A. Punt

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Potential of ToxCast Data in the Safety Assessment of Food Chemicals

A. Boobis, M. Cronin, J. P. Gosling, 2020, Toxicological sciences : an official journal of the Society of Toxicology.

Quantitative in vitro-to-in vivo extrapolation (QIVIVE) of estrogenic and anti-androgenic potencies of BPA and BADGE analogues

A. Peijnenburg, A. Gerssen, R. Hoogenboom, 2019, Archives of Toxicology.

Non-animal approaches for toxicokinetics in risk evaluations of food chemicals.

Ans Punt, Hans Bouwmeester, H. Bouwmeester, 2017, ALTEX.

Gene expression profiling in Caco-2 human colon cells exposed to TCDD, benzo[a]pyrene, and natural Ah receptor agonists from cruciferous vegetables and citrus fruits.

F. V. van Schooten, T. D. de Kok, A. Peijnenburg, 2008, Toxicology in vitro : an international journal published in association with BIBRA.

Impact of nanoparticle surface functionalization on the protein corona and cellular adhesion, uptake and transport

H. Bouwmeester, I. Rietjens, M. van der Zande, 2018, Journal of Nanobiotechnology.

Expert opinions on the acceptance of alternative methods in food safety evaluations: Formulating recommendations to increase acceptance of non‐animal methods for kinetics

H. Bouwmeester, A. Peijnenburg, A. Punt, 2018, Regulatory toxicology and pharmacology : RTP.

Evaluation of Interindividual Human Variation in Bioactivation and DNA Adduct Formation of Estragole in Liver Predicted by Physiologically Based Kinetic/Dynamic and Monte Carlo Modeling.

Alicia Paini, Benoit Schilter, Ans Punt, 2016, Chemical research in toxicology.

Defining in vivo dose‐response curves for kidney DNA adduct formation of aristolochic acid I in rat, mouse and human by an in vitro and physiologically based kinetic modeling approach

I. Rietjens, J. Louisse, A. Punt, 2020, Journal of applied toxicology : JAT.

Evaluation of the interindividual human variation in bioactivation of methyleugenol using physiologically based kinetic modeling and Monte Carlo simulations.

P. van Bladeren, I. Rietjens, A. Punt, 2015, Toxicology and applied pharmacology.

In vitro‐in silico‐based analysis of the dose‐dependent in vivo oestrogenicity of the soy phytoestrogen genistein in humans

I. Rietjens, A. Punt, A. Spenkelink, 2017, British journal of pharmacology.

Physiologically based kinetic modeling of bioactivation and detoxification of the alkenylbenzene methyleugenol in human as compared with rat.

P. van Bladeren, I. Rietjens, A. Punt, 2012, Toxicology and applied pharmacology.

Matrix modulation of the bioactivation of estragole by constituents of different alkenylbenzene-containing herbs and spices and physiologically based biokinetic modeling of possible in vivo effects.

P. van Bladeren, I. Rietjens, B. Schilter, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

A physiologically based kinetic (PBK) model describing plasma concentrations of quercetin and its metabolites in rats.

I. Rietjens, A. Punt, A. Spenkelink, 2014, Biochemical pharmacology.

Identification of nevadensin as an important herb-based constituent inhibiting estragole bioactivation and physiology-based biokinetic modeling of its possible in vivo effect.

P. van Bladeren, J. Vervoort, I. Rietjens, 2010, Toxicology and applied pharmacology.

Use of physiologically based kinetic (PBK) modeling to study interindividual human variation and species differences in plasma concentrations of quercetin and its metabolites.

I. Rietjens, A. Punt, A. Spenkelink, 2015, Biochemical pharmacology.

In vitro-in silico based analysis of the dose-dependent in vivo estrogenicity of the soy phytoestrogen genistein in humans Running Title : In vitro-in silico for genistein estrogenicity

I. Rietjens, A. Punt, A. Spenkelink, 2017 .

Conversion of major soy isoflavone glucosides and aglycones in in vitro intestinal models.

A. Murk, I. Rietjens, A. Punt, 2014, Molecular nutrition & food research.

Matrix-derived combination effects influencing absorption, distribution, metabolism and excretion (ADME) of food-borne toxic compounds: implications for risk assessment

I. Rietjens, B. Tyrakowska, A. Punt, 2015 .

Predictive Performance of Next Generation Human Physiologically Based Kinetic (PBK) Models Based on In Vitro and In Silico Input Data

E. Fabian, P. Carmichael, T. Moxon, 2022 .

In vivo validation and physiologically based biokinetic modeling of the inhibition of SULT-mediated estragole DNA adduct formation in the liver of male Sprague-Dawley rats by the basil flavonoid nevadensin.

P. van Bladeren, I. Rietjens, B. Schilter, 2013, Molecular nutrition & food research.

Towards best use and regulatory acceptance of generic physiologically based kinetic (PBK) models for in vitro-to-in vivo extrapolation (IVIVE) in chemical risk assessment

A. Piersma, T. Gant, J. Wambaugh, 2022, Archives of Toxicology.

Predicting points of departure for risk assessment based on in vitro cytotoxicity data and physiologically based kinetic (PBK) modeling: The case of kidney toxicity induced by aristolochic acid I.

I. Rietjens, A. Punt, Rozaini Abdullah, 2016, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Combining in vitro embryotoxicity data with physiologically based kinetic (PBK) modelling to define in vivo dose–response curves for developmental toxicity of phenol in rat and human

R. Woutersen, I. Rietjens, A. Punt, 2013, Archives of Toxicology.

A physiologically based in silico model for trans-2-hexenal detoxification and DNA adduct formation in rat.

I. Rietjens, A. Punt, R. Kiwamoto, 2012, Chemical research in toxicology.

A physiologically based in silico model for trans-2-hexenal detoxification and DNA adduct formation in human including interindividual variation indicates efficient detoxification and a negligible genotoxicity risk

I. Rietjens, A. Punt, A. Spenkelink, 2013, Archives of Toxicology.

Relative embryotoxic potency of p-substituted phenols in the embryonic stem cell test (EST) and comparison to their toxic potency in vivo and in the whole embryo culture (WEC) assay.

R. Woutersen, I. Rietjens, A. Punt, 2012, Toxicology letters.

Malabaricone C-containing mace extract inhibits safrole bioactivation and DNA adduct formation both in vitro and in vivo.

Alicia Paini, Ans Punt, Ivonne M C M Rietjens, 2014, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Physiologically based biokinetic (PBBK) modeling of safrole bioactivation and detoxification in humans as compared with rats.

Ans Punt, Ivonne M C M Rietjens, P. van Bladeren, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Differences in simulated liver concentrations of toxic coumarin metabolites in rats and different human populations evaluated through physiologically based biokinetic (PBBK) modeling.

Ans Punt, Ivonne M C M Rietjens, I. Rietjens, 2008, Toxicology in vitro : an international journal published in association with BIBRA.

Inhibition of methyleugenol bioactivation by the herb-based constituent nevadensin and prediction of possible in vivo consequences using physiologically based kinetic modeling.

P. van Bladeren, J. Vervoort, I. Rietjens, 2013, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Physiologically based kinetic models for the alkenylbenzene elemicin in rat and human and possible implications for risk assessment.

J. Vervoort, I. Rietjens, A. Punt, 2012, Chemical research in toxicology.

Human cytochrome p450 enzyme specificity for the bioactivation of estragole and related alkenylbenzenes.

P. van Bladeren, N. Cnubben, I. Rietjens, 2007, Chemical research in toxicology.

Basil extract inhibits the sulfotransferase mediated formation of DNA adducts of the procarcinogen 1'-hydroxyestragole by rat and human liver S9 homogenates and in HepG2 human hepatoma cells.

Ans Punt, Ivonne M C M Rietjens, Thierry Delatour, 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Development of a Combined In Vitro Physiologically Based Kinetic (PBK) and Monte Carlo Modelling Approach to Predict Interindividual Human Variation in Phenol-Induced Developmental Toxicity

R. Woutersen, I. Rietjens, A. Punt, 2017, Toxicological sciences : an official journal of the Society of Toxicology.

Effect of combining in vitro estrogenicity data with kinetic characteristics of estrogenic compounds on the in vivo predictive value.

Annemarie P van Wezel, Merijn Schriks, Ans Punt, 2013, Toxicology in vitro : an international journal published in association with BIBRA.

In vivo validation of DNA adduct formation by estragole in rats predicted by physiologically based biodynamic modelling.

Alicia Paini, Benoît Schilter, Eric Gremaud, 2012, Mutagenesis.

Physiologically based biokinetic model of bioactivation and detoxification of the alkenylbenzene methyleugenol in rat.

Ans Punt, Ivonne M C M Rietjens, Jacques Vervoort, 2011, Toxicology in vitro : an international journal published in association with BIBRA.

Use of Physiologically Based Biokinetic (PBBK) Modeling to Study Estragole Bioactivation and Detoxification in Humans as Compared with Male Rats

Andreas P. Freidig, Alicia Paini, Benoît Schilter, 2009, Toxicological sciences : an official journal of the Society of Toxicology.

A physiologically based biokinetic (PBBK) model for estragole bioactivation and detoxification in rat.

Benoît Schilter, Ans Punt, Ivonne M C M Rietjens, 2008, Toxicology and applied pharmacology.

Physiologically based kinetic modeling of hesperidin metabolism and its use to predict in vivo effective doses in humans.

Ans Punt, Ivonne M C M Rietjens, I. Rietjens, 2017, Molecular nutrition & food research.

Combining in vitro embryotoxicity data with physiologically based kinetic (PBK) modelling to define in vivo dose–response curves for developmental toxicity of phenol in rat and human

R. Woutersen, I. Rietjens, A. Punt, 2013, Archives of Toxicology.

Development of a Web-Based Toolbox to Support Quantitative In-Vitro-to-In-Vivo Extrapolations (QIVIVE) within Nonanimal Testing Strategies

A. Peijnenburg, J. Louisse, A. Punt, 2020, Chemical research in toxicology.

Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2.

Mustafa Usta, Ans Punt, Ivonne M C M Rietjens, 2005, Biochemical pharmacology.

EURL ECVAM WORKSHOP ON NEW GENERATION OF PHYSIOLOGICALLY-BASED KINETIC MODELS IN RISK ASSESSMENT

George Loizou, Judith C. Madden, Eann A. Patterson, 2017 .

A physiologically based biodynamic (PBBD) model for estragole DNA binding in rat liver based on in vitro kinetic data and estragole DNA adduct formation in primary hepatocytes.

Alicia Paini, Maricel Marin-Kuan, Benoît Schilter, 2010, Toxicology and applied pharmacology.

Toxicokinetics in Risk Evaluations

Ans Punt, A. Punt, 2018, Chemical research in toxicology.

New approach methodologies (NAMs) for human-relevant biokinetics predictions: Meeting the paradigm shift in toxicology towards an animal-free chemical risk assessment.

Bas J Blaauboer, Alicia Paini, Paul Jennings, 2020, ALTEX.

Integrating in vitro data and physiologically based kinetic (PBK) modelling to assess the in vivo potential developmental toxicity of a series of phenols

Ans Punt, Ivonne M C M Rietjens, Ruud A Woutersen, 2016, Archives of Toxicology.

The use of physiologically based kinetic (PBK) models in the risk assessment of plant genotoxins

I. Rietjens, A. Punt, 2017 .

Towards harmonization of test methods for in vitro hepatic clearance studies.

Sandra Coecke, Ans Punt, Jochem Louisse, 2019, Toxicology in vitro : an international journal published in association with BIBRA.

Tutorial on physiologically based kinetic modeling in molecular nutrition and food research.

Ans Punt, Ivonne M C M Rietjens, Jochem Louisse, 2011, Molecular nutrition & food research.

A Computational Inter-Species Study on Safrole Phase I Metabolism-Dependent Bioactivation: A Mechanistic Insight into the Study of Possible Differences among Species

J. Dorne, C. Dall’Asta, Luca Dellafiora, 2023, Toxins.

Impact of in vitro experimental variation in kinetic parameters on physiologically based kinetic (PBK) model simulations.

J. Louisse, A. Punt, B. Hakkert, 2022, ALTEX.

Predictive performance of next generation human physiologically based kinetic (PBK) model predictions based on in vitro and in silico input data_suppl2

A. Punt, 2022, ALTEX.

Evaluation of human interindividual variation in bioactivation of estragole using physiologically based biokinetic modeling.

Benoît Schilter, Ans Punt, Gabriele Scholz, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

Next generation physiologically based kinetic (NG-PBK) models in support of regulatory decision making

A Worth, N Suciu, J C Madden, 2019, Computational toxicology.

Evaluation of research activities and research needs to increase the impact and applicability of alternative testing strategies in risk assessment practice.

Bas J Blaauboer, Ans Punt, Marie-Jeanne W A Schiffelers, 2011, Regulatory toxicology and pharmacology : RTP.

Exploring the Potential of ToxCast Data in Supporting Read-Across for Evaluation of Food Chemical Safety.

A. Boobis, M. Cronin, A. Thiel, 2020, Chemical research in toxicology.

Quantitative in vitro-to-in vivo extrapolation (QIVIVE) of estrogenic and anti-androgenic potencies of BPA and BADGE analogues

A. Peijnenburg, A. Gerssen, R. Hoogenboom, 2019, Archives of Toxicology.

A congener-specific modelling approach for the transfer of polychlorinated dibenzo-p-dioxins and dibenzofurans and dioxin-like polychlorinated biphenyls from feed to eggs of laying hens

B. Bokkers, M. Zeilmaker, R. Hoogenboom, 2022, Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.

In silico methods for physiologically based biokinetic models describing bioactivation and detoxification of coumarin and estragole: implications for risk assessment.

Benoît Schilter, Ans Punt, Gabriele Scholz, 2010, Molecular nutrition & food research.

Predictive Performance of Next Generation Physiologically Based Kinetic (PBK) Model Predictions in Rats Based on In Vitro and In Silico Input Data

E. Fabian, B. van Ravenzwaay, J. Louisse, 2021, Toxicological sciences : an official journal of the Society of Toxicology.

Predictive performance of next generation human physiologically based kinetic (PBK) model predictions based on in vitro and in silico input data_suppl1

A. Punt, 2022, ALTEX.

Perfluoroalkyl substances (PFASs) are substrates of the renal human organic anion transporter 4 (OAT4)

J. Dorne, F. Russel, J. B. Koenderink, 2022, Archives of Toxicology.

Tandem mass spectrometry analysis of N2-(trans-Isoestragol-3'-yl)-2'-deoxyguanosine as a strategy to study species differences in sulfotransferase conversion of the proximate carcinogen 1'-hydroxyestragole.

Benoît Schilter, Ans Punt, Ivonne M C M Rietjens, 2007, Chemical research in toxicology.

Data Analyses and Modelling for Risk Based Monitoring of Mycotoxins in Animal Feed

H. J. van der Fels-Klerx, E. V. van Asselt, A. Punt, 2018, Toxins.

Fipronil and fipronil sulfone in chicken: From in vitro experiments to in vivo PBK model predictions.

R. Hoogenboom, G. Stoopen, A. Punt, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Dose-dependent DNA adduct formation by cinnamaldehyde and other food-borne α,β-unsaturated aldehydes predicted by physiologically based in silico modelling.

A. Punt, I. Rietjens, A. Punt, 2016, Toxicology in vitro : an international journal published in association with BIBRA.

An integrated QSAR-PBK/D modelling approach for predicting detoxification and DNA adduct formation of 18 acyclic food-borne α,β-unsaturated aldehydes.

A. Punt, I. Rietjens, A. Punt, 2015, Toxicology and applied pharmacology.