S. Siedlak

M. Montano, Michiko Watanabe, S. Siedlak, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Distinct chronology of neuronal cell cycle re-entry and tau pathology in the 3xTg-AD mouse model and Alzheimer's disease patients.

Hyoung-Gon Lee, Hyun-pil Lee, S. Siedlak, 2014, Journal of Alzheimer's disease : JAD.

Apolipoprotein E interaction with the neurofibrillary tangles and senile plaques in Alzheimer disease: implications for disease pathogenesis.

M. Smith, S. Siedlak, P. Richey, 1995, Biochemical and biophysical research communications.

Paraffin-embedded tissue (PET) blot method: Application to Alzheimer disease

M. Tabaton, R. Castellani, Mark A. Smith, 2010, Journal of Neuroscience Methods.

Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortex

Wenzhang Wang, Hyoung-Gon Lee, Xiongwei Zhu, 2018, Molecular Neurodegeneration.

Oxidative stress mechanisms and potential therapeutics in Alzheimer disease

M. Smith, P. Moreira, X. Zhu, 2005, Journal of Neural Transmission.

Amyloid-β overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

Xiongwei Zhu, G. Casadesus, P. Moreira, 2008, Proceedings of the National Academy of Sciences.

Mislocalization of CDK11/PITSLRE, a regulator of the G2/M phase of the cell cycle, in Alzheimer disease

Hyoung-Gon Lee, Xiongwei Zhu, Mark A. Smith, 2011, Cellular & Molecular Biology Letters.

Neuroprotective properties of Bcl‐w in Alzheimer disease

Hyoung-Gon Lee, Xiongwei Zhu, M. Tabaton, 2004, Journal of neurochemistry.

Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's disease

Hyoung-Gon Lee, Xiongwei Zhu, A. Takeda, 2009, Molecular Neurodegeneration.

Mitochondrial abnormalities in Alzheimer disease

A. Nunomura, Mark A. Smith, K. Hirai, 2000, Neurobiology of Aging.

Neurodegenerative processes in Alzheimer's disease: an overview of pathogenesis with strategic biomarker potential

Hyoung-Gon Lee, Xiongwei Zhu, Mark A. Smith, 2011 .

Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease

Hyoung-Gon Lee, R. Castellani, Mark A. Smith, 2009, Aging.

Neurofilament proteins in neurodegenerative diseases

M. Smith, A. Nunomura, P. Moreira, 2004, Cellular and Molecular Life Sciences CMLS.

Artifactual strain-specific signs of incipient brain amyloidosis in APP transgenic mice

B. Greenberg, D. Lowery, S. Siedlak, 1996, Neurobiology of Aging.

The Inhibition of TDP-43 Mitochondrial Localization Blocks Its Neuronal Toxicity

Hu Li, Wenzhang Wang, Junjie Lu, 2016, Nature Medicine.

Tau modifiers as therapeutic targets for Alzheimer's disease.

Hyoung-Gon Lee, Xiongwei Zhu, A. Nunomura, 2005, Biochimica et biophysica acta.

DNA Damage in Alzheimer Disease Lymphocytes and Its Relation to Premature Centromere Division

S. Siedlak, B. Spremo-Potparević, L. Živković, 2013, Neurodegenerative Diseases.

Premature centromere division of metaphase chromosomes in peripheral blood lymphocytes of Alzheimer's disease patients: relation to gender and age.

Mark A. Smith, G. Ocić, S. Siedlak, 2010, The journals of gerontology. Series A, Biological sciences and medical sciences.

Autophagocytosis of mitochondria is prominent in Alzheimer disease

A. Nunomura, M. Tabaton, P. Moreira, 2007, Journal of the Neurological Sciences.

Upregulation of Glutaredoxin-1 Activates Microglia and Promotes Neurodegeneration: Implications for Parkinson's Disease.

Xiongwei Zhu, J. Mieyal, S. Siedlak, 2016, Antioxidants & redox signaling.

METTL3-dependent RNA m6A dysregulation contributes to neurodegeneration in Alzheimer’s disease through aberrant cell cycle events

Wenzhang Wang, Xiongwei Zhu, Chuan He, 2021, Molecular neurodegeneration.

Human Tau Isoform Aggregation and Selective Detection of Misfolded Tau from Post-Mortem Alzheimer’s Disease Brains

G. Bloom, Xiongwei Zhu, R. Helm, 2020, bioRxiv.

Erythrocyte, plasma, and serum antioxidant activities in untreated toxic multinodular goiter patients.

M. Smith, S. Siedlak, Y. Alicigüzel, 2001, Free radical biology & medicine.

Oxidative Damage to Nucleic Acids in Human Prion Disease

H. Budka, R. Castellani, Mark A. Smith, 2002, Neurobiology of Disease.

A Novel Origin for Granulovacuolar Degeneration in Aging and Alzheimer’s Disease: Parallels to Stress Granules

Hyoung-Gon Lee, Xiongwei Zhu, M. Tabaton, 2011, Laboratory Investigation.

Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortex

Wenzhang Wang, Hyoung-Gon Lee, Xiongwei Zhu, 2018, Molecular Neurodegeneration.

Skin α-Synuclein Aggregation Seeding Activity as a Novel Biomarker for Parkinson Disease

Xiongwei Zhu, B. Caughey, Shu G. Chen, 2020, JAMA neurology.

Distribution, levels and phosphorylation of Raf‐1 in Alzheimer's disease

Xiongwei Zhu, B. Su, M. Chao, 2006, Journal of neurochemistry.

Glutaredoxin deficiency exacerbates neurodegeneration in C. elegans models of Parkinson's disease.

Wenzhang Wang, Xiongwei Zhu, G. Caldwell, 2015, Human molecular genetics.

Protein disulfide isomerase in Alzheimer disease.

R. L. Russell, M. Smith, S. Shimohama, 2000, Antioxidants & redox signaling.

Amyloid‐β Deposition in Alzheimer Transgenic Mice Is Associated with Oxidative Stress

M. Tabaton, Mark A. Smith, K. Hirai, 1998, Journal of neurochemistry.

In Alzheimer's Disease, Heme Oxygenase Is Coincident with Alz50, an Epitope of τ Induced by 4‐Hydroxy‐2‐Nonenal Modification

Xiongwei Zhu, A. Nunomura, A. Takeda, 2000, Journal of neurochemistry.

High Molecular Weight Neurofilament Proteins Are Physiological Substrates of Adduction by the Lipid Peroxidation Product Hydroxynonenal*

D. Price, A. Nunomura, S. Shimohama, 2002, The Journal of Biological Chemistry.

Telomeres and telomerase in Alzheimer’s disease: Epiphenomena or a new focus for therapeutic strategy?

M. Blasco, Mark A. Smith, S. Franco, 2006, Alzheimer's & Dementia.

Overexpression of GRK2 in alzheimer disease and in a chronic hypoperfusion rat model is an early marker of brain mitochondrial lesions

George Perry, Gjumrakch Aliev, M. Obrenovich, 2006, Neurotoxicity Research.

Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease

George Perry, Xiongwei Zhu, Hyoung-Gon Lee, 2010, Redox report : communications in free radical research.

Immunolocalization of the amyloid precursor protein within the senile plaque.

P. Gambetti, S. Siedlak, L. Maggiora, 1989, Progress in clinical and biological research.

c‐Jun phosphorylation in Alzheimer disease

Xiongwei Zhu, Mark A. Smith, S. Siedlak, 2007, Journal of neuroscience research.

Abortive apoptosis in Alzheimer's disease

Xiongwei Zhu, A. Nunomura, A. Raina, 2001, Acta Neuropathologica.

MFN2 Couples Glutamate Excitotoxicity and Mitochondrial Dysfunction in Motor Neurons*♦

Wenzhang Wang, Li Li, B. Su, 2014, The Journal of Biological Chemistry.

, Neurons and Mitochondrial Dysfunction in Motor MFN 2 Couples Glutamate Excitotoxicity

Wenzhang Wang, Li Li, B. Su, 2014 .

Tau protein directly interacts with the amyloid β-protein precursor: Implications for Alzheimer's disease

R. Kalaria, F. Tagliavini, O. Bugiani, 1995, Nature Medicine.

Demonstration of a novel neurofilament associated antigen with the neurofibrillary pathology of Alzheimer and related diseases

M. Tabaton, M. Vandermeeren, M. Mercken, 1991, Brain Research.

Quantitative solubilization and analysis of insoluble paired helical filaments from alzheimer disease

Mark A. Smith, R. Nagaraj, S. Siedlak, 1996, Brain Research.

The sterol regulatory element‐binding protein 2 is dysregulated by tau alterations in Alzheimer disease

Wenzhang Wang, Hyoung-Gon Lee, Xiongwei Zhu, 2019, Brain pathology.

Antimicrobial peptide β-defensin-1 expression is upregulated in Alzheimer’s brain

Xiongwei Zhu, R. Castellani, Mark A. Smith, 2013, Journal of Neuroinflammation.

Compensatory responses induced by oxidative stress in Alzheimer disease.

Xiongwei Zhu, Mark A. Smith, P. Moreira, 2006, Biological research.

Indices of Metabolic Dysfunction and Oxidative Stress

George Perry, Paula I. Moreira, G. Casadesus, 2007, Neurochemical Research.

Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation.

N. Holbrook, M. Smith, A. Nunomura, 1999, Neuroreport.

Ribosomal RNA in Alzheimer Disease Is Oxidized by Bound Redox-active Iron*

Xiongwei Zhu, A. Nunomura, S. Shimohama, 2005, Journal of Biological Chemistry.

The Cell Cycle Regulator Phosphorylated Retinoblastoma Protein Is Associated With Tau Pathology in Several Tauopathies

Hyoung-Gon Lee, Xiongwei Zhu, M. Tabaton, 2011, Journal of neuropathology and experimental neurology.

Posttranslational modifications of α-tubulin in alzheimer disease

Hyoung-Gon Lee, Xiongwei Zhu, B. Su, 2015, Translational Neurodegeneration.

Mitochondria and vascular lesions as a central target for the development of Alzheimer's disease and Alzheimer disease-like pathology in transgenic mice

H. Vinters, J. LaManna, M. Obrenovich, 2003, Neurological research.

Atherosclerotic Lesions and Mitochondria DNA Deletions in Brain Microvessels as a Central Target for the Development of Human AD and AD‐Like Pathology in Aged Transgenic Mice

C. Cotman, H. Vinters, J. LaManna, 2002, Annals of the New York Academy of Sciences.

Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence.

George Perry, Jian Dong, Mark A. Smith, 2003, Biochemistry.

Frontiers in Alzheimer’s disease therapeutics

Xiongwei Zhu, G. Casadesus, R. Castellani, 2011, Therapeutic advances in chronic disease.

Vascular oxidative stress in Alzheimer disease

Xiongwei Zhu, G. Casadesus, A. Nunomura, 2007, Journal of the Neurological Sciences.

Individual Case Analysis of Postmortem Interval Time on Brain Tissue Preservation

Robert B. Petersen, Xiongwei Zhu, Hyoung-Gon Lee, 2016, PloS one.

Distribution, levels, and activation of MEK1 in Alzheimer's disease

George Perry, Xiongwei Zhu, Hyoung-Gon Lee, 2003, Journal of neurochemistry.

Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover.

Xiongwei Zhu, R. Castellani, Mark A. Smith, 2012, Free radical biology & medicine.

Oxidative Stress in Alzheimer’s Disease: A Critical Appraisal of the Causes and the Consequences

Xiongwei Zhu, G. Casadesus, A. Nunomura, 2011 .

Basic fibroblast growth factor binding is a marker for extracellular neurofibrillary tangles in Alzheimer disease.

P. Cras, S. Siedlak, M. Kawai, 1991, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Mfn2 Ablation in the Adult Mouse Hippocampus and Cortex Causes Neuronal Death

Wenzhang Wang, Xiongwei Zhu, S. Siedlak, 2020, Cells.

Abnormal localization of iron regulatory protein in Alzheimer's disease

J. Connor, Mark A. Smith, S. Siedlak, 1998, Brain Research.

In Vivo and In Silico Evidence: Hippocampal Cholesterol Metabolism Decreases with Aging and Increases with Alzheimers Disease -- Modeling Brain Aging and Disease

Clyde F. Phelix, Greg Villareal, Richard G. LeBaron, 2011, 2011 IEEE 11th International Conference on Data Mining Workshops.

Retinoblastoma protein phosphorylation at multiple sites is associated with neurofibrillary pathology in Alzheimer disease.

Hyoung-Gon Lee, Xiongwei Zhu, G. Casadesus, 2008, International journal of clinical and experimental pathology.

Activation of P38 kinase links π phosphorylation, oxidative stress and cell cycle-related events in Alzheimer disease

Xiongwei Zhu, A. Takeda, A. Raina, 2000, Neurobiology of Aging.

Neuronal binucleation in Alzheimer disease hippocampus

Yufei Wang, M. Smith, R. Castellani, 2008, Neuropathology and applied neurobiology.

Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes

Hyoung-Gon Lee, Xiongwei Zhu, R. Castellani, 2008, AGE.

The p38 pathway is activated in Pick disease and progressive supranuclear palsy: a mechanistic link between mitogenic pathways, oxidative stress, and tau

Xiongwei Zhu, R. Castellani, Mark A. Smith, 2002, Neurobiology of Aging.

METTL3-dependent RNA m6A dysregulation contributes to neurodegeneration in Alzheimer’s disease through aberrant cell cycle events

Wenzhang Wang, Xiongwei Zhu, B. Tang, 2021, Molecular Neurodegeneration.

Damaged mitochondria coincide with presynaptic vesicle loss and abnormalities in alzheimer’s disease brain

Wenzhang Wang, Xiongwei Zhu, S. Siedlak, 2023, Acta Neuropathologica Communications.

Microtubule reduction in Alzheimer's disease and aging is independent of tau filament formation.

George Perry, Xiongwei Zhu, Gjumrakch Aliev, 2003, The American journal of pathology.

Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans

T. Montine, A. Nunomura, S. Shimohama, 2002, Neuroscience Letters.

Antimicrobial peptide β-defensin-1 expression is upregulated in Alzheimer’s brain

Xiongwei Zhu, R. Castellani, Mark A. Smith, 2013, Journal of Neuroinflammation.

Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross-linking in Alzheimer disease

P. Cras, Mark A. Smith, S. Siedlak, 2004, Acta Neuropathologica.

Estrogen receptor-α is localized to neurofibrillary tangles in Alzheimer’s disease

Xiongwei Zhu, B. Tang, S. Siedlak, 2016, Scientific Reports.

The Autistic Phenotype Exhibits a Remarkably Localized Modification of Brain Protein by Products of Free Radical-Induced Lipid Oxidation

W. J. Walsh, Xiongwei Zhu, S. Hazen, 2008 .

Mathematical modeling of microtubule dynamics: Insights into physiology and disease

George Perry, Gavin A. Buxton, Mark A. Smith, 2010, Progress in Neurobiology.

Soluble derivatives of the beta amyloid protein precursor of Alzheimer's disease are labeled by antisera to the beta amyloid protein.

D. Selkoe, S. Younkin, B. Greenberg, 1989, Biochemical and biophysical research communications.

Dissociated amyloid-β antibody levels as a serum biomarker for the progression of Alzheimer’s disease: A population-based study

M. Tabaton, Mark A. Smith, A. Lerner, 2010, Experimental Gerontology.

Beta protein immunoreactivity is found in the majority of neurofibrillary tangles of Alzheimer's disease.

M. Tabaton, P. Cras, S. Siedlak, 1992, The American journal of pathology.

Dystrophic neurites infiltrate extracellular neurofibrillary tangles in Alzheimer disease

M. Tabaton, P. Cras, B. Greenberg, 1991, Brain Research.

Immunocytochemical evidence that the beta-protein precursor is an integral component of neurofibrillary tangles of Alzheimer's disease.

R. Kalaria, B. Greenberg, S. Siedlak, 1993, The American journal of pathology.

Immunocytochemical Evidence that the B-Protein Precursor is an Integral Component of Neurofibrillary Tangles of Alzheimer's Disease

Mark A. Smith, B. Greenberg, S. Siedlak, 2020 .

Immunocytochemical Evidence That the ( 3-Protein Precursor Is an Integral Component of Neurofibrillary Tangles of Alzheimer ' s Disease

Mark A. Smith, B. Greenberg, S. Siedlak, 2014 .

Short Communication Immunocytochemical Evidence That the (3-Protein Precursor Is an Integral Component of Neurofibrillary Tangles of Alzheimer's Disease

Mark A. Smith, B. Greenberg, S. Siedlak, 2007 .

Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance

Hyoung-Gon Lee, Xiongwei Zhu, G. Jicha, 2014, Journal of neurochemistry.

INTERACTION OF t WITH AMYLOID DEPOSITS

R. Kalaria, S. Siedlak, P. Richey, 1993 .

INTERACTION OF τ WITH AMYLOID ß DEPOSITS

R. Kalaria, S. Siedlak, P. Richey, 1993 .

Natural oxidant balance in Parkinson disease.

Xiongwei Zhu, A. Nunomura, Mark A. Smith, 2009, Archives of neurology.

Increased isoprostane and prostaglandin are prominent in neurons in Alzheimer disease

Xiongwei Zhu, G. Casadesus, Mark A. Smith, 2007, Molecular Neurodegeneration.

Conditional Haploinsufficiency of β-Catenin Aggravates Neuronal Damage in a Paraquat-Based Mouse Model of Parkinson Disease

Xiongwei Zhu, B. Tang, S. Siedlak, 2018, Molecular Neurobiology.

Conditional Haploinsufficiency of β-Catenin Aggravates Neuronal Damage in a Paraquat-Based Mouse Model of Parkinson Disease

Xiongwei Zhu, B. Tang, S. Siedlak, 2018, Molecular Neurobiology.

Reexamining Alzheimer's disease: evidence for a protective role for amyloid-beta protein precursor and amyloid-beta.

George Perry, Xiongwei Zhu, Hyoung-Gon Lee, 2009, Journal of Alzheimer's disease : JAD.

LRRK2 in Parkinson's disease and dementia with Lewy bodies

Xiongwei Zhu, T. Iwatsubo, Mark A. Smith, 2006, Molecular Neurodegeneration.

Prion Protein Protects against Renal Ischemia/Reperfusion Injury

Xiongwei Zhu, R. Petersen, J. Sedor, 2015, PloS one.

Cerebrovascular muscle atrophy is a feature of Alzheimer's disease

Mark A. Smith, R. Friedland, S. Siedlak, 1998, Brain Research.

Widespread distribution of reticulon‐3 in various neurodegenerative diseases

Hyoung-Gon Lee, Xiongwei Zhu, R. Castellani, 2010, Neuropathology : official journal of the Japanese Society of Neuropathology.

Oxidative Stress Signaling in Blast TBI-Induced Tau Phosphorylation

Wenzhang Wang, Xiongwei Zhu, E. Peskind, 2021, Antioxidants.

ROLE OF VASCULAR SMOOTH MUSCLE CELLS IN AMYLOID DEPOSITION IN CEREBRAL AMYLOID ANGIOPATHY: 211

P. Cras, B. Greenberg, D. Lowery, 1990 .

Oxidative damage is present in the fatal brain edema of diabetic ketoacidosis

R. Castellani, Mark A. Smith, S. Siedlak, 2011, Brain Research.

Mfn2 protects dopaminergic neurons exposed to paraquat both in vitro and in vivo: Implications for idiopathic Parkinson's disease.

Wenzhang Wang, Xiongwei Zhu, B. Tang, 2017, Biochimica et biophysica acta. Molecular basis of disease.

Increased neuronal glucose-6-phosphate dehydrogenase and sulfhydryl levels indicate reductive compensation to oxidative stress in Alzheimer disease.

R. L. Russell, A. Raina, S. Siedlak, 1999, Archives of biochemistry and biophysics.

The pathology of Alzheimer disease elicits an in vivo immunological response

Mark A. Smith, R. Friedland, S. Siedlak, 2007 .

Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease

G. Casadesus, Mark A. Smith, C. Atwood, 2009, Free radical research.

VPS35 D620N knockin mice recapitulate cardinal features of Parkinson’s disease

Wenzhang Wang, Xiongwei Zhu, S. Siedlak, 2021, Aging cell.

Redox active iron at the center of oxidative stress in Alzheimer disease

Xiongwei Zhu, Mark A. Smith, P. Moreira, 2005 .