Bryan P. Kwan

发表

Identification of bacteria-selective threonyl-tRNA synthetase substrate inhibitors by structure-based design.

M. Hilgers, M. Teng, M. Cunningham, 2013, Journal of medicinal chemistry.

Tricyclic GyrB/ParE (TriBE) Inhibitors: A New Class of Broad-Spectrum Dual-Targeting Antibacterial Agents

Felice C. Lightstone, Toan B. Nguyen, Sergio E. Wong, 2013, PloS one.

Anthracimycin Activity Against Contemporary Methicillin-Resistant Staphylococcus aureus

V. Nizet, M. Hensler, N. Haste, 2014, The Journal of Antibiotics.

Distinguishing On-Target versus Off-Target Activity in Early Antibacterial Drug Discovery Using a Macromolecular Synthesis Assay

M. Cunningham, Bryan P. Kwan, K. Shaw, 2013, Journal of biomolecular screening.

Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines.

Mark Stidham, Mark Hilgers, John Finn, 2011, Bioorganic & medicinal chemistry letters.

Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE), Part II: development of inhibitors with broad spectrum, Gram-negative antibacterial activity.

Toan B. Nguyen, Sergio E. Wong, F. Lightstone, 2013, Bioorganic & medicinal chemistry letters.

Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines.

M. Hilgers, M. Cunningham, Bryan P. Kwan, 2014, Journal of medicinal chemistry.

Macromolecular Synthesis Assay Distinguishing On-Target versus Off-Target Activity in Early Antibacterial Drug Discovery Using a

L. Cunningham, Bryan P. Kwan, K. Shaw, 2013 .

Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.

Toan B. Nguyen, Sergio E. Wong, J. Nix, 2013, Bioorganic & medicinal chemistry letters.