K. Lowes

发表

Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.

W. D. Fairlie, Brian J. Smith, J. Baell, 2011, Journal of medicinal chemistry.

Structure-guided design of a selective BCL-X(L) inhibitor.

Brian J. Smith, J. Baell, P. Colman, 2013, Nature chemical biology.

Effective detection of corrected dystrophin loci in mdx mouse myogenic precursors

M. Cook, R. Kapsa, A. Quigley, 2007, Human mutation.

Engineering a multimodal nerve conduit for repair of injured peripheral nerve

G. Wallace, J. Razal, M. Cook, 2013, Journal of neural engineering.

The effect of N-methylation on transition state mimetic inhibitors of the Plasmodium protease, plasmepsin V

Brian J. Smith, A. Cowman, B. Sleebs, 2015 .

Oval cell‐mediated liver regeneration: Role of cytokines and growth factors

J. Olynyk, G. Yeoh, E. Croager, 2003, Journal of gastroenterology and hepatology.

Evaluation of Sca‐1 and c‐Kit As Selective Markers for Muscle Remodelling by Nonhemopoietic Bone Marrow Cells

M. Cook, R. Kapsa, A. Quigley, 2007, Stem cells.

Basis for drug selectivity of plasmepsin IX and X inhibition in Plasmodium falciparum and vivax.

T. Triglia, A. Cowman, W. Tham, 2022, Structure.

Basis for drug selectivity of plasmepsin IX and X inhibition in Plasmodium falciparum and vivax.

T. Triglia, A. Cowman, J. McCauley, 2021, Structure.

HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death

J. Murphy, J. Hildebrand, J. Silke, 2016, Cell Death and Disease.

Upregulation of lymphotoxin β expression in liver progenitor (oval) cells in chronic hepatitis C

J. Olynyk, G. Yeoh, E. Croager, 2003 .

Upregulation of lymphotoxin beta expression in liver progenitor (oval) cells in chronic hepatitis C.

J. Olynyk, G. Yeoh, E. Croager, 2003, Gut.

Oval cell numbers in human chronic liver diseases are directly related to disease severity.

J. Olynyk, G. Yeoh, K. Lowes, 1999, The American journal of pathology.

Exploration of the P3 region of PEXEL peptidomimetics leads to a potent inhibitor of the Plasmodium protease, plasmepsin V.

A. Cowman, B. Sleebs, K. Lowes, 2016, Bioorganic & medicinal chemistry.

Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL.

Erinna F. Lee, W. D. Fairlie, J. Baell, 2013, Journal of medicinal chemistry.

Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity.

J. Baell, A. Cowman, P. Gilson, 2017, Journal of medicinal chemistry.

Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes

Brian J. Smith, T. Triglia, A. Cowman, 2015, Nature Structural &Molecular Biology.

Transition state mimetics of the Plasmodium export element are potent inhibitors of Plasmepsin V from P. falciparum and P. vivax.

Brian J. Smith, A. Cowman, B. Sleebs, 2014, Journal of medicinal chemistry.

Structure activity refinement of phenylsulfonyl piperazines as antimalarials that block erythrocytic invasion.

Danny W. Wilson, P. Gilson, T. D. de Koning-Ward, 2021, European journal of medicinal chemistry.

Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy

Dolores Diaz, Jun Chen, Deepak Sampath, 2015, Science Translational Medicine.

Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2

Gerbrand J. van der Heden van Noort, H. Ovaa, J. Newman, 2020, The EMBO journal.

Mechanism and inhibition of SARS-CoV-2 PLpro

H. Ovaa, J. Newman, D. Komander, 2020, bioRxiv.

Colorectal Cancer Cell Line Proteomes Are Representative of Primary Tumors and Predict Drug Sensitivity.

Daniel C. Liebler, Xiaojing Wang, Bing Zhang, 2017, Gastroenterology.

Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3.

G. Manning, J. Sandow, Cheree Fitzgibbon, 2019, Cell reports.

A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis

Erinna F. Lee, Laura F. Dagley, P. Colman, 2019, Nature Chemical Biology.

Optimisation of 2-(N-phenyl carboxamide) triazolopyrimidine antimalarials with moderate to slow acting erythrocytic stage activity.

Danny W. Wilson, G. McFadden, A. Cowman, 2021, Bioorganic chemistry.

Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4

A. Cowman, Adele M. Lehane, D. Fidock, 2023, Journal of medicinal chemistry.

A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production

J. Sandow, M. Parker, J. Holien, 2015, Nature Communications.

betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis.

Michael S. Cohen, J. Taunton, M. Pagano, 2009, Molecular cell.

DNA electroporation in vivo targets mature fibres in dystrophic mdx muscle

R. Kapsa, A. Quigley, A. Kornberg, 2005, Neuromuscular Disorders.

The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL

Cheree Fitzgibbon, J. Silke, G. Lessene, 2022, Cell Death & Disease.

Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors

J. Newman, D. Komander, B. C. Lechtenberg, 2022, Frontiers in Chemistry.

RH5.1-CyRPA-Ripr antigen combination vaccine shows little improvement over RH5.1 in a preclinical setting

A. Cowman, V. Kotraiah, J. Healer, 2022, Frontiers in Cellular and Infection Microbiology.

Inhibition of Plasmepsin V Activity Demonstrates Its Essential Role in Protein Export, PfEMP1 Display, and Survival of Malaria Parasites

Brian J. Smith, A. Cowman, L. Whitehead, 2014, PLoS biology.

The Invention of WM382, a Highly Potent PMIX/X Dual Inhibitor toward the Treatment of Malaria.

Manuel de Lera Ruiz, A. Cowman, Zhuyan Guo, 2022, ACS medicinal chemistry letters.

TrCP-and Rsk 1 / 2-Mediated Degradation of BimEL Inhibits Apoptosis

Michael S. Cohen, J. Taunton, M. Pagano, 2009 .

The VEGFR/PDGFR tyrosine kinase inhibitor, ABT-869, blocks necroptosis by targeting RIPK1 kinase

Cheree Fitzgibbon, J. Hildebrand, J. Silke, 2023, The Biochemical journal.

Structure-based development of potent Plasmodium falciparum M1 and M17 aminopeptidase selective and dual inhibitors via S1'-region optimisation.

S. McGowan, P. Scammells, K. Lowes, 2022, European journal of medicinal chemistry.

Property activity refinement of 2-anilino 4-amino substituted quinazolines as antimalarials with fast acting asexual parasite activity.

Danny W. Wilson, A. Cowman, P. Gilson, 2021, Bioorganic chemistry.

Colorectal Cancer Cell Line Proteomes Are Representative of Primary Tumors and Predict Drug Sensitivity.

C. Yau, R. Jorissen, O. Sieber, 2017, Gastroenterology.

Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity.

J. Baell, A. Cowman, P. Gilson, 2017, Journal of medicinal chemistry.