B. Dayton

发表

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

L. Lam, C. Tse, Cheol‐Min Park, 2013, Nature Medicine.

Identification and characterization of amino-piperidinequinolones and quinazolinones as MCHr1 antagonists.

M. Maguire, Courtney A. Cullis, C. Blackburn, 2006, Bioorganic & medicinal chemistry letters.

Pharmacological characterization of A-127722: an orally active and highly potent ETA-selective receptor antagonist.

S. Magnuson, K. Marsh, J. R. Wu-wong, 1996, The Journal of pharmacology and experimental therapeutics.

Souers AJ, Leverson JD, Boghaert ER et al.ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat Med 19:202-208

L. Lam, C. Tse, Cheol‐Min Park, 2013 .

Characterization of ghrelin rec eptor activity in a rat pituitary cell line RC4 B / C H

C. Collins, B. Dayton, W. Kaszubska, 2006 .

Characterization of ghrelin receptor activity in a rat pituitary cell line RC-4B/C.

C. Collins, B. Dayton, W. Kaszubska, 2006, Journal of molecular endocrinology.

Endothelin-stimulated glucose uptake: effects of intracellular Ca(2+), cAMP and glucosamine.

J. R. Wu-wong, B. Dayton, C. Berg, 2002, Clinical science.

Selective antagonism of the ET(A) receptor reduces neointimal hyperplasia after balloon-induced vascular injury in pigs.

C. Wegner, B. Dayton, J. Wessale, 1997, Journal of cardiovascular pharmacology.

Endothelin-1-evoked arachidonic acid release: a Ca(2+)-dependent pathway.

J. R. Wu-wong, B. Dayton, T. Opgenorth, 1996, The American journal of physiology.

Identification and preliminary characterization of a potent, safe, and orally efficacious inhibitor of acyl-CoA:diacylglycerol acyltransferase 1.

Steven C. Cullen, P. Hajduk, A. Souers, 2012, Journal of medicinal chemistry.

Validation of diacyl glycerolacyltransferase I as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor.

A. Souers, G. Diaz, H. Sham, 2008, Journal of medicinal chemistry.

Upregulation of endothelin B receptors in kidneys of DOCA-salt hypertensive rats.

J. Pollock, D. Pollock, B. Dayton, 2000, American journal of physiology. Renal physiology.

Pharmacology of endothelin receptor antagonists ABT-627, ABT-546, A-182086 and A-192621: ex vivo and in vivo studies.

K. Marsh, J. R. Wu-wong, B. Dayton, 2002, Clinical science.

Enrichment with wood blocks does not affect toxicity assessment in an exploratory toxicology model using Sprague-Dawley rats.

Jill M. Wetter, B. Dayton, W. Buck, 2014, Journal of the American Association for Laboratory Animal Science : JAALAS.

ABT-627, an endothelin ET(A) receptor-selective antagonist, attenuates tactile allodynia in a diabetic rat model of neuropathic pain.

M. Jarvis, J. J. Lynch, B. Dayton, 2000, European journal of pharmacology.

Endothelin receptor antagonist has limited access to the fetal compartment during chronic maternal administration late in pregnancy.

L. Thaete, Sylvia Synowiec, B. Dayton, 2012, Life sciences.

Direct determination of endothelin receptor antagonist levels in plasma using a scintillation proximity assay.

J. R. Wu-wong, B. Dayton, W. Chiou, 2000, Life sciences.

Pharmacology of A-216546: a highly selective antagonist for endothelin ET(A) receptor.

K. Marsh, J. Wu-Wong, B. Dayton, 1999, European journal of pharmacology.

Effects of angiotensinase inhibitors on plasma protein binding and IC50 determinations of renin inhibitors.

S. Rosenberg, B. Dayton, W. Baker, 1992, Clinical chemistry.

Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1.

A. Vasudevan, A. Souers, C. Collins, 2004, Bioorganic & medicinal chemistry letters.

Characterization of a neuronal cell line expressing native human melanin-concentrating hormone receptor 1 (MCHR1).

C. Collins, L. Frost, B. Dayton, 2006, The international journal of biochemistry & cell biology.

Aminopiperidine indazoles as orally efficacious melanin concentrating hormone receptor-1 antagonists.

Ju Gao, Anil Vasudevan, John K Lynch, 2005, Bioorganic & medicinal chemistry letters.

Discovery and characterization of aminopiperidinecoumarin melanin concentrating hormone receptor 1 antagonists.

Thomas Fey, Robin Shapiro, Ju Gao, 2005, Journal of medicinal chemistry.

An evaluation of 3,4-methylenedioxy phenyl replacements in the aminopiperidine chromone class of MCHr1 antagonists.

A. Souers, G. Diaz, H. Sham, 2007, Bioorganic & medicinal chemistry letters.

CC-1065 (NSC 298223), a novel antitumor agent that interacts strongly with double-stranded DNA.

W. C. Krueger, S. Kuentzel, W. Krueger, 1982, Cancer research.

Mechanism of interaction of CC-1065 (NSC 298223) with DNA.

W. C. Krueger, L. Hurley, J. Rokem, 1982, Cancer research.

Identification of 2-(4-benzyloxyphenyl)-N- [1-(2-pyrrolidin-1-yl-ethyl)-1H-indazol-6-yl]acetamide, an orally efficacious melanin-concentrating hormone receptor 1 antagonist for the treatment of obesity.

Robin Shapiro, Ju Gao, Anil Vasudevan, 2005, Journal of medicinal chemistry.

Peptide substrates and inhibitors of the HIV-1 protease.

C. Debouck, J. Strickler, T. Meek, 1989, Biochemical and biophysical research communications.

A radiometric assay for HIV-1 protease.

T. Meek, A. Shu, B. Dayton, 1990, Analytical biochemistry.

Plasma and cerebrospinal fluid pharmacokinetics of ABT-888 after oral administration in non-human primates

V. Giranda, T. Horton, B. Dayton, 2008, Cancer Chemotherapy and Pharmacology.

Potent and selective non-benzodioxole-containing endothelin-A receptor antagonists.

A. Tasker, K. Marsh, B. Dayton, 1997, Journal of medicinal chemistry.

Slow, tight binding to human renin of some nonpeptidic renin inhibitors containing a 4‐methoxymethoxypiperidinylamide at the P4 position

S. Rosenberg, B. Dayton, H. Kleinert, 1992, FEBS letters.

Characterization and autoprocessing of precursor and mature forms of human immunodeficiency virus type 1 (HIV 1) protease purified from Escherichia coli

C. Debouck, J. Strickler, T. Meek, 1989, Proteins.

Human immunodeficiency virus 1 protease expressed in Escherichia coli behaves as a dimeric aspartic protease.

C. Debouck, J. Strickler, M. Rosenberg, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Optimization of chromone-2-carboxamide melanin concentrating hormone receptor 1 antagonists: assessment of potency, efficacy, and cardiovascular safety.

G. Diaz, E. Bush, H. Sham, 2006, Journal of medicinal chemistry.

Identification of ortho-amino benzamides and nicotinamides as MCHr1 antagonists.

Anil Vasudevan, Christopher Blackburn, A. Vasudevan, 2005, Bioorganic & medicinal chemistry letters.

Azole endothelin antagonists. 3. Using delta log P as a tool to improve absorption.

K. Marsh, J. R. Wu-wong, B. Dayton, 1996, Journal of medicinal chemistry.

Endothelin receptor in benign prostatic hyperplastic cells. Binding and functional studies.

S. Magnuson, S. Ng, J. R. Wu-wong, 1997, Receptors & signal transduction.

Synthesis and evaluation of urea-based indazoles as melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity.

Robin Shapiro, Ju Gao, A. Souers, 2005, Bioorganic & medicinal chemistry letters.

Identification and characterization of A-105972, an antineoplastic agent.

D. Burns, S. Tahir, L. Alder, 2001, Cancer research.

Identification of aminopiperidine benzamides as MCHr1 antagonists.

A. Vasudevan, A. Souers, C. Blackburn, 2005, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 2.

Anil Vasudevan, A. Vasudevan, A. Souers, 2004, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 3.

Ju Gao, Anil Vasudevan, A. Vasudevan, 2004, Bioorganic & medicinal chemistry letters.

Efficient Synthesis of Disulfide Bridge Containing Peptides: Melanin Concentrating Hormone (MCH) and Brain Natriuretic Peptide (BNP)

P. Richardson, B. Dayton, S. Brodjian, 2006 .

Identification of diamino chromone-2-carboxamides as MCHr1 antagonists with minimal hERG channel activity.

G. Gintant, A. Souers, G. Diaz, 2007, Bioorganic & medicinal chemistry letters.

Constrained 7-fluorocarboxychromone-4-aminopiperidine based Melanin-concentrating hormone receptor 1 antagonists: the effects of chirality on substituted indan-1-ylamines.

A. Souers, G. Diaz, E. Bush, 2007, Bioorganic & medicinal chemistry letters.

Screening for cardiovascular safety: a structure-activity approach for guiding lead selection of melanin concentrating hormone receptor 1 antagonists.

Ju Gao, Anil Vasudevan, John K Lynch, 2006, Journal of medicinal chemistry.