Xiaoguang Chen

发表

Identification of potential indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitors by an FBG-based 3D QSAR pharmacophore model.

Lu Zhang, Fang-fang Lai, Xiaoguang Chen, 2020, Journal of molecular graphics & modelling.

Design and Synthesis of Indoleamine 2,3-Dioxygenase 1 Inhibitors and Evaluation of Their Use as Anti-Tumor Agents

Fang-fang Lai, Xiaoguang Chen, Hui Wen, 2019, Molecules.

Antiproliferative effect of HSP90 inhibitor Y306zh against pancreatic cancer is mediated by interruption of AKT and MAPK signaling pathways.

Sen Zhang, Xiaoguang Chen, Nina Xue, 2014, Current cancer drug targets.

Design, synthesis and biological evaluation of novel indolin-2-ones as potent anticancer compounds.

K. Lee, Lei Yan, Fang-fang Lai, 2017, Bioorganic & medicinal chemistry letters.

C15-methoxyphenylated 18-deoxy-herbimycin A analogues, their in vitro anticancer activity and heat shock protein 90 binding affinity.

Xiaoguang Chen, Nina Xue, Rui Yan, 2016, Bioorganic & medicinal chemistry letters.

Targeted delivery of chlorogenic acid by mannosylated liposomes to effectively promote the polarization of TAMs for the treatment of glioblastoma

Yan-fang Yang, Xiaoguang Chen, Yuling Liu, 2020, Bioactive materials.

Internal Ribosome Entry Site-Based Bicistronic In Situ Reporter Assays for Discovery of Transcription-Targeted Lead Compounds.

Xiaoguang Chen, H. Ding, Shi-Yong Sun, 2015, Chemistry & biology.

A Synthetic Manassantin A Derivative Inhibits Hypoxia-Inducible Factor 1 and Tumor Growth

Chunhong Yan, Y. Li, Xiaoguang Chen, 2014, PloS one.

Drug-free mannosylated liposomes inhibit tumor growth by promoting the polarization of tumor-associated macrophages

Yan-fang Yang, Yingying Meng, Xiaoguang Chen, 2019, International Journal of Nanomedicine.

Effects of limonene, salvia miltiorrhiza and turmeric derivatives on H-ras oncogene expression and gap junction intercellular communication in human solid tumor cell lines

Xiaoguang Chen, Hasuma Taday oshi, Yano Yoshihisa, 1998 .

Discovery of novel indirubin-3'-monoxime derivatives as potent inhibitors against CDK2 and CDK9.

Lei Yan, Fang-fang Lai, Xiaoguang Chen, 2015, Bioorganic & medicinal chemistry letters.

The retinoid X receptor-selective ligand, LGD1069, inhibits tumor-induced angiogenesis via suppression of VEGF in human non-small cell lung cancer.

Yan Ding, Dan Huang, Xiaoguang Chen, 2007, Cancer letters.

Synthesis and biological evaluation of pyrimidine derivatives as novel human Pin1 inhibitors.

Xiaoguang Chen, Jing Jin, R. Cao, 2018, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of novel human Pin1 inhibitors with benzophenone skeleton.

Jie Zhou, Xiaoguang Chen, Chang Liu, 2012, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of novel quinazoline-derived human Pin1 inhibitors.

Yan-shen Guo, Xiaoguang Chen, Chang Liu, 2011, Bioorganic & medicinal chemistry.

Design, synthesis and in vitro antitumor evaluation of novel diaryl urea derivatives bearing sulfonamide moiety

Y. Li, Xiaoguang Chen, Ke Tang, 2013, Science China Chemistry.

Function of Aurora kinase A in Taxol-resistant breast cancer and its correlation with P-gp.

Y. Li, Xiaoguang Chen, Ke Tang, 2011, Molecular medicine reports.

The effect of Aurora kinases on cell proliferation, cell cycle regulation and metastasis in renal cell carcinoma.

Bin Tean Teh, Yan Li, Xiaoguang Chen, 2012, International journal of oncology.

Silencing Aurora A leads to re-sensitization of breast cancer cells to Taxol through downregulation of SRC-mediated ERK and mTOR pathways

Y. Li, Jindong Chen, Xiaoguang Chen, 2017, Oncology reports.

Skimmin, a coumarin, suppresses the streptozotocin-induced diabetic nephropathy in wistar rats.

Y. Li, Sen Zhang, Xiaoguang Chen, 2012, European journal of pharmacology.

Identification and Structure-Activity Relationship (SAR) of potent and selective oxadiazole-based agonists of sphingosine-1-phosphate receptor (S1P1).

Wenqiang Jia, Xiaojian Wang, Xiaoguang Chen, 2019, Bioorganic chemistry.

Oral SMEDDS promotes lymphatic transport and mesenteric lymph nodes target of chlorogenic acid for effective T-cell antitumor immunity

Y. Li, Yan-fang Yang, Xiaoguang Chen, 2021, Journal for ImmunoTherapy of Cancer.

(–)Gossypol and its combination with imatinib induce apoptosis in human chronic myeloid leukemic cells

Y. Li, Xiaoguang Chen, Hongyan Li, 2007, Leukemia & lymphoma.

Drug-free mannosylated liposomes inhibit tumor growth by promoting the polarization of tumor-associated macrophages

Yan-fang Yang, Yingying Meng, Xiaoguang Chen, 2019, International journal of nanomedicine.

Nicousamide normalizes renovascular hypertension in two-kidney one-clip hypertensive rats.

Y. Li, Sen Zhang, Xiaoguang Chen, 2013, Biomedical reports.

A high-resolution method to assess cell multinucleation with cytoplasm-localized fluorescent probes.

X. Zhang, Q. Cui, Fang-fang Lai, 2016, The Analyst.

4,5,6,7-Tetrahydro-[1,2,3]triazolo[1,5-a]pyrazine as a new scaffold for heat shock protein 90 inhibitors

Xiaoguang Chen, Wei Li, Nina Xue, 2016 .

Synthesis and antiproliferative evaluation of novel benzoimidazole-contained oxazole-bridged analogs of combretastatin A-4.

Xiaoguang Chen, Jing Jin, Jie-Xing Zhou, 2013, European journal of medicinal chemistry.

Total Coumarins from Hydrangea paniculata Show Renal Protective Effects in Lipopolysaccharide-Induced Acute Kidney Injury via Anti-inflammatory and Antioxidant Activities

Sen Zhang, Xiaoguang Chen, Dongming Zhang, 2017, Front. Pharmacol..

CAT3, a novel agent for medulloblastoma and glioblastoma treatment, inhibits tumor growth by disrupting the Hedgehog signaling pathway.

C. Li, Y. Li, Qin Zhou, 2016, Cancer letters.

Ferroptosis: An emerging therapeutic opportunity for cancer

Chunhong Yan, Xiaoguang Chen, Li-yuan Wang, 2020, Genes & diseases.

Validating a Selective S1P1 Receptor Modulator Syl930 for Psoriasis Treatment.

Sen Zhang, Fang-fang Lai, Xiaoguang Chen, 2018, Biological & pharmaceutical bulletin.

Total coumarin derivates from Hydrangea paniculata attenuate renal injuries in cationized-BSA induced membranous nephropathy by inhibiting complement activation and interleukin 10-mediated interstitial fibrosis.

Weida Wang, Xiaoguang Chen, Dongming Zhang, 2021, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Prediction Value of Serum NGAL in the Diagnosis and Prognosis of Experimental Acute and Chronic Kidney Injuries

Sen Zhang, Weida Wang, Xiaoguang Chen, 2020, Biomolecules.

Nicousamide protects kidney podocyte by inhibiting the TGFβ receptor II phosphorylation and AGE-RAGE signaling.

Sen Zhang, Fang-fang Lai, Xiaoguang Chen, 2017, American journal of translational research.

XLF-III-43, a novel coumarin-aspirin compound, prevents diabetic nephropathy in rats via inhibiting advanced glycation end products.

Xuguang Zheng, Xiaoguang Chen, Hongbo Wang, 2010, European journal of pharmacology.

Development of 3-alkyl-6-methoxy-7-hydroxy-chromones (AMHCs) from natural isoflavones, a new class of fluorescent scaffolds for biological imaging.

G. F. Ruda, Fang-fang Lai, Xiaoguang Chen, 2015, Chemical communications.

Discovery of 1-substituted benzyl-quinazoline-2,4(1H,3H)-dione derivatives as novel poly(ADP-ribose)polymerase-1 inhibitors.

Xiaoguang Chen, R. Cao, Jie-Xing Zhou, 2015, Bioorganic & medicinal chemistry.

Development and validation of high-throughput screening assays for poly(ADP-ribose) polymerase-2 inhibitors.

Xiaoguang Chen, Nina Xue, Jing Jin, 2014, Analytical biochemistry.

A novel orally active microtubule destabilizing agent S-40 targets the colchicine-binding site and shows potent antitumor activity.

T. Du, Qinghua Wang, Xiaoguang Chen, 2020, Cancer letters.

Efficient synthesis and cytotoxicity of novel microtubule-stabilizing agent ceratamine A analogues

Xiaoguang Chen, Zhanzhu Liu, M. Ji, 2017 .

A novel PI3K inhibitor XH30 suppresses orthotopic glioblastoma and brain metastasis in mice models

Xiaoguang Chen, Jing Jin, M. Ji, 2021, Acta pharmaceutica Sinica. B.

Discovery of oxazole and triazole derivatives as potent and selective S1P(1) agonists through pharmacophore-guided design.

Xiaojian Wang, Qiong Xiao, Xiaoguang Chen, 2014, European journal of medicinal chemistry.

Ultrasound-promoted specific chiroptical sensing of cysteine in aqueous solution and cells

T. Du, Xiaoguang Chen, Bei-bei Yang, 2020 .

Discovery of novel quinazoline-2,4(1H,3H)-dione derivatives as potent PARP-2 selective inhibitors.

Fang-fang Lai, Xiaoguang Chen, Jie-Xing Zhou, 2017, Bioorganic & medicinal chemistry.

Analysis of intracellular nucleoside triphosphate levels in normal and tumor cell lines by high-performance liquid chromatography.

Dan Huang, Xiaoguang Chen, Yazhuo Zhang, 2003, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

A novel S1P1 modulator IMMH002 ameliorates psoriasis in multiple animal models

Xiaojian Wang, Qiong Xiao, Yuan-Fei Liu, 2019, Acta pharmaceutica Sinica. B.

Synthesis and cytotoxicity of a novel series of saframycin-ecteinascidin analogs containing tetrahydro-β-carboline moieties.

Xiaoguang Chen, Zhiyan Xiao, Zhanzhu Liu, 2017, European journal of medicinal chemistry.

Hypoglycemia following the use of glucagon-like peptide-1 receptor agonists: a real-world analysis of post-marketing surveillance data

Xiaoguang Chen, Huijuan Zhu, Zhengyi Zhao, 2021, Annals of translational medicine.

A Morphological identification cell cytotoxicity assay using cytoplasm-localized fluorescent probe (CLFP) to distinguish living and dead cells.

Fang-fang Lai, Xiaoguang Chen, Hui Wen, 2017, Biochemical and biophysical research communications.

Syl611, a novel semisynthetic taxane derivative, reverses multidrug resistance by p-glycoprotein inhibition and facilitating inward transmembrane action

R. Qu, Y. Li, Xiaoguang Chen, 2010, Cancer Chemotherapy and Pharmacology.

Synthesis and biological evaluation of taxinine analogues as orally active multidrug resistance reversal agents in cancer.

Xiaoguang Chen, D. Yin, Xin Zhao, 2004, Bioorganic & medicinal chemistry letters.

Skimmin, a Coumarin from Hydrangea paniculata, Slows down the Progression of Membranous Glomerulonephritis by Anti-Inflammatory Effects and Inhibiting Immune Complex Deposition

Y. Li, Sen Zhang, Xiaoguang Chen, 2013, Evidence-based complementary and alternative medicine : eCAM.

Novel nitric oxide-releasing derivatives of pyranocarbazole as antitumor agents: Design, synthesis, biological evaluation, and nitric oxide release studies.

Fang-fang Lai, Xiaoguang Chen, Dongming Zhang, 2022, European journal of medicinal chemistry.

Novel nitric oxide-releasing derivatives of triptolide as antitumor and anti-inflammatory agents: Design, synthesis, biological evaluation, and nitric oxide release studies.

Fang-fang Lai, Xiaoguang Chen, Ke Liu, 2020, European journal of medicinal chemistry.

Activity of the potent dual Abl/Src tyrosine kinase inhibitor FB2 against Bcr-Abl positive cell lines in vitro and in vivo.

Xiangyan Li, Xiaoguang Chen, Zhiqiang Feng, 2011, Leukemia research.

Activity of FB2, a novel dual Abl/Src tyrosine kinase inhibitor, against imatinib-resistant chronic myeloid leukemia in vivo and in vitro

Hongbo Wang, Sen Zhang, Xiaoguang Chen, 2009, Leukemia & lymphoma.

The novel anti-neuroblastoma agent PF403, inhibits proliferation and invasion in vitro and in brain xenografts.

C. Li, Y. Li, Shaowu Li, 2015, International journal of oncology.

Design and Optimization of Thienopyrimidine Derivatives as Potent and Selective PI3Kδ Inhibitors for the Treatment of B-Cell Malignancies.

Xiaoguang Chen, Jing Jin, Deyu Wu, 2022, Journal of medicinal chemistry.

Discovery of Benzocyclic Sulfone Derivatives as Potent CXCR2 Antagonists for Cancer Immunotherapy.

W. Ye, Xiaoguang Chen, Yan Li, 2021, Journal of medicinal chemistry.

Rational design, synthesis, and biological evaluation of novel C6-modified geldanamycin derivatives as potent Hsp90 inhibitors and anti-tumor agents

Xiaoguang Chen, Nina Xue, Xiaoming Yu, 2022, Chinese Chemical Letters.

Lx2-32c, a novel taxane and its antitumor activities in vitro and in vivo.

Xiaoguang Chen, Hongbo Wang, Hongyan Li, 2008, Cancer letters.

Nicousamide blocks the effects of advanced glycation end products on renal cells.

Xuguang Zheng, Xiaoguang Chen, Hongbo Wang, 2012, European journal of pharmacology.

Discovery of 2-substituted 1H-benzo[d]immidazole-4-carboxamide derivatives as novel poly(ADP-ribose)polymerase-1 inhibitors with in vivo anti-tumor activity.

Xiaoguang Chen, R. Cao, Jie-Xing Zhou, 2017, European journal of medicinal chemistry.

A Novel PARP Inhibitor YHP-836 For the Treatment of BRCA-Deficiency Cancers

Jie Zhou, T. Du, Xiaoguang Chen, 2022, Frontiers in Pharmacology.

Discovery of Quinazoline-2,4(1H,3H)-dione Derivatives Containing 3-Substituted Piperizines as Potent PARP-1/2 Inhibitors─Design, Synthesis, In Vivo Antitumor Activity, and X-ray Crystal Structure Analysis.

Xiaoguang Chen, Yan Li, L. Sheng, 2021, Journal of medicinal chemistry.

Bioactive sesquiterpenoids from the roots of Artabotrys hexapetalus

Fengmin Xi, Xiaoguang Chen, Yu-huan Li, 2017 .

Chlorogenic Acid Prevents UVA-Induced Skin Photoaging through Regulating Collagen Metabolism and Apoptosis in Human Dermal Fibroblasts

Xiaoguang Chen, Nina Xue, Jing Jin, 2022, International journal of molecular sciences.

Lx2-32c, a novel taxane derivative, exerts anti-resistance activity by initiating intrinsic apoptosis pathway in vitro and inhibits the growth of resistant tumor in vivo.

Y. Li, Xiaoguang Chen, Jing Jin, 2012, Biological & pharmaceutical bulletin.

Somatostatin receptor ligands suppressed proliferation and lipogenesis in 3T3‐L1 preadipocytes

F. Gong, Xiaoguang Chen, Huijuan Zhu, 2022, Basic & clinical pharmacology & toxicology.

Fragilolides A-Q, norditerpenoid and briarane diterpenoids from the gorgonian coral Junceella fragilis

Wenhan Lin, Xiaoguang Chen, Siwang Yu, 2017 .

Extracellular HSP90α-LRP1 Signaling Promote Pancreatic Cancer Metastasis and Chemoresistance Via Regulating Epithelial-To-Mesenchymal Transition

T. Du, Xiaoguang Chen, Nina Xue, 2021 .

Chaperone-mediated autophagy degradation of IGF-1Rβ induced by NVP-AUY922 in pancreatic cancer

T. Du, Chunhong Yan, Sen Zhang, 2019, Cellular and Molecular Life Sciences.

FLZ inhibited γ-secretase selectively and decreased Aβ mitochondrial production in APP-SH-SY5Y cells

Xiaoguang Chen, X. Bao, Dan Zhang, 2013, Naunyn-Schmiedeberg's Archives of Pharmacology.

Synthesis and cytotoxicities of icogenin analogues with disaccharide residues.

P. Lei, Xiaoguang Chen, Fu-qin Su, 2009, Bioorganic & medicinal chemistry letters.

Chlorogenic Acid Relieves the Lupus Erythematosus-like Skin Lesions and Arthritis in MRL/lpr Mice

X. Yang, Xiaoguang Chen, Mengyao Hao, 2022, Pharmaceuticals.

Urinary biomarker evaluation for early detection of gentamycin-induced acute kidney injury.

Xiaobing Zhou, Xiaoguang Chen, Yanwei Yang, 2019, Toxicology letters.

S1PR1 serves as a viable drug target against pulmonary fibrosis by increasing the integrity of the endothelial barrier of the lung

Bai Liping, Xiaoguang Chen, Nina Xue, 2022, Acta pharmaceutica Sinica. B.

Design, Synthesis and Biological Evaluation of Phenyl Urea Derivatives as IDO1 Inhibitors

Chuan Zhou, Xiaoguang Chen, Yan Li, 2020, Molecules.

Chiral resolution, absolute configuration determination, and stereo-activity relationship study of IDO1 inhibitor NLG919

Li Li, Xiaoguang Chen, Yan Li, 2018, Tetrahedron.

Yaoshanenolides A and B: new spirolactones from the bark of Machilus yaoshansis.

Y. Liu, Sheng Lin, Jiachen Zi, 2012, Organic letters.

Renal-protective effect of nicousamide on hypertensive nephropathy in spontaneously hypertensive rats.

Xuguang Zheng, Y. Li, Sen Zhang, 2013, Biomedical reports.

Optimization of Benzamide Derivatives as Potent and Orally Active Tubulin Inhibitors Targeting the Colchicine Binding Site.

Tingting Du, Xiaoguang Chen, Yan Li, 2022, Journal of medicinal chemistry.

Chemical constituents of the bark of Machilus wangchiana and their biological activities.

Wei Cheng, Xiaoguang Chen, Xiaona Fan, 2009, Journal of natural products.

Microbial transformations of taxadienes and the multi-drug resistant tumor reversal activities of the metabolites

Xiaoguang Chen, D. Xie, Jian-hua Zou, 2012 .

A furantaxane with an unusual 6/8/6/5 ring system and potent tumor MDR reversal activity obtained via microbial transformation.

Xiaoguang Chen, D. Xie, Jian-hua Zou, 2012, Organic letters.

Pentacyclic triterpenoids from leaves of Excoecaria agallocha.

Xiaoguang Chen, Jian-hua Zou, J. Dai, 2006, Chemical & pharmaceutical bulletin.

Microbial transformation of cephalomannine by Luteibacter sp.

Xiaoguang Chen, J. Dai, P. Zhu, 2007, Journal of natural products.

Anti-tumor activity of a 3-oxo derivative of oleanolic acid.

Y. Li, Yan Ding, Dan Huang, 2006, Cancer letters.

Cytotoxic dimeric xanthanolides from fruits of Xanthium chinense.

Xiaoguang Chen, Shuang-Gang Ma, Shishan Yu, 2016, Phytochemistry.

Discovery of quinazoline-2,4(1H,3H)-dione derivatives as novel PARP-1/2 inhibitors: design, synthesis and their antitumor activity.

Xiaoguang Chen, R. Cao, Jie-Xing Zhou, 2018, Organic & biomolecular chemistry.

Synthesis and Pin1 inhibitory activity of thiazole derivatives.

Xiaoguang Chen, Jing Jin, Bailing Xu, 2016, Bioorganic & medicinal chemistry.

Phelligridins C-F: cytotoxic pyrano[4,3-c][2]benzopyran-1,6-dione and furo[3,2-c]pyran-4-one derivatives from the fungus Phellinus igniarius.

Guang-xiong Zhou, Xiaoguang Chen, S. Mo, 2004, Journal of natural products.

Enantiopure Simple Analogues of Annonaceous Acetogenins with Remarkable Selective Cytotoxicity Towards Tumor Cell Lines.

Xiaoguang Chen, Yu-lin Wu, Yikang Wu, 2000 .

Two New Aryltetralin Lignans from the Roots of Dolomiaea souliei

P. Xiao, Chunnian He, Yong Peng, 2012, Molecules.

Sesquiterpenes from Artemisia argyi: Absolute Configurations and Biological Activities†

Kewu Zeng, P. Tu, Yong Jiang, 2014 .

Cytotoxic oleanane triterpene saponins from Albizia chinensis.

Sen Zhang, Y. Pei, Xiaoguang Chen, 2009, Journal of natural products.

Cytotoxic oxygenated triterpenoid saponins from Symplocos chinensis.

Xiaoguang Chen, Shishan Yu, Guang-miao Fu, 2006, Journal of natural products.

Abietane and C20-norabietane diterpenes from the stem bark of Fraxinus sieboldiana and their biological activities.

Jiachen Zi, Xiaoguang Chen, Xiaona Fan, 2010, Journal of natural products.

Sesquiterpenes from Artemisia argyi: Absolute Configurations and Biological Activities.

Kewu Zeng, P. Tu, Yong Jiang, 2014 .

Chemical Constituents of the Roots of Euphorbia micractina.

Xiaoguang Chen, Xiaona Fan, Xiaoguang Chen, 2009, Journal of natural products.

Cucurbitane glucosides from the root of Machilus yaoshansis.

Sheng Lin, Jiachen Zi, Xiaoguang Chen, 2011, Journal of natural products.

Sphingosine-1-Phosphate Receptor Subtype 1 (S1P1) Modulator IMMH001 Regulates Adjuvant- and Collagen-Induced Arthritis

Xiaojian Wang, Qiong Xiao, Xiaoguang Chen, 2019, Front. Pharmacol..

Cytotoxic Triterpenoid Saponins from the Stems of Gordonia longicarpa

Xiaoguang Chen, Lei Yu, Dongming Zhang, 2013, Planta Medica.

Neolignans and sesquiterpenes from cell cultures of Stellera chamaejasme.

Xiaoguang Chen, Jian-hua Zou, J. Dai, 2012, Planta medica.

Highly acylated diterpenoids with a new 3,4-secograyanane skeleton from the flower buds of Rhododendron molle.

Sheng Lin, Xiaoguang Chen, Jianjun Zhang, 2010, Organic letters.

Carbazole alkaloids with bioactivities from the stems of Clausena lansium

N. Chen, Xiaoguang Chen, Dong‐ming Zhang, 2020 .

Psiguamers A–C, three cytotoxic meroterpenoids bearing a methylated benzoylphloroglucinol framework from Psidium guajava and total synthesis of 1 and 2

Xiaoguang Chen, Dongming Zhang, Chuang-jun Li, 2020 .

L-519, a phenolic compound, inhibits metabolism of benzo(a)pyrene and mutagenesis induced by benzo(a)pyrene

Xiaoguang Chen, R. Han, Z. Fu, 1995 .

Bioactive 18(4 → 3)-abeo-abietanoid derivatives from the leaves of Tripterygium wilfordii

Xiaoguang Chen, Li Li, Dong‐ming Zhang, 2015 .

Bistachybotrysins A-C, three phenylspirodrimane dimers with cytotoxicity from Stachybotrys chartarum.

M. Zhang, Xiaoguang Chen, J. Dai, 2017, Bioorganic & medicinal chemistry letters.

Design, synthesis and evaluation of novel diaryl urea derivatives as potential antitumor agents.

Y. Li, P. Li, Xiaoguang Chen, 2014, European journal of medicinal chemistry.

Inhibition of gastric tumor growth by a novel Hsp90 inhibitor.

J. Buolamwini, Chunhong Yan, Hemantkumar S. Deokar, 2013, Biochemical pharmacology.

Synthesis and structure-activity relationships of sinenxan A derivatives as multidrug resistance reversal agents.

Meng Huang, Xiaoguang Chen, D. Yin, 2010, Bioorganic & medicinal chemistry letters.

Synthesis of cholestane saponins as mimics of OSW-1 and their cytotoxic activities.

P. Lei, Xiaoguang Chen, Yanpeng Xu, 2011, Bioorganic & medicinal chemistry letters.

ATF3 promotes erastin-induced ferroptosis by suppressing system Xc–

T. Du, H. Ding, Junran Zhang, 2019, Cell Death & Differentiation.

Characterization of Chlorogenic Acid as a Two-Photon Fluorogenic Probe that Regulates Glycolysis in Tumor Cells under Hypoxia.

T. Du, Jian-Dong Jiang, Qingyang Zhang, 2023, Journal of medicinal chemistry.

Growth inhibition and differentiation induced by peroxisome proliferator activated receptor gamma ligand rosiglitazone in human melanoma cell line A375

Y. Li, Xiaoguang Chen, Hongyan Li, 2006, Medical oncology.

Stachybotrysins A-G, Phenylspirodrimane Derivatives from the Fungus Stachybotrys chartarum.

Liyan Yu, Jian-yuan Zhao, Xiaoguang Chen, 2017, Journal of natural products.

Isolation and structural elucidation of bioactive obovatol dimeric neolignans from the bark of Magnolia officinalis var. biloba.

Xiaoguang Chen, Dongming Zhang, Chuang-jun Li, 2021, Phytochemistry.

Chlorogenic acid inhibits glioblastoma growth through repolarizating macrophage from M2 to M1 phenotype

Qin Zhou, Jing Jia, Wenbin Li, 2017, Scientific Reports.

Long non-coding RNAs: From disease code to drug role

Sen Zhang, Xiaoguang Chen, Yuanyuan Chen, 2020, Acta pharmaceutica Sinica. B.

A novel PI3K/mTOR dual inhibitor XH002 exhibited robust antitumor activity in NSCLC

T. Du, Xiaoguang Chen, Nina Xue, 2018, Journal of drug targeting.

ATF3 promotes the serine synthesis pathway and tumor growth under dietary serine restriction

H. Ding, Junran Zhang, Chunhong Yan, 2021, Cell reports.

Discovery and Optimization of 2-Amino-4-methylquinazoline Derivatives as Highly Potent Phosphatidylinositol 3-Kinase Inhibitors for Cancer Treatment.

Xiaoguang Chen, Yan Li, L. Sheng, 2018, Journal of medicinal chemistry.

Discovery of new thienopyrimidine derivatives as potent and orally efficacious phosphoinositide 3-kinase inhibitors.

Xiaoguang Chen, Yan Li, L. Sheng, 2017, Bioorganic & medicinal chemistry.

Simultaneous Determination of a Novel PD-L1 Inhibitor, IMMH-010, and Its Active Metabolite, YPD-29B, in Rat Biological Matrices by Polarity-Switching Liquid Chromatography-Tandem Mass Spectrometry: Application to ADME Studies

Xiaoguang Chen, Yuke Liu, Yan Li, 2021, Frontiers in Pharmacology.

Discovery of 4-Methyl Quinazoline Based PI3K Inhibitors for the Potential Treatment of Idiopathic Pulmonary Fibrosis.

T. Du, Xiaoguang Chen, Yan Li, 2019, Journal of Medicinal Chemistry.

Bt354 as a new STAT3 signaling pathway inhibitor against triple negative breast cancer

S. Zhang, Yue Chen, Xiaoguang Chen, 2018, Journal of drug targeting.

Discovery of new thieno[2,3-d]pyrimidine and thiazolo[5,4-d]pyrimidine derivatives as orally active phosphoinositide 3-kinase inhibitors.

Xiaoguang Chen, Yan Li, L. Sheng, 2020, Bioorganic & medicinal chemistry.

Design, Synthesis, and Biological Evaluation of 4-Methyl Quinazoline Derivatives as Anticancer Agents Simultaneously Targeting Phosphoinositide 3-Kinases and Histone Deacetylases.

Xiaoguang Chen, Yan Li, L. Sheng, 2019, Journal of medicinal chemistry.

Design, synthesis and biological evaluation of indole-2-carboxylic acid derivatives as IDO1/TDO dual inhibitors.

Xiaoguang Chen, Bailing Xu, Xiaoyu Wang, 2019, European journal of medicinal chemistry.

Development of a selective S1P1 receptor agonist, Syl930, as a potential therapeutic agent for autoimmune encephalitis.

Xiaojian Wang, Qiong Xiao, Xiaoguang Chen, 2014, Biochemical pharmacology.

Poly (ADP-ribose) polymerases inhibitor, Zj6413, as a potential therapeutic agent against breast cancer.

Qin Zhou, Xiaoguang Chen, Nina Xue, 2016, Biochemical pharmacology.

Design, synthesis and docking-based 3D-QSAR study of novel 2-substituted 2-aminopropane-1,3-diols as potent and selective agonists of sphingosine-1-phosphate 1 (S1P1) receptor

Xiaojian Wang, Qiong Xiao, Xiaoguang Chen, 2013 .

Chaperone-mediated autophagy degradation of IGF-1Rβ induced by NVP-AUY922 in pancreatic cancer

T. Du, Chunhong Yan, Sen Zhang, 2019, Cellular and Molecular Life Sciences.

The molecular mechanisms of a novel multi-kinase inhibitor ZLJ33 in suppressing pancreatic cancer growth.

C. Li, Y. Li, Xiaoguang Chen, 2015, Cancer letters.

Xiaoguang Chen, Huijuan Zhu, Zhengyi Zhao, 2021, Frontiers in Oncology.

The PI3K Inhibitor XH30 Enhances Response to Temozolomide in Drug-Resistant Glioblastoma via the Noncanonical Hedgehog Signaling Pathway

Xiaoguang Chen, Nina Xue, Jing Jin, 2021, Frontiers in Pharmacology.

Competitive ubiquitination activates the tumor suppressor p53

T. Du, H. Ding, Junran Zhang, 2019, Cell Death & Differentiation.

Induction of Apoptosis by Icariside II through Extrinsic and Intrinsic Signaling Pathways in Human Breast Cancer MCF7 Cells

P. Xiao, T. Shen, Xiaoguang Chen, 2012, Bioscience, biotechnology, and biochemistry.

Design, Synthesis, and Biological Evaluation of Amidobenzimidazole Derivatives as Stimulator of Interferon Genes (STING) Receptor Agonists.

Wenqiang Jia, Xiaojian Wang, Xiaoguang Chen, 2019, Journal of medicinal chemistry.

Nicousamide, a potent inhibitor of phosphorylation by TGF-β receptor II

Y. Li, Sen Zhang, Xiaoguang Chen, 2011 .

Specific methylation and epoxidation of sinenxan A by Mucor genevensis and the multi-drug resistant tumor reversal activities of the metabolites

R. Qu, Xiaoguang Chen, J. Dai, 2007 .

YPD-30, a prodrug of YPD-29B, is an oral small-molecule inhibitor targeting PD-L1 for the treatment of human cancer

T. Du, Yunchen Wang, Xiaoguang Chen, 2022, Acta pharmaceutica Sinica. B.

Bt354 as a new STAT3 signaling pathway inhibitor against triple negative breast cancer

S. Zhang, Yue Chen, Xiaoguang Chen, 2018, Journal of drug targeting.

Virtual Calibration Quantitative Mass Spectrometry Imaging for Accurately Mapping Analytes across Heterogenous Biotissue.

C. Li, Y. Li, Ruiping Zhang, 2019, Analytical chemistry.

Variable p53/Nrf2 crosstalk contributes to triptolide-induced hepatotoxic process.

T. Du, Wenqun Li, Weida Wang, 2023, Toxicology letters.

Structural diversification of taxanes by whole-cell biotransformation

R. Qu, Xiaoguang Chen, Jian-hua Zou, 2008 .

Biotransformation and tumor multidrug resistance reversal potency of polyoxygenated taxadienes

Xiaoguang Chen, Jian-hua Zou, J. Dai, 2008 .

Synthesis and Biological Evaluation of New 4‐Deacety‐1,7,9‐trideoxy‐10‐oxopaclitaxel via Sinenxan A

Xiaoguang Chen, D. Yin, Yan Li, 2007 .

Biotransformation of a taxadiene by ginkgo cell cultures and the tumor multi-drug resistant reversal activities of the metabolites.

Xiaoguang Chen, D. Xie, Jian-hua Zou, 2011, Chemical & pharmaceutical bulletin.

Construction of chlorogenic acid-containing liposomes with prolonged antitumor immunity based on T cell regulation

Yan-fang Yang, Yingying Meng, Xiaoguang Chen, 2020, Science China Life Sciences.

Depleting MEKK1 expression inhibits the ability of invasion and migration of human pancreatic cancer cells

Xiaoguang Chen, Hongyan Li, B. Jia, 2009, Journal of Cancer Research and Clinical Oncology.

XLN306 induces apoptosis in human breast carcinoma MX-1 cells

Y. Li, Xiaoguang Chen, Jing Jin, 2011 .

CAT3, a prodrug of 13a(S)-3-hydroxyl-6,7-dimethoxyphenanthro[9,10-b]-indolizidine, circumvents temozolomide-resistant glioblastoma via the Hedgehog signaling pathway, independently of O6-methylguanine DNA methyltransferase expression

Xiaoguang Chen, Nina Xue, Jing Jin, 2018, OncoTargets and therapy.

The Development of a Biotinylated NAD+-Applied Human Poly(ADP-Ribose) Polymerase 3 (PARP3) Enzymatic Assay

Sen Zhang, Xiaoguang Chen, Nina Xue, 2018, SLAS discovery : advancing life sciences R & D.

S-72, a Novel Orally Available Tubulin Inhibitor, Overcomes Paclitaxel Resistance via Inactivation of the STING Pathway in Breast Cancer

T. Du, Weida Wang, Xiaoguang Chen, 2023, Pharmaceuticals.

SHMT2 Promotes Gastric Cancer Development through Regulation of HIF1α/VEGF/STAT3 Signaling

T. Du, Sen Zhang, Weida Wang, 2023, International journal of molecular sciences.

Design, Synthesis, and Biological Evaluation of a Novel Photocaged PI3K Inhibitor toward Precise Cancer Treatment.

Xiaoguang Chen, Yan Y. Zhang, M. Ji, 2021, Journal of medicinal chemistry.

Identification of 3, 4-disubstituted pyridine derivatives as novel CDK8 inhibitors.

K. Lee, Xiaoguang Chen, Zhiyan Xiao, 2021, European journal of medicinal chemistry.

Cryptotanshinone inhibits esophageal squamous-cell carcinoma in vitro and in vivo through the suppression of STAT3 activation

T. Du, Chunhong Yan, Yubin Ji, 2019, OncoTargets and therapy.

Identification ACTA2 and KDR as key proteins for prognosis of PD‐1/PD‐L1 blockade therapy in melanoma

Xiaoguang Chen, Yuchen Wang, Z. Li, 2020, Animal models and experimental medicine.

A Dual PI3K/HDAC Inhibitor Downregulates Oncogenic Pathways in Hematologic Tumors In Vitro and In Vivo

Xiaoguang Chen, M. Ji, Zheng Yan, 2021, Frontiers in Pharmacology.

Pathophysiology and system biology of rat c-BSA induced immune complex glomerulonephritis and pathway comparison with human gene sequencing data.

Sen Zhang, Xiaoguang Chen, Xiaodi Zhao, 2022, International immunopharmacology.

A New 2α,5α,10β,14β-tetraacetoxy-4(20),11-taxadiene (SIA) Derivative Overcomes Paclitaxel Resistance by Inhibiting MAPK Signaling and Increasing Paclitaxel Accumulation in Breast Cancer Cells

Feng You, Y. Li, Xiaoguang Chen, 2014, PloS one.

caT 3 , a prodrug of 13a(s)-3-hydroxyl-6,7-dimethoxyphenanthro[9,10-b]-indolizidine, circumvents temozolomide-resistant glioblastoma via the hedgehog signaling pathway, independently of O 6 -methylguanine Dna methyltransferase expression

Xiaoguang Chen, Nina Xue, Jing Jin, 2018 .

Chagosendines A – C, New Metal Complexes of Imidazole Alkaloids from the Calcareous Sponge Leucetta chagosensis

Wei Cheng, Wenhan Lin, N. D. de Voogd, 2018, Chemistry & biodiversity.

Metabolism and Interspecies Variation of IMMH-010, a Programmed Cell Death Ligand 1 Inhibitor Prodrug

L. Luo, Xiaoguang Chen, Yuke Liu, 2021, Pharmaceutics.

Nicousamide attenuates renal dysfunction and glomerular injury in remnant kidneys by inhibiting TGF‐&bgr;1 internalisation and renin activity

C. Xiaoguang, Y. Li, Xiaoguang Chen, 2019, European journal of pharmacology.

Development of 3-alkyl-6-methoxy-7-hydroxy-chromones (AMHCs) from natural isoflavones, a new class of fluorescent scaffolds for biological imaging.

G. F. Ruda, Xiaoguang Chen, Hui Wen, 2015, Chemical communications.

The pseudoginsenoside F11 ameliorates cisplatin-induced nephrotoxicity without compromising its anti-tumor activity in vivo

Jingwei Tian, F. Fu, Xiaoguang Chen, 2014, Scientific Reports.

Validating a Selective S1P1 Receptor Modulator Syl930 for Psoriasis Treatment.

Sen Zhang, Xiaoguang Chen, Yuchen Wang, 2018, Biological & pharmaceutical bulletin.

The effect of Aurora kinases on cell proliferation, cell cycle regulation and metastasis in renal cell carcinoma.

B. Teh, Y. Li, Xiaoguang Chen, 2012, International journal of oncology.

7-hydroxycoumarin-β-D-glucuronide protects against cisplatin-induced acute kidney injury via inhibiting p38MAPK-mediated apoptosis in mice.

Xiaodi Zhao, Clarence T T Wong, Sen Zhang, 2023, Life sciences.

The molecular mechanisms of a novel multi-kinase inhibitor ZLJ33 in suppressing pancreatic cancer growth.

C. Li, Y. Li, Xiaoguang Chen, 2015, Cancer letters.

Discovery of a Novel Photocaged PI3K Inhibitor Capable of Real-Time Reporting of Drug Release.

Y. Li, T. Du, Xiaoguang Chen, 2023, ACS medicinal chemistry letters.

Total Synthesis of (10R)- and (10S)-Corossolin: Determination of the Stereochemistry at C-10 of the Natural Corossolin and the Differential Toxicity toward Cancer Cells Caused by the Configuration at C-10

Z. Yao, Xiaoguang Chen, Yu‐lin Wu, 1999 .

Simultaneous determination of skimmin, apiosylskimmin, 7-hydroxycoumarin and 7-hydroxycoumarin glucuronide in rat plasma by liquid chromatography-Orbitrap mass spectrometry and its application to pharmacokinetics.

Sen Zhang, L. Luo, Xiaoguang Chen, 2021, Biomedical chromatography : BMC.