N. Wishart

发表

Thienopyrimidine ureas as novel and potent multitargeted receptor tyrosine kinase inhibitors.

K. Glaser, S. Davidsen, V. Stoll, 2005, Journal of medicinal chemistry.

Synthesis of α-amino acids using amino acid γ-anion equivalents: synthesis of 5-oxo α-amino acids, homophenylalanine derivatives and pentenylglycines

M. Wythes, N. Wishart, J. Fraser, 1998 .

Purification and kinetic characterization of recombinant human mitogen-activated protein kinase kinase kinase COT and the complexes with its cellular partner NF-kappa B1 p105.

Kevin M. Clark, Anca Clabbers, N. Wishart, 2005, Archives of biochemistry and biophysics.

In vitro and in vivo characterization of the JAK1 selectivity of upadacitinib (ABT-494)

L. Olson, M. Friedman, N. Wishart, 2018, BMC Rheumatology.

THU0127 Pharmacodynamics of A Novel JAK1 Selective Inhibitor in Rat Arthritis and Anemia Models and in Healthy Human Subjects

L. Olson, M. Friedman, N. Wishart, 2014 .

Syk Inhibition Induces Platelet Dependent Peri-islet Hemorrhage in the Rat Pancreas

I. Mikaelian, E. Sampson, M. Hoemann, 2016, Toxicologic pathology.

Benzyl (2S)-2-tert-butoxycarbonylamino-5-(2-furyl)-5-oxopentanoate

N. Wishart, W. Clegg, R. Jackson, 2003 .

2,4-Diaminopyrimidine MK2 inhibitors. Part II: Structure-based inhibitor optimization.

Eric F. Johnson, R. Dixon, D. Borhani, 2010, Bioorganic & medicinal chemistry letters.

Preparation of enantiomerically pure protected 4-oxo .alpha.-amino acids and 3-aryl .alpha.-amino acids from serine

K. James, A. Wood, M. Wythes, 1992 .

Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models.

Jill M. Wetter, M. McPherson, J. Sullivan, 2008, Journal of medicinal chemistry.

Design and synthesis of tricyclic cores for kinase inhibition.

Brian J. Kotecki, Philip J. Merta, S. Shekhar, 2013, Bioorganic & medicinal chemistry letters.

Synthesis and X-ray crystal structure of a homoleptic bismuth amide

R. Errington, N. C. Norman, N. Wishart, 1989 .

Discovery of thieno[2,3-c]pyridines as potent COT inhibitors.

R. Dixon, Anca Clabbers, C. Barberis, 2008, Bioorganic & medicinal chemistry letters.

Alkyl and aryl dimetalla-bismuthine complexes

R. Errington, N. C. Norman, N. Wishart, 1990 .

Phase II Study of ABT‐122, a Tumor Necrosis Factor– and Interleukin‐17A–Targeted Dual Variable Domain Immunoglobulin, in Patients With Psoriatic Arthritis With an Inadequate Response to Methotrexate

P. Peloso, M. Genovese, M. Weinblatt, 2018, Arthritis & rheumatology.

Structure-activity studies on a series of a 2-aminopyrimidine-containing histamine H4 receptor ligands.

Jill M. Wetter, U. Warrior, M. McPherson, 2008, Journal of medicinal chemistry.

Comparative analysis of various in vitro COT kinase assay formats and their applications in inhibitor identification and characterization.

Anca Clabbers, Yajun Xu, R. Talanian, 2006, Analytical biochemistry.

Reaction of a serine-derived organozinc reagent with chloroformates and ethyl oxalyl chloride under palladium catalysis. Preparation of protected (2S, 6S)-4-oxo-2,6-diaminopimelic acid and (2S)-4-oxoglutamic acid

M. Wythes, N. Wishart, R. Jackson, 1992 .

Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor

R. Dixon, D. Borhani, R. Talanian, 2012, BMC Structural Biology.

Identification of a selective thieno[2,3-c]pyridine inhibitor of COT kinase and TNF-alpha production.

R. Dixon, Anca Clabbers, A. Salmeron, 2009, Bioorganic & Medicinal Chemistry Letters.

Preparation of a Serine-Derived Organozinc Reagent in Tetrahydrofuran: Synthesis of Novel, Enantiomerically Pure Allenic, Acetylenic and Heteroaryl Amino Acids

M. Dunn, J. Pietruszka, M. Wythes, 1993 .

Structure activity optimization of 6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazines as Jak1 kinase inhibitors.

Ana L. Aguirre, E. Tarcsa, Bin Li, 2015, Bioorganic & medicinal chemistry letters.

Minimum Significant Ratio of Selectivity Ratios (MSRSR) and Confidence in Ratio of Selectivity Ratios (CRSR)

Viswanath Devanarayan, Christopher M Harris, V. Devanarayan, 2012, Journal of biomolecular screening.

Preparation of Enantiomerically Pure Protected 4-Oxo-α-amino Acids and 3-Aryl-α-amino Acids from Serine.

K. James, A. Wood, M. Wythes, 1992 .

A New α-Amino Acid γ-Anion Equivalent: Direct Synthesis of Enantiomercially Pure Protected Amino Acids

M. Wythes, N. Wishart, R. Jackson, 1993 .

Phase 2 Study of ABT-122, a TNF- and IL-17A-Targeted Dual Variable Domain Immunoglobulin, in Psoriatic Arthritis With Inadequate Methotrexate Response.

P. Peloso, M. Genovese, M. Weinblatt, 2018 .

Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models.

Jill M. Wetter, M. McPherson, J. Sullivan, 2008, Journal of medicinal chemistry.