J. Huwyler

发表

Rheological characterization and injection forces of concentrated protein formulations: an alternative predictive model for non-Newtonian solutions.

Hanns‐Christian Mahler, Andrea Allmendinger, Stefan Fischer, 2014, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

In Vivo Stability of Therapeutic Proteins

Joachim Schuster, P. Detampel, A. Koulov, 2020, Pharmaceutical Research.

Mechanisms of halothane toxicity: novel insights.

U. Christen, J. Huwyler, J. Gut, 1993, Pharmacology & therapeutics.

The Norepinephrine Transporter Inhibitor Reboxetine Reduces Stimulant Effects of MDMA (“Ecstasy”) in Humans

M. Liechti, M. Hoener, E. Grouzmann, 2011, Clinical pharmacology and therapeutics.

Translational Medicine: Nanoscience and Nanotechnology to Improve Patient Care

P. Cattin, B. Müller, M. Walter, 2015 .

An Impedance-Based Method to Determine Reconstitution Time for Freeze-Dried Pharmaceuticals.

Hanns‐Christian Mahler, J. Huwyler, M. Hafner, 2015, Journal of pharmaceutical sciences.

Characterization of (R,S)‐5,7‐di‐tert‐butyl‐3‐hydroxy‐3‐trifluoromethyl‐3H‐benzofuran‐2‐one as a positive allosteric modulator of GABAB receptors

W. Spooren, E. Prinssen, A. Sleight, 2008, British journal of pharmacology.

Measuring Subvisible Particles in Protein Formulations Using a Modified Light Obscuration Sensor with Improved Detection Capabilities.

A. Koulov, Hanns‐Christian Mahler, J. Huwyler, 2015, Analytical chemistry.

Tracking the physical stability of fluorescent-labeled mAbs under physiologic invitro conditions in human serum and PBS.

A. Racher, Joachim Schuster, P. Detampel, 2020, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Halothane metabolism. Impairment of hepatic omega-oxidation of leukotrienes in vivo and in vitro.

D. Keppler, J. Huwyler, J. Gut, 1992, European journal of biochemistry.

Transformation of 5-hydroperoxyeicosatetraenoic acid into dihydroxy- and cysteinyl-leukotrienes by rat hepatocytes: effects of glutathione.

J. Huwyler, J. Gut, T. Zeugin, 1991, Molecular pharmacology.

Leukotriene B4 formation upon halothane-induced lipid peroxidation in liver membrane fractions under low O2 concentrations in vitro.

J. Huwyler, J. Gut, 1994, European journal of biochemistry.

Single-step organic extraction of leukotrienes and related compounds and their simultaneous analysis by high-performance liquid chromatography.

J. Huwyler, J. Gut, 1990, Analytical biochemistry.

Sodium arsenite but not aluminum chloride stimulates ABC transporter activity in renal proximal tubules of killifish (Fundulus heteroclitus).

G. Fricker, J. Huwyler, J. S. Bolten, 2022, Aquatic toxicology.

Molecular mimicry of trifluoroacetylated human liver protein adducts by constitutive proteins and immunochemical evidence for its impairment in halothane hepatitis.

U. Christen, J. G. Kenna, J. Huwyler, 1992, European journal of biochemistry.

Exposure to the chlorofluorocarbon substitute 2,2-dichloro-1,1,1- trifluoroethane and the anesthetic agent halothane is associated with transient protein adduct formation in the heart.

J. Huwyler, J. Gut, 1992, Biochemical and biophysical research communications.

Be Aggressive! Amorphous Excipients Enabling Single-Step Freeze-Drying of Monoclonal Antibody Formulations

W. Friess, Andrea Allmendinger, J. Huwyler, 2019, Pharmaceutics.

Imaging Techniques to Characterize Cake Appearance of Freeze-Dried Products.

W. Friess, Andrea Allmendinger, J. Huwyler, 2018, Journal of pharmaceutical sciences.

The effect of formulation, process and method variables on the reconstitution time in dual chamber syringes.

J. Huwyler, M. Hafner, T. Werk, 2016, PDA journal of pharmaceutical science and technology.

The Effect of Formulation, Process, and Method Variables on the Reconstitution Time in Dual Chamber Syringes

J. Huwyler, M. Hafner, T. Werk, 2016, PDA Journal of Pharmaceutical Science and Technology.

Measuring Tissue Back-Pressure - In Vivo Injection Forces During Subcutaneous Injection

Andrea Allmendinger, Stefan Fischer, J. Huwyler, 2014, Pharmaceutical Research.

Excipients for room temperature stable freeze-dried monoclonal antibody formulations.

W. Friess, Andrea Allmendinger, J. Huwyler, 2019, Journal of pharmaceutical sciences.

Discovery of carmegliptin: a potent and long-acting dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

Holger Fischer, Bernd Kuhn, B. Kuhn, 2010, Bioorganic & medicinal chemistry letters.

Stability of Monoclonal Antibodies after Simulated Subcutaneous Administration.

Joachim Schuster, J. Huwyler, R. Mathaes, 2021, Journal of pharmaceutical sciences.

Evaluation of Glass Delamination Risk in Pharmaceutical 10 mL/10R Vials.

Andrea Allmendinger, J. Huwyler, H. Roehl, 2018, Journal of pharmaceutical sciences.

Impact of Vial Washing and Depyrogenation on Surface Properties and Delamination Risk of Glass Vials

Andrea Allmendinger, J. Huwyler, H. Roehl, 2018, Pharmaceutical Research.

Characterization of surface properties of glass vials used as primary packaging material for parenterals

Andrea Allmendinger, J. Huwyler, H. Roehl, 2018, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

The pharmaceutical vial capping process: Container closure systems, capping equipment, regulatory framework, and seal quality tests.

Philippe Lam, Roman Mathaes, Hanns-Christian Mahler, 2016, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Pharmacological characterization of designer cathinones in vitro

M. Liechti, M. Donzelli, M. Hoener, 2013, British journal of pharmacology.

Evaluation of the NR2B-selective NMDA receptor antagonist Ro 63-1908 on rodent behaviour: evidence for an involvement of NR2B NMDA receptors in response inhibition

J. Kemp, G. Higgins, T. Ballard, 2003, Neuropharmacology.

Drug-excipient interactions by Vitamin E-TPGS: in vitro studies on inhibition of P-glycoprotein and colonic drug absorption

M. Kuentz, B. Bohrmann, J. Huwyler, 2008 .

Aryl- and heteroaryl-substituted aminobenzo[a]quinolizines as dipeptidyl peptidase IV inhibitors.

Daniel Hunziker, Holger Fischer, Bernd Kuhn, 2010, Bioorganic & medicinal chemistry letters.

Sterile Filtration of Highly Concentrated Protein Formulations: Impact of Protein Concentration, Formulation Composition, and Filter Material.

Hanns-Christian Mahler, Andrea Allmendinger, Stefan Fischer, 2015, Journal of pharmaceutical sciences.

Analytical Challenges Assessing Protein Aggregation and Fragmentation Under Physiologic Conditions.

Joachim Schuster, J. Huwyler, R. Mathaes, 2021, Journal of pharmaceutical sciences.

Factors Governing the Accuracy of Subvisible Particle Counting Methods.

Hanns-Christian Mahler, Christof Finkler, Joerg Huwyler, 2016, Journal of pharmaceutical sciences.

Evidence that nicotinic alpha(7) receptors are not involved in the hyperlocomotor and rewarding effects of nicotine.

G. Higgins, A. Grottick, P. Malherbe, 2000, The Journal of pharmacology and experimental therapeutics.

Influence of Different Container Closure Systems and Capping Process Parameters on Product Quality and Container Closure Integrity (CCI) in GMP Drug Product Manufacturing

Y. Roggo, J. Huwyler, R. Mathaes, 2016, PDA Journal of Pharmaceutical Science and Technology.

Stabilizing Polysorbate 20 and 80 Against Oxidative Degradation.

A. Koulov, M. Jahn, J. Huwyler, 2020, Journal of pharmaceutical sciences.

Insights into possibilities for grouping and read-across for nanomaterials in EU chemicals legislation

G. Flament, N. Jeliazkova, M. Alessandrelli, 2018, Nanotoxicology.

In Vivo Stability of Therapeutic Proteins

Joachim Schuster, P. Detampel, A. Koulov, 2020, Pharmaceutical Research.

Factors Governing the Precision of Subvisible Particle Measurement Methods – A Case Study with a Low-Concentration Therapeutic Protein Product in a Prefilled Syringe

A. Koulov, J. Huwyler, J. Lamerz, 2016, Pharmaceutical Research.

Factors Governing the Precision of Subvisible Particle Measurement Methods – A Case Study with a Low-Concentration Therapeutic Protein Product in a Prefilled Syringe

A. Koulov, J. Huwyler, J. Lamerz, 2015, Pharmaceutical Research.

Impact of Vial Capping on Residual Seal Force and Container Closure Integrity

Y. Roggo, M. Vogt, J. Huwyler, 2016, PDA journal of pharmaceutical science and technology.

The Pharmaceutical Capping Process—Correlation between Residual Seal Force, Torque Moment, and Flip-off Removal Force

Y. Roggo, J. Huwyler, R. Mathaes, 2016, PDA Journal of Pharmaceutical Science and Technology.

The kidney as a novel target tissue for protein adduct formation associated with metabolism of halothane and the candidate chlorofluorocarbon replacement 2,2-dichloro-1,1,1-trifluoroethane.

D. Aeschlimann, U. Christen, J. Huwyler, 1992, European journal of biochemistry.

Measuring Tissue Back-Pressure - In Vivo Injection Forces During Subcutaneous Injection

Andrea Allmendinger, Stefan Fischer, J. Huwyler, 2015, Pharmaceutical Research.

Report from the EPAA workshop: in vitro ADME in safety testing used by EPAA industry sectors.

J Scheel, S Coecke, V Rogiers, 2011, Toxicology in vitro : an international journal published in association with BIBRA.

Particle Analysis of Biotherapeutics in Human Serum using Machine Learning.

Kai D. Schleicher, Joachim Schuster, J. Huwyler, 2020, Journal of pharmaceutical sciences.