K. Watson

发表

Structure-guided design of a selective BCL-X(L) inhibitor.

Brian J. Smith, J. Baell, P. Colman, 2013, Nature chemical biology.

Spiroleucettadine: synthetic studies and investigations towards structural revision

Brian J. Smith, G. Lessene, K. Watson, 2007 .

In Vitro Activity of Expanded-Spectrum Pyridazinyl Oxime Ethers Related to Pirodavir: Novel Capsid-Binding Inhibitors with Potent Antipicornavirus Activity

D. Smee, S. Tucker, D. Barnard, 2004, Antimicrobial Agents and Chemotherapy.

Fluorescence and analytical ultracentrifugation analyses of the interaction of the tyrosine kinase inhibitor, tyrphostin AG 1478-mesylate, with albumin.

A. Burgess, E. Nice, M. Perugini, 2005, Analytical biochemistry.

Formaldehyde-activated WEHI-150 induces DNA interstrand crosslinks with unique structural features.

J. Collins, S. Cutts, B. Sleebs, 2019, Bioorganic & medicinal chemistry.

Synthesis of a polymeric 4-N-linked sialoside which inhibits influenza virus hemagglutinin.

B. Jin, G. Krippner, K. Watson, 2000, Bioorganic & medicinal chemistry letters.

Conversion of Cyclic Nitrones to Thiolactams by Reaction with Carbon Disulfide

K. Watson, D. Black, 1972 .

Tethered neuraminidase inhibitors that bind an influenza virus: a first step towards a diagnostic method for influenza.

P. Colman, J. McKimm-Breschkin, S. Tucker, 2003, Angewandte Chemie.

Trypanothione Reductase High-Throughput Screening Campaign Identiﬁes Novel Classes of Inhibitors with Antiparasitic Activity (cid:1) †

A. Fairlamb, J. Baell, G. Holloway, 2009 .

An Orally Available 3-Ethoxybenzisoxazole Capsid Binder with Clinical Activity against Human Rhinovirus.

M. Parker, C. Morton, S. Feil, 2012, ACS medicinal chemistry letters.

An orally bioavailable oxime ether capsid binder with potent activity against human rhinovirus.

S. Tucker, D. Barnard, R. Sidwell, 2003, Journal of medicinal chemistry.

Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL.

Brian J. Smith, J. Baell, G. Nikolakopoulos, 2014, ACS medicinal chemistry letters.

DIASTEREOSELECTIVE ROUTES TO SIDE-CHAIN TRUNCATED ANALOGUES OF N-ACETYLNEURAMINIC ACID

K. Watson, D. Hockless, M. Banwell, 1998 .

Asymmetric syntheses of (+)-diltiazem hydrochloride

W. R. Jackson, K. Watson, M. Gredley, 1990 .

Synthesis, insecticidal and anti-acetylcholinesterase activity of a new class of heterocyclic methanesulfonates

G. Holan, K. Watson, C. Virgona, 1996 .

Stereoselective Syntheses of Ephedrine and Related 2-Amino Alcohols of High Optical Purity from Protected Cyanohydrins.

W. R. Jackson, K. Watson, G. S. Jayatilake, 1990 .

Stereoselective syntheses of ephedrine and related 2-aminoalcohols of high optical purity from protected cyanohydrins

W. R. Jackson, K. Watson, G. S. Jayatilake, 1990 .

Synthesis of threo-3-aryl-2,3-dihydroxypropanoic acid derivatives with high optical purity

W. R. Jackson, K. Watson, H. Gountzos, 1989 .

2-Ethoxybenzoxazole as a bioisosteric replacement of an ethyl benzoate group in a human rhinovirus (HRV) capsid binder.

S. Tucker, D. Chalmers, G. Krippner, 2005, Bioorganic & medicinal chemistry letters.

Synthesis of threo-3-Aryl-2,3-dihydroxypropanoic Acid Derivatives with High Optical Purity.

W. R. Jackson, K. Watson, H. Gountzos, 1990 .

Applications of Optically Active Aryl Cyanohydrins in the Synthesis of α-Hydroxy Aldehydes, α-Hydroxy Ketones and β-Hydroxy Amines

W. R. Jackson, K. Watson, G. S. Jayatilake, 1990 .

Synthesis and biological evaluation of analogues of the anti-tumor alkaloid naamidine A.

E. Nice, K. Watson, N. Aberle, 2007, Bioorganic & medicinal chemistry letters.

Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL.

Erinna F. Lee, W. D. Fairlie, J. Baell, 2013, Journal of medicinal chemistry.

Synthesis and Anti-Acetylcholinesterase Activity of Some 5-Substituted 1-Methyl-1H-1,2,4-triazol-3-yl Methanesulfonates

G. Holan, K. Watson, C. Virgona, 1997 .

Mitoxantrone, More than Just Another Topoisomerase II Poison

S. Cutts, B. Sleebs, D. Phillips, 2016, Medicinal research reviews.

First total synthesis of (+)-3-deoxy-D-glycero-D-galacto-2-nonulosonic acid (KDN) from a non-carbohydrate source

K. Watson, M. Banwell, C. D. Savi, 1998 .

Diastereoselective synthesis of (–)-N-acetylneuraminic acid (Neu5Ac) from a non-carbohydrate source

Martin G. Banwell, K. Watson, M. Banwell, 1998 .

Cyclohexane-1,3-dione Oxime Ether Grass-Specific Herbicides and the Discovery of Butroxydim

K. Watson, 2011 .

Diastereoselective route to the tetrahydropyranoid core of the polyketide herbicide herboxidiene

K. Watson, M. Banwell, G. Simpson, 1996 .

A concise total synthesis of naamidine A.

G. Lessene, K. Watson, N. Aberle, 2006, Organic letters.

Enantioselective synthesis of a potential key intermediate for the total synthesis of fumagillin

P. Perlmutter, K. Watson, M. Ciampini, 2007 .

Alternative modes of 1,3-dipolar cycloaddition of nitrones to arylisothiocyanates

K. Watson, D. Black, 1972 .

Synthesis of Aryl Carbohydrate Synthons and 2,3-Dihydroxypropanoic Acid-Derivatives of High Optical Purity

W. R. Jackson, K. Watson, B. Matthews, 1990 .

Nitrones and oxaziridines. VIII. Cycloaddition reactions of nitrones with isothiocyanates

K. Watson, D. Black, 1973 .

Discovery of novel and potent benzhydryl-tropane trypanocides highly selective for Trypanosoma cruzi.

J. Baell, G. Holloway, J. Parisot, 2010, Bioorganic & medicinal chemistry letters.

Inhibitors of Leishmania GDP-Mannose Pyrophosphorylase Identified by High-Throughput Screening of Small-Molecule Chemical Library

J. Baell, L. Kedzierski, E. Handman, 2010, Antimicrobial Agents and Chemotherapy.

Assimilation of the antipodal forms of squalene 2,3-oxide by mammalian, yeast, and plant systems

T. Jarman, K. Watson, D. Barton, 1974 .

Nitrones and oxaziridines. X. Photorearrangement of some bicyclic oxaziridines

K. Watson, D. Black, 1973 .

Synthesis and Characterization of a Series of Liquid Crystal Monomers Containing a Novel Spacer Group Based on Vinylacetic Acid

W. R. Jackson, G. Simon, K. Watson, 1992 .

NITRONES AND OXAZIRIDINES PART 9, CYCLOADDITION REACTIONS OF NITRONES WITH THIOKETONES AND THE THERMAL AND PHOTOCHEMICAL PROPERTIES OF SOME RESULTING 1,4,2-OXATHIAZOLIDINES

K. Watson, D. Black, 1974 .

Syntheses of the d-Aldopentoses from Non-carbohydrate Sources

K. Watson, D. Hockless, M. Banwell, 1999 .

Syntheses of the D-Aldopentoses from Non-Carbohydrate Sources.

K. Watson, D. Hockless, M. Banwell, 1999 .

A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis

Erinna F. Lee, Laura F. Dagley, P. Colman, 2019, Nature Chemical Biology.

Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors

Chin Wee Tan, J. Visvader, Maohui Luo, 2021, Cell Death & Disease.

Dimeric zanamivir conjugates with various linking groups are potent, long-lasting inhibitors of influenza neuraminidase including H5N1 avian influenza.

Stephanie Hamilton, Rachel Cameron, Simon J F Macdonald, 2005, Journal of medicinal chemistry.

Potent and Long-Acting Dimeric Inhibitors of Influenza Virus Neuraminidase Are Effective at a Once-Weekly Dosing Regimen

H. T. Jones, Andy M Mason, S. Tucker, 2004, Antimicrobial Agents and Chemotherapy.

M2, a novel anthracenedione, elicits a potent DNA damage response that can be subverted through checkpoint kinase inhibition to generate mitotic catastrophe.

S. Cutts, R. Forrest, B. Sleebs, 2011, Biochemical pharmacology.

Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.

Brian J. Smith, C. Tse, A. Petros, 2014, ACS medicinal chemistry letters.

Preparation of thermotrophic liquid crystalline polymers involving a novel spacer unit based on vinylacetic acid

W. R. Jackson, G. Simon, K. Watson, 1992 .

Trypanothione Reductase High-Throughput Screening Campaign Identifies Novel Classes of Inhibitors with Antiparasitic Activity

A. Fairlamb, J. Baell, G. Holloway, 2009, Antimicrobial Agents and Chemotherapy.

Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening.

A. Fairlamb, J. Baell, G. Holloway, 2007, Bioorganic & medicinal chemistry letters.

Preparation of 4,6-Disubstituted 5-Pyrimidinesulfonamides

S. Thang, K. Watson, W. Best, 1998 .

Preparation of 4,6‐Disubstituted 5‐Pyrimidinesulfonamides

S. Thang, K. Watson, W. Best, 1998 .

Catalytic hydrogenation of isoflavones. The preparation of (±)-equol and related isoflavans

K. Watson, J. Lamberton, H. Suares, 1978 .

CATALYTIC HYDROGENATION OF ISOFLAVONES. THE PREPARATION OF (.+-.)-EQUOL AND RELATED ISOFLAVANS

K. Watson, J. Lamberton, H. Suares, 1978 .

Dimeric cyclohexane-1,3-dione oximes inhibit wheat acetyl-CoA carboxylase and show anti-malarial activity.

G. McFadden, G. Holloway, K. Watson, 2010, Bioorganic & medicinal chemistry letters.

A different mechanism for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by tepraloxydim

Liang Tong, Song Xiang, L. Tong, 2009, Proceedings of the National Academy of Sciences.

Apicoplast acetyl Co-A carboxylase of the human malaria parasite is not targeted by cyclohexanedione herbicides.

G. McFadden, G. Holloway, K. Watson, 2014, International journal for parasitology.

Highly potent and long-acting trimeric and tetrameric inhibitors of influenza virus neuraminidase.

Andy M Mason, S. Tucker, Wen-Yang Wu, 2004, Bioorganic & medicinal chemistry letters.

Nitrones and oxaziridines. XI. Reactions of oxaziridines with ferrous ions

K. Watson, D. Black, 1973 .

Interaction of the transactivating protein HIV-1 tat with sulphated polysaccharides.

R. Edwards, D. Davies, N. Gooderham, 1999, Biochemical pharmacology.

New anthracenedione derivatives with improved biological activity by virtue of stable drug-DNA adduct formation.

J. Collins, A. Nudelman, S. Cutts, 2010, Journal of medicinal chemistry.