M. Tawada

发表

Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins.

Yuta Tanaka, T. Kawamoto, T. Ishikawa, 2013, Journal of medicinal chemistry.

Identification of a selective DDX3X inhibitor with newly developed quantitative high-throughput RNA helicase assays.

Masahiro Ito, S. Aparicio, T. Kawamoto, 2020, Biochemical and biophysical research communications.

Design of potent dipeptidyl peptidase IV (DPP-4) inhibitors by employing a strategy to form a salt bridge with Lys554.

M. Tawada, N. Suzuki, S. Tsubotani, 2017, Bioorganic & medicinal chemistry letters.

Structure-based design of a new series of N-(piperidin-3-yl)pyrimidine-5-carboxamides as renin inhibitors.

C. Behnke, G. Snell, M. Tawada, 2016, Bioorganic & medicinal chemistry.

Identification of 3-aminomethyl-1,2-dihydro-4-phenyl-1-isoquinolones: a new class of potent, selective, and orally active non-peptide dipeptidyl peptidase IV inhibitors that form a unique interaction with Lys554.

M. Sasaki, J. Yano, K. Aertgeerts, 2011, Bioorganic & medicinal chemistry.

Discovery of Novel and Potent Stearoyl Coenzyme A Desaturase 1 (SCD1) Inhibitors as Anticancer Agents.

R. Nishigaki, T. Miyazaki, Naoki Tomita, 2017, Bioorganic & medicinal chemistry.

Symmetrical approach of spiro-pyrazolidinediones as acetyl-CoA carboxylase inhibitors.

A. Mizukami, Y. Nakano, N. Amano, 2012, Bioorganic & medicinal chemistry letters.

Structure-based design, synthesis, and evaluation of imidazo[1,2-b]pyridazine and imidazo[1,2-a]pyridine derivatives as novel dual c-Met and VEGFR2 kinase inhibitors.

H. Oki, K. Okada, M. Tawada, 2013, Bioorganic & medicinal chemistry.

Discovery of orally efficacious RORγt inverse agonists. Part 2: Design, synthesis, and biological evaluation of novel tetrahydroisoquinoline derivatives.

T. Imada, M. Tawada, M. Shirasaki, 2018, Bioorganic & medicinal chemistry.

TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma

K. Saikatendu, C. Arrowsmith, M. Schapira, 2018, Oncotarget.

Discovery of potent, selective, and orally bioavailable quinoline-based dipeptidyl peptidase IV inhibitors targeting Lys554.

J. Yano, K. Aertgeerts, K. Takeuchi, 2011, Bioorganic & medicinal chemistry.

Design, synthesis, and evaluation of novel VEGFR2 kinase inhibitors: discovery of [1,2,4]triazolo[1,5-a]pyridine derivatives with slow dissociation kinetics.

M. Tawada, Naoki Miyamoto, Yuya Oguro, 2013, Bioorganic & medicinal chemistry.

Melanin-concentrating hormone receptor 1 antagonists: synthesis, structure-activity relationship, docking studies, and biological evaluation of 2,3,4,5-tetrahydro-1H-3-benzazepine derivatives.

Koki Kato, Y. Nakano, M. Tawada, 2011, Bioorganic & medicinal chemistry.

Discovery, synthesis, and structure-activity relationship of 6-aminomethyl-7,8-dihydronaphthalenes as human melanin-concentrating hormone receptor 1 antagonists.

Koki Kato, Y. Nakano, S. Endo, 2011, Bioorganic & Medicinal Chemistry.

A Back-to-Front Fragment-Based Drug Design Search Strategy Targeting the DFG-Out Pocket of Protein Tyrosine Kinases.

H. Oki, J. Lawson, Terufumi Takagi, 2012, ACS medicinal chemistry letters.

Novel approach of fragment-based lead discovery applied to renin inhibitors.

H. Oki, Toshimasa Tanaka, C. Behnke, 2016, Bioorganic & medicinal chemistry.

Discovery of a Novel Series of Potent, Selective, Orally Available, and Brain-Penetrable C1s Inhibitors for Modulation of the Complement Pathway

C.-H. Chen, Kenjiro Sato, D. Dougan, 2023, Journal of medicinal chemistry.

Identification of 2,6-Disubstituted-3Η-imidazo[4,5-b]pyridines as Therapeutic Agents for Dysferlinopathies through Phenotypic Screening on Patient-Derived iPSCs.

H. Sakurai, A. Kaieda, Tomoya Sameshima, 2019, Journal of medicinal chemistry.

Melanin-concentrating hormone receptor 1 antagonists: synthesis, structure-activity relationship, docking studies, and biological evaluation of 2,3,4,5-tetrahydro-1H-3-benzazepine derivatives.

Koki Kato, Y. Nakano, M. Tawada, 2011, Bioorganic & Medicinal Chemistry.

Discovery of a Novel and Brain-Penetrant O-GlcNAcase Inhibitor via Virtual Screening, Structure-Based Analysis, and Rational Lead Optimization.

M. Fushimi, R. Tjhen, S. Endo, 2021, Journal of medicinal chemistry.

Corrigendum to “Discovery of potent, selective, and orally bioavailable quinoline-based dipeptidyl peptidase IV inhibitors targeting Lys554” [Bioorg. Med. Chem. 19 (2011) 4482–4498]

J. Yano, K. Aertgeerts, K. Takeuchi, 2011 .