Lei Xu

发表

Discovery of novel inhibitors targeting the macrophage migration inhibitory factor via structure-based virtual screening and bioassays.

Youyong Li, Xuechu Zhen, L. Zheng, 2014, Journal of medicinal chemistry.

Synthesis of 2-ethoxycarbonylthieno[2,3-b]quinolines in biomass-derived solvent γ-valerolactone and their biological evaluation against protein tyrosine phosphatase 1B

Yu-bo Zhou, R. Satheeshkumar, Jia Li, 2021, RSC advances.

Protein Kinase A Rescues Microtubule Affinity-regulating Kinase 2-induced Microtubule Instability and Neurite Disruption by Phosphorylating Serine 409*

Linyin Feng, Yi Zang, Jia Li, 2014, The Journal of Biological Chemistry.

BMS309403 Stimulates Glucose Uptake in Myotubes through Activation of AMP-Activated Protein Kinase

Donghai Wu, Shouguang Jin, Jingya Li, 2012, PloS one.

Bufalin enhances the killing efficacy of NK cells against hepatocellular carcinoma by inhibiting MICA shedding.

Jia Li, Fangyue Guo, Lei Xu, 2021, International immunopharmacology.

Discovery of toxoflavin, a potent IRE1α inhibitor acting through structure-dependent oxidative inhibition

Yu-bo Zhou, Jia Li, Lei Xu, 2022, Acta Pharmacologica Sinica.

Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders.

Xiaomin Luo, Yu-bo Zhou, Jia Li, 2021, European journal of medicinal chemistry.

Development of Macrocyclic Peptides Containing Epoxyketone with Oral Availability as Proteasome Inhibitors.

J. Yu, Xiaodong Ma, Xiaowu Dong, 2018, Journal of medicinal chemistry.

Downregulation of c-Myc expression confers sensitivity to CHK1 inhibitors in hematologic malignancies

Yongzhou Hu, Tao Wang, Jianwei Yang, 2021, Acta pharmacologica Sinica.

Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino)pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies.

Yongzhou Hu, Yu-bo Zhou, Jia Li, 2019, European journal of medicinal chemistry.

Design, Synthesis, and Evaluation of 3‐Aryl‐4‐pyrrolyl‐maleimides as Glycogen Synthase Kinase‐3β Inhibitors

M. Li, Yongzhou Hu, Yu-bo Zhou, 2013, Archiv der Pharmazie.

Synthesis and Biological Evaluation of 3-Benzisoxazolyl-4-indolylmaleimides as Potent, Selective Inhibitors of Glycogen Synthase Kinase-3β

M. Li, Weisi Wang, Yu-bo Zhou, 2013, Molecules.

Optimization of piperidine constructed peptidyl derivatives as proteasome inhibitors.

Yu-bo Zhou, Jia Li, Lei Xu, 2020, Bioorganic & medicinal chemistry.

Curcusone D, a novel ubiquitin-proteasome pathway inhibitor via ROS-induced DUB inhibition, is synergistic with bortezomib against multiple myeloma cell growth.

Yu-bo Zhou, Jia Li, Lei Xu, 2014, Biochimica et biophysica acta.

A novel GSK-3β inhibitor YQ138 prevents neuronal injury induced by glutamate and brain ischemia through activation of the Nrf2 signaling pathway

Yu-bo Zhou, Jia Li, Jian-rong Gao, 2016, Acta Pharmacologica Sinica.

Searching for the Multi-Target-Directed Ligands against Alzheimer's disease: discovery of quinoxaline-based hybrid compounds with AChE, H₃R and BACE 1 inhibitory activities.

Li Tang, Yongzhou Hu, Ying Shi, 2011, Bioorganic & medicinal chemistry.

Synthesis and Evaluation of 3‐(furo[2,3‐b]pyridin‐3‐yl)‐4‐(1H‐indol‐3‐yl)‐maleimides as Novel GSK‐3β Inhibitors and Anti‐Ischemic Agents

Luyong Zhang, Jian-rong Gao, Jia Li, 2015, Chemical biology & drug design.

Synthesis and biological evaluation of 3-([1,2,4]triazolo[4,3-a]pyridin-3-yl)-4-(indol-3-yl)-maleimides as potent, selective GSK-3β inhibitors and neuroprotective agents.

Luyong Zhang, Jian-rong Gao, Jia Li, 2015, Bioorganic & medicinal chemistry.

Synthesis and Evaluation of 3-(Indol-3-yl)-4-(Pyrazolo[3,4-c]Pyridazin-3-yl)-Maleimides as Potent Mutant Isocitrate Dehydrogenase-1 Inhibitors

Chunqi Hu, Jian-rong Gao, Lei Xu, 2021, Pharmaceutical Chemistry Journal.

Design, synthesis and biological evaluation of pyrazol-furan carboxamide analogues as novel Akt kinase inhibitors.

Bo Yang, Yongzhou Hu, Xiaodong Ma, 2016, European journal of medicinal chemistry.

Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-based Design.

Qiaojun He, Bo Yang, Yongzhou Hu, 2019, Journal of medicinal chemistry.

Discovery of pyrazole as C-terminus of selective BACE1 inhibitors.

Yechun Xu, Li Li, Jian Li, 2013, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of novel tripeptidyl epoxyketone derivatives constructed from β-amino acid as proteasome inhibitors.

Jia Li, Tao Liu, Lei Xu, 2014, Bioorganic & medicinal chemistry.

Design, synthesis, and molecular docking study of 3H‐imidazole[4,5‐c]pyridine derivatives as CDK2 inhibitors

J. Chen, Yongzhou Hu, Huazhou Ying, 2018, Archiv der Pharmazie.

Alstonlarsines A-D, Four Rearranged Indole Alkaloids from Alstonia scholaris.

Jiang-Ping Wu, J. Yue, Lei Xu, 2019, Organic letters.

Discovery of benzofuran-3(2H)-one derivatives as novel DRAK2 inhibitors that protect islet β-cells from apoptosis.

B. Han, Jie Tang, Lei Xu, 2017, European journal of medicinal chemistry.

3‐(7‐Azaindolyl)‐4‐indolylmaleimides as a novel class of mutant isocitrate dehydrogenase‐1 inhibitors: Design, synthesis, and biological evaluation

Jian-rong Gao, Jia Li, Lei Xu, 2018, Archiv der Pharmazie.

Downregulation of c-Myc expression confers sensitivity to CHK1 inhibitors in hematologic malignancies

Yongzhou Hu, Tao Liu, Lei Xu, 2021, Acta Pharmacologica Sinica.

Synthesis and biological evaluation of 3-aryl-4-indolyl-maleimides as potent mutant isocitrate dehydrogenase-1 inhibitors.

Jian-rong Gao, Jia Li, Lei Xu, 2019, Bioorganic & medicinal chemistry.

Activation of unfolded protein response overcomes Ibrutinib resistance in diffuse large B-cell lymphoma

Lei Xu, An-hui Gao, Chunmei Xia, 2020, Acta Pharmacologica Sinica.

Activation of unfolded protein response overcomes Ibrutinib resistance in diffuse large B-cell lymphoma

Lei Xu, An-hui Gao, Chunmei Xia, 2020, Acta pharmacologica Sinica.

Novel thieno[2,3-b]quinoline-procaine hybrid molecules: A new class of allosteric SHP-1 activators evolved from PTP1B inhibitors

Tingjun Hou, Jia Li, Qianwen Mu, 2022, Chinese Chemical Letters.

Discovery of a novel inhibitor of NAD(P)+-dependent malic enzyme (ME2) by high-throughput screening

Li-Hong Hu, Lei Xu, Jing Gao, 2014, Acta Pharmacologica Sinica.

A novel GSK-3β inhibitor YQ138 prevents neuronal injury induced by glutamate and brain ischemia through activation of the Nrf2 signaling pathway

Jian-rong Gao, Jia Li, Lei Xu, 2016, Acta Pharmacologica Sinica.

Exploration of novel macrocyclic dipeptide N-benzyl amides as proteasome inhibitors.

Jia Li, Tao Liu, Lei Xu, 2019, European journal of medicinal chemistry.

Covalent docking modelling-based discovery of tripeptidyl epoxyketone proteasome inhibitors composed of aliphatic-heterocycles.

Yongzhou Hu, Xiaowu Dong, J. Che, 2019, European journal of medicinal chemistry.

Design, Synthesis and Biological Evaluation of Peptidyl Epoxyketone Proteasome Inhibitors Composed of β‐amino Acids

Jia Li, Yongzhou Hu, Xiaodong Ma, 2014, Chemical biology & drug design.

Novel Small-Molecule AMP-Activated Protein Kinase Allosteric Activator with Beneficial Effects in db/db Mice

M. Gu, Lei Xu, Yuan-yuan Li, 2013, PloS one.

Low-current & high-frequency electrical stunning increased oxidative stress, lipid peroxidation, and gene transcription of the mitogen-activated protein kinase/nuclear factor-erythroid 2-related factor 2/antioxidant responsive element (MAPK/Nrf2/ARE) signaling pathway in breast muscle of broilers.

G. Qi, Lei Xu, Hong‐yuan Yue, 2018, Food chemistry.

Design, synthesis, and biological evaluation of novel phenol ether derivatives as non-covalent proteasome inhibitors.

Jia Li, Tao Liu, Lei Xu, 2019, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of novel non-covalent piperidine-containing peptidyl proteasome inhibitors.

Jia Li, Yidan Shao, Shourong Liu, 2016, Bioorganic & medicinal chemistry.

Identification of novel inhibitors of Aurora A with a 3-(pyrrolopyridin-2-yl)indazole scaffold.

Xiaodong Ma, Tao Liu, Lei Xu, 2015, Bioorganic & medicinal chemistry.

Discovery of Preclinical Candidate AD1058 as a Highly Potent, Selective, and Brain-Penetrant ATR Inhibitor for the Treatment of Advanced Malignancies.

Lei Xu, Kailong Jiang, Xiaobei Hu, 2024, Journal of medicinal chemistry.