K. Otoguro

发表

S. Ōmura, I. Kuwajima, T. Nagamitsu, 2004, Organic letters.

Generation of anti-trypanosomal agents through concise synthesis and structural diversification of sesquiterpene analogues.

S. Ōmura, H. Oikawa, H. Oguri, 2011, Journal of the American Chemical Society.

Antimalarial activity of biflavonoids from Ochna integerrima.

S. Ōmura, H. Kiyohara, K. Otoguro, 2006, Planta medica.

Peyer's patch-immunomodulating glucans from sugar cane enhance protective immunity through stimulation of the hemopoietic system.

S. Ōmura, H. Kiyohara, K. Otoguro, 2019, International journal of biological macromolecules.

In vitro antitrypanosomal activity of the cyclodepsipeptides, cardinalisamides A–C, from the insect pathogenic fungus Cordyceps cardinalis NBRC 103832

S. Ōmura, K. Otoguro, Midori Suenaga, 2013, The Journal of Antibiotics.

In Vitro Antitrypanosomal Activity of the Secondary Metabolites from the Mutant Strain IU-3 of the Insect Pathogenic Fungus Ophiocordyceps coccidiicola NBRC 100683.

S. Ōmura, M. Noji, K. Otoguro, 2016, Chemical & pharmaceutical bulletin.

The mode of action of a novel 18-membered macrolide, virustomycin A (AM-2604 A), on Trichomonas foetus.

S. Ōmura, H. Tanaka, K. Otoguro, 1983, The Journal of antibiotics.

Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells.

S. Ōmura, H. Tanaka, K. Otoguro, 1991, The Journal of antibiotics.

Mangromicins A and B: structure and antitrypanosomal activity of two new cyclopentadecane compounds from Lechevalieria aerocolonigenes K10-0216

S. Ōmura, K. Shiomi, Yōko Takahashi, 2013, The Journal of Antibiotics.

Spoxazomicins A–C, novel antitrypanosomal alkaloids produced by an endophytic actinomycete, Streptosporangium oxazolinicum K07-0460T

S. Ōmura, K. Shiomi, Yōko Takahashi, 2011, The Journal of Antibiotics.

Screening for new nematocidal substances of microbial origin by a new method using the pine wood nematode.

S. Ōmura, Y. Li, Y. Iwai, 1988, The Journal of antibiotics.

Screening for new antitrichomonal substances of microbial origin and antitrichomonal activity of trichostatin A.

S. Ōmura, R. Oiwa, Y. Iwai, 1988, The Journal of antibiotics.

Aggreceride, a new platelet aggregation inhibitor from Streptomyces.

S. Ōmura, A. Nakagawa, K. Otoguro, 1986, The Journal of antibiotics.

Rapid and Systematic Exploration of Chemical Space Relevant to Artemisinins: Anti-malarial Activities of Skeletally Diversified Tetracyclic Peroxides and 6-Aza-artemisinins.

S. Ōmura, H. Oikawa, H. Oguri, 2020, The Journal of organic chemistry.

Design and De Novo Synthesis of 6-Aza-artemisinins.

H. Oikawa, H. Oguri, K. Otoguro, 2018, Organic letters.

Synthesis and stereochemical determination of an antiparasitic pseudo-aminal type monoterpene indole alkaloid

S. Ōmura, K. Otoguro, T. Sunazuka, 2016, Journal of Natural Medicines.

Borrelidin analogues with antimalarial activity: design, synthesis and biological evaluation against Plasmodium falciparum parasites.

S. Ōmura, Yōko Takahashi, K. Otoguro, 2013, Bioorganic & medicinal chemistry letters.

Total synthesis of borrelidin.

S. Ōmura, I. Kuwajima, T. Nagamitsu, 2007, The Journal of organic chemistry.

Selective and Potent in Vitro Antitrypanosomal Activities of Ten Microbial Metabolites

S. Ōmura, R. Masuma, K. Shiomi, 2008, The Journal of Antibiotics.

In vitro and in vivo antitrypanosomal activities of three peptide antibiotics: leucinostatin A and B, alamethicin I and tsushimycin

S. Ōmura, R. Masuma, K. Shiomi, 2009, The Journal of Antibiotics.

In vitro and in vivo antitrypanosomal activities of three peptide antibiotics: leucinostatin A and B, alamethicin I and tsushimycin

S. Ōmura, R. Masuma, K. Shiomi, 2009, The Journal of Antibiotics.

Isolation and Total Synthesis of Hoshinolactam, an Antitrypanosomal Lactam from a Marine Cyanobacterium.

A. Iwasaki, K. Suenaga, K. Otoguro, 2017, Organic letters.

Antitrypanosomal peptaibiotics, trichosporins B-VIIa and B-VIIb, produced by Trichoderma polysporum FKI-4452

S. Ōmura, R. Masuma, K. Shiomi, 2010, The Journal of Antibiotics.

In vitro antimalarial activities of the microbial metabolites.

S. Ōmura, R. Masuma, K. Shiomi, 2003, The Journal of antibiotics.

Heme-dependent radical generation: possible involvement in antimalarial action of non-peroxide microbial metabolites, nanaomycin A and radicicol.

S. Ōmura, Y. Tanaka, K. Otoguro, 1999, Journal of antibiotics (Tokyo. 1968).

Effects of erythromycin and its derivatives on interleukin-8 release by human bronchial epithelial cell line BEAS-2B cells.

S. Ōmura, K. Suzuki, K. Otoguro, 1999, The Journal of antibiotics.

In vitro antitrypanosomal activity of some phenolic compounds from propolis and lactones from Fijian Kawa (Piper methysticum)

S. Ōmura, Y. Asakawa, H. Kiyohara, 2011, Journal of Natural Medicines.

A new antibiotic, cypemycin. Taxonomy, fermentation, isolation and biological characteristics.

S. Ōmura, M. Hayashi, Y. Takahashi, 1993, The Journal of antibiotics.

Clofazimine Inhibits the Growth of Babesia and Theileria Parasites In Vitro and In Vivo

S. Ōmura, I. Igarashi, M. AbouLaila, 2016, Antimicrobial Agents and Chemotherapy.

Anti-trypanosomal compound, sagamilactam, a new polyene macrocyclic lactam from Actinomadura sp. K13-0306

S. Ōmura, Yukihiro Asami, K. Shiomi, 2016, The Journal of Antibiotics.

In vitro antitrypanosomal activity of plant terpenes against Trypanosoma brucei.

S. Ōmura, Y. Asakawa, H. Kiyohara, 2011, Phytochemistry.

Synthesis and biological properties of tensyuic acids B, C, and E, and investigation of the optical purity of natural tensyuic acid B

S. Ōmura, T. Fukuda, H. Tomoda, 2008 .

Penicillium viticola, a new species isolated from a grape in Japan

S. Ōmura, R. Masuma, K. Shiomi, 2011, Mycoscience.

Semisynthesis of Antitrypanosomal p-Quinone Analog Possesing the Komaroviquinone Pharmacophore.

S. Ōmura, T. Matsuzaki, K. Otoguro, 2022, Chemical & pharmaceutical bulletin.

Semisynthesis of salviandulin E analogues and their antitrypanosomal activity.

S. Ōmura, K. Otoguro, H. Yamada, 2014, Bioorganic & medicinal chemistry letters.

Parallel and four-step synthesis of natural-product-inspired scaffolds through modular assembly and divergent cyclization

S. Ōmura, H. Oikawa, H. Oguri, 2012, Beilstein journal of organic chemistry.

In vitro antitrypanosomal activity of bis(bibenzyls)s and bibenzyls from liverworts against Trypanosoma brucei

S. Ōmura, Y. Asakawa, H. Kiyohara, 2011, Journal of Natural Medicines.

Sinefungin VA and dehydrosinefungin V, new antitrypanosomal antibiotics produced by Streptomyces sp. K05-0178

S. Ōmura, K. Shiomi, Yōko Takahashi, 2010, The Journal of Antibiotics.

In vitro and in vivo anti-Trypanosoma brucei activities of phenazinomycin and related compounds

S. Ōmura, K. Otoguro, H. Yamada, 2010, The Journal of Antibiotics.

Pyrenocine I, a new pyrenocine analog produced by Paecilomyces sp. FKI-3573

S. Ōmura, R. Masuma, K. Shiomi, 2010, The Journal of Antibiotics.

In vitro antitrypanosomal activity of 12 low-molecular-weight antibiotics and observations of structure/activity relationships

S. Ōmura, R. Masuma, Yōko Takahashi, 2010, The Journal of Antibiotics.

Promising lead compounds for novel antiprotozoals

S. Ōmura, K. Otoguro, H. Yamada, 2010, The Journal of Antibiotics.

In vitro and in vivo antiprotozoal activities of bispolides and their derivatives

S. Ōmura, Seigo Sato, M. Hatsu, 2010, The Journal of Antibiotics.

Antitrypanosomal activity of some pregnane glycosides isolated from Caralluma species.

S. Ōmura, H. Kiyohara, E. Abdel-Sattar, 2009, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Antiplasmodial and antitrypanosomal activity of plants from the Kingdom of Saudi Arabia

S. Ōmura, H. Kiyohara, E. Abdel-Sattar, 2009, Journal of Natural Medicines.

In Vitro and in Vivo Antitrypanosomal Activitiy of Two Microbial Metabolites, KS-505a and Alazopeptin

S. Ōmura, R. Masuma, K. Shiomi, 2008, The Journal of Antibiotics.

Acylated pregnane glycosides from Caralluma tuberculata and their antiparasitic activity.

S. Ōmura, H. Kiyohara, E. Abdel-Sattar, 2008, Phytochemistry.

Potent antimalarial activities of polyether antibiotic, X-206.

S. Ōmura, H. Yamada, K. Shiomi, 2001, The Journal of antibiotics.

Structure determination and total synthesis of (+)-16-hydroxy-16,22-dihydroapparicine.

S. Ōmura, K. Otoguro, T. Sunazuka, 2013, Chemistry.

The first total synthesis of (+/-)-arisugacin A, a potent, orally bioavailable inhibitor of acetylcholinesterase.

S. Ōmura, I. Kuwajima, K. Otoguro, 2002, Organic letters.

Convergent synthesis of arisugacin skeletons and their acetylcholinesterase inhibitory activity.

S. Ōmura, K. Otoguro, Y. Harigaya, 2001, The Journal of antibiotics.

Arisugacin, a novel and selective inhibitor of acetylcholinesterase from Penicillium sp. FO-4259.

S. Ōmura, R. Masuma, Y. Iwai, 1995, The Journal of antibiotics.

Arisugacins, selective acetylcholinesterase inhibitors of microbial origin.

S. Ōmura, K. Otoguro, F. Kuno, 1997, Pharmacology & therapeutics.

Arisugacins C and D, novel acetylcholinesterase inhibitors and their related novel metabolites produced by Penicilium sp. FO-4259-11.

S. Ōmura, R. Masuma, Y. Iwai, 2000, The Journal of antibiotics.

Arisugacins A and B, novel and selective acetylcholinesterase inhibitors from Penicillium sp. FO-4259. I. Screening, taxonomy, fermentation, isolation and biological activity.

S. Ōmura, Y. Iwai, K. Shiomi, 1996, The Journal of antibiotics.

Merobatzelladines A and B, anti-infective tricyclic guanidines from a marine sponge Monanchora sp.

S. Ōmura, S. Matsunaga, K. Otoguro, 2009, Organic letters.

Absolute stereochemistries and total synthesis of (+)-arisugacins A and B, potent, orally bioactive and selective inhibitors of acetylcholinesterase

S. Ōmura, I. Kuwajima, K. Otoguro, 2004 .

Panowamycins A and B, new antitrypanosomal isochromans produced by Streptomyces sp. K07-0010

S. Ōmura, K. Shiomi, Yōko Takahashi, 2012, The Journal of Antibiotics.

Asymmetric Total Synthesis of Indole Alkaloids Containing an Indoline Spiroaminal Framework.

S. Ōmura, K. Otoguro, Takeshi Yamada, 2015, Chemistry.

Synthesis and stereochemical determination of an antiparasitic pseudo-aminal type monoterpene indole alkaloid

S. Ōmura, K. Otoguro, T. Sunazuka, 2016, Journal of Natural Medicines.

Kozupeptins, Antimalarial Agents Produced by Paracamarosporium Species: Isolation, Structural Elucidation, Total Synthesis, and Bioactivity.

K. Shiomi, K. Otoguro, T. Sunazuka, 2019, Organic letters.

The first total synthesis and reassignment of the relative stereochemistry of 16-hydroxy-16,22-dihydroapparicine

S. Ōmura, K. Otoguro, T. Sunazuka, 2012 .

In vitro and in vivo antimalarial activity of puberulic acid and its new analogs, viticolins A–C, produced by Penicillium sp. FKI-4410

S. Ōmura, R. Masuma, K. Shiomi, 2011, The Journal of Antibiotics.

In vitro and in vivo antimalarial activities of the monoglycoside polyether antibiotic, K-41 against drug resistant strains of Plasmodia.

S. Ōmura, Yōko Takahashi, K. Otoguro, 2002, The Journal of antibiotics.

The structure of virustomycin A.

J. L. Smith, S Omura, N Imamura, 1983, The Journal of antibiotics.

In vitro and in vivo antimalarial activities of a non-glycosidic 18-membered macrolide antibiotic, borrelidin, against drug-resistant strains of Plasmodia.

S. Ōmura, H. Tomoda, R. Masuma, 2003, The Journal of antibiotics.

In vitro antimalarial activity of biflavonoids from Wikstroemia indica.

S. Ōmura, H. Kiyohara, K. Otoguro, 2004, Planta medica.

In vitro antimalarial activity of prenylated flavonoids from Erythrina fusca

S. Ōmura, H. Kiyohara, N. Ruangrungsi, 2008, Journal of Natural Medicines.

Solid-phase synthesis and biological activity of malformin C and its derivatives

S. Ōmura, K. Otoguro, Y. Kojima, 2009, The Journal of Antibiotics.

New lycorine-type alkaloid from Lycoris traubii and evaluation of antitrypanosomal and antimalarial activities of lycorine derivatives.

Satoshi Omura, Aki Ishiyama, S. Ōmura, 2008, Bioorganic & medicinal chemistry.

Structures of jietacines: unique alpha,beta-unsaturated azoxy antibiotics.

S. Ōmura, N. Imamura, H. Kuga, 1989, The Journal of antibiotics.

Jietacins A and B, new nematocidal antibiotics from a Streptomyces sp. Taxonomy, isolation, and physico-chemical and biological properties.

S. Ōmura, Y. Takahashi, Y. Tanaka, 1987, The Journal of antibiotics.

Saturated fatty acid-starved cells of Saccharomyces cerevisiae grown in the presence of cerulenin and oleic acid.

S. Ōmura, H. Tanaka, K. Otoguro, 1981, Journal of biochemistry.

Antimalarial C-9 oxime derivatives from desmycosin, produced by click chemistry

S. Ōmura, Ayumi Tsutsui, H. Matsui, 2012, The Journal of Antibiotics.

Macrolides with Promotive Activity of Monocyte to Macrophage Differentiation

S. Ōmura, K. Akagawa, T. Nagamitsu, 2005, The Journal of Antibiotics.

Effect of 14-membered macrolide compounds on monocyte to macrophage differentiation.

S. Ōmura, K. Akagawa, Y. Iwai, 2003, The Journal of antibiotics.

Effect of 14-membered ring macrolide compounds on rat leucocyte chemotaxis and the structure-activity relationships.

S. Ōmura, Y. Iwai, K. Otoguro, 2000, The Journal of antibiotics.

In vitro antitrypanosomal activity of five low-MW antibiotics

S. Ōmura, Yōko Takahashi, K. Otoguro, 2011, The Journal of Antibiotics.

AM-2604 A, a new antiviral antibiotic produced by a strain of Streptomyces.

S. Ōmura, H. Hashimoto, A. Nakagawa, 1982, The Journal of antibiotics.

Antimalarial troponoids, puberulic acid and viticolins; divergent synthesis and structure-activity relationship studies

S. Ōmura, K. Otoguro, T. Sunazuka, 2017, Scientific Reports.

Actinoallolides A-E, new anti-trypanosomal macrolides, produced by an endophytic actinomycete, Actinoallomurus fulvus MK10-036.

S. Ōmura, M. Kaiser, Yōko Takahashi, 2015, Organic letters.

Setamycin, a new antibiotic.

S. Ōmura, T. Nishikiori, R. Oiwa, 1981, The Journal of antibiotics.

In vitro and in vivo antimalarial activities of a carbohydrate antibiotic, prumycin, against drug-resistant strains of Plasmodia.

S. Ōmura, H. Tomoda, K. Otoguro, 2004, The Journal of antibiotics.

Borrelidin, a potent antimalarial: stage-specific inhibition profile of synchronized cultures of Plasmodium falciparum

S. Ōmura, Yōko Takahashi, K. Otoguro, 2011, The Journal of Antibiotics.

Simaomicin α: Effects on the Cell Cycle of Synchronized, Cultured Plasmodium falciparum

S. Ōmura, R. Masuma, K. Shiomi, 2008, The Journal of Antibiotics.

Selective and Potent In Vitro Antimalarial Activities Found in Four Microbial Metabolites

S. Ōmura, K. Shiomi, Yōko Takahashi, 2007, The Journal of Antibiotics.

Satoshi Omura: in pursuit of nature's bounty.

K. Otoguro, A. Crump, 2005, Trends in parasitology.

Boromycin derivatives: synthesis and antimalarial activity in vitro and in vivo

Masuma, S. Ōmura, Ayumi Tsutsui, 2010 .

Chemotherapeutic efficacies of a clofazimine and diminazene aceturate combination against piroplasm parasites and their AT-rich DNA-binding activity on Babesia bovis

S. Ōmura, I. Igarashi, M. Rizk, 2017, Scientific Reports.

Jogyamycin, a new antiprotozoal aminocyclopentitol antibiotic, produced by Streptomyces sp. a-WM-JG-16.2

S. Ōmura, Yoshio Watanabe, B. Marwoto, 2012, The Journal of Antibiotics.

Type of diaminopimelic acid different in aerial and vegetative mycelia of setamycin-producing actinomycete KM-6054.

S. Ōmura, Y. Takahashi, R. Oiwa, 1981, The Journal of antibiotics.

Janadolide, a Cyclic Polyketide-Peptide Hybrid Possessing a tert-Butyl Group from an Okeania sp. Marine Cyanobacterium.

S. Ōmura, A. Iwasaki, K. Suenaga, 2016, Journal of natural products.

An In Vitro Cytotoxicity Assay Using Rat Hepatocytes and MTT and Coomassie Blue Dye as Indicators

C. Tyson, K. Komiyama, K. Otoguro, 1991 .

Hygromycin A, an antitreponemal substance. I. Screening method and therapeutic effect for Treponema hyodysenteriae-caused infection in CF-1 mice.

S. Ōmura, A. Nakagawa, K. Otoguro, 1987, The Journal of antibiotics.

In vitro antitrypanosomal activity of some phenolic compounds from propolis and lactones from Fijian Kawa (Piper methysticum)

S. Ōmura, Y. Asakawa, H. Kiyohara, 2012, Journal of Natural Medicines.

Synthetic conversion of ACAT inhibitor to acetylcholinesterase inhibitor.

S. Ōmura, H. Tomoda, K. Otoguro, 2000, Bioorganic & medicinal chemistry letters.

Total syntheses of the AChE inhibitors (-)-arisugacins F and G.

S. Ōmura, K. Otoguro, Y. Harigaya, 2003, The Journal of antibiotics.

Diatretol, an α, α′-dioxo-diketopiperazine, is a potent in vitro and in vivo antimalarial

H. Miura, K. Otoguro, A. Ishiyama, 2021, The Journal of Antibiotics.

Hand Disinfectant Activities of Two Kind of Electrolyzed Acid Aqueous Solutions by Globe Juice Method

J. Cyong, K. Komiyama, K. Otoguro, 1996 .

Structure-Activity Relationship between Thiol Group-Trapping Ability of Morphinan Compounds with a Michael Acceptor and Anti-Plasmodium falciparum Activities

S. Ōmura, Y. Nagumo, H. Nagase, 2020, Molecules.

A new antifungal antibiotic, 3'-O-decarbamoylirumamycin.

S. Ōmura, Y. Tanaka, A. Nakagawa, 1985, The Journal of antibiotics.

In vitro and in vivo Antitrypanosomal Activity of Two Microbial Metabolites, KS-505a and Alazopeptin.

K. Otoguro, 2009 .

Arisugacins A and B, novel and selective acetylcholinesterase inhibitors from Penicillium sp. FO-4259. II. Structure elucidation.

K. Shiomi, K. Otoguro, T. Sunazuka, 1996, The Journal of antibiotics.

Antimalarial activity of kinase inhibitor, nilotinib, in vitro and in vivo

S. Ōmura, M. Sawa, K. Otoguro, 2015, The Journal of Antibiotics.

In vitro antitrypanosomal activity of bis(bibenzyls)s and bibenzyls from liverworts against Trypanosoma brucei

S. Ōmura, Y. Asakawa, H. Kiyohara, 2012, Journal of Natural Medicines.

Screening of Thai medicinal plant extracts and their active constituents for In Vitro antimalarial activity

S. Ōmura, H. Kiyohara, H. Yamada, 2006, Phytotherapy research : PTR.

Setamycin, a 16-membered macrolide antibiotic. Identification and nematocidal activity.

S. Ōmura, A. Nakagawa, K. Otoguro, 1988, The Journal of antibiotics.

Zamamidine C, 3,4-dihydro-6-hydroxy-10,11-epoxymanzamine A, and 3,4-dihydromanzamine J N-oxide, new manzamine alkaloids from sponge Amphimedon sp.

S. Ōmura, J. Kobayashi, J. Fromont, 2009 .

Meroterpenoids with various biological activities produced by fungi

S. Ōmura, H. Tomoda, K. Shiomi, 1999 .