J. Diaz, Betsy McCollum, 2015, Case reports in psychiatry.

The association between high nicotine dependence and severe mental illness may be consistent across countries.

E. Becoña, J. de Leon, A. Gonzalez-Pinto, 2002, The Journal of clinical psychiatry.

Can Valproic Acid be an Inducer of Clozapine Metabolism?

C. Eap, E. Spina, J. de Leon, 2014, Pharmacopsychiatry.

Epidemiology of Comorbid Tobacco Use and Schizophrenia: Thinking About Risks and Protective Factors

J. de Leon, F. J. Diaz, M. Gurpegui, 2007 .

Nicotine dependence and symptoms in schizophrenia

J. de Leon, F. J. Diaz, M. Gurpegui, 2005, British Journal of Psychiatry.

Apolipoprotein-E gene variants associated with cardiovascular risk factors in antipsychotic recipients

M. Arranz, J. de Leon, M. Susce, 2009, European Psychiatry.

Smoking cessation in patients with psychiatric disorders.

N. Rigotti, A. Gelenberg, A. Evins, 2008, The Journal of clinical psychiatry.

A systematic review and combined analysis of therapeutic drug monitoring studies for oral paliperidone

E. Spina, C. Hiemke, J. de Leon, 2018, Expert review of clinical pharmacology.

A systematic review and combined analysis of therapeutic drug monitoring studies for long-acting paliperidone

E. Spina, C. Hiemke, J. de Leon, 2018, Expert review of clinical pharmacology.

Pharmacokinetic drug interactions with oral haloperidol in adults: dose correction factors from a combined weighted analysis

E. Spina, C. Hiemke, J. de Leon, 2022, Expert opinion on drug metabolism & toxicology.

Patterns of Comorbidity of Suicide Attempters: An Update

L. Giner, H. Blasco-Fontecilla, J. de Leon, 2016, Current Psychiatry Reports.

Antipsychotic medication exposure, clozapine, and pneumonia: results from a self‐controlled study

D. Siskind, J. Nielsen, J. de Leon, 2019, Acta psychiatrica Scandinavica.

Worldwide impact of economic cycles on suicide trends over 3 decades: differences according to level of development. A mixed effect model study

E. Baca-García, H. Galfalvy, P. Fernández-Navarro, 2012, BMJ Open.

Serum Antimuscarinic Activity During Clozapine Treatment

G. Simpson, T. Cooper, R. Josiassen, 2003, Journal of clinical psychopharmacology.

Effectiveness of Initiating Deep Vein Thrombosis Prophylaxis in Patients With Stroke: An Integrative Review

J. de Leon, M. Dizon, 2018, The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses.

Do Asian Patients Require Only Half of the Clozapine Dose Prescribed for Caucasians? A Critical Overview

Chuan-Yue Wang, J. Kane, K. Hong, 2020, Indian journal of psychological medicine.

Dysmorphophobia: body dysmorphic disorder or delusional disorder, somatic subtype?

G. Simpson, J. de Leon, J. Leon, 1989, Comprehensive psychiatry.

What is needed to incorporate clinical pharmacogenetic tests into the practice of psychopharmacotherapy?

E. Spina, J. de Leon, 2016, Expert review of clinical pharmacology.

Beyond the "hype" on the association between metabolic syndrome and atypical antipsychotics: the confounding effects of cohort, typical antipsychotics, severe mental illness, comedications, and comorbid substance use.

J. de Leon, 2008, Journal of clinical psychopharmacology.

Clozapine levels and caffeine.

J. de Leon, A. Odom-White, 1996, The Journal of clinical psychiatry.

Adverse drug reactions to oxycodone and hydrocodone in CYP2D6 ultrarapid metabolizers.

J. de Leon, P. Wedlund, Lori Dinsmore, 2003, Journal of clinical psychopharmacology.

A Poor Metabolizer for Cytochromes P450 2D6 and 2C19: A Case Report on Antidepressant Treatment

J. de Leon, M. Susce, E. Murray-Carmichael, 2006, CNS Spectrums.

Obesity and associated complications in patients with severe mental illnesses: a cross-sectional survey.

J. de Leon, F. J. Diaz, M. Susce, 2005, The Journal of clinical psychiatry.

Pilot study of the cytochrome P450-2D6 genotype in a psychiatric state hospital.

J. Boyle, J. de Leon, J. Leon, 1998, American Journal of Psychiatry.

Lack of replication of the association of low serum cholesterol and attempted suicide in another country raises more questions.

E. Baca-García, J. de Leon, M. Susce, 2011, Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists.

Possible interaction between warfarin and quetiapine.

J. de Leon, T. Rogers, D. Atcher, 1999, Journal of clinical psychopharmacology.

Nicotine exposure can be detected in cerebrospinal fluid of active and passive smokers.

P. Crooks, J. de Leon, Abeer M. Al-Ghananeem, 2009, Journal of pharmaceutical and biomedical analysis.

Tobacco smoking and bipolar disorder.

F. Aizpuru, F. Mosquera, A. González-Pinto, 1998, The Journal of clinical psychiatry.

S2045796018000628jed 473..477

H. Blasco-Fontecilla, J. de Leon, P. Artieda-Urrutia, 2019 .

A proposal for using the ratio of attempted to completed suicides across several countries worldwide

H. Blasco-Fontecilla, J. de Leon, P. Artieda-Urrutia, 2018, Epidemiology and Psychiatric Sciences.

Can the Holmes-Rahe Social Readjustment Rating Scale (SRRS) Be Used as a Suicide Risk Scale? An Exploratory Study

E. Baca-García, D. Delgado-Gómez, H. Blasco-Fontecilla, 2012, Archives of suicide research : official journal of the International Academy for Suicide Research.

Clozapine is strongly associated with the risk of pneumonia and inflammation

Chuanyue Wang, H. Verdoux, J. de Leon, 2020, General Psychiatry.

Formal thought disorder in schizophrenia: a factor analytic study.

V. Peralta, M. Cuesta, J. de Leon, 1992, Comprehensive psychiatry.

Management of suicidal behaviour: Is the world upside down?

D. Palao, H. Blasco-Fontecilla, J. de Leon, 2014, The Australian and New Zealand journal of psychiatry.

Smoking and vulnerability for schizophrenia.

J. de Leon, de Leon, 1996, Schizophrenia bulletin.

A prospective study of the paradoxical relationship between impulsivity and lethality of suicide attempts.

E. Baca-García, E. Basurte, J. Saiz-ruiz, 2001, The Journal of clinical psychiatry.

Dealing with Difficult Medical Colleagues

G. Fava, R. Balon, J. de Leon, 2018, Psychotherapy and Psychosomatics.

Using therapeutic drug monitoring to personalize clozapine dosing in Asians

J. Kane, J. de Leon, G. Schoretsanitis, 2020, Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists.

Clozapine Metabolism in East Asians and Caucasians: A Pilot Exploration of the Prevalence of Poor Metabolizers and a Systematic Review

Chuan-Yue Wang, E. Spina, J. de Leon, 2019, Journal of clinical psychopharmacology.

No association between the Ser9Gly polymorphism of the dopamine D3 receptor gene and schizophrenia in a Spanish sample

E. Baca-García, J. Saiz-ruiz, J. de Leon, 2007, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

A pilot effort to determine benztropine equivalents of anticholinergic medications.

G. Simpson, J. de Leon, C. Canuso, 1994, Hospital & community psychiatry.

Excessive antipsychotic dosing in 2 U.S. State hospitals.

J. de Leon, F. J. Diaz, 2002, The Journal of clinical psychiatry.

First episode in bipolar disorder: misdiagnosis and psychotic symptoms.

F. Mosquera, A. González-Pinto, M. Gutiérrez, 1998, Journal of affective disorders.

The Relationship Between Menstrual Cycle Phases and Suicide Attempts

E. Baca-García, J. Saiz-ruiz, J. de Leon, 2000, Psychosomatic medicine.

A case report that suggested that aspirin's effects on valproic acid metabolism may contribute to valproic acid's inducer effects on clozapine metabolism.

Andrew T. Cooley, J. de Leon, A. Riesselman, 2013, Journal of clinical psychopharmacology.

Published population pharmacokinetic models of valproic acid in adult patients: a systematic review and external validation in a Chinese sample of inpatients with bipolar disorder

J. de Leon, Can-Jun Ruan, Yan-Nan Zang, 2022, Expert review of clinical pharmacology.

Highlights of drug package inserts and the website DailyMed: the need for further improvement in package inserts to help busy prescribers.

J. de Leon, 2011, Journal of clinical psychopharmacology.

Precision psychiatry: The complexity of personalizing antipsychotic dosing.

J. de Leon, 2022, European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.

Atypical antipsychotic dosing: the effect of smoking and caffeine.

J. de Leon, 2004, Psychiatric services.

Horror Vacui: Emptiness Might Distinguish between Major Suicide Repeaters and Nonmajor Suicide Repeaters: A Pilot Study

E. Baca-García, P. Courtet, H. Blasco-Fontecilla, 2015, Psychotherapy and Psychosomatics.

Serum IgG antibodies against the NR1 subunit of the NMDA receptor not detected in schizophrenia.

K. Berman, J. Masdeu, J. Dalmau, 2012, The American journal of psychiatry.

The pharmacokinetics of paliperidone versus risperidone.

J. de Leon, Gary H Wynn, Neil B. Sandson, 2010, Psychosomatics.

Adding Oral Contraceptives to Clozapine May Require Halving the Clozapine Dose: A New Case and a Literature Review.

J. Kane, J. de Leon, G. Schoretsanitis, 2020, Journal of clinical psychopharmacology.

Pneumonia Can Cause Clozapine Intoxication: A Case Report.

W. Guo, Chuan-Yue Wang, J. de Leon, 2017, Psychosomatics.

Metabolic drug interactions with newer antipsychotics: a comparative review.

E. Spina, J. de Leon, 2007, Basic & clinical pharmacology & toxicology.

Prolactin levels: sex differences in the effects of risperidone, 9-hydroxyrisperidone levels, CYP2D6 and ABCB1 variants.

J. de Leon, F. J. Diaz, G. Schoretsanitis, 2018, Pharmacogenomics.

Possible Pharmacodynamic and Pharmacokinetic Drug-Drug Interactions That Are Likely to Be Clinically Relevant and/or Frequent in Bipolar Disorder

E. Spina, J. de Leon, 2018, Current Psychiatry Reports.

Clobazam Therapeutic Drug Monitoring: A Comprehensive Review of the Literature With Proposals to Improve Future Studies

E. Spina, J. de Leon, F. J. Diaz, 2013, Therapeutic drug monitoring.

Pharmacokinetic drug-drug interactions between olanzapine and valproate need to be better studied.

E. Spina, J. de Leon, F. J. Diaz, 2010, The Journal of clinical psychiatry.

Risperidone half-life in a patient taking paroxetine -- a case report.

J. de Leon, F. J. Diaz, M. Susce, 2005, Pharmacopsychiatry.

Risperidone and cytochrome P450 3A.

J. de Leon, J. Leon, J. Bork, 1997, The Journal of clinical psychiatry.

Interaction of sertraline with clozapine.

J. de Leon, J. Leon, N. Pinninti, 1997, Journal of clinical psychopharmacology.

Around 3% of 1,300 Levels Were Elevated during Infections in a Retrospective Review of 131 Beijing Hospital In-Patients with More than 24,000 Days of Clozapine Treatment

Chuan-Yue Wang, J. de Leon, Can-Jun Ruan, 2020, Psychotherapy and Psychosomatics.

Clinically Significant Drug–Drug Interactions with Agents for Attention-Deficit/Hyperactivity Disorder

J. Kane, C. Eap, J. de Leon, 2019, CNS Drugs.

Exploring the Prevalence of Clozapine Phenotypic Poor Metabolizers in 4 Asian Samples: They Ranged Between 2% and 13.

Chuan-Yue Wang, K. Hong, Yi-lang Tang, 2019, Journal of clinical psychopharmacology.

Studies of Half-Lives of Long-Acting Antipsychotics are Needed.

J. de Leon, G. Schoretsanitis, A. Villasante-Tezanos, 2018, Pharmacopsychiatry.

Weight Gain During a Double-Blind Multidosage Clozapine Study

G. Simpson, T. Cooper, R. Josiassen, 2007, Journal of clinical psychopharmacology.

Haloperidol Half-life After Chronic Dosing

G. Simpson, T. Cooper, R. Josiassen, 2004, Journal of clinical psychopharmacology.

Misidentification Syndromes in Schizophrenia: Case Reviews with Implications for Classification and Prevalence

G. Simpson, J. de Leon, B. Cloud, 1995, The Australian and New Zealand journal of psychiatry.

Tools for optimising pharmacotherapy in psychiatry (therapeutic drug monitoring, molecular brain imaging and pharmacogenetic tests): focus on antidepressants

E. Corruble, R. Lanzenberger, J. Meyer, 2021, The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.

Adjunctive Electroconvulsive Therapy for Schizophrenia: A Meta-analysis of Randomized Rater-Masked Controlled Trials [RETRACTED].

Yi-lang Tang, G. Ungvari, Y. Xiang, 2016, The journal of ECT.

Diagnostic stability and evolution of bipolar disorder in clinical practice: a prospective cohort study

J. Leiva-Murillo, E. Baca-García, M. Oquendo, 2007, Acta psychiatrica Scandinavica.

Clinically Relevant Interactions between Atypical Antipsychotics and Anti-Infective Agents

E. Spina, J. de Leon, G. Cicala, 2020, Pharmaceuticals.

Clinically relevant interactions between newer antidepressants and second-generation antipsychotics

E. Spina, J. de Leon, 2014, Expert opinion on drug metabolism & toxicology.

Nucleotide variation in central nervous system genes among male suicide attempters

M. Gratacós, X. Estivill, J. Leiva-Murillo, 2009, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

Tyramine and New Monoamine Oxidase Inhibitor Drugs

J. de Leon, G. M. Simpson, 1989, British Journal of Psychiatry.

Suicide attempts among women during low estradiol/low progesterone states.

E. Baca-García, M. Oquendo, J. López-Castromán, 2010, Journal of psychiatric research.

Glucuronidation enzymes, genes and psychiatry.

J. de Leon, J. de Leon, Jose de Leon, 2003, The international journal of neuropsychopharmacology.

Delusion of parasitosis or chronic tactile hallucinosis: hypothesis about their brain physiopathology.

G. Simpson, J. de Leon, R. E. Antelo, 1992, Comprehensive psychiatry.

Schizophrenia and smoking: an epidemiological survey in a state hospital.

G. Simpson, J. de Leon, J. Leon, 1995, The American journal of psychiatry.

Metformin for Weight Gain and Metabolic Abnormalities Associated With Antipsychotic Treatment: Meta-Analysis of Randomized Placebo-Controlled Trials

Yi-lang Tang, J. de Leon, Xian-Bin Li, 2015, Journal of clinical psychopharmacology.

Focusing on drug versus disease mechanisms and on clinical subgrouping to advance personalised medicine in psychiatry

J. de Leon, 2013, Acta Neuropsychiatrica.

The effects of antiepileptic inducers in neuropsychopharmacology, a neglected issue. Part II: Pharmacological issues and further understanding

J. de Leon, J. Leon, 2015 .

False-Negative Studies May Systematically Contaminate the Literature on the Effects of Inducers in Neuropsychopharmacology. Part I: Focus on Epilepsy

J. de Leon, 2014, Journal of clinical psychopharmacology.

APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer's disease

J. Licinio, S. Easteal, F. Lopera, 2015, Molecular Psychiatry.

New GABAA receptor alpha5 subunit gene polymorphism that may confound genotyping

E. Baca-García, J. Fernández-Piqueras, J. Saiz-ruiz, 2004, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

Practical guidelines for the use of new generation antipsychotic drugs (except clozapine) in adult individuals with intellectual disabilities.

Nirbhay N. Singh, J. de Leon, M. Sabaawi, 2009, Research in developmental disabilities.

Are major repeater patients addicted to suicidal behavior?

H. Blasco-Fontecilla, J. de Leon, Luis Iruela-Cuadrado, 2014, Adicciones.

Periodic Catatonia Marked by Hypercortisolemia and Exacerbated by the Menses: A Case Report and Literature Review

J. de Leon, S. Zwiebel, Alejandro G. Villasante-Tejanos, 2018, Case reports in psychiatry.

Variables associated with hospitalization decisions by emergency psychiatrists after a patient's suicide attempt.

E. Baca-García, J. Saiz-ruiz, J. de Leon, 2004, Psychiatric services.

The Addictive Model of Self-Harming (Non-suicidal and Suicidal) Behavior

H. Blasco-Fontecilla, J. de Leon, L. Colino, 2016, Front. Psychiatry.

Personality disorders and health problems distinguish suicide attempters from completers in a direct comparison.

E. Baca-García, L. Giner, M. Oquendo, 2013, Journal of affective disorders.

Lack of Association between Testosterone and Suicide Attempts

E. Baca-García, J. López-Castromán, J. Saiz-ruiz, 2010, Neuropsychobiology.

Polymorphic Variations in GSTM1, GSTT1, PgP, CYP2D6, CYP3A5, and Dopamine D2 and D3 Receptors and Their Association With Tardive Dyskinesia in Severe Mental Illness

W. Koch, J. de Leon, M. Susce, 2005, Journal of clinical psychopharmacology.

Interactions between antiepileptics and second-generation antipsychotics

E. Spina, J. de Leon, Concetta D'Arrigo, 2012, Expert opinion on drug metabolism & toxicology.

Association between myocarditis and antipsychotics other than clozapine: a systematic literature review and a pharmacovigilance study using VigiBase

E. Sanz, J. de Leon, C. Rohde, 2022, Expert review of clinical pharmacology.

An update on the complex relationship between clozapine and pneumonia

H. Verdoux, E. Spina, J. de Leon, 2021, Expert review of clinical pharmacology.

Pneumonia risk: approximately one‐third is due to clozapine and two‐thirds is due to treatment‐resistant schizophrenia

J. Nielsen, J. de Leon, C. Rohde, 2020, Acta psychiatrica Scandinavica.

A comprehensive review of swallowing difficulties and dysphagia associated with antipsychotics in adults

E. Spina, J. de Leon, G. Cicala, 2019, Expert review of clinical pharmacology.

ADGRL3 (LPHN3) variants predict substance use disorder

N. Volkow, F. Castellanos, S. Easteal, 2019, Translational Psychiatry.

Association Between the Menses and Suicide Attempts: A Replication Study

E. Baca-García, J. Saiz-ruiz, J. de Leon, 2003, Psychosomatic medicine.

Variables associated with alcohol, drug, and daily smoking cessation in patients with severe mental illnesses.

J. de Leon, D. Rendon, F. J. Diaz, 2005, The Journal of clinical psychiatry.

Estimating the size of the effects of co-medications on plasma clozapine concentrations using a model that controls for clozapine doses and confounding variables.

E. Spina, J. de Leon, F. J. Diaz, 2008, Pharmacopsychiatry.

QT Interval Prolongation Associated with Intramuscular Ziprasidone in Chinese Patients: A Case Report and a Comprehensive Literature Review with Meta-Analysis

Yi-lang Tang, J. de Leon, Chuan-Yue Wang, 2014, Case reports in psychiatry.

Eosinophilic pleural effusion associated with the addition of sodium valproate.

J. de Leon, J. Álvarez-Dobaño, J. Suárez-Antelo, 2009, Journal of clinical psychopharmacology.

Smoking cessation in patients with psychiatric disorders.

N. Rigotti, A. Gelenberg, A. Evins, 2007, Primary care companion to the Journal of clinical psychiatry.

Efficacy and Safety of Adjunctive Aripiprazole in Schizophrenia: Meta-Analysis of Randomized Controlled Trials

Yi-lang Tang, J. de Leon, Xian-Bin Li, 2016, Journal of clinical psychopharmacology.

Positive and negative symptoms/syndromes in schizophrenia: reliability and validity of different diagnostic systems

V. Peralta, M. Cuesta, J. de Leon, 1995, Psychological Medicine.

Is psychiatry only neurology? Or only abnormal psychology? Déjà vu after 100 years

J. de Leon, 2014, Acta Neuropsychiatrica.

The effect of atypical versus typical antipsychotics on tardive dyskinesia: a naturalistic study.

J. de Leon, 2007, European archives of psychiatry and clinical neuroscience.

An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels.

D. Kelly, E. Seifritz, Abraham Weizman, 2021, Pharmacopsychiatry.

Future Studies on the Interaction between Clozapine and Valproic Acid Should Aspire to Include Longitudinal Designs and Free Valproate Concentrations, and Should Consider that Inducer and/or Inhibitory Effects May Vary with Time, the Individual, and the Auto-induction of Valproic Acid.

J. de Leon, 2019, Therapeutic drug monitoring.

The Impact of Smoking, Sex, Infection, and Comedication Administration on Oral Olanzapine: A Population Pharmacokinetic Model in Chinese Psychiatric Patients

J. de Leon, Can-Jun Ruan, Gui-Xin Guo, 2021, European Journal of Drug Metabolism and Pharmacokinetics.

Reduction in serum concentration of valproic acid secondary to the intake of ibuprofen as an example of valproic acid auto-induction metabolism.

J. de Leon, F. Lana, J. Martí-Bonany, 2016, Actas espanolas de psiquiatria.

Anticholinergics to treat clozapine withdrawal.

G. Simpson, J. de Leon, J. Stanilla, 1994, The Journal of clinical psychiatry.

The CYP2D6 poor metabolizer phenotype may be associated with risperidone adverse drug reactions and discontinuation.

W. Koch, J. de Leon, M. Susce, 2005, The Journal of clinical psychiatry.

DNA Microarray Technology in the Clinical Environment: The AmpliChip CYP450 Test for CYP2D6 and CYP2C19 Genotyping

F. Chiafari, E. Pomarol-Clotet, Johnson, 2009, CNS Spectrums.

Association study of two polymorphisms of the serotonin‐2A receptor gene and suicide attempts

E. Baca-García, L. Giner, J. Fernández-Piqueras, 2008, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

Clinical applications of CYP genotyping in psychiatry

E. Spina, J. de Leon, 2014, Journal of Neural Transmission.

CYP2D6 genotyping for psychiatric patients treated with risperidone: considerations for cost-effectiveness studies.

D. Gurwitz, A. Llerena, C. Rodríguez-Antona, 2009, Pharmacogenomics.

A Critical Commentary on the 2017 AGNP Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology

J. de Leon, 2017, Pharmacopsychiatry.

Translating Pharmacogenetics to Clinical Practice: Do Cytochrome P450 2D6 Ultrarapid Metabolizers Need Higher Atomoxetine Doses?

J. de Leon, 2015, Journal of the American Academy of Child and Adolescent Psychiatry.

The crucial role of the therapeutic window in understanding the clinical relevance of the poor versus the ultrarapid metabolizer phenotypes in subjects taking drugs metabolized by CYP2D6 or CYP2C19.

J. de Leon, 2007, Journal of clinical psychopharmacology.

An HPLC method for the simultaneous determination of neurotoxic dipyridyl isomers in human plasma.

P. Crooks, J. de Leon, Abeer M. Al-Ghananeem, 2007, Journal of pharmaceutical and biomedical analysis.

A Case Report That Suggested That the Patient Was Very Sensitive to Induction and Needed 1600 mg/d of Lamotrigine to Get Therapeutic Concentrations.

J. de Leon, Betsy McCollum, J. Jackson, 2015, Journal of clinical psychopharmacology.

Relaxin polymorphisms associated with metabolic disturbance in patients treated with antipsychotics

Victoria Kay, M. Arranz, A. Blakemore, 2012, Journal of psychopharmacology.

The Effect of Body Weight Changes on Total Plasma Clozapine Concentrations Determined by Applying a Statistical Model to the Data From a Double-Blind Trial

R. Josiassen, J. de Leon, F. J. Diaz, 2018, Journal of clinical psychopharmacology.

Young Researchers and Young Clinicians Should Not Pay Much Attention to the Journal Impact Factor When Selecting a Journal for Publishing Articles: Comment on the Editorial "The Impact Non-Factor" by Greenblatt and Shader.

J. de Leon, 2018, Journal of clinical psychopharmacology.

Tobacco smoking behaviors in bipolar disorder: a comparison of the general population, schizophrenia, and major depression.

D. James, J. de Leon, F. J. Diaz, 2009, Bipolar disorders.

Subjective effects and the main reason for smoking in outpatients with schizophrenia: a case-control study.

J. de Leon, J. Leon, F. J. Diaz, 2007, Comprehensive psychiatry.

Datapoints: Smoking and smoking cessation among persons with severe mental illnesses.

J. de Leon, D. Rendon, F. J. Diaz, 2006, Psychiatric services.

A brief measure of high nicotine dependence for busy clinicians and large epidemiological surveys.

E. Saltó, C. Pinet, L. Salleras, 2005, The Australian and New Zealand journal of psychiatry.

Exploring brief measures of nicotine dependence for epidemiological surveys.

E. Becoña, J. de Leon, A. Gonzalez-Pinto, 2003, Addictive behaviors.

Plasma cotinine, 3'-hydroxycotinine, and their glucuronides in white and black smokers.

L. Dwoskin, P. Crooks, J. de Leon, 2003, Journal of clinical psychopharmacology.

Smoking in bipolar and schizophrenic patients.

J. de Leon, F. J. Diaz, 2002, The Journal of clinical psychiatry.

A Rational Use of Clozapine Based on Adverse Drug Reactions, Pharmacokinetics, and Clinical Pharmacopsychology

J. de Leon, G. Schoretsanitis, Can-Jun Ruan, 2020, Psychotherapy and Psychosomatics.

Catatonia Secondary to Sudden Clozapine Withdrawal: A Case with Three Repeated Episodes and a Literature Review

John Bilbily, J. de Leon, Betsy McCollum, 2017, Case reports in psychiatry.

The dosing of atypical antipsychotics.

J. de Leon, S. C. Armstrong, K. Cozza, 2005, Psychosomatics.

Two cases of high serum clozapine concentrations occurring during inflammation in Chinese patients

W. Guo, J. de Leon, Fu-chun Zhou, 2018, International journal of psychiatry in medicine.

Self-Report for Measuring and Predicting Medication Adherence: Experts’ Experience in Predicting Adherence in Stable Psychiatric Outpatients and in Pharmacokinetics

J. de Leon, C. de Las Cuevas, 2020, Patient preference and adherence.

Catatonia Following Abrupt Cessation of Oxcarbazepine in a Patient With Prader-Willi Syndrome.

Abner Rayapati, J. de Leon, S. Zwiebel, 2019, Psychosomatics.

Catatonia in Older Adult Individuals with Intellectual Disabilities

J. de Leon, M. White, Warren E. Milteer, 2015, Case reports in psychiatry.

A case report with ziprasidone-induced catatonic symptoms.

J. de Leon, C. Markham-Abedi, Connie McNeely, 2007, The Journal of neuropsychiatry and clinical neurosciences.

Clozapine withdrawal resulting in delirium with psychosis: a report of three cases.

G. Simpson, J. de Leon, J. Stanilla, 1997, The Journal of clinical psychiatry.

A study of bedside screening procedures for cognitive deficits in chronic psychiatric inpatients.

G. Simpson, J. de Leon, R. Doonan, 1996, Comprehensive psychiatry.

Clozapine levels after clozapine discontinuation.

G. Simpson, J. de Leon, J. Stanilla, 1996, Journal of clinical psychopharmacology.

Pharmacokinetic and pharmacodynamic interactions between antiepileptics and antidepressants

E. Spina, D. Italiano, J. de Leon, 2014, Expert opinion on drug metabolism & toxicology.

Comparison of the Heavy Smoking Index and of the Fagerstrom Test for Nicotine Dependence in a sample of 749 cigarette smokers.

H. Chabrol, J. de Leon, M. Niezborala, 2005, Addictive behaviors.

Paradoxical Excitation on Diphenhydramine May Be Associated with Being a CYP2D6 Ultrarapid Metabolizer: Three Case Reports

J. de Leon, D. Nikoloff, D. Michele Nikoloff, 2008, CNS Spectrums.

Extension of a pilot study: impact from the cytochrome P450 2D6 polymorphism on outcome and costs associated with severe mental illness.

M. Cronin, T. Ryder, M. Pho, 2000, Journal of clinical psychopharmacology.

A simple high performance liquid chromatographic method for the quantification of total cotinine, total 3'-hydroxycotinine and caffeine in the plasma of smokers.

L. Dwoskin, P. Crooks, J. de Leon, 2000, Journal of pharmaceutical and biomedical analysis.

Trajectories of symptom dimensions in short-term response to antipsychotic treatment in patients with a first episode of non-affective psychosis

R. Tabarés-Seisdedos, B. Crespo-Facorro, R. Perez-Iglesias, 2013, Psychological Medicine.

Pharmacogenetic testing in psychiatry: a review of features and clinical realities.

G. Ruaño, M. Arranz, J. de Leon, 2008, Clinics in laboratory medicine.

A preliminary attempt to personalize risperidone dosing using drug-drug interactions and genetics: part I.

J. de Leon, K. Cozza, Neil B. Sandson, 2008, Psychosomatics.

An investigation of the α1A‐adrenergic receptor gene and antipsychotic‐induced side‐effects

R. Kerwin, P. Sáiz, M. Arranz, 2008, Human psychopharmacology.

Clinimetric Criteria for Patient-Reported Outcome Measures

J. Concato, A. Nierenberg, T. Furukawa, 2021, Psychotherapy and Psychosomatics.

Effect of necessity‐concern framework and polypharmacy on treatment adherence in psychiatric patients. Comparing an Argentinian with a Spanish sample

J. de Leon, C. de Las Cuevas, A. Villasante-Tezanos, 2021, Human psychopharmacology.

The necessity‐concern framework in the assessment of treatment adherence of psychiatric patients and the role of polypharmacy in a Spanish sample

J. de Leon, Moisés Betancort, C. de Las Cuevas, 2020, Human psychopharmacology.

Association study of serotonergic gene variants with antipsychotic-induced adverse reactions

P. Sáiz, M. Arranz, A. Blakemore, 2009, Psychiatric genetics.

The future (or lack of future) of personalized prescription in psychiatry.

J. de Leon, 2009, Pharmacological research.

Total Cotinine in Plasma: A Stable Biomarker for Exposure to Tobacco Smoke

L. Dwoskin, P. Crooks, J. de Leon, 2002, Journal of clinical psychopharmacology.

Reviving Research on Medication Attitudes for Improving Pharmacotherapy: Focusing on Adherence

J. de Leon, C. de Las Cuevas, 2017, Psychotherapy and Psychosomatics.

Clozapine and the risk of haematological malignancies.

C. Correll, E. Sanz, J. de Leon, 2022, The lancet. Psychiatry.

Rapid Titration and Decreased Clozapine Clearance May Help Explain Five Cases of Clozapine-Induced Myocarditis in a New York Hospital.

J. de Leon, David W Rhee, Andrea Kondracke, 2019, Psychosomatics.

Clinically significant pharmacokinetic drug interactions of antiepileptic drugs with new antidepressants and new antipsychotics.

E. Spina, F. Pisani, J. de Leon, 2016, Pharmacological research.

Dimensions of suicidal behavior according to patient reports

E. Baca-García, J. Saiz-ruiz, J. de Leon, 2003, European Archives of Psychiatry and Clinical Neuroscience.

Is poor insight in psychotic disorders associated with poor performance on the Wisconsin Card Sorting Test?

V. Peralta, M. Cuesta, J. de Leon, 1995, The American journal of psychiatry.

Two Sudden and Unexpected Deaths of Patients with Schizophrenia Associated with Intramuscular Injections of Antipsychotics and Practice Guidelines to Limit the Use of High Doses of Intramuscular Antipsychotics

J. de Leon, A. Brenzel, Nasratullah Wahidi, 2016, Case reports in psychiatry.

The Art of Pharmacotherapy: Reflections on Pharmacophobia.

J. de Leon, C. de Las Cuevas, 2017, Journal of clinical psychopharmacology.

Is it time to awaken Sleeping Beauty? European psychiatry has been sleeping since 1980.

J. de Leon, 2014, Revista de psiquiatria y salud mental.

A pilot study on risperidone metabolism: the role of cytochromes P450 2D6 and 3A.

J. de Leon, P. Wedlund, J. de Leon, 1999, The Journal of clinical psychiatry.

A Brief Measure of High Nicotine Dependence for Busy Clinicians and Large Epidemiological Surveys

E. Saltó, C. Pinet, L. Salleras, 2005 .

Age at onset in bipolar I disorder: two may be better than three subgroups.

F. Mosquera, S. Barbeito, J. de Leon, 2009, Revista de psiquiatria y salud mental.

CYP2D6 Genetic Polymorphisms and Risperidone Pharmacokinetics: A Systematic Review and Meta‐analysis

J. Bishop, J. de Leon, Adam M. Lee, 2020, Pharmacotherapy.

Factors influencing adherence to psychopharmacological medications in psychiatric patients: a structural equation modeling approach

W. Peñate, J. de Leon, C. de Las Cuevas, 2017, Patient preference and adherence.

Clozapine-induced myocarditis may be associated with rapid titration

J. de Leon, N. Chopra, 2016, International journal of psychiatry in medicine.

From the Serotonin Model of Suicide to a Mental Pain Model of Suicide

E. Baca-García, H. Blasco-Fontecilla, J. de Leon, 2015, Psychotherapy and Psychosomatics.

How safe are psychiatric medications after a voluntary overdose?

E. Baca-García, J. Saiz-ruiz, J. de Leon, 2002, European Psychiatry.

Absence of changes in antidiuretic hormone, angiotensin II, and atrial natriuretic peptide with clozapine treatment of polydipsia-hyponatremia: 2 case reports.

G. Simpson, J. de Leon, M. Phillips, 1998, The Journal of clinical psychiatry.

False-Negative Studies May Systematically Contaminate the Literature on the Effects of Inducers in Neuropsychopharmacology: Part II Focus on Bipolar Disorder

J. de Leon, 2014, Journal of clinical psychopharmacology.

Why Do You Keep Telling Me That Drug-Drug Interactions Are Important in Psychopharmacology When I Do Not See Them in My Clinical Practice?: My Failure to Convince Clinicians.

J. de Leon, 2019, Journal of clinical psychopharmacology.

Development and validation of the Patient’s Health Belief Questionnaire on Psychiatric Treatment

J. de Leon, C. de Las Cuevas, 2019, Patient preference and adherence.

European Whites May Need Lower Minimum Therapeutic Clozapine Doses Than Those Customarily Proposed

E. Molden, M. Kopeček, E. Spina, 2021, Journal of clinical psychopharmacology.

Reply to the Multifaceted Aspects of Suicide Behavior by Tondo

E. Baca-García, H. Blasco-Fontecilla, J. de Leon, 2016, Psychotherapy and Psychosomatics.

Clozapine and jaw dyskinesia: a case report.

J. de Leon, L. Moral, C. Camuñas, 1991, The Journal of clinical psychiatry.

A cross-sectional study of major repeaters: a distinct phenotype of suicidal behavior.

Enrique Baca-Garcia, Philippe Courtet, Isabelle Jaussent, 2014, The primary care companion for CNS disorders.

Gemfibrozil May Decrease Norclozapine Elimination: A Case Report.

J. de Leon, G. Schoretsanitis, Betsy McCollum, 2019, Journal of clinical psychopharmacology.

Respiratory infections rather than antibiotics may increase clozapine levels: a critical review of the literature.

J. de Leon, 2004, The Journal of clinical psychiatry.

Double-blind study of clozapine dose response in chronic schizophrenia.

G. Simpson, R. Josiassen, J. de Leon, 1999, The American journal of psychiatry.

Lower gastrointestinal bleeding and paroxetine use: two case reports.

H. Blasco-Fontecilla, J. de Leon, 2012, Psychosomatics.

Paying attention to pharmacokinetic and pharmacodynamic mechanisms to progress in the area of anticholinergic use in geriatric patients.

J. de Leon, 2011, Current drug metabolism.

Thirty Years of Both Ignorance and Clinical Experience Suggest That Clozapine Intoxication During Co-Occurring Infections and Inflammation May Have Higher Morbidity and Mortality Than Is Currently Believed.

J. de Leon, Can-Jun Ruan, 2019, Psychosomatics.

Low serum cholesterol may be associated with suicide attempt history.

E. Baca-García, M. Oquendo, J. Saiz-ruiz, 2008, The Journal of clinical psychiatry.

Pharmacogenomics: the promise of personalized medicine for CNS disorders.

J. de Leon, 2009, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.

Caffeine intake in outpatients with schizophrenia.

J. de Leon, F. J. Diaz, J. Martínez-Ortega, 2004, Schizophrenia bulletin.

A pilot study on differences in aggression in New York City and Madrid, Spain, and their possible impact on suicidal behavior.

E. Baca-García, J. Mann, M. Oquendo, 2006, The Journal of clinical psychiatry.

Suicide attempts in bipolar patients.

F. Mosquera, A. González-Pinto, M. Gutiérrez, 2001, The Journal of clinical psychiatry.

Skepticism and pharmacophobia toward medication may negatively impact adherence to psychiatric medications: a comparison among outpatient samples recruited in Spain, Argentina, and Venezuela

J. de Leon, T. Baptista, C. de Las Cuevas, 2018, Patient Preference and Adherence.

CYP2D6 ultra-rapid metabolizer phenotype not associated with attempted suicide in a large sample of psychiatric inpatients.

J. de Leon, Dustin B. Stephens, 2016, Pharmacogenomics.

A Clinimetric Approach for Improving the Measurement of Pharmacophobia with Replication in Two Other Samples

J. de Leon, C. de Las Cuevas, 2019, Psychotherapy and Psychosomatics.

Dysmorphophobia misdiagnosed as obsessive-compulsive disorder.

B. Vitiello, J. de Leon, 1990, Psychosomatics.

Role of Statistical Random-Effects Linear Models in Personalized Medicine

Hung-Wen Yeh, Francisco J Diaz, H. Yeh, 2012, Current pharmacogenomics and personalized medicine.

Quantitative determination of risperidone, paliperidone and olanzapine in human serum by liquid chromatography-tandem mass spectrometry coupled with on-line solid-phase extraction.

W. Guo, J. de Leon, M. Zhou, 2018, Biomedical chromatography : BMC.

Assessing drug-drug interactions through therapeutic drug monitoring when administering oral second-generation antipsychotics

E. Spina, C. Hiemke, J. de Leon, 2016, Expert opinion on drug metabolism & toxicology.

Letter to the Editor: Clinical versus statistical significance of pharmacogenomic-guided antidepressant therapy: What's really being measured and marketed?

R. McIntyre, S. Preskorn, J. Rosenblat, 2019, Journal of Psychiatric Research.

An international clozapine titration guideline to increase its safety and move forward on the route started by German-speaking psychiatrists in the 1960s

C. Correll, J. Kane, J. de Leon, 2022, European Archives of Psychiatry and Clinical Neuroscience.

Four cases of myocarditis in US hospitals possibly associated with clozapine poor metabolism and a comparison with prior published cases.

J. de Leon, J. Coleman, Robert O. Cotes, 2022, Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology.

Adding other antipsychotics to clozapine.

J. de Leon, C. Cooke, 1999, Journal of Clinical Psychiatry.

The association of clozapine and haematological malignancies needs to be replicated by other studies and more importantly by analyses of subsamples from VigiBase

H. Verdoux, E. Sanz, J. de Leon, 2020, Psychological Medicine.

Paradoxes of US Psychopharmacology Practice in 2013: Undertreatment of Severe Mental Illness and Overtreatment of Minor Psychiatric Problems

J. de Leon, 2014, Journal of clinical psychopharmacology.

Is Psychiatry Scientific? A Letter to a 21st Century Psychiatry Resident

J. de Leon, 2013, Psychiatry investigation.

Rapid Development of Lorazepam Tolerance Within 48 Hours in an Adult With Intellectual Disability Who Presented With Stuporous Catatonia and Refused Electroconvulsive Therapy.

J. de Leon, Nasratullah Wahidi, 2018, The Primary Care Companion For CNS Disorders.

Ethnopsychopharmacology study of patients' beliefs regarding concerns about and necessity of taking psychiatric medications

J. de Leon, T. Baptista, C. de Las Cuevas, 2019, Human psychopharmacology.

Predictive validity of the Sidorkiewicz instrument in Spanish: Assessing individual drug adherence in psychiatric patients

W. Peñate, J. de Leon, C. de Las Cuevas, 2017, International journal of clinical and health psychology : IJCHP.

Clozapine Addition Following Brain Surgery in Severe Primary Obsessive-Compulsive Disorder With Tardive Movement Disorder.

J. de Leon, T. Baptista, H. Araujo, 2019, Journal of clinical psychopharmacology.

Acute dystonic reaction to lithium and risperidone.

J. de Leon, S. Durrenberger, 1999, The Journal of neuropsychiatry and clinical neurosciences.

DSM-5 and the research domain criteria: 100 years after Jaspers' General psychopathology.

J. de Leon, 2014, The American journal of psychiatry.

Pharmacokinetic Drug Interaction Studies Must Consider Pharmacological Heterogeneity, Use of Repeated Dosing, and Translation Into a Message Understandable to Practicing Clinicians

E. Spina, J. de Leon, F. J. Diaz, 2009, Journal of clinical psychopharmacology.

Poor Adherence to Oral Psychiatric Medication in Adults with Depression: Psychological Reactance May Have Specific Effects in Depression.

J. de Leon, T. Baptista, J. Lazary, 2021, Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology.

Adherence to psychiatric medications: Comparing patients with schizophrenia, bipolar disorder and major depression.

J. de Leon, J. Lazary, C. de Las Cuevas, 2021, Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology.

Poor Adherence to Oral Psychiatric Medication in Adults with Schizophrenia May Be Influenced by Pharmacophobia, High Internal Health Locus of Control and Treatment Duration.

J. de Leon, T. Baptista, J. Lazary, 2021, Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology.

Poor Adherence to Oral Psychiatric Medication in Adults with Bipolar Disorder: The Psychiatrist May have More Influence than in Other Severe Mental Illnesses.

J. de Leon, T. Baptista, J. Lazary, 2021, Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology.

APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer's disease

J. Licinio, S. Easteal, F. Lopera, 2015, Molecular Psychiatry.

Pathophysiology and clinical trials have limitations in some areas of medicine: focus on psychiatry (letter commenting: J Clin Epidemiol. 2014;67(4):361-363.).

J. de Leon, Dustin B. Stephens, 2016, Journal of Clinical Epidemiology.

Positive response to clozapine augmentation in a patient with obsessive-compulsive disorder complicated by a tardive movement disorder

J. de Leon, T. Baptista, 2018, Revista Brasileira de Psiquiatria.

Clozapine Augmentation With Antiepileptic Drugs for Treatment-Resistant Schizophrenia: A Meta-Analysis of Randomized Controlled Trials.

Y. Xiang, J. de Leon, Wei Zheng, 2017, The Journal of clinical psychiatry.

AmpliChip CYP450 Test: personalized medicine has arrived in psychiatry

J. de Leon, Jose de Leon, 2006, Expert review of molecular diagnostics.

An exploratory study of the relationship between diverse life events and specific personality disorders in a sample of suicide attempters.

E. Baca-García, P. Courtet, P. Duberstein, 2010, Journal of personality disorders.