Ruth L. Martin

发表

Discovery of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted receptor tyrosine kinase inhibitor.

K. Glaser, S. Davidsen, V. Stoll, 2007, Journal of medicinal chemistry.

Utility of hERG Assays as Surrogate Markers of Delayed Cardiac Repolarization and QT Safety

Gary A Gintant, Zhi Su, G. Gintant, 2006, Toxicologic pathology.

Block of hERG channel by ziprasidone: biophysical properties and molecular determinants.

G. Gintant, M. Gopalakrishnan, Ruth L. Martin, 2006, Biochemical pharmacology.

Characterization of A-935142, a hERG enhancer, in the presence and absence of standard hERG blockers.

G. Gintant, G. Diaz, Ruth L. Martin, 2012, Life sciences.

Mesoridazine: an open-channel blocker of human ether-a-go-go-related gene K+ channel.

G. Gintant, Ruth L. Martin, B. Cox, 2004, Journal of molecular and cellular cardiology.

Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours

Chunaram Choudhary, Saul H. Rosenberg, Ronen Marmorstein, 2017, Nature.

Drug-induced QT prolongation: Concordance of preclinical anesthetized canine model in relation to published clinical observations for ten CiPA drugs.

G. Gintant, Y. Koshman, S. Mittelstadt, 2020, Journal of pharmacological and toxicological methods.

1,4-Dihydroindeno[1,2-c]pyrazoles with acetylenic side chains as novel and potent multitargeted receptor tyrosine kinase inhibitors with low affinity for the hERG ion channel.

S. Davidsen, G. Gintant, Eric F. Johnson, 2007, Journal of medicinal chemistry.

A novel secretagogue increases cardiac contractility by enhancement of L-type Ca2+ current.

G. Gintant, G. Diaz, Ruth L. Martin, 2010, Biochemical pharmacology.

Comparative analysis of inactivated-state block of N-type (Cav2.2) calcium channels

D. Donnelly-roberts, A. Swensen, T. Neelands, 2011, Inflammation Research.

Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor.

Chaohong Sun, L. Hasvold, Chang H. Park, 2017, Journal of Medicinal Chemistry.

Electrophysiologic characterization of a novel hERG channel activator.

G. Gintant, A. Souers, G. Diaz, 2009, Biochemical pharmacology.

Functional consequences of methionine oxidation of hERG potassium channels.

G. Gintant, S. Heinemann, R. Xu, 2007, Biochemical pharmacology.

ALTERING EXTRACELLULAR POTASSIUM CONCENTRATION DOES NOT MODULATE DRUG BLOCK OF HUMAN ETHER‐A‐GO‐GO‐RELATED GENE (hERG) CHANNELS

G. Gintant, Ruth L. Martin, B. Cox, 2006, Clinical and experimental pharmacology & physiology.

Hydroxypropyl β-Cyclodextrins: A Misleading Vehicle for the In Vitro hERG Current Assay

G. Gintant, Ruth L. Martin, M. Long, 2007, Journal of cardiovascular pharmacology.

Discovery of Spirohydantoins as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases.

Mikkel A. Algire, K. Bromberg, M. Michaelides, 2021, Bioorganic & medicinal chemistry letters.

In vitro studies on a class of quinoline containing histamine H3 antagonists.

G. Diaz, J. Brioni, Ruth L. Martin, 2010, Bioorganic & medicinal chemistry letters.

The effects of plasma proteins on delayed repolarization in vitro with cisapride, risperidone, and D, L-sotalol.

G. Gintant, Ruth L. Martin, B. Cox, 2007, Journal of pharmacological and toxicological methods.

The [3H]dofetilide binding assay is a predictive screening tool for hERG blockade and proarrhythmia: Comparison of intact cell and membrane preparations and effects of altering [K+]o.

Gary A Gintant, Zhi Su, G. Gintant, 2004, Journal of pharmacological and toxicological methods.

ABT-089: pharmacological properties of a neuronal nicotinic acetylcholine receptor agonist for the potential treatment of cognitive disorders.

D. Donnelly-roberts, G. Gintant, J. Sullivan, 2006, CNS drug reviews.

Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction.

D. Donnelly-roberts, Jill M. Wetter, G. Gintant, 2006, Journal of medicinal chemistry.

An evaluation of 3,4-methylenedioxy phenyl replacements in the aminopiperidine chromone class of MCHr1 antagonists.

A. Souers, G. Diaz, H. Sham, 2007, Bioorganic & medicinal chemistry letters.

In Vitro Preclinical Cardiac Assessment of Tolterodine and Terodiline: Multiple Factors Predict the Clinical Experience

Gary A Gintant, Zhi Su, G. Gintant, 2006, Journal of cardiovascular pharmacology.

Preclinical Characterization of A‐582941: A Novel α7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition‐Enhancing Properties

J. Waring, S. Otte, K. Browman, 2008, CNS neuroscience & therapeutics.

Newly Cloned Threshold Channels

J. Tytgat, C. Ulens, D. Hanck, 2011 .

The Utility of hERG and Repolarization Assays in Evaluating Delayed Cardiac Repolarization: Influence of Multi-Channel Block

Gary A Gintant, G. Gintant, Ruth L. Martin, 2004, Journal of cardiovascular pharmacology.

Negative inotropic effect of a CB2 agonist A-955840 in isolated rabbit ventricular myocytes is independent of CB1 and CB2 receptors.

G. Gintant, G. Diaz, Ruth L. Martin, 2011, Current Drug Safety.

Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension.

V. Stoll, G. Gintant, Eric F. Johnson, 2007, Journal of medicinal chemistry.

Ventricular rate adaptation: a novel, rapid, cellular-based in-vitro assay to identify proarrhythmic and torsadogenic compounds.

G. Gintant, G. Diaz, Stan Kantor, 2011, Journal of pharmacological and toxicological methods.

Mibefradil block of cloned T-type calcium channels.

Jung-Ha Lee, D. Hanck, E. Perez-Reyes, 2000, The Journal of pharmacology and experimental therapeutics.

Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours

Mikkel A. Algire, L. Lam, Chaohong Sun, 2017, Nature.

Chang H. Park, D. Albert, Emily J. Faivre, 2017, Journal of medicinal chemistry.

Characterization of A-935142, a hERG enhancer, in the presence and absence of standard hERG blockers.

G. Gintant, G. Diaz, Ruth L. Martin, 2012, Life sciences.