S. Malan

发表

Drug Design and Discovery in Alzheimer’s Disease

Kenneth J. Witt, M. Z. Ahmad, Eric A. Owens, 2014 .

Prioritization of anti-malarial hits from nature: chemo-informatic profiling of natural products with in vitro antiplasmodial activities and currently registered anti-malarial drugs

A. Christoffels, S. Malan, J. Syce, 2016, Malaria Journal.

Hexacyclododecylamines with Sigma-1 Receptor Affinity and Calcium Channel Modulating Ability

W. Geldenhuys, J. Joubert, S. Malan, 2019, The Open Medicinal Chemistry Journal.

3D-QSAR and docking studies of pentacycloundecylamines at the sigma-1 (σ1) receptor.

W. Geldenhuys, C. J. Van der Schyf, S. Malan, 2013, Bioorganic & medicinal chemistry letters.

Polycyclic Cage Structures as Lipophilic Scaffolds for Neuroactive Drugs

W. Geldenhuys, T. Govender, Hendrik G. Kruger, 2012, ChemMedChem.

Developments in drug delivery technologies : molecular and crystal design, cellular response and targeted and site-specific delivery : review article

M. M. Villiers, S. Malan, 2003 .

Inhibition of monoamine oxidase by indole and benzofuran derivatives.

J. P. Petzer, L. H. Prins, S. Malan, 2010, European journal of medicinal chemistry.

Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues.

J. P. Petzer, S. Malan, N. Castagnoli, 2010, Bioorganic & medicinal chemistry.

Structure-activity relationships in the inhibition of monoamine oxidase B by 1-methyl-3-phenylpyrroles.

J. P. Petzer, S. Malan, N. Castagnoli, 2008, Bioorganic & medicinal chemistry.

Structure-activity relationships of pentacycloundecylamines at the N-methyl-d-aspartate receptor.

W. Geldenhuys, C. J. Van der Schyf, J. Bloomquist, 2007, Bioorganic & medicinal chemistry.

Exploration of Scaffolds from Natural Products with Antiplasmodial Activities, Currently Registered Antimalarial Drugs and Public Malarial Screen Data

A. Christoffels, S. Malan, J. Syce, 2016, Molecules.

Antimycobacterial Activity, Synergism, and Mechanism of Action Evaluation of Novel Polycyclic Amines against Mycobacterium tuberculosis

D. Warner, R. Sharma, S. Sampson, 2021, Advances in pharmacological and pharmaceutical sciences.

Adamantane amine-linked chloroquinoline derivatives as chloroquine resistance modulating agents in Plasmodium falciparum.

Dale Taylor, J. Joubert, S. Malan, 2018, Bioorganic & medicinal chemistry letters.

Dual inhibition of monoamine oxidase B and antagonism of the adenosine A(2A) receptor by (E,E)-8-(4-phenylbutadien-1-yl)caffeine analogues.

J. P. Petzer, S. Malan, N. Castagnoli, 2008, Bioorganic & medicinal chemistry.

Design, synthesis and biological evaluation of edaravone derivatives bearing the N-benzyl pyridinium moiety as multifunctional anti-Alzheimer’s agents

J. Joubert, S. Malan, Luke S Zondagh, 2020, Journal of enzyme inhibition and medicinal chemistry.

International nonproprietary names for monoclonal antibodies: an evolving nomenclature system

Andrew C. R. Martin, A. Plückthun, M. Lefranc, 2022, mAbs.

The INN global nomenclature of biological medicines: A continuous challenge.

M. Rizzi, W. Chui, S. Malan, 2019, Biologicals : journal of the International Association of Biological Standardization.

Histamine‐3 receptor antagonists reduce superoxide anion generation and lipid peroxidation in rat brain homogenates

S. Malan, S. Daya, S. Dyk, 2005, The Journal of pharmacy and pharmacology.

Antioxidant properties of 4-quinolones and structurally related flavones.

J. Joubert, S. Malan, J. Greeff, 2012, Bioorganic & medicinal chemistry.

Open and rearranged norbornane derived polycyclic cage molecules as potential neuroprotective agents through attenuation of MPP+- and calcium overload-induced excitotoxicity in neuroblastoma SH-SY5Y cells.

V. Palchykov, J. Joubert, S. Malan, 2020, European journal of medicinal chemistry.

Design, synthesis, biological evaluation and docking studies of sulfonyl isatin derivatives as monoamine oxidase and caspase-3 inhibitors

J. Joubert, S. Malan, Mohsen Tavari, 2016 .

Screening of novel pentacyclo-undecylamines for neuroprotective activity.

W. Geldenhuys, C. J. Van der Schyf, S. Malan, 2003, European journal of pharmacology.

Neurotoxicity studies with the monoamine oxidase B substrate 1-methyl-3-phenyl-3-pyrroline.

J. P. Petzer, S. Malan, K. Castagnoli, 2007, Life sciences.

The Relationship Between Surface Adsorption and the Hydrolysis of Amitraz in Anionic Surfactant Solutions

M. D. de Villiers, W. Liebenberg, W. Kolling, 2005, Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.

The high performance liquid chromatography (HPLC) analysis of ultraviolet (UV) irradiated chlorophyll a and secondary plant compounds

J. D. Preez, S. Malan, S. Dyk, 2011 .

Synthesis and Biological Evaluations of NO-Donating Oxa- and Aza-Pentacycloundecane Derivatives as Potential Neuroprotective Candidates

R. Sharma, J. Joubert, S. Malan, 2018, Molecules.

Computational drug repurposing strategy predicted peptide-based drugs that can potentially inhibit the interaction of SARS-CoV-2 spike protein with its target (humanACE2)

B. Fielding, S. Malan, S. Egieyeh, 2021, PloS one.

Polycyclic propargylamine derivatives as multifunctional neuroprotective agents

J. Joubert, S. Malan, Frank T. Zindo, 2015 .

Physical transformation of niclosamide solvates in pharmaceutical suspensions determined by DSC and TG analysis.

M. D. de Villiers, W. Liebenberg, E. C. van Tonder, 2004, Die Pharmazie.

Inhibition of monoamine oxidase B by selec- tive 7-substituted coumarin derivatives

J. P. Petzer, S. Malan, J. Bergh, 2008 .

Synthesis, evaluation and application of polycyclic fluorescent analogues as N-methyl-D-aspartate receptor and voltage gated calcium channel ligands.

I. Green, J. Joubert, S. Malan, 2011, European journal of medicinal chemistry.

Molecular modelling and simulation studies of the Mycobacterium tuberculosis multidrug efflux pump protein Rv1258c

A. Christoffels, J. Joubert, S. Malan, 2018, PloS one.

Polycyclic cage structures as carrier molecules for neuroprotective non-steroidal anti-inflammatory drugs.

L. H. Prins, S. Malan, J. D. du Preez, 2009, European journal of medicinal chemistry.

Fluorescent ligands for the histamine H2 receptor: synthesis and preliminary characterization.

R. Leurs, H. Timmerman, S. Malan, 2004, Bioorganic & medicinal chemistry.

Propargylamine as functional moiety in the design of multifunctional drugs for neurodegenerative disorders: MAO inhibition and beyond.

J. Joubert, S. Malan, Frank T. Zindo, 2015, Future medicinal chemistry.

Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease.

B. P. Repsold, J. Joubert, S. Malan, 2017, European journal of medicinal chemistry.

Multi-targeted directed ligands for Alzheimer’s disease: design of novel lead coumarin conjugates

B. P. Repsold, J. Joubert, S. Malan, 2018, SAR and QSAR in environmental research.

Versatility of 7-Substituted Coumarin Molecules as Antimycobacterial Agents, Neuronal Enzyme Inhibitors and Neuroprotective Agents

D. Warner, S. Sampson, E. Streicher, 2017, Molecules.

Effect of polycyclic cage amines on the transmembrane potential of neuronal cells.

S. Malan, A. Grobler, C. J. van der Schyf, 2006, Bioorganic & medicinal chemistry.

Pharmacology and structure‐activity relationships of bioactive polycyclic cage compounds: A focus on pentacycloundecane derivatives

W. Geldenhuys, J. Bloomquist, A. P. Marchand, 2005, Medicinal research reviews.

Synthesis and biological evaluation of pentacyclo[5.4.0.02,6.03,10.05,9]undecane derivatives as potential therapeutic agents in Parkinson's disease

W. Geldenhuys, J. Bloomquist, S. Malan, 2004 .

Physicochemical prediction of a brain-blood distribution profile in polycyclic amines.

Sarel F Malan, S. Malan, G. Terre’Blanche, 2003, Bioorganic & medicinal chemistry.

Inhibition of monoamine oxidase by (E)-styrylisatin analogues.

D. Edmondson, J. P. Petzer, S. Malan, 2009, Bioorganic & medicinal chemistry letters.

Inhibition of monoamine oxidase B by analogues of the adenosine A2A receptor antagonist (E)-8-(3-chlorostyryl)caffeine (CSC).

J. P. Petzer, S. Malan, N. Castagnoli, 2006, Bioorganic & Medicinal Chemistry.

Indazole derivatives and their therapeutic applications: a patent review (2013-2017)

J. Joubert, S. Malan, Ireen Denya, 2018, Expert opinion on therapeutic patents.

Medicinal chemistry of polycyclic cage compounds in drug discovery research

S. Malan, D. Oliver, 2008, Medicinal Chemistry Research.

Structure-Solubility Relationship and Thermal Decomposition of Furosemide

M. D. de Villiers, S. Malan, J. G. van der Watt, 2000, Drug development and industrial pharmacy.

Antibacterial activity and QSAR of homoisoflavanones isolated from six Hyacinthaceae species

J. Staden, S. Malan, D. Mulholland, 2007 .

Antimalarial compounds from Parinari capensis.

S. Malan, R. V. Van Zyl, S. van Dyk, 2002, Bioorganic & medicinal chemistry letters.

Quantitative structure–activity relationship studies on acetylcholinesterase enzyme inhibitory effects of Amaryllidaceae alkaloids

Sarel F. Malan, G. Stafford, J. Staden, 2006 .

Anti-inflammatory activity and QSAR studies of compounds isolated from Hyacinthaceae species and Tachiadenus longiflorus Griseb. (Gentianaceae).

J. van Staden, S. Malan, D. Mulholland, 2005, Bioorganic & medicinal chemistry.

Physicochemical properties of drugs and membrane permeability : review article

S. Malan, D. Chetty, J. Plessis, 2002 .

Design, synthesis, and evaluation of 3,7-substituted coumarin derivatives as multifunctional Alzheimer’s disease agents

J. Joubert, S. Malan, O. Ekpo, 2021, Journal of enzyme inhibition and medicinal chemistry.

The importance of including toxicity assays when screening plant extracts for antimalarial activity

S. Malan, S. Dyk, R. L. V. Zyl, 2009 .

The activity of p-methoxybenzylisothiocyanate against Neisseria gonorrhoeae, Haemophilus ducreyi, and other microorganisms.

S. Malan, S. van Dyk, H. Swart, 2002, Bioorganic & medicinal chemistry letters.

4-Oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione Derivatives as NMDA Receptor- and VGCC Blockers with Neuroprotective Potential

J. Joubert, S. Malan, O. Ekpo, 2020, Molecules.

Small Molecule Efflux Pump Inhibitors in Mycobacterium tuberculosis: A Rational Drug Design Perspective.

S. Sampson, J. Joubert, S. Malan, 2017, Mini reviews in medicinal chemistry.

The dissolution and complexing properties of ibuprofen and ketoprofen when mixed with N-methylglucamine.

M. D. de Villiers, W. Liebenberg, S. Malan, 1999, Drug development and industrial pharmacy.

Comparison of the Physical and Chemical Stability of Niclosamide Crystal Forms in Aqueous Versus Nonaqueous Suspensions

A. P. Lötter, M. D. de Villiers, W. Liebenberg, 2004, Drug development and industrial pharmacy.

Multifunctional enzyme inhibition for neuroprotection: a focus on MAO, NOS, and AChE inhibitors

B. P. Repsold, J. P. Petzer, J. Joubert, 2014 .

Synthesis, crystal structure, DFT studies and biological evaluation of N-benzamido derivatives of oxahexacycloundecyl amines: A case of enantiomerism leading to molecular disorder

M. Caira, R. Sharma, J. Joubert, 2020, Journal of Molecular Structure.

Preparation and physicochemical characterization of 5 niclosamide solvates and 1 hemisolvate

M. Caira, W. Liebenberg, M. M. Villiers, 2004, AAPS PharmSciTech.

Inhibition of monoamine oxidase B by selected benzimidazole and caffeine analogues.

J. P. Petzer, S. Malan, N. Castagnoli, 2007, Bioorganic & medicinal chemistry.

Polycyclic amines as chloroquine resistance modulating agents in Plasmodium falciparum.

Peter J. Smith, Dale Taylor, J. Joubert, 2016, Bioorganic & medicinal chemistry letters.

Cheminformatics techniques in antimalarial drug discovery and development from natural products 1: basic concepts

Alan Christoffels, Sarel F. Malan, Samuel Egieyeh, 2019, Physical Sciences Reviews.

Pentacycloundecylamines and conjugates thereof as chemosensitizers and reversed chloroquine agents.

Peter J. Smith, Dale Taylor, J. Joubert, 2014, Bioorganic & medicinal chemistry letters.

Novel nitric oxide synthase inhibitors: a patent review

J. Joubert, S. Malan, 2011, Expert opinion on therapeutic patents.

Design, synthesis and evaluation of indole derivatives as multifunctional agents against Alzheimer's disease.

J. Joubert, S. Malan, O. Ekpo, 2018, MedChemComm.

Novel Nitric Oxide Synthase (NOS) Inhibitors: a Patent Review

J. Joubert, S. Malan, 2014 .

Crystal Structure of a Rearranged Cage Compound, 3-Hydroxy-4-aza-8-oxoheptacyclo [9.4.1.02,10.03,14.04,9.09,13.012,15]tetradecane

M. Caira, L. H. Prins, S. Malan, 2008 .

Design, synthesis and evaluation of pentacycloundecane and hexacycloundecane propargylamine derivatives as multifunctional neuroprotective agents.

J. Joubert, S. Malan, O. Ekpo, 2019, European journal of medicinal chemistry.

Role of monoamine oxidase, nitric oxide synthase and regional brain monoamines in the antidepressant-like effects of methylene blue and selected structural analogues.

G. Wegener, B. Harvey, S. Malan, 2010, Biochemical pharmacology.

Predictive classifier models built from natural products with antimalarial bioactivity using machine learning approach

Samuel Egieyeh, James Syce, Sarel F Malan, 2018, PloS one.

Tacrine, Trolox and Tryptoline as Lead Compounds for the Design and Synthesis of Multi-target Agents for Alzheimer’s Disease Therapy

J. Joubert, S. Malan, Gerard A. K. Teponnou, 2017, The open medicinal chemistry journal.

Discovery and biological evaluation of an adamantyl-amide derivative with likely MmpL3 inhibitory activity.

D. Warner, S. Sampson, A. Dippenaar, 2023, Tuberculosis.

Synthesis and evaluation of fluorescent heterocyclic aminoadamantanes as multifunctional neuroprotective agents.

I. Green, J. Joubert, S. Malan, 2011, Bioorganic & medicinal chemistry.

Synthesis and Biological Evaluation of Pentacycloundecylamines and Triquinylamines as Voltage‐Gated Calcium Channel Blockers

W. Geldenhuys, C. J. Van der Schyf, S. Malan, 2016, Archiv der Pharmazie.

Tricycloundecane Derivatives as Potential N‐Methyl‐D‐aspartate (NMDA) Receptor and Voltage‐Gated Calcium Channel Modulators

J. Joubert, S. Malan, Ayodeji O. Egunlusi, 2015, ChemMedChem.

Adamantane amine derivatives as dual acting NMDA receptor and voltage-gated calcium channel inhibitors for neuroprotection

J. Joubert, S. Malan, E. Kapp, 2014 .

Polycyclic propargylamine and acetylene derivatives as multifunctional neuroprotective agents.

J. Joubert, S. Malan, J. Bergh, 2014, European journal of medicinal chemistry.

Triquinane scaffolds: Shape and geometry as a function of saturation and bridgehead groups

M. Zeller, W. Geldenhuys, S. Malan, 2013 .

Fluorescent polycyclic ligands for nitric oxide synthase (NOS) inhibition.

J. Joubert, S. Malan, S. van Dyk, 2008, Bioorganic & medicinal chemistry.

Structure‐Activity Relationships of Polycyclic Aromatic Amines with Calcium Channel Blocking Activity

S. Malan, C. J. van der Schyf, J. van der Walt, 2000, Archiv der Pharmazie.

S-nitrosylation and attenuation of excessive calcium flux by pentacycloundecane derivatives.

F. H. van der Westhuizen, J. Joubert, S. Malan, 2012, Medicinal chemistry.

Synthesis and Structural Analysis of Novel Neuroprotective Pentacyclo[5.4.1.02,6.03,10.05,9]undecane- and Adamantane-Derived Propargylamines

M. Caira, J. Joubert, S. Malan, 2014, Journal of Chemical Crystallography.

Microwave-assisted methods for the synthesis of pentacyclo[5.4.0.02,6.03,10.05,9]undecylamines

R. Sharma, J. Joubert, S. Malan, 2013 .

Nitric Oxide Synthase Inhibition by Pentacycloundecane Conjugates of Aminoguanidine and Tryptamine

S. Malan, D. Oliver, A. D. de Vries, 2009, Archiv der Pharmazie.

Pharmacist-initiated antiretroviral therapy (PIMART).

F. Suleman, S. Malan, I. Truter, 2021, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

Synthesis and in vitro evaluation of pteridine analogues as monoamine oxidase B and nitric oxide synthase inhibitors.

L. H. Prins, S. Malan, J. Petzer, 2009, Bioorganic & medicinal chemistry.

Pharmacology and structure‐activity relationships of bioactive polycyclic cage compounds: A focus on pentacycloundecane derivatives

W. Geldenhuys, C. J. Van der Schyf, J. Bloomquist, 2005, Medicinal research reviews.

The Structure and Ion Channel Activity of 6‐Benzylamino‐3‐hydroxyhexa‐cyclo[6.5.0.03, 7.04, 12.05, 10.09, 13]tridecane

K. Dyason, S. Malan, J. van der Walt, 2003, Archiv der Pharmazie.

The Structure and Ion Channel Activity of 6-Benzylamino-3-hydroxyhexacyclo [6.5.0.03,7.04,12.05,10.09,13] tridecane.

K. Dyason, S. Malan, C. J. Schyf, 2003 .

Design, synthesis and evaluation of indole derivatives as multifunctional agents against Alzheimer's disease.

J. Joubert, S. Malan, O. Ekpo, 2018, MedChemComm.

Role of monoamine oxidase, nitric oxide synthase and regional brain monoamines in the antidepressant-like effects of methylene blue and selected structural analogues.

G. Wegener, B. Harvey, S. Malan, 2010, Biochemical pharmacology.