M. Cunningham

发表

Identification of bacteria-selective threonyl-tRNA synthetase substrate inhibitors by structure-based design.

M. Hilgers, M. Teng, M. Cunningham, 2013, Journal of medicinal chemistry.

Anthracimycin Activity Against Contemporary Methicillin-Resistant Staphylococcus aureus

V. Nizet, M. Hensler, N. Haste, 2014, The Journal of Antibiotics.

The crystal structure of trypanothione reductase from the human pathogen Trypanosoma cruzi at 2.3 Å resolution

A. Fairlamb, W. Hunter, C. Bond, 1996, Protein science : a publication of the Protein Society.

Mechanism of inhibition of trypanothione reductase and glutathione reductase by trivalent organic arsenicals.

M. Zvelebil, A. Fairlamb, M. Cunningham, 1994, European journal of biochemistry.

Characterisation of melarsen-resistant Trypanosoma brucei brucei with respect to cross-resistance to other drugs and trypanothione metabolism.

A. Fairlamb, N. Carter, M. Cunningham, 1992, Molecular and biochemical parasitology.

Dual Action of Antimonial Drugs on Thiol Redox Metabolism in the Human Pathogen Leishmania donovani*

A. Fairlamb, S. Wyllie, M. Cunningham, 2004, Journal of Biological Chemistry.

Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors.

M. Berriman, A. Fairlamb, W. Hunter, 1999, Structure.

Down-regulation of Leishmania donovani trypanothione reductase by heterologous expression of a trans-dominant mutant homologue: effect on parasite intracellular survival.

A. Fairlamb, S. Croft, M. Cunningham, 1998, Proceedings of the National Academy of Sciences of the United States of America.

The role of enzymology in a structure-based drug discovery program: bacterial DNA gyrase.

M. Cunningham, 2012, Methods in molecular biology.

Monoacylglycerol Lipase Inhibition in Human and Rodent Systems Supports Clinical Evaluation of Endocannabinoid Modulators

Cheryl A. Grice, G. O'neill, I. Fraser, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Distinguishing On-Target versus Off-Target Activity in Early Antibacterial Drug Discovery Using a Macromolecular Synthesis Assay

M. Cunningham, Bryan P. Kwan, K. Shaw, 2013, Journal of biomolecular screening.

Anti-plasmodial and anti-trypanosomal activity of synthetic naphtho[2,3-b]thiopen-4,9-quinones.

A. Fairlamb, A. Romanha, M. Cunningham, 1997, Bioorganic & medicinal chemistry.

Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines.

Mark Stidham, Mark Hilgers, John Finn, 2011, Bioorganic & medicinal chemistry letters.

Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE), Part II: development of inhibitors with broad spectrum, Gram-negative antibacterial activity.

Toan B. Nguyen, Sergio E. Wong, F. Lightstone, 2013, Bioorganic & medicinal chemistry letters.

Pteridine salvage throughout the Leishmania infectious cycle: implications for antifolate chemotherapy.

S. Beverley, S. Beverley, M. Cunningham, 2001, Molecular and biochemical parasitology.

Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines.

M. Hilgers, M. Cunningham, Bryan P. Kwan, 2014, Journal of medicinal chemistry.

Regulation of Differentiation to the Infective Stage of the Protozoan Parasite Leishmania major by Tetrahydrobiopterin

R. Titus, S. Beverley, S. Turco, 2001, Science.

Trypanothione reductase from Leishmania donovani. Purification, characterisation and inhibition by trivalent antimonials.

A. Fairlamb, M. Cunningham, Mark Cunningham, 1995, European journal of biochemistry.

Trypanothione Reductase from Leishmania donovani

A. Fairlamb, M. Cunningham, 1995 .

Site-directed mutagenesis of the redox-active cysteines of Trypanosoma cruzi trypanothione reductase.

A. Fairlamb, M. Cunningham, A. Borges, 1995, European journal of biochemistry.

Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages

Martin Olivier, Marc Ouellette, Jorge Tovar, 1997, The EMBO journal.

Tricyclic GyrB/ParE (TriBE) Inhibitors: A New Class of Broad-Spectrum Dual-Targeting Antibacterial Agents

Felice C. Lightstone, Toan B. Nguyen, Sergio E. Wong, 2013, PloS one.

Characterization of quinonoid-Dihydropteridine Reductase (QDPR) from the Lower Eukaryote Leishmania major *

S. Beverley, M. Cunningham, L. Lye, 2002, The Journal of Biological Chemistry.

Trypanosoma cruzi trypanothione reductase. Crystallization, unit cell dimensions and structure solution.

A. Fairlamb, C. Bond, J. Naismith, 1993, Journal of molecular biology.

Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.

Toan B. Nguyen, Sergio E. Wong, J. Nix, 2013, Bioorganic & medicinal chemistry letters.

Conservation of the LD1 region in Leishmania includes DNA implicated in LD1 amplification.

S. Sunkin, P. Myler, P. McDonagh, 2001, Molecular and biochemical parasitology.

The Leishmania donovani LD1 locus gene ORFG encodes a biopterin transporter (BT1).

P. Myler, S. Yan, R. Madhubala, 1999, Molecular and biochemical parasitology.

Conservation of the LD 1 region in Leishmania includes DNA implicated in LD 1 amplification

S. Sunkin, P. Myler, P. McDonagh, 2001 .

The Leishmania dono 6 ani LD 1 locus gene ORFG encodes a biopterin transporter ( BT 1 )

P. Myler, R. Madhubala, K. Stuart, 1999 .