Zhiyan Xiao

发表

Identification of potential indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitors by an FBG-based 3D QSAR pharmacophore model.

Lu Zhang, Fang-fang Lai, Xiaoguang Chen, 2020, Journal of molecular graphics & modelling.

Design, synthesis and biological evaluation of novel indolin-2-ones as potent anticancer compounds.

K. Lee, Lei Yan, Fang-fang Lai, 2017, Bioorganic & medicinal chemistry letters.

Identification of natural products as selective PTP1B inhibitors via virtual screening.

Zhiyan Xiao, Ying Yang, Jinlong Tian, 2020, Bioorganic chemistry.

Discovery of novel indirubin-3'-monoxime derivatives as potent inhibitors against CDK2 and CDK9.

Lei Yan, Fang-fang Lai, Xiaoguang Chen, 2015, Bioorganic & medicinal chemistry letters.

Discovery of novel 5-fluoro-N2,N4-diphenylpyrimidine-2,4-diamines as potent inhibitors against CDK2 and CDK9.

Li Huang, Chin-Ho Chen, K. Lee, 2015, MedChemComm.

Lignans in treatment of cancer and other diseases†

K. Lee, Zhiyan Xiao, 2004, Phytochemistry Reviews.

Design, synthesis and biological evaluation of dipeptides as novel non-covalent 20S proteasome inhibitors

Fang-fang Lai, Zhiyan Xiao, Xiao-guang Chen, 2021, Journal of Asian natural products research.

Podophyllotoxins and analogs

K. Lee, Zhiyan Xiao, 2005 .

5 Podophyllotoxins and Analogs 1

K. Lee, Zhiyan Xiao, 2005 .

SAR study on N2,N4-disubstituted pyrimidine-2,4-diamines as effective CDK2/CDK9 inhibitors and antiproliferative agents

K. Lee, Zhiyan Xiao, M. Goto, 2018, RSC advances.

Design and synthesis of naphthoquinone derivatives as antiproliferative agents and 20S proteasome inhibitors.

Li Huang, Chin-Ho Chen, K. Lee, 2012, Bioorganic & medicinal chemistry letters.

Discovery of novel CDK inhibitors via scaffold hopping from CAN508.

Zhiyan Xiao, Yan-bo Tang, Liandong Jing, 2018, Bioorganic & medicinal chemistry letters.

Discovery of novel non-covalent inhibitors selective to the β5-subunit of the human 20S proteasome.

Li Huang, Chin-Ho Chen, Zhiyan Xiao, 2015, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of triaryl compounds as novel 20S proteasome inhibitors.

Fang-fang Lai, Zhiyan Xiao, B. Wu, 2020, Bioorganic & medicinal chemistry letters.

Two Novel Fungal Phenolic UDP Glycosyltransferases from Absidia coerulea and Rhizopus japonicus

Zhiyan Xiao, Ri-dao Chen, J. Dai, 2017, Applied and Environmental Microbiology.

Isolation, modification, and aldose reductase inhibitory activity of rosmarinic acid derivatives from the roots of Salvia grandifolia.

Quan Liu, Z. Shen, Zhiyan Xiao, 2016, Fitoterapia.

PTP1B inhibitor improves both insulin resistance and lipid abnormalities in vivo and in vitro

Yi-ming Ma, Xiao-lin Zhang, Zhiyan Xiao, 2011, Molecular and Cellular Biochemistry.

Carboxylic Acid-Promoted Single-Step Indole Construction from Simple Anilines and Ketones via Aerobic Cross-Dehydrogenative Coupling.

Zhiyan Xiao, Yongcheng Wang, Long Ren, 2018, The Journal of organic chemistry.

Synthesis and cytotoxicity of a novel series of saframycin-ecteinascidin analogs containing tetrahydro-β-carboline moieties.

Xiaoguang Chen, Zhiyan Xiao, Zhanzhu Liu, 2017, European journal of medicinal chemistry.

Integrated Approach to Identify Selective PTP1B Inhibitors Targeting the Allosteric Site

Lei Zhang, Ying Yang, Jinying Tian, 2021, J. Chem. Inf. Model..

Induction of cell cycle arrest by GL331 via triggering an ATM-dependent DNA damage response in HepG2 cells

Zhiyan Xiao, Xiao-guang Chen, Ya-jie Wang, 2012, Journal of Asian natural products research.

Design, synthesis and biological evaluation of a series of novel GPR40 agonists containing nitrogen heterocyclic rings.

Z. Shen, Yi Huan, Zhiyan Xiao, 2018, Bioorganic & medicinal chemistry letters.

Identification of Novel 4′-O-Demethyl-epipodophyllotoxin Derivatives as Antitumor Agents Targeting Topoisomerase II

Hua Sun, K. Lee, Zhiyan Xiao, 2022, Molecules.

Antitumor agents 222. Synthesis and anti-androgen activity of new diarylheptanoids.

Chawnshang Chang, K. Lee, Zhiyan Xiao, 2003, Bioorganic & medicinal chemistry.

Antitumor agents. 217. Curcumin analogues as novel androgen receptor antagonists with potential as anti-prostate cancer agents.

Chawnshang Chang, K. Lee, J. Ishida, 2002, Journal of medicinal chemistry.

Synthesis and biological relationships of 3',6-substituted 2-phenyl-4-quinolone-3-carboxylic acid derivatives as antimitotic agents.

S. Kuo, Li‐Jiau Huang, T. Yamori, 2005, Bioorganic & medicinal chemistry.

Discovery of novel andrographolide derivatives as cytotoxic agents.

K. Lee, H. Hua, Zhiyan Xiao, 2013, Bioorganic & medicinal chemistry letters.

Strategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates

Zhiyan Xiao, Susan L Morris-Natschke, Kuo-Hsiung Lee, 2016, Medicinal research reviews.

Discovery of novel 1,2,4-triazole derivatives as xanthine oxidoreductase inhibitors with hypouricemic effects.

Zhiyan Xiao, Jinying Tian, Xuechen Li, 2022, Bioorganic chemistry.

Identification of xanthine oxidase inhibitors through hierarchical virtual screening

Zhiyan Xiao, Ying Yang, F. Ye, 2020, RSC advances.

Antitumor agents. 234. Design, synthesis, and biological evaluation of novel 4beta-[(4' '-benzamido)-amino]-4'-o-demethyl-epipodophyllotoxin derivatives.

K. Lee, Zhiyan Xiao, K. Bastow, 2004, Journal of medicinal chemistry.

Design and synthesis of novel cytotoxic podophyllotoxin derivatives

Zhiyan Xiao, Wenying Xi, Hua Sun, 2010 .

Anti-AIDS agents. Part 61: Anti-HIV activity of new podophyllotoxin derivatives.

K. Lee, Zhiyan Xiao, L. Cosentino, 2004, Bioorganic & medicinal chemistry.

Antitumor Agents. Part 232. Synthesis of Cyclosulfite Podophyllotoxin Analogues as Novel Prototype Antitumor Agents.

K. Lee, Zhiyan Xiao, Shiqing Han, 2004 .

Antitumor agents. Part 227: Studies on novel 4'-O-demethyl-epipodophyllotoxins as antitumor agents targeting topoisomerase II.

K. Lee, Zhiyan Xiao, K. Bastow, 2004, Bioorganic & medicinal chemistry.

Antitumor agents. Part 235: Novel 4'-ester etoposide analogues as potent DNA topoisomerase II inhibitors with improved therapeutic potential.

A. Brossi, K. Lee, Zhiyan Xiao, 2004, Bioorganic & medicinal chemistry.

Antitumor agents. Part 232: Synthesis of cyclosulfite podophyllotoxin analogues as novel prototype antitumor agents.

K. Lee, Zhiyan Xiao, Shiqing Han, 2004, Bioorganic & medicinal chemistry letters.

Total Synthesis of Taxoids

K. Lee, Zhiyan Xiao, H. Itokawa, 2004 .

Investigation on the Enzymatic Profile of Mulberry Alkaloids by Enzymatic Study and Molecular Docking

Shuainan Liu, Quan Liu, Z. Shen, 2019, Molecules.

Identification of novel xanthine oxidase inhibitors via virtual screening with enhanced characterization of molybdopterin binding groups.

Lu Zhang, Zhiyan Xiao, Ying Yang, 2022, European journal of medicinal chemistry.

NPRL-Z-1, as a New Topoisomerase II Poison, Induces Cell Apoptosis and ROS Generation in Human Renal Carcinoma Cells

Szu-Ying Wu, C. Teng, S. Pan, 2014, PloS one.

QS‐ZYX‐1‐61 induces apoptosis through topoisomerase II in human non‐small‐cell lung cancer A549 cells

Qian Shi, Zhiyan Xiao, C. Teng, 2012, Cancer science.

Antitumor agents. Part 230: C4'-esters of GL-331 as cytotoxic agents and DNA topoisomerase II inhibitors.

K. Lee, Zhiyan Xiao, Shiqing Han, 2004, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of novel podophyllotoxin analogs.

Shipeng Zhang, K. Lee, H. Hua, 2012, Bioorganic & medicinal chemistry letters.

Antitumor agents. 213. Modeling of epipodophyllotoxin derivatives using variable selection k nearest neighbor QSAR method.

Alexander Golbraikh, Alexander Tropsha, Zhiyan Xiao, 2002, Journal of medicinal chemistry.

Modeling of p38 mitogen-activated protein kinase inhibitors using the Catalyst HypoGen and k-nearest neighbor QSAR methods.

Alexander Tropsha, Zhiyan Xiao, Yun-De Xiao, 2004, Journal of molecular graphics & modelling.

DNA damage and apoptosis induced by a potent orally podophyllotoxin derivative in breast cancer

Zhiyan Xiao, Gang Zhang, Ya-jie Wang, 2018, Cell Communication and Signaling.

XWL-1-48 exerts antitumor activity via targeting topoisomerase II and enhancing degradation of Mdm2 in human hepatocellular carcinoma

Zhiyan Xiao, Dan Zhang, Hua Sun, 2017, Scientific Reports.

Rational selection of training and test sets for the development of validated QSAR models

Alexander Golbraikh, Min Shen, Alexander Tropsha, 2003, J. Comput. Aided Mol. Des..

Receptor-based 3D-QSAR in Drug Design: Methods and Applications in Kinase Studies.

Cheng Fang, Zhiyan Xiao, Zhiyan Xiao, 2016, Current topics in medicinal chemistry.

XWL-1-48 exerts antitumor activity via targeting topoisomerase II and enhancing degradation of Mdm2 in human hepatocellular carcinoma

Zhiyan Xiao, Ya-jie Wang, Dan Zhang, 2017, Scientific Reports.

Generation and validation of the first predictive pharmacophore model for cyclin-dependent kinase 9 inhibitors.

Zhiyan Xiao, Cheng Fang, Zongru Guo, 2011, Journal of molecular graphics & modelling.

Identification of N, C-capped di- and tripeptides as selective immunoproteasome inhibitors.

Zhiyan Xiao, Ying Yang, Yun-xuan Li, 2022, European journal of medicinal chemistry.

Identification of 3, 4-disubstituted pyridine derivatives as novel CDK8 inhibitors.

K. Lee, Xiaoguang Chen, Zhiyan Xiao, 2021, European journal of medicinal chemistry.

Novel benzamido derivatives as PTP1B inhibitors with anti-hyperglycemic and lipid-lowering efficacy

Xiao-lin Zhang, Zhiyan Xiao, F. Ye, 2018, Acta pharmaceutica Sinica. B.

Design, synthesis and insulin-sensitising effects of novel PTP1B inhibitors.

Zhon-Yin Zhang, Chun Hu, Zhiyan Xiao, 2013, Bioorganic & medicinal chemistry letters.

Design, synthesis and biological evaluation of exiguamine A analogues as IDO1 inhibitors.

Zhiyan Xiao, J. Dong, Guangyan Zhang, 2021, European journal of medicinal chemistry.

DNA damage and apoptosis induced by a potent orally podophyllotoxin derivative in breast cancer

Zhiyan Xiao, Gang Zhang, Ya-jie Wang, 2018, Cell Communication and Signaling.

Strategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates

K. Lee, S. Morris-Natschke, Zhiyan Xiao, 2016, Medicinal research reviews.

Discovery of Novel Biphenyl Carboxylic Acid Derivatives as Potent URAT1 Inhibitors.

Zhiyan Xiao, Yajun Yang, Yongcheng Wang, 2023, Molecules.

Non-peptidic immunoproteasome β5i-selective inhibitor as potential treatment for idiopathic pulmonary fibrosis: Virtual screening, hit evolution and lead identification.

Zhiyan Xiao, Ying Yang, Guanglei Nan, 2023, European journal of medicinal chemistry.