S. Sogabe

发表

Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins.

Yuta Tanaka, T. Kawamoto, T. Ishikawa, 2013, Journal of medicinal chemistry.

Neutralizing epitopes on the extracellular interferon gamma receptor (IFNgammaR) alpha-chain characterized by homolog scanning mutagenesis and X-ray crystal structure of the A6 fab-IFNgammaR1-108 complex.

F. Winkler, J. Robinson, S. Sogabe, 1997, Journal of molecular biology.

Synthesis and Structure Activity Relationship Studies of Benzothieno[3,2- b ]furan Derivatives as a Novel Class of IKKβ Inhibitors

H. Oki, Toshimasa Tanaka, T. Kawamoto, 2007 .

Discovery of 6-[5-(4-fluorophenyl)-3-methyl-pyrazol-4-yl]-benzoxazin-3-one derivatives as novel selective nonsteroidal mineralocorticoid receptor antagonists.

Atsushi Mizukami, Jun Fujimoto, Koji Fuji, 2014, Bioorganic & medicinal chemistry.

Discovery of a B-Cell Lymphoma 6 Protein-Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach.

H. Oki, Kotaro Sakamoto, G. Snell, 2017, Journal of medicinal chemistry.

Discovery of an Irreversible and Cell-Active BCL6 Inhibitor Selectively Targeting Cys53 Located at the Protein-Protein Interaction Interface.

Kotaro Sakamoto, Ikuo Miyahisa, S. Sogabe, 2018, Biochemistry.

Synthesis and biological activities of benzofuran antifungal agents targeting fungal N-myristoyltransferase.

K. Kawasaki, S. Sogabe, K. Morikami, 2003, Bioorganic & medicinal chemistry.

Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (2).

Toshimasa Tanaka, T. Kawamoto, M. Yamaguchi, 2008, Bioorganic & medicinal chemistry.

Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1).

Toshimasa Tanaka, T. Kawamoto, M. Yamaguchi, 2008, Bioorganic & medicinal chemistry.

Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 3.

S. Niizuma, K. Kawasaki, S. Sogabe, 2003, Bioorganic & medicinal chemistry letters.

Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 1.

K. Kawasaki, S. Sogabe, N. Shimma, 2001, Bioorganic & medicinal chemistry letters.

Identification of the first highly selective inhibitor of human lactate dehydrogenase B

T. Soga, N. Takakura, T. Kawamoto, 2020, Scientific Reports.

Discovery of GPX4 inhibitory peptides from random peptide T7 phage display and subsequent structural analysis.

A. Kadotani, Kotaro Sakamoto, S. Sogabe, 2017, Biochemical and biophysical research communications.

STRUCTURAL ANALYSIS OF THE MECHANISM OF INHIBITION AND ALLOSTERIC ACTIVATION OF THE KINASE DOMAIN OF HER 2

Toshimasa Tanaka, Biching Sang, J. Yano, 2011 .

Design and synthesis of novel human epidermal growth factor receptor 2 (HER2)/epidermal growth factor receptor (EGFR) dual inhibitors bearing a pyrrolo[3,2-d]pyrimidine scaffold.

T. Taniguchi, Toshimasa Tanaka, J. Yano, 2011, Journal of medicinal chemistry.

Discovery of selective ATP-competitive eIF4A3 inhibitors.

Masahiro Ito, S. Aparicio, T. Kawamoto, 2017, Bioorganic & medicinal chemistry.

Docking Site for Soluble Electron Carriers on the Tetraheme Cytochrome Subunit Bound to the Bacterial Photosynthetic Reaction Center

K. Miki, Makoto Yoshida, K. Shimada, 1998 .

N. Kasai, K. Miki, A. Uno, 1994, FEBS letters.

Design and synthesis of pyrrolo[3,2-d]pyrimidine human epidermal growth factor receptor 2 (HER2)/epidermal growth factor receptor (EGFR) dual inhibitors: exploration of novel back-pocket binders.

Toshimasa Tanaka, T. Ohashi, T. Ishikawa, 2012, Journal of medicinal chemistry.

Identification of benzoxazin-3-one derivatives as novel, potent, and selective nonsteroidal mineralocorticoid receptor antagonists.

Hideki Matsui, Shoji Fukumoto, Midori Ono, 2011, Journal of medicinal chemistry.

Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 3.

S. Niizuma, K. Kawasaki, S. Sogabe, 2003, Bioorganic & medicinal chemistry letters.

Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases.

Robert I. Davis, C. Heyser, G. Snyder, 2016, Journal of medicinal chemistry.

Structure-based design of beta-lactamase inhibitors. 1. Synthesis and evaluation of bridged monobactams.

M. Page, F. Winkler, C. Oefner, 1998, Journal of medicinal chemistry.

The Crystal Structure and Stereospecificity of Levodione Reductase from Corynebacterium aquaticum M-13*

M. Wada, H. Takagi, S. Sogabe, 2003, Journal of Biological Chemistry.

Identification of cytidine-5-triphosphate synthase1-selective inhibitory peptide from random peptide library displayed on T7 phage

H. Oki, Y. Ishibashi, S. Sogabe, 2017, Peptides.

Structural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 Protein

Yoshikazu Ohta, Tomoyasu Ishikawa, Andy Jennings, 2011, The Journal of Biological Chemistry.

Discovery of a novel B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor by utilizing structure-based drug design.

Terufumi Takagi, Kotaro Sakamoto, G. Snell, 2017, Bioorganic & medicinal chemistry.

Crystal Structure of a Human K-Ras G12D Mutant in Complex with GDP and the Cyclic Inhibitory Peptide KRpep-2d.

S. Sogabe, Tomoya Sameshima, M. Kamaura, 2017, ACS medicinal chemistry letters.

Structure-Based Approach for the Discovery of Pyrrolo[3,2-d]pyrimidine-Based EGFR T790M/L858R Mutant Inhibitors.

Yoshikazu Ohta, Tomoyasu Ishikawa, Terufumi Takagi, 2013, ACS medicinal chemistry letters.

Design, synthesis, and structure-activity relationships of dihydrofuran-2-one and dihydropyrrol-2-one derivatives as novel benzoxazin-3-one-based mineralocorticoid receptor antagonists.

Atsushi Mizukami, Hideki Matsui, Shoji Fukumoto, 2013, Bioorganic & medicinal chemistry.

Discovery of a Kelch-like ECH-associated protein 1-inhibitory tetrapeptide and its structural characterization.

A. Kadotani, Kotaro Sakamoto, S. Sogabe, 2017, Biochemical and biophysical research communications.

Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement

S. Sogabe, Y. Kosugi, T. Kaku, 2021, Scientific Reports.

TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window

S. Sogabe, Y. Kosugi, T. Kaku, 2018, Neuropsychopharmacology.

HBT1, a Novel AMPA Receptor Potentiator with Lower Agonistic Effect, Avoided Bell-Shaped Response in In Vitro BDNF Production

S. Sogabe, H. Kimura, Yasukazu Tajima, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3-Oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl Moiety.

L. Qin, S. Gay, D. Dougan, 2021, Journal of medicinal chemistry.

Design, Synthesis, and Evaluation of Piperazinyl Pyrrolidin-2-ones as a Novel Series of Reversible Monoacylglycerol Lipase Inhibitors.

M. Fushimi, S. Sogabe, Kazunobu Aoyama, 2018, Journal of medicinal chemistry.

Discovery of high-affinity BCL6-binding peptide and its structure-activity relationship.

Kotaro Sakamoto, S. Sogabe, Y. Imaeda, 2017, Biochemical and biophysical research communications.

Crystal structures of Candida albicans N-myristoyltransferase with two distinct inhibitors.

F. Winkler, D. Banner, A. D'arcy, 2002, Chemistry & biology.

Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 2.

K. Kawasaki, S. Sogabe, K. Morikami, 2002, Bioorganic & medicinal chemistry letters.

Crystal structure of the oxidized cytochrome c 2 from Blastochloris viridis

K. Miki, S. Sogabe, 2001, FEBS letters.

HBT1, a novel AMPA receptor potentiator with lower agonistic effect, avoided bell-shaped response in in vitro BDNF production.

S. Sogabe, H. Kimura, Yasukazu Tajima, 2018 .

Different Mechanisms of the Binding of Soluble Electron Donors to the Photosynthetic Reaction Center ofRubrivivax gelatinosus and Blastochloris viridis *

K. Miki, K. Shimada, K. Matsuura, 2001, The Journal of Biological Chemistry.

Comparison of the binding sites for high-potential iron-sulfur protein and cytochrome c on the tetraheme cytochrome subunit bound to the bacterial photosynthetic reaction center.

K. Miki, K. Shimada, K. Matsuura, 1999, Biochemistry.

Interaction site for soluble cytochromes on the tetraheme cytochrome subunit bound to the bacterial photosynthetic reaction center mapped by site-directed mutagenesis.

M. Yoshida, K. Miki, K. Shimada, 1998, Biochemistry.

Synthesis and Structure Activity Relationship Studies of Benzothieno[3,2‐b]furan Derivatives as a Novel Class of IKKβ Inhibitors.

H. Oki, Toshimasa Tanaka, T. Kawamoto, 2007 .

Design and synthesis of novel pyrimido[4,5-b]azepine derivatives as HER2/EGFR dual inhibitors.

Tomohiro Ohashi, Yoshikazu Ohta, Tomoyasu Ishikawa, 2013, Bioorganic & medicinal chemistry.

Synthesis and structure activity relationship studies of benzothieno[3,2-b]furan derivatives as a novel class of IKKbeta inhibitors.

H. Oki, Toshimasa Tanaka, T. Kawamoto, 2007, Chemical and pharmaceutical bulletin.

Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (2).

Toshimasa Tanaka, T. Kawamoto, M. Yamaguchi, 2008, Bioorganic & medicinal chemistry.

Discovery of a Kelch-like ECH-associated protein 1-inhibitory tetrapeptide and its structural characterization.

A. Kadotani, Kotaro Sakamoto, S. Sogabe, 2017, Biochemical and biophysical research communications.