M. Koehler

发表

Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.

W. D. Fairlie, Brian J. Smith, J. Baell, 2011, Journal of medicinal chemistry.

Potent, selective, and orally bioavailable inhibitors of mammalian target of rapamycin (mTOR) kinase based on a quaternary substituted dihydrofuropyrimidine.

C. Ly, S. Sideris, S. Malek, 2011, Journal of medicinal chemistry.

Phosphate ester serum albumin affinity tags greatly improve peptide half-life in vivo.

D. Combs, M. Beresini, K. Zobel, 2003, Bioorganic & medicinal chemistry letters.

Synthesis of the First Members of a New Class of Biologically Active Bryostatin Analogues

P. Wender, M. Koehler, P. Harran, 1998 .

Potent, selective, and orally bioavailable inhibitors of the mammalian target of rapamycin kinase domain exhibiting single agent antiproliferative activity.

C. Ly, S. Sideris, S. Malek, 2012, Journal of medicinal chemistry.

Albumin affinity tags increase peptide half-life in vivo.

D. Combs, R. Lazarus, M. Beresini, 2002, Bioorganic & medicinal chemistry letters.

Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists.

S. Hymowitz, W. Fairbrother, K. Deshayes, 2009, ACS chemical biology.

The rational design of potential chemotherapeutic agents: Synthesis of bryostatin analogues

K. Hinkle, P. Wender, M. Koehler, 1999, Medicinal research reviews.

Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL.

Brian J. Smith, J. Baell, G. Nikolakopoulos, 2014, ACS medicinal chemistry letters.

Discovery of Inhibitors of the Lipopolysaccharide Transporter MsbA: From a Screening Hit to Potent Wild-Type Gram-Negative Activity.

Benjamin D. Sellers, Jun Liang, C. Koth, 2022, Journal of medicinal chemistry.

Optimized arylomycins are a new class of Gram-negative antibiotics

Min Xu, D. Yan, Min Xu, 2018, Nature.

A new synthetic approach to the C ring of known as well as novel bryostatin analogues.

P. Wender, M. Koehler, Martin Sendzik, 2003, Organic letters.

Optimized arylomycins are a new class of Gram-negative antibiotics

Min Xu, D. Yan, W. Phung, 2018, Nature.

Design and Development of a Series of Potent and Selective Type II Inhibitors of CDK8.

K. Bowman, Jiansheng Wu, R. Firestein, 2016, ACS medicinal chemistry letters.

Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres.

C. Ly, W. Fairbrother, V. Tsui, 2010, Bioorganic & medicinal chemistry letters.

Structural basis for dual-mode inhibition of the ABC transporter MsbA

Benjamin D. Sellers, Jun Liang, Y. Franke, 2018, Nature.

Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2.

Jane R Kenny, Philippe Bergeron, Ignacio Aliagas, 2013, Journal of medicinal chemistry.

Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2.

Jane R Kenny, Philippe Bergeron, Tian Jin, 2012, Journal of medicinal chemistry.

Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.

Brian J. Smith, C. Tse, A. Petros, 2014, ACS medicinal chemistry letters.

The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1.

P. Wender, M. Koehler, P. Harran, 1998, Proceedings of the National Academy of Sciences of the United States of America.

A Putative Bacterial ABC Transporter Circumvents the Essentiality of Signal Peptidase

Shailesh V. Date, Z. Modrušan, D. Yan, 2016, mBio.

GDC-0449-a potent inhibitor of the hedgehog pathway.

K. Kotkow, L. Rubin, D. Sutherlin, 2009, Bioorganic & medicinal chemistry letters.

Potent Killing of Pseudomonas aeruginosa by an Antibody-Antibiotic Conjugate

D. Seshasayee, G. Nakamura, J. Payandeh, 2021, mBio.

Disrupting Gram-Negative Bacterial Outer Membrane Biosynthesis through Inhibition of the Lipopolysaccharide Transporter MsbA

Benjamin D. Sellers, Cécile Chalouni, C. Koth, 2018, Antimicrobial Agents and Chemotherapy.

Origins of PDZ Domain Ligand Specificity

Sachdev S Sidhu, Nicholas J Skelton, S. Sidhu, 2003, The Journal of Biological Chemistry.

The Erbin PDZ Domain Binds with High Affinity and Specificity to the Carboxyl Termini of δ-Catenin and ARVCF*

K. Kosik, S. Sidhu, K. Deshayes, 2002, The Journal of Biological Chemistry.

Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells.

Philippe Bergeron, Kevin R Clark, James R Kiefer, 2016, ACS medicinal chemistry letters.

Pyrimidoaminotropanes as potent, selective, and efficacious small molecule kinase inhibitors of the mammalian target of rapamycin (mTOR).

S. Sideris, L. Friedman, S. Malek, 2013, Journal of medicinal chemistry.

Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349.

M. Belvin, C. Ly, S. Sideris, 2013, ACS medicinal chemistry letters.

An integrated suite of modeling tools that empower scientists in structure- and property-based drug design

Jeffrey M. Blaney, Philippe Bergeron, Man-Ling Lee, 2015, Journal of Computer-Aided Molecular Design.

Mapping Phorbol Ester Binding Domains of Protein Kinase C (PKC): The Design, Synthesis and Biological Activity of Novel Phorbol Ester Dimers

K. Irie, P. Wender, M. Koehler, 1999 .

Corrigendum to “GDC-0449—A potent inhibitor of the hedgehog pathway” [Bioorg. Med. Chem. Lett. 19 (2009) 5576]

K. Kotkow, L. Rubin, D. Sutherlin, 2010 .

Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells.

K. Bowman, Jiansheng Wu, R. Firestein, 2016, ACS medicinal chemistry letters.