T. Shafer

发表

Putative adverse outcome pathways relevant to neurotoxicity

K. Crofton, A. Rolaki, C. Suñol, 2015, Critical reviews in toxicology.

Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity.

Windy A. Boyd, E. S. Hunter, K. Jarema, 2015, Neurotoxicology and teratology.

Evaluation of Chemical Effects on Network Formation in Cortical Neurons Grown on Microelectrode Arrays.

Jasmine P Brown, Kathleen A. Wallace, T. Shafer, 2019, Toxicological sciences : an official journal of the Society of Toxicology.

Characterization of Early Cortical Neural Network Development in Multiwell Microelectrode Array Plates

Stephen J. Eglen, William R. Mundy, Ellese Cotterill, 2016, Journal of biomolecular screening.

Development of Micro-Electrode Array Based Tests for Neurotoxicity: Assessment of Interlaboratory Reproducibility with Neuroactive Chemicals

M. Chiappalone, S. Martinoia, F. Benfenati, 2011, Front. Neuroeng..

Integration of toxicodynamic and toxicokinetic new approach methods into a weight-of-evidence analysis for pesticide developmental neurotoxicity assessment: A case-study with DL- and L-glufosinate.

B. Wetmore, Kathleen A. Wallace, Anna Kreutz, 2022, Regulatory toxicology and pharmacology : RTP.

Concentration–response evaluation of ToxCast compounds for multivariate activity patterns of neural network function

Skylar W. Marvel, David M. Reif, A. Richard, 2019, Archives of Toxicology.

Application of Microelectrode Array Approaches to Neurotoxicity Testing and Screening.

T. Shafer, 2019, Advances in neurobiology.

A multi‐laboratory evaluation of microelectrode array‐based measurements of neural network activity for acute neurotoxicity testing

Sergio Martinoia, Michela Chiappalone, Antonio Novellino, 2017, Neurotoxicology.

Screening the ToxCast phase II libraries for alterations in network function using cortical neurons grown on multi-well microelectrode array (mwMEA) plates

Ann M Richard, Timothy J Shafer, Keith A Houck, 2017, Archives of Toxicology.

In vitro screening of silver nanoparticles and ionic silver using neural networks yields differential effects on spontaneous activity and pharmacological responses.

William R Lefew, K. Dreher, J. Crooks, 2016, Toxicology.

Editor's Highlight: Evaluation of a Microelectrode Array-Based Assay for Neural Network Ontogeny Using Training Set Chemicals.

Kathleen Wallace, Timothy J Shafer, William R Mundy, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

A multiplexed assay for determination of neurotoxicant effects on spontaneous network activity and viability from microelectrode arrays.

Kathleen Wallace, Timothy J Shafer, William R Mundy, 2015, Neurotoxicology.

Burst and principal components analyses of MEA data for 16 chemicals describe at least three effects classes.

Andrew F M Johnstone, Timothy J Shafer, Lyle D Burgoon, 2014, Neurotoxicology.

Multi-well microelectrode array recordings detect neuroactivity of ToxCast compounds.

Timothy J Shafer, Keith A Houck, William R Lefew, 2014, Neurotoxicology.

Screening with High-Throughput Microelectrode Arrays axion BioSystems

William R Lefew, M. McClain, T. Shafer, 2013 .

Evaluation of multi-well microelectrode arrays for neurotoxicity screening using a chemical training set.

Timothy J Shafer, Emma R McConnell, William R Lefew, 2012, Neurotoxicology.

Pyrethroid modulation of spontaneous neuronal excitability and neurotransmission in hippocampal neurons in culture.

Andrew F M Johnstone, Timothy J Shafer, D. A. Meyer, 2008, Neurotoxicology.

Expanding the test set: Chemicals with potential to disrupt mammalian brain development.

Timothy J Shafer, Kevin M Crofton, William R Mundy, 2015, Neurotoxicology and teratology.

Toward a Better Testing Paradigm for Developmental Neurotoxicity: OECD Efforts and Regulatory Considerations

A. Terron, M. Sachana, T. Shafer, 2021, Biology.

Testing for developmental neurotoxicity using a battery of in vitro assays for key cellular events in neurodevelopment☆

Kathleen A. Wallace, J. Harrill, W. Mundy, 2018, Toxicology and applied pharmacology.

Neural progenitor cells as models for high-throughput screens of developmental neurotoxicity: state of the science.

D. D. de Groot, E. Fritsche, T. Shafer, 2010, Neurotoxicology and teratology.

Volatile organic compounds inhibit human and rat neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes.

P. Bushnell, V. Benignus, T. Shafer, 2005, Toxicology and applied pharmacology.

Developmentally-regulated sodium channel subunits are differentially sensitive to alpha-cyano containing pyrethroids.

P. Brodfuehrer, T. Shafer, C. A. Meacham, 2008, Toxicology and applied pharmacology.

Concentration-dependent accumulation of [3H]-deltamethrin in sodium channel Nav1.2/beta1 expressing Xenopus laevis oocytes.

K. Crofton, T. Shafer, C. A. Meacham, 2007, Toxicology in Vitro.

Acute in vitro effects on embryonic rat dorsal root ganglion (DRG) cultures by in silico predicted neurotoxic chemicals: Evaluations on cytotoxicity, neurite length, and neurophysiology.

A. Johnstone, R. LoPachin, T. Shafer, 2020, Toxicology in vitro : an international journal published in association with BIBRA.

Aluminum-Induced Alteration of Phosphoinositide and Calcium Signaling

W. Mundy, T. Shafer, 2001 .

The Next Generation Blueprint of Computational Toxicology at the U.S. Environmental Protection Agency.

Ann M Richard, Imran Shah, Thomas B Knudsen, 2019, Toxicological sciences : an official journal of the Society of Toxicology.

Glufosinate binds N-methyl-D-aspartate receptors and increases neuronal network activity in vitro.

J. Casida, Kathleen A. Wallace, T. Shafer, 2014, Neurotoxicology.

Use of alternative assays to identify and prioritize potential developmental and neurotoxicity of emerging organophosphorous flame retardants

Windy A. Boyd, E. S. Hunter, K. Jarema, 2015 .

Mechanisms of Pyrethroid Insecticide-Induced Stimulation of Calcium Influx in Neocortical Neurons

T. F. Murray, T. Shafer, Zhengyu Cao, 2011, Journal of Pharmacology and Experimental Therapeutics.

Methylmercury effects on ion channels and electrical activity in neurons: future directions.

T. Shafer, 2000, Cellular and molecular biology.

Extrapolating Dosein Vitroto Dosein Vivoof a Neurotoxic Pyrethroid Pesticide Using Empirical Approaches and a PBPK Model

M. DeVito, J. Starr, T. Shafer, 2012 .

Effects of the chlorotriazine herbicide, cyanazine, on GABA(A) receptors in cortical tissue from rat brain.

T. Ward, R. Cooper, T. Shafer, 1999, Toxicology.

Microelectrode arrays: a physiologically based neurotoxicity testing platform for the 21st century.

Andrew F M Johnstone, Guenter W Gross, Dieter G Weiss, 2010, Neurotoxicology.

Effects of an environmentally‐relevant mixture of pyrethroid insecticides on spontaneous activity in primary cortical networks on microelectrode arrays

C. Gennings, A. Johnstone, K. Crofton, 2017, Neurotoxicology.

Assaying Spontaneous Network Activity and Cellular Viability Using Multi-well Microelectrode Arrays.

Jasmine P Brown, T. Shafer, Brittany S Lynch, 2017, Methods in molecular biology.

Acute toluene exposure alters expression of genes in the central nervous system associated with synaptic structure and function.

P. Bushnell, S. Hester, A. Johnstone, 2011, Neurotoxicology and teratology.

Polychlorinated biphenyl-stimulation of Ca(2+) oscillations in developing neocortical cells: a role for excitatory transmitters and L-type voltage-sensitive Ca(2+) channels.

T. Shafer, J. R. Inglefield, 2000, The Journal of pharmacology and experimental therapeutics.

Electrophysiological Methods for Analysis of Effects of Neurotoxicants on Synaptic Transmission

T. Shafer, W. Atchison, 1995 .

Transmitter, ion channel and receptor properties of pheochromocytoma (PC12) cells: a model for neurotoxicological studies.

T. Shafer, W. Atchison, 1991, Neurotoxicology.

Current status and future directions for a neurotoxicity hazard assessment framework that integrates in silico approaches.

Daniel M. Wilson, G. Myatt, M. Pavan, 2022, Computational toxicology.

Assessment of chemical effects on neurite outgrowth in PC12 cells using high content screening.

Timothy J Shafer, William R Mundy, Nicholas M. Radio, 2008, Toxicological sciences : an official journal of the Society of Toxicology.

Extracellular calcium is required for the polychlorinated biphenyl-induced increase of intracellular free calcium levels in cerebellar granule cell culture.

H. Tilson, W. Mundy, T. Shafer, 1999, Toxicology.

Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity.

Mardas Daneshian, Tanja Waldmann, Marcel Leist, 2018, ALTEX.

Developmental Neurotoxicity of Pyrethroid Insecticides: Critical Review and Future Research Needs

Kevin M. Crofton, Timothy J. Shafer, D. A. Meyer, 2004, Environmental health perspectives.

Effects of gestational methylmercury exposure on immunoreactivity of specific isoforms of PKC and enzyme activity during post-natal development of the rat brain.

S. Barone, W. Mundy, T. Shafer, 1998, Brain research. Developmental brain research.

Effects of Cd2+, Pb2+ and CH3Hg+ on high voltage-activated calcium currents in pheochromocytoma (PC12) cells: potency, reversibility, interactions with extracellular Ca2+ and mechanisms of block.

T. Shafer, 1998, Toxicology letters.

Mechanisms underlying AlCl3 inhibition of agonist-stimulated inositol phosphate accumulation. Role of calcium, G-proteins, phospholipase C and protein kinase C.

H. Tilson, W. Mundy, T. Shafer, 1994, Biochemical pharmacology.

Aluminum decreases muscarinic, adrenergic, and metabotropic receptor-stimulated phosphoinositide hydrolysis in hippocampal and cortical slices from rat brain

H. Tilson, W. Mundy, T. Shafer, 1993, Brain Research.

Development of a high-throughput screening assay for chemical effects on proliferation and viability of immortalized human neural progenitor cells.

Timothy J Shafer, William R Mundy, Nicholas M. Radio, 2008, Toxicological sciences : an official journal of the Society of Toxicology.

Comparison of Acute Effects of Neurotoxic Compounds on Network Activity in Human and Rodent Neural Cultures.

Marius Wernig, Kathleen A. Wallace, M. Mall, 2021, Toxicological sciences : an official journal of the Society of Toxicology.

Mammalian cell culture models

T. Shafer, T. Freudenrich, 2020 .

Inositol 1,4,5-triphosphate receptor-sensitive Ca(2+) release, store-operated Ca(2+) entry, and cAMP responsive element binding protein phosphorylation in developing cortical cells following exposure to polychlorinated biphenyls.

W. Mundy, T. Shafer, J. R. Inglefield, 2001, The Journal of pharmacology and experimental therapeutics.

Neurotoxicological outcomes of perinatal heptachlor exposure in the rat.

T. Ward, V. Moser, R. Chapin, 2001, Toxicological sciences : an official journal of the Society of Toxicology.

Complete inhibition of spontaneous activity in neuronal networks in vitro by deltamethrin and permethrin.

G. Gross, T. Shafer, S. O. Rijal, 2008, Neurotoxicology.

Additivity of Pyrethroid Actions on Sodium Influx in Cerebrocortical Neurons in Primary Culture

C. Gennings, K. Crofton, T. F. Murray, 2011, Environmental health perspectives.

Effects of pyrethroids on voltage-sensitive calcium channels: a critical evaluation of strengths, weaknesses, data needs, and relationship to assessment of cumulative neurotoxicity.

Timothy J Shafer, D. A. Meyer, T. Shafer, 2004, Toxicology and applied pharmacology.

Permethrin, but not deltamethrin, increases spontaneous glutamate release from hippocampal neurons in culture.

D. A. Meyer, T. Shafer, 2006, Neurotoxicology.

Toluene inhibits voltage-sensitive calcium channels expressed in pheochromocytoma cells

J. Woodward, T. Shafer, Riddick Tillar, 2002, Neurochemistry International.

Time and concentration dependent accumulation of [3H]-deltamethrin in Xenopus laevis oocytes.

K. Crofton, J. Harrill, T. Shafer, 2005, Toxicology letters.

Accumulation of pyrethroid compounds in primary cultures from rat cortex.

T. Shafer, M. Hughes, 2010, Toxicology in vitro : an international journal published in association with BIBRA.

Accumulation of methylmercury or polychlorinated biphenyls in in vitro models of rat neuronal tissue.

M. Gilbert, S. Barone, W. Mundy, 2005, Toxicology and applied pharmacology.

Perturbation by the PCB mixture aroclor 1254 of GABA(A) receptor-mediated calcium and chloride responses during maturation in vitro of rat neocortical cells.

T. Shafer, J. R. Inglefield, 2000, Toxicology and applied pharmacology.

Improving in vitro to in vivo extrapolation by incorporating toxicokinetic measurements: a case study of lindane-induced neurotoxicity.

William R. Mundy, Marina V. Evans, Timothy J. Shafer, 2015, Toxicology and applied pharmacology.

In vitro exposure to aluminum does not alter long-term potentiation or glutamate release in rat hippocampal slices.

M. Gilbert, T. Shafer, 1996, Neurotoxicology and teratology.

Perturbation of Voltage-Sensitive Ca2+ Channel Function by Volatile Organic Solvents

P. Bushnell, V. Benignus, J. Woodward, 2005, Journal of Pharmacology and Experimental Therapeutics.

Approaches to extrapolating animal toxicity data on organic solvents to public health.

P. Bushnell, V. Benignus, W. Boyes, 2007, Neurotoxicology.

Developing an exposure-dose-response model for the acute neurotoxicity of organic solvents: overview and progress on in vitro models and dosimetry.

P. Bushnell, J. E. Simmons, Trachette L. Jackson, 2005, Environmental toxicology and pharmacology.

Evaluating the NMDA-glutamate receptor as a site of action for toluene, in vivo.

P. Bushnell, V. Benignus, W. Boyes, 2007, Toxicological sciences : an official journal of the Society of Toxicology.

International Regulatory and Scientific Effort for Improved Developmental Neurotoxicity Testing

Magdalini Sachana, Andrea Terron, Susanne H Bennekou, 2018, Toxicological sciences : an official journal of the Society of Toxicology.

Can the mechanisms of aluminum neurotoxicity be integrated into a unified scheme?

R. Garruto, W. Mundy, T. Shafer, 1996, Journal of toxicology and environmental health.

Effects of methylmercury on perineurial Na+ and Ca2+-dependent potentials at neuromuscular junctions of the mouse

T. Shafer, W. Atchison, 1992, Brain Research.

Effects of aluminum on neuronal signal transduction: mechanisms underlying disruption of phosphoinositide hydrolysis.

W. Mundy, T. Shafer, 1995, General pharmacology.

Evaluation of microelectrode array data using Bayesian modeling as an approach to screening and prioritization for neurotoxicity testing.

Timothy J Shafer, Emma R McConnell, William R Lefew, 2013, Neurotoxicology.

Comparison of chemical-induced changes in proliferation and apoptosis in human and mouse neuroprogenitor cells.

Timothy J Shafer, Joshua A Harrill, William R Mundy, 2012, Neurotoxicology.

Developmental neurotoxicity testing: A path forward

Timothy J Shafer, Kevin M Crofton, William R Mundy, 2012, Congenital anomalies.

In Vitro Assessment of Developmental Neurotoxicity: Use of Microelectrode Arrays to Measure Functional Changes in Neuronal Network Ontogeny1

Joshua A. Harrill, William R. Mundy, Timothy J. Shafer, 2010, Front. Neuroeng..

Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicity.

Magdalini Sachana, Anna Bal-Price, Ellen Fritsche, 2017, Neurotoxicology.

Evaluation of Per- and Polyfluoroalkyl Substances (PFAS) In Vitro Toxicity Testing for Developmental Neurotoxicity.

G. Patlewicz, A. Richard, B. Wetmore, 2023, Chemical research in toxicology.

Concentration–response evaluation of ToxCast compounds for multivariate activity patterns of neural network function

Skylar W. Marvel, A. Richard, D. Reif, 2019, Archives of Toxicology.

Defining toxicological tipping points in neuronal network development☆

Imran Shah, Kathleen Wallace, Timothy J Shafer, 2018, Toxicology and applied pharmacology.

From the Cover: Developmental Neurotoxicants Disrupt Activity in Cortical Networks on Microelectrode Arrays Results of Screening 86 Compounds During Neural Network Formation

Kathleen Wallace, Timothy J Shafer, William R Mundy, 2017, Toxicological sciences : an official journal of the Society of Toxicology.

Sensitivity of neuroprogenitor cells to chemical-induced apoptosis using a multiplexed assay suitable for high-throughput screening.

Kathleen Wallace, Timothy J Shafer, Ingrid Druwe, 2015, Toxicology.

Differential effects of polychlorinated biphenyl congeners on phosphoinositide hydrolysis and protein kinase C translocation in rat cerebellar granule cells

H. Tilson, T. Ward, W. Mundy, 1994, Brain Research.

Channelopathies: summary of the hot topic keynotes session.

Isaac Pessah, T. Shafer, J. Magby, 2011, Neurotoxicology.

Repeated exposure of adult rats to Aroclor 1254 causes brain region-specific changes in intracellular Ca2+ buffering and protein kinase C activity in the absence of changes in tyrosine hydroxylase.

H. Tilson, S. Barone, W. Mundy, 1998, Toxicology and applied pharmacology.

Ontogeny of voltage-sensitive calcium channel α1A and α1E subunit expression and synaptic function in rat central nervous system

S. Barone, T. Shafer, C. A. Meacham, 2003 .

Methylmercury blocks N- and L-type Ca++ channels in nerve growth factor-differentiated pheochromocytoma (PC12) cells.

T. Shafer, W. Atchison, 1991, The Journal of pharmacology and experimental therapeutics.

Characterization of interactions of methylmercury with Ca2+ channels in synaptosomes and pheochromocytoma cells: radiotracer flux and binding studies.

M. Contreras, T. Shafer, W. Atchison, 1990, Molecular pharmacology.

Block of 45Ca uptake into synaptosomes by methylmercury: Ca++- and Na+-dependence.

T. Shafer, W. Atchison, 1989, The Journal of pharmacology and experimental therapeutics.

In vitro screening of metal oxide nanoparticles for effects on neural function using cortical networks on microelectrode arrays

William R Lefew, K. Dreher, J. Crooks, 2016, Nanotoxicology.

A multivariate extension of mutual information for growing neural networks

Christopher Grant, William R. Mundy, Kenneth Ball, 2017, Neural Networks.

Role of NMDA, nicotinic, and GABA receptors in the steady-state visual-evoked potential in rats

P. Bushnell, W. Boyes, T. Shafer, 2005, Pharmacology Biochemistry and Behavior.

Pervasive environmental chemicals impair oligodendrocyte development

P. Tesar, T. Shafer, M. Madhavan, 2023, bioRxiv.

Effects of prolonged exposure to nanomolar concentrations of methylmercury on voltage-sensitive sodium and calcium currents in PC12 cells.

S. Barone, T. Shafer, C. A. Meacham, 2002, Brain research. Developmental brain research.

Acute toluene exposure and rat visual function in proportion to momentary brain concentration.

P. Bushnell, V. Benignus, W. Boyes, 2007, Toxicological sciences : an official journal of the Society of Toxicology.

Mechanisms of Pyrethroid Insecticide-Induced Stimulation of Calcium Influx in Neocortical Neurons

T. F. Murray, T. Shafer, Zhengyu Cao, 2011, Journal of Pharmacology and Experimental Therapeutics.

In vitro aluminum inhibition of brain phosphoinositide metabolism: comparison of neonatal and adult rats.

W. Mundy, T. Shafer, T. Freudenrich, 1995, Neurotoxicology.

An expert-driven literature review of "negative" chemicals for developmental neurotoxicity (DNT) in vitro assay evaluation.

Nancy C. Baker, M. Gilbert, W. Boyes, 2022, Neurotoxicology and teratology.

Integrating data from in vitro New Approach Methodologies for Developmental Neurotoxicity.

J. Harrill, T. Shafer, K. Paul Friedman, 2022, Toxicological sciences : an official journal of the Society of Toxicology.

Comparison of Human Induced Pluripotent Stem Cell-Derived Neurons and Rat Primary Cortical Neurons as In Vitro Models of Neurite Outgrowth

T. Shafer, T. Freudenrich, DruweIngrid, 2016 .

Use of Neural Models of Proliferation and Neurite Outgrowth to Screen Environmental Chemicals in the ToxCast Phase I Library

R. Judson, K. Houck, Matt T. Martin, 2015 .

Multi-well microelectrode array recordings detect neuroactivity of ToxCast compounds.

William R Lefew, K. Houck, Matt T. Martin, 2014, Neurotoxicology.

Identification of neurotoxicology (NT)/developmental neurotoxicology (DNT) adverse outcome pathways and key event linkages with in vitro DNT screening assays.

T. Shafer, Emily M. Pitzer, David W. Herr, 2023, Neurotoxicology.

Inhibition of rat brain phosphatidylinositol-specific phospholipase C by aluminum: regional differences, interactions with aluminum salts, and mechanisms.

S. Padilla, W. Mundy, T. Shafer, 1996, Toxicology and applied pharmacology.