T. Waldmann

发表

Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests

J. Rahnenführer, J. Hengstler, M. Leist, 2016, Archives of Toxicology.

Adverse outcome pathways: opportunities, limitations and open questions

S. H. Bennekou, F. Oesch, S. Dooley, 2017, Archives of Toxicology.

Development of a neural rosette formation assay (RoFA) to identify neurodevelopmental toxicants and to characterize their transcriptome disturbances

M. Berthold, J. Rahnenführer, N. Blüthgen, 2019, Archives of Toxicology.

Application of “Omics” Technologies to In Vitro Toxicology

H. Hogberg, M. Leist, Liang Zhao, 2014 .

Impairment of human neural crest cell migration by prolonged exposure to interferon-beta

J. Rahnenführer, M. Leist, A. Sachinidis, 2017, Archives of Toxicology.

Arginine methylation of the B cell antigen receptor promotes differentiation

R. Schneider, M. Reth, M. Jung, 2010, The Journal of experimental medicine.

Kinetic modeling of stem cell transcriptome dynamics to identify regulatory modules of normal and disturbed neuroectodermal differentiation

J. Rahnenführer, N. Blüthgen, J. Hengstler, 2020, Nucleic acids research.

Establishment of an a priori protocol for the implementation and interpretation of an in‐vitro testing battery for the assessment of developmental neurotoxicity

A. Mosig, M. Leist, E. Fritsche, 2020 .

Examination of microcystin neurotoxicity using central and peripheral human neurons.

D. Dietrich, M. Leist, Lisa Hoelting, 2020, ALTEX.

A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors

Nils Blüthgen, Tanja Waldmann, Jan G. Hengstler, 2015, Archives of Toxicology.

Structure-specific binding of the proto-oncogene protein DEK to DNA.

M. Baack, T. Waldmann, N. Richter, 2003, Nucleic acids research.

The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods

Alice Krebs, Barbara M. A. van Vugt-Lussenburg, Tanja Waldmann, 2020, Archives of Toxicology.

Histone Octamer Dissociation Is Not Required for in Vitro Replication of Simian Virus 40 Minichromosomes*

T. Waldmann, C. Gruss, B. Vestner, 2000, The Journal of Biological Chemistry.

The DEK protein--an abundant and ubiquitous constituent of mammalian chromatin.

R. Knippers, I. Scholten, F. Kappes, 2004, Gene.

Functional Domains of the Ubiquitous Chromatin Protein DEK

I. Scholten, F. Kappes, T. Waldmann, 2004, Molecular and Cellular Biology.

High Accuracy Classification of Developmental Toxicants by In Vitro Tests of Human Neuroepithelial and Cardiomyoblast Differentiation

J. Rahnenführer, K. Edlund, N. Blüthgen, 2022, Cells.

Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration

J. Rahnenführer, J. Hengstler, M. Leist, 2015, Archives of Toxicology.

Automated quantification of histone relocation in cell nuclei

O. Deussen, M. Leist, D. Merhof, 2011 .

A human stem cell-derived test system for agents modifying neuronal N-methyl-d-aspartate-type glutamate receptor Ca2+-signalling

M. Leist, J. Schwamborn, T. Waldmann, 2021, Archives of Toxicology.

From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects

Michael R. Berthold, Raivo Kolde, Tanja Waldmann, 2014, Archives of Toxicology.

Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity.

Mardas Daneshian, Tanja Waldmann, Marcel Leist, 2018, ALTEX.

Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration

Tanja Waldmann, Jan G. Hengstler, Giorgia Pallocca, 2015, Archives of Toxicology.

Grouping of histone deacetylase inhibitors and other toxicants disturbing neural crest migration by transcriptional profiling.

Nils Blüthgen, Michael R Berthold, Tanja Waldmann, 2015, Neurotoxicology.

Profiling of drugs and environmental chemicals for functional impairment of neural crest migration in a novel stem cell-based test battery

J. G. Hengstler, S. Bosgra, K. Krause, 2014, Archives of Toxicology.

Methylation of H2AR29 is a novel repressive PRMT6 target

B. Garcia, B. Sarg, H. Lindner, 2011, Epigenetics & Chromatin.

Stage‐specific metabolic features of differentiating neurons: Implications for toxicant sensitivity

Katharina Nöh, Sebastian Niedenführ, Falk Schreiber, 2017, Toxicology and applied pharmacology.

Stem Cell‐Derived Immature Human Dorsal Root Ganglia Neurons to Identify Peripheral Neurotoxicants

Nils Blüthgen, Tanja Waldmann, Marcel Leist, 2016, Stem cells translational medicine.

Rapid, complete and large‐scale generation of post‐mitotic neurons from the human LUHMES cell line

Tanja Waldmann, Marcel Leist, Matthias Weng, 2011, Journal of neurochemistry.

Chromatin dynamics during epigenetic reprogramming in the mouse germ line

M. Surani, Caroline Lee, R. Schneider, 2008, Nature.

Design of a high-throughput human neural crest cell migration assay to indicate potential developmental toxicants.

Tanja Waldmann, Marcel Leist, Christiaan Karreman, 2016, ALTEX.

Extensive Transcriptional Regulation of Chromatin Modifiers during Human Neurodevelopment

Tanja Waldmann, Marc P. Broeg, Marcel Leist, 2012, PloS one.

Markers of murine embryonic and neural stem cells, neurons and astrocytes: reference points for developmental neurotoxicity testing.

Tanja Waldmann, Karl-Heinz Krause, Marcel Leist, 2010, ALTEX.

Lineage-Specific Regulation of Epigenetic Modifier Genes in Human Liver and Brain

J. Hengstler, M. Leist, M. Weng, 2014, PloS one.

Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome.

Tanja Waldmann, Smita Jagtap, Marcel Leist, 2012, Human molecular genetics.

Toxicogenomics directory of chemically exposed human hepatocytes

R. Stierum, G. Myatt, J. Rahnenführer, 2014, Archives of Toxicology.

Design Principles of Concentration-Dependent Transcriptome Deviations in Drug-Exposed Differentiating Stem Cells

Raivo Kolde, Tanja Waldmann, Jan G. Hengstler, 2014, Chemical research in toxicology.

Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach

Hedi Peterson, Daniel Gerhard, Raivo Kolde, 2012, Archives of Toxicology.

The protein encoded by the proto-oncogene DEK changes the topology of chromatin and reduces the efficiency of DNA replication in a chromatin-specific manner.

M. Mann, R. Knippers, T. Waldmann, 2000, Genes & development.

HP1 Binds Specifically to Lys26-methylated Histone H1.4, whereas Simultaneous Ser27 Phosphorylation Blocks HP1 Binding*

Tanja Waldmann, R. Schneider, S. Daujat, 2005, Journal of Biological Chemistry.

A LUHMES 3D dopaminergic neuronal model for neurotoxicity testing allowing long-term exposure and cellular resilience analysis

T. Hartung, L. Smirnova, T. Hartung, 2015, Archives of Toxicology.

The SAF-box domain of chromatin protein DEK

H. Matsuo, R. Knippers, I. Scholten, 2005, Nucleic acids research.

Comparison of a teratogenic transcriptome-based predictive test based on human embryonic versus inducible pluripotent stem cells

Nils Blüthgen, Tanja Waldmann, Marcel Leist, 2016, Stem Cell Research & Therapy.

Major changes of cell function and toxicant sensitivity in cultured cells undergoing mild, quasi-natural genetic drift

P. May, Abhimanyu Krishna, M. Leist, 2018, Archives of Toxicology.

Histone H2A C-Terminus Regulates Chromatin Dynamics, Remodeling, and Histone H1 Binding

K. Rippe, G. Längst, R. Schneider, 2010, PLoS genetics.

Histone H 2 A C-Terminus Regulates Chromatin Dynamics , Remodeling , and Histone H 1 Binding

K. Rippe, G. Längst, R. Schneider, 2010 .

90K, an interferon-stimulated gene product, reduces the infectivity of HIV-1

Tanja Waldmann, Frank Kirchhoff, Jan Münch, 2013, Retrovirology.

Bacterial Growth Inhibition Screen (BGIS) identifies a loss‐of‐function mutant of the DEK oncogene, indicating DNA modulating activities of DEK in chromatin

E. Ferrando-May, B. Lüscher, F. Kappes, 2021, FEBS letters.

Targeting histone modifications--epigenetics in cancer.

R. Schneider, T. Waldmann, 2013, Current opinion in cell biology.

The DEK oncoprotein is a Su(var) that is essential to heterochromatin integrity.

A. Chinnaiyan, Jindan Yu, D. Markovitz, 2011, Genes & development.

The Ubiquitous Chromatin Protein DEK Alters the Structure of DNA by Introducing Positive Supercoils*

C. Eckerich, M. Baack, T. Waldmann, 2002, The Journal of Biological Chemistry.

Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing

W. Koh, M. Leist, B. Tan, 2011, Cell Death and Differentiation.

90K, an interferon-stimulated gene product, reduces the infectivity of HIV-1

F. Kirchhoff, J. Münch, C. Goffinet, 2013, Retrovirology.

Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data.

Barry Hardy, Francois Busquet, Alice Krebs, 2019, ALTEX.

Stem Cell Transcriptome Responses and Corresponding Biomarkers That Indicate the Transition from Adaptive Responses to Cytotoxicity.

Tanja Waldmann, Anna-Katharina Holzer, Jan G Hengstler, 2017, Chemical research in toxicology.

The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods

Thomas E. Exner, Andrea Paola Cediel Ulloa, Ugis Sarkans, 2020, Archives of Toxicology.

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation.

Tanja Waldmann, Smita Jagtap, Marcel Leist, 2015, Journal of visualized experiments : JoVE.

Classification of Developmental Toxicants in a Human iPSC Transcriptomics-Based Test

J. Rahnenführer, K. Edlund, N. Blüthgen, 2022, Chemical research in toxicology.

Combination of multiple neural crest migration assays to identify environmental toxicants from a proof-of-concept chemical library

Alice Krebs, Tanja Waldmann, Xenia Dolde, 2017, Archives of Toxicology.

Erratum to Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data.

Barry Hardy, Francois Busquet, Alice Krebs, 2020, ALTEX.

Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration

J. Rahnenführer, J. Hengstler, M. Leist, 2015, Archives of Toxicology.

Toxicogenomics directory of chemically exposed human hepatocytes

R. Stierum, G. Myatt, J. Rahnenführer, 2014, Archives of Toxicology.

The DEK oncoprotein is a Su(var) that is essential to heterochromatin integrity.

A. Chinnaiyan, Jindan Yu, D. Markovitz, 2011, Genes & development.

Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome.

M. Leist, J. Hescheler, M. Weng, 2012, Human molecular genetics.