Longbin Liu

发表

Discovery of a potent, selective, and orally bioavailable c-Met inhibitor: 1-(2-hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (AMG 458).

K. Rex, Matthew R. Lee, C. Dominguez, 2008, Journal of Medicinal Chemistry.

Structure-based design of novel class II c-Met inhibitors: 2. SAR and kinase selectivity profiles of the pyrazolone series.

D. Whittington, Matthew R. Lee, C. Dominguez, 2012, Journal of medicinal chemistry.

Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase-Glucokinase Regulatory Protein (GK-GKRP) Binding: Strategic Use of a N → S (nN → σ*S-X) Interaction for Conformational Constraint.

Kristin L. Andrews, Jiandong Zhang, S. Chmait, 2015, Journal of medicinal chemistry.

Discovery of AMG 458: A Potent, Selective, and Orally Bioavailable c-Met Inhibitor

K. Rex, Matthew R. Lee, S. Bellon, 2008 .

A soluble base for the copper-catalyzed imidazole N-arylations with aryl halides.

C. Dominguez, R. Hungate, Longbin Liu, 2005, The Journal of organic chemistry.

Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles.

R. Kunz, Jiandong Zhang, S. Chmait, 2014, Journal of medicinal chemistry.

PROTEINS WITH PROLONGED HALF-LIFE 3 . R : 39

Longbin Liu, C. Fronda, 2017 .

Total synthesis of FK-506. Part 1: Construction of the C16–C34 fragment☆

Longbin Liu, R. Ireland, T. Roper, 1997 .

Purinylpyridinylamino-based DFG-in/αC-helix-out B-Raf inhibitors: Applying mutant versus wild-type B-Raf selectivity indices for compound profiling.

D. Whittington, H. Bregman, Matthew R. Lee, 2016, Bioorganic & medicinal chemistry.

Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis.

S. Chmait, M. Bartberger, S. Jordan, 2015, Journal of medicinal chemistry.

Total synthesis of FK-506. Part 2: Completion of the synthesis☆

J. L. Gleason, Longbin Liu, R. Ireland, 1997 .

Discovery and optimization of a series of benzothiazole phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors.

Daniel J. Freeman, R. Wahl, J. McCarter, 2011, Journal of medicinal chemistry.

Comparative approaches toward diamines containing spatially separated homobenzylic and benzylic nitrogen stereocenters

Michal M. Achmatowicz, M. Faul, Longbin Liu, 2007 .

Discovery of a covalent inhibitor of KRASG12C (AMG 510) for the treatment of solid tumors.

N. Chen, J. McCarter, K. Rex, 2019, Journal of medicinal chemistry.

Structure-based design of novel class II c-Met inhibitors: 1. Identification of pyrazolone-based derivatives.

K. Rex, Matthew R. Lee, C. Dominguez, 2012, Journal of medicinal chemistry.

Design, synthesis, and biological evaluation of potent c-Met inhibitors.

Yuan Cheng, K. Rex, A. Coxon, 2008, Journal of medicinal chemistry.

USE OF THIAZYL CHLORIDES, ALKYL CARBAMATES, AND THIONYL CHLORIDE TO FUSE 1,2,5-THIADIAZOLES TO QUINONES AND TO OXIDIZE, CHLORINATE, AND AMINATE THEM

B. Yang, T. J. Katz, Longbin Liu, 1995 .

An efficient one-pot construction of substituted pyrimidinones

C. Dominguez, M. Bartberger, P. Ibrahim, 2006 .

Binding of Thrombin to the G-protein-linked Receptor, and Not to Glycoprotein Ib, Precedes Thrombin-mediated Platelet Activation*

J. Freedman, F. Ofosu, Longbin Liu, 1997, The Journal of Biological Chemistry.

Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.

Daniel J. Freeman, J. McCarter, Nancy Zhang, 2012, Journal of medicinal chemistry.

Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series.

R. Kunz, S. Chmait, M. Bartberger, 2014, Journal of medicinal chemistry.

Synthesis and structure-activity relationships of dual PI3K/mTOR inhibitors based on a 4-amino-6-methyl-1,3,5-triazine sulfonamide scaffold.

Daniel J. Freeman, J. McCarter, Nancy Zhang, 2012, Bioorganic & medicinal chemistry letters.

Structure-based design of a novel series of potent, selective inhibitors of the class I phosphatidylinositol 3-kinases.

Daniel J. Freeman, J. McCarter, D. Whittington, 2012, Journal of medicinal chemistry.

High-Content Screening Analysis of the p38 Pathway: Profiling of Structurally Related p38α Kinase Inhibitors Using Cell-Based Assays

C. Dominguez, D. Powers, S. Ross, 2006 .

The development of a structurally distinct series of BACE1 inhibitors via the (Z)-fluoro-olefin amide bioisosteric replacement.

N. Chen, D. Whittington, M. Bartberger, 2020, Bioorganic & medicinal chemistry letters.

Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors

R. Wahl, Jiandong Zhang, S. Chmait, 2013, Nature.

Phospshoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors: discovery and structure-activity relationships of a series of quinoline and quinoxaline derivatives.

Daniel J. Freeman, Hongyu Liao, Nancy Zhang, 2011, Journal of medicinal chemistry.

Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways

Dirk E. Smith, J. Johnston, O. Homann, 2018, bioRxiv.

Electron Delocalization in Helical Quinone Anion Radicals

C. Liberko, B. Yang, L. Miller, 1991 .

An Efficient Synthesis of Functionalized Helicenes

C. Nuckolls, N. Willmore, A. Rheingold, 1997 .

Selective β-Hydroxyethylation at the N-1 Position of a Pyrazolone: Synthesis of Benzyl 1-(β-Hydroxyethyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylate

R. Bürli, C. Dominguez, Longbin Liu, 2008 .