Yisheng Lai

发表

Effective Virtual Screening Strategy toward heme-containing proteins: Identification of novel IDO1 inhibitors.

Qiang Xu, Wenjie Guo, Yihua Zhang, 2019, European journal of medicinal chemistry.

Novel Derivative of Bardoxolone Methyl Improves Safety for the Treatment of Diabetic Nephropathy.

Ping Li, Xiaojun Xu, Jide Tian, 2017, Journal of medicinal chemistry.

3D-QSAR, molecular docking and molecular dynamics simulations study of 3-pyrimidin-4-yl-oxazolidin-2-one derivatives to explore the structure requirements of mutant IDH1 inhibitors

Jie Yang, P. Cao, Peng-Yu Liu, 2019, Journal of Molecular Structure.

Systematic study of imidazoles inhibiting IDO1 via the integration of molecular mechanics and quantum mechanics calculations.

Qiang Xu, Wenjie Guo, F. Wang, 2017, European journal of medicinal chemistry.

Discovery of potent IDO1 inhibitors derived from tryptophan using scaffold-hopping and structure-based design approaches.

Qiang Xu, Wenjie Guo, F. Wang, 2017, European journal of medicinal chemistry.

Novel nitric oxide-releasing derivatives of farnesylthiosalicylic acid: synthesis and evaluation of antihepatocellular carcinoma activity.

Yong Ling, Jide Tian, Yihua Zhang, 2011, Journal of medicinal chemistry.

Studies on the enantiomers of ZJM-289: synthesis and biological evaluation of antiplatelet, antithrombotic and neuroprotective activities.

Xiaoli Wang, Yihua Zhang, H. Ji, 2012, Organic & biomolecular chemistry.

Design, synthesis and evaluation of nitric oxide releasing derivatives of 3-n-butylphthalide as antiplatelet and antithrombotic agents.

Yihua Zhang, H. Ji, Yisheng Lai, 2011, Organic & biomolecular chemistry.

Biological characterisation and application of human MTH1 and monoclonal antibody preparation.

Yisheng Lai, Rongrong Di, Xuemei Ji, 2018, Oncology reports.

Discovery of a potential anti-ischemic stroke agent: 3-pentylbenzo[c]thiophen-1(3H)-one.

Jing Wu, Jide Tian, Yihua Zhang, 2012, Journal of medicinal chemistry.

Discovery of a potential anti-inflammatory agent: 3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile.

L. Sha, Yihua Zhang, H. Ji, 2013, Journal of medicinal chemistry.

Discovery of New Monocarbonyl Ligustrazine-Curcumin Hybrids for Intervention of Drug-Sensitive and Drug-Resistant Lung Cancer.

Jide Tian, Yihua Zhang, C. Ren, 2016, Journal of medicinal chemistry.

Correction to "Hybrid Molecule from O2-(2,4-Dinitrophenyl)diazeniumdiolate and Oleanolic Acid: A Glutathione S-Transferase π-Activated Nitric Oxide Prodrug with Selective Anti-Human Hepatocellular Carcinoma Activity and Improved Stability".

Jide Tian, Yihua Zhang, H. Ji, 2013, Journal of medicinal chemistry.

Synthesis and evaluation of novel O2-derived diazeniumdiolates as photochemical and real-time monitoring nitric oxide delivery agents

Jin-jian Lu, Yihua Zhang, Yisheng Lai, 2017 .

Enantioselective Bromo-oxycyclization of Silanol.

Jin-Ming Gao, Yisheng Lai, Jiadong Hu, 2016, Organic letters.

Combination of apatinib with apo-IDO1 inhibitor for the treatment of colorectal cancer.

Qiang Xu, Wenjie Guo, Yi He, 2022, International immunopharmacology.

Effective virtual screening strategy focusing on the identification of novel Bruton's tyrosine kinase inhibitors.

Yihua Zhang, Yi Zou, Yisheng Lai, 2015, Journal of molecular graphics & modelling.

Chiral Ion‐Pair Organocatalyst Promotes Highly Enantioselective 3‐Exo Iodo‐Cycloetherification of Allyl Alcohols.

Yisheng Lai, H. Zhang, Jiadong Hu, 2016 .

Chiral ion-pair organocatalyst promotes highly enantioselective 3-exo iodo-cycloetherification of allyl alcohols

Yisheng Lai, H. Zhang, Jiadong Hu, 2015, Chemical science.

Synthesis and biological evaluation of 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives as novel COX-1/2 and 5-LOX inhibitors.

Jide Tian, Yihua Zhang, H. Ji, 2010, Bioorganic & medicinal chemistry letters.

The anti-inflammatory effects of ZLJ-6, a novel dual cyclooxygenase/5-lipoxygenase inhibitor.

Yihua Zhang, H. Ji, Yisheng Lai, 2009, European journal of pharmacology.

Ethylene glycol-linked amino acid diester prodrugs of oleanolic acid for PepT1-mediated transport: synthesis, intestinal permeability and pharmacokinetics.

Q. Ping, Feng Cao, L. Sha, 2012, Molecular pharmaceutics.

Novel hybrids of optically active ring-opened 3-n-butylphthalide derivative and isosorbide as potential anti-ischemic stroke agents.

Jide Tian, Lin-na Wang, Xiaoli Wang, 2013, Journal of medicinal chemistry.

One-pot synthesis of 2-（1-acyloxypentyl） benzoic acids

Yisheng Lai, S. Peng, Z. Min, 2008 .

Asymmetric synthesis of 3-butylphthalide using isomannide and isosorbide as chiral auxiliaries

Yisheng Lai, S. Peng, Z. Min, 2007 .

Synthesis and biological evaluation of furoxan-based nitric oxide-releasing derivatives of glycyrrhetinic acid as anti-hepatocellular carcinoma agents.

Jide Tian, Yihua Zhang, H. Ji, 2010, Bioorganic & medicinal chemistry letters.

Apo-Form Selective Inhibition of IDO for Tumor Immunotherapy

Qiang Xu, Wenjie Guo, Shushan Ge, 2022, The Journal of Immunology.

Synthesis and biological evaluation of novel uracil and 5-fluorouracil-1-yl acetic acid-colchicine conjugate

Yanhui Kang, Aibing Wang, Yisheng Lai, 2015, Chemical Research in Chinese Universities.

Synthesis and Cytotoxic Evaluation of Novel Dimethyl [1,1′‐Biphenyl]‐2,2′‐dicarboxylates Bearing 1,3,4‐Thiadiazole Moieties

Yisheng Lai, S. Peng, Yi-hua Zhang, 2008, Chemistry & biodiversity.

Design, synthesis, and evaluation of 4(1H)-quinolinone and urea derivatives as KRASG12C inhibitors with potent antitumor activity against KRAS-mutant non-small cell lung cancer.

Yaliang Zhang, Jianzhuan Wu, Yihua Zhang, 2022, European journal of medicinal chemistry.

Pharmacokinetic, Distribution, Metabolism, and Excretion of (Z)-2-Amino-1,5-Dihydro-1-Methyl-5-[4-(Mesyl)Benzylidene]-4H-Imidazol-4-One Mesilate (ZLJ-601) in Sprague-Dawley Rats

Yihua Zhang, H. Ji, Yisheng Lai, 2012, Pharmacology.

Physicochemical characterization and an injection formulation study of water insoluble ZCVI4-2, a novel NO-donor anticancer compound

Yihua Zhang, Yisheng Lai, Jianjun Zhang, 2012, Archives of pharmacal research.

Synthesis and Biological Evaluation of Nitric Oxide‐Donating Thalidomide Analogues as Anticancer Agents

H. Ji, Yisheng Lai, S. Peng, 2009, Chemistry & biodiversity.

Synthesis and anti-human hepatocellular carcinoma activity of new nitric oxide-releasing glycosyl derivatives of oleanolic acid.

Luyong Zhang, Q. Guo, Li Zhao, 2010, Organic & biomolecular chemistry.

Synthesis of symmetrical and unsymmetrical N,N'-diaryl guanidines via copper/N-methylglycine-catalyzed arylation of guanidine nitrate.

Yongwen Jiang, Yisheng Lai, D. Ma, 2012, The Journal of organic chemistry.

A Re2O7 catalyzed cycloetherification of monoallylic diols

Yisheng Lai, Jiadong Hu, Yu-Peng He, 2017 .

Synthesis and cytotoxic evaluation of new colchicine derivatives bearing 1,3,4-thiadiazole moieties

Hong‐yu Li, Yisheng Lai, Hui Shang, 2013 .

Highly asymmetric bromocyclization of tryptophol: unexpected accelerating effect of DABCO-derived bromine complex.

Yisheng Lai, D. Ma, Guangde Jiang, 2014, Organic letters.

Synthesis and evaluation of nitric oxide-releasing derivatives of 3-n-butylphthalide as anti-platelet agents.

Xiaoli Wang, Yihua Zhang, Yisheng Lai, 2011, Bioorganic & medicinal chemistry letters.

Nanometre-sized titanium dioxide-catalyzed reactions of nitric oxide with aliphatic cyclic and aromatic amines.

Yihua Zhang, Yisheng Lai, Lei Fang, 2009, Chemical communications.

Synthesis and Biological Evaluation of Novel Olean-28,13β-lactams as Potential Antiprostate Cancer Agents.

Jide Tian, Yihua Zhang, H. Ji, 2015, Journal of medicinal chemistry.

Copper-Catalyzed Diaryl Ether Formation from (Hetero)aryl Halides at Low Catalytic Loadings.

W. Zhou, Mengyang Fan, Yisheng Lai, 2017, The Journal of organic chemistry.

Darbufelone, a novel anti-inflammatory drug, induces growth inhibition of lung cancer cells both in vitro and in vivo

Yihua Zhang, H. Ji, Yihua Sun, 2010, Cancer Chemotherapy and Pharmacology.

Asymmetric, Regioselective Bromohydroxylation of 2-Aryl-2-propen-1-ols Catalyzed by Quinine-Derived Catalysts

Yisheng Lai, D. Ma, Ye Zhang, 2013 .

Tandem allylic alcohol isomerization/oxo-Michael addition reaction promoted by Re2O7

Jin-Ming Gao, Yisheng Lai, Mumin Shi, 2016 .

Synthesis of Symmetrical and Unsymmetrical N,N′‐Diaryl Guanidines via Copper/N‐Methylglycine‐Catalyzed Arylation of Guanidine Nitrate.

Yongwen Jiang, Yisheng Lai, D. Ma, 2012 .

Highly enantioselective bromocyclization of tryptamines and its application in the synthesis of (-)-chimonanthine.

Yisheng Lai, D. Ma, Jiadong Hu, 2013, Angewandte Chemie.

Synthesis of CDDO-amino acid-nitric oxide donor trihybrids as potential antitumor agents against both drug-sensitive and drug-resistant colon cancer.

Jide Tian, Yihua Zhang, Yong Ai, 2015, Journal of medicinal chemistry.

Total Synthesis of (-)-Conolutinine.

Jin-Ming Gao, Yisheng Lai, Jiadong Hu, 2015, Organic letters.

Discovery of imidazoleisoindole derivatives as potent IDO1 inhibitors: Design, synthesis, biological evaluation and computational studies.

Qiang Xu, Wenjie Guo, F. Wang, 2017, European journal of medicinal chemistry.

Identification of nitric oxide-releasing derivatives of oleanolic acid as potential anti-colon cancer agents

Huibin Zhang, Yihua Zhang, Yisheng Lai, 2015 .

Glycosylated diazeniumdiolate-based oleanolic acid derivatives: synthesis, in vitro and in vivo biological evaluation as anti-human hepatocellular carcinoma agents.

Jide Tian, Yihua Zhang, H. Ji, 2012, Organic & biomolecular chemistry.

CuI/8‐Hydroxyquinalidine Promoted N‐Arylation of Indole and Azoles

Yihua Zhang, Yongwen Jiang, Yisheng Lai, 2012 .

Synthesis and evaluation of 2-anilinopyrimidines bearing 3-aminopropamides as potential epidermal growth factor receptor inhibitors.

H. Ji, Chun Han, Yihua Zhang, 2014, European journal of medicinal chemistry.

Nitric oxide donating anilinopyrimidines: synthesis and biological evaluation as EGFR inhibitors.

H. Ji, Chun Han, Yihua Zhang, 2013, European journal of medicinal chemistry.

Synthesis and evaluation of nitric oxide-releasing derivatives of farnesylthiosalicylic acid as anti-tumor agents.

Yong Ling, Jide Tian, Yihua Zhang, 2010, Bioorganic & medicinal chemistry.

Identification of phenoxyacetamide derivatives as novel DOT1L inhibitors via docking screening and molecular dynamics simulation.

Yihua Zhang, Yi Zou, Yisheng Lai, 2016, Journal of molecular graphics & modelling.

Structure-based discovery of novel 4,5,6-trisubstituted pyrimidines as potent covalent Bruton's tyrosine kinase inhibitors.

Yihua Zhang, Zheng-chao Tu, Yi Zou, 2016, Bioorganic & medicinal chemistry letters.

Design, Synthesis, and Evaluation of o-(Biphenyl-3-ylmethoxy)nitrophenyl Derivatives as PD-1/PD-L1 Inhibitors with Potent Anticancer Efficacy In Vivo.

Qiang Xu, Wenjie Guo, Yuezhen Li, 2021, Journal of medicinal chemistry.

Discovery of secondary sulphonamides as IDO1 inhibitors with potent antitumour effects in vivo

Qiang Xu, Wenjie Guo, Shushan Ge, 2020, Journal of enzyme inhibition and medicinal chemistry.

Hybrid molecule from O2-(2,4-dinitrophenyl)diazeniumdiolate and oleanolic acid: a glutathione S-transferase π-activated nitric oxide prodrug with selective anti-human hepatocellular carcinoma activity and improved stability.

Jide Tian, Yihua Zhang, H. Ji, 2013, Journal of medicinal chemistry.

Synthesis and biological evaluation of bifendate-chalcone hybrids as a new class of potential P-glycoprotein inhibitors.

Hui Peng, Xiaobo Tang, Yuanfang Ma, 2012, Bioorganic & medicinal chemistry.

ONTD induces apoptosis of human hepatoma Bel-7402 cells via a MAPK-dependent mitochondrial pathway and the depletion of intracellular glutathione.

Lin-na Wang, H. Ji, Yisheng Lai, 2013, The international journal of biochemistry & cell biology.

Synthesis and biological evaluation of novel thalidomide analogues as potential anticancer drugs

H. Ji, Yisheng Lai, S. Peng, 2008 .

Effective Virtual Screening Strategy toward Covalent Ligands: Identification of Novel NEDD8-Activating Enzyme Inhibitors

Ying Li, Yihua Zhang, Yisheng Lai, 2014, J. Chem. Inf. Model..

Physicochemical characterization and an injection formulation study of water insoluble ZCVI4-2, a novel NO-donor anticancer compound

Yihua Zhang, Yisheng Lai, Jianjun Zhang, 2012, Archives of pharmacal research.

Synthesis and biological evaluation of novel bifendate derivatives bearing 6,7-dihydro-dibenzo[c,e]azepine scaffold as potent P-glycoprotein inhibitors.

Qing Zhao, Hui Peng, Xiaobo Tang, 2012, European journal of medicinal chemistry.

Synthesis and Biological Evaluation of Novel Bifendate Derivatives Bearing 6, 7-Dihydro-dibenzo[c,e]azepine Scaffold as Potent P-Glycoprotein Inhibitors.

Qing Zhao, Hui Peng, Xiaobo Tang, 2012 .

ZLJ-6, a novel COX/5-LOX inhibitor, attenuates TNF-α-induced endothelial E-selectin, ICAM-1 and VCAM-1 expression and monocyte-endothelial interactions via a COX/5-LOX-independent mechanism.

H. Ji, Yisheng Lai, Yi-hua Zhang, 2011, Vascular pharmacology.

Synthesis and evaluation of nitrate derivatives of colchicine as anticancer agents

Yisheng Lai, Li Liu, Li Shen, 2011 .

Synthesis and evaluation of nitric oxide-releasing DDB derivatives as potential Pgp-mediated MDR reversal agents in MCF-7/Adr cells.

Hui Peng, Xiaobo Tang, Guangji Wang, 2012, Bioorganic & medicinal chemistry letters.

Molecular modeling studies to discover novel mIDH2 inhibitors with high selectivity for the primary and secondary mutants

Yisheng Lai, Peng Cao, Wenbin Liu, 2020, Comput. Biol. Chem..

ONTD induces growth arrest and apoptosis of human hepatoma Bel-7402 cells though a peroxisome proliferator-activated receptor γ-dependent pathway.

W. Shen, H. Ji, Yisheng Lai, 2017, Toxicology in vitro : an international journal published in association with BIBRA.

DDQ-promoted dehydrogenation from natural rigid polycyclic acids or flexible alkyl acids to generate lactones by a radical ion mechanism.

Yihua Zhang, Jian Yin, Yisheng Lai, 2011, Chemical communications.

Discovery of a potent apo-IDO1 inhibitor for cancer immunotherapy

Wenjie Guo, Shushan Ge, Yue Hu, 2020 .

Identification of phenoxyacetamide derivatives as novel DOT1L inhibitors via docking screening and molecular dynamics simulation.

Yihua Zhang, Yi Zou, Yisheng Lai, 2016, Journal of molecular graphics & modelling.

The anti-inflammatory effects of ZLJ-6, a novel dual cyclooxygenase/5-lipoxygenase inhibitor.

Yihua Zhang, H. Ji, Yisheng Lai, 2009, European journal of pharmacology.

Synthesis and evaluation of novel O2-derived diazeniumdiolates as photochemical and real-time monitoring nitric oxide delivery agents

Jin-jian Lu, Yihua Zhang, Yisheng Lai, 2017 .