N. Xi

发表

Discovery of a potent, selective, and orally bioavailable c-Met inhibitor: 1-(2-hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (AMG 458).

K. Rex, Matthew R. Lee, C. Dominguez, 2008, Journal of Medicinal Chemistry.

Structure-based design of novel class II c-Met inhibitors: 2. SAR and kinase selectivity profiles of the pyrazolone series.

D. Whittington, Matthew R. Lee, C. Dominguez, 2012, Journal of medicinal chemistry.

Design of potent, orally available antagonists of the transient receptor potential vanilloid 1. Structure-activity relationships of 2-piperazin-1-yl-1H-benzimidazoles.

J. Treanor, C. Dominguez, C. Fotsch, 2006, Journal of medicinal chemistry.

Interaction of Cu(II) 3,5-diisopropylsalicylate with human serum albumin - an evaluation of spectroscopic data

F. Greenaway, N. Xi, J. Hahn, 2004, Biometals.

Elevated Conformational Rigidity in Dipeptides Incorporating Piperazic Acid Derivatives

L. B. Alemany, M. Ciufolini, N. Xi, 1998 .

Drug interaction of ningetinib and gefitinib involving CYP1A1 and efflux transporters in non‐small cell lung cancer patients

Xiaoyan Chen, Ming Li, Cen Xie, 2020, British journal of clinical pharmacology.

Discovery of AMG 458: A Potent, Selective, and Orally Bioavailable c-Met Inhibitor

K. Rex, Matthew R. Lee, S. Bellon, 2008 .

Research letter: is monitoring for CD4 counts still needed for the management of patients with long-term HIV RNA suppression?

C. Stephan, N. Xi, A. Hill, 2012, Journal of acquired immune deficiency syndromes.

Melanocortin subtype-4 receptor agonists containing a piperazine core with substituted aryl sulfonamides.

N. Chen, C. Fotsch, A. Bannon, 2005, Bioorganic & medicinal chemistry letters.

Studies on structural requirements for atropisomerism in N -phenyl γ-lactams

L. Xiaobo, N. Xi, X. Bai, 2018, Tetrahedron.

Noncovalent Interactions of Fluorine with Amide and CH2 Groups in N-Phenyl γ-Lactams: Covalently Identical Fluorine Atoms in Nonequivalent Chemical Environments.

N. Xi, X. Bai, Mingming Sun, 2018, The Journal of organic chemistry.

A soluble base for the copper-catalyzed imidazole N-arylations with aryl halides.

C. Dominguez, R. Hungate, Longbin Liu, 2005, The Journal of organic chemistry.

N-Aryl-γ-lactams as integrin αvβ3 antagonists

Jiandong Zhang, A. Tasker, C. Dominguez, 2004 .

Total synthesis of luzopeptin C

M. Ciufolini, N. Xi, P. Belmont, 2001 .

Preclinical characterization and phase I clinical trial of CT053PTSA targets MET, AXL, and VEGFR2 in patients with advanced solid tumors

N. Xi, W. Fang, Yu-xiang Ma, 2022, Frontiers in Immunology.

Practical synthesis of bicyclic pyrazol-5-one derivatives

N. Xi, Michael A. Xi, Feng Xuejin, 2017 .

Interleukin-6 and C-reactive protein levels after 3 years of treatment with darunavir/ritonavir monotherapy or darunavir/ritonavir + two nucleoside reverse transcriptase inhibitors in the MONET trial.

J. Arribas, N. Xi, A. Hill, 2012, The Journal of antimicrobial chemotherapy.

Total Synthesis of Luzopeptin E2

M. Ciufolini, N. Xi, Delphine Valognes, 2000 .

NITROGEN HETEROCYCLES FROM FURANS : THE AZA-ACHMATOWICZ REACTION

M. Ciufolini, Toshio Shimizu, N. Xi, 1998 .

Studies toward Luzopeptins: Assembly of the Elusive Serine-PCA Dipeptide.

M. Ciufolini, N. Xi, 1997, The Journal of organic chemistry.

Discovery and optimization of a series of benzothiazole phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors.

Daniel J. Freeman, R. Wahl, J. McCarter, 2011, Journal of medicinal chemistry.

Synthesis and evaluation of thiazole carboxamides as vanilloid receptor 1 (TRPV1) antagonists.

J. Treanor, R. Hungate, E. Doherty, 2005, Bioorganic & medicinal chemistry letters.

Design of a new peptidomimetic agonist for the melanocortin receptors based on the solution structure of the peptide ligand, Ac-Nle-cyclo[Asp-Pro-DPhe-Arg-Trp-Lys]-NH(2).

Michael G Kelly, J. Cheetham, M. Jarosinski, 2003, Bioorganic & medicinal chemistry letters.

A protection scheme for the preparation of acid chlorides of serine and threonine

M. Ciufolini, N. Xi, 1995 .

Synthesis, chemistry and conformational properties of piperazic acids

M. Ciufolini, N. Xi, 1998 .

Synthesis and chemical properties of PCA, an unusual amino acid in luzopeptins

M. Ciufolini, N. Xi, 1994 .

19F NMR spectroscopy as a tool to detect rotations in fluorine substituted phenyl compounds

N. Xi, Zhen-Jiang Liu, Wuhong Chen, 2020 .

4-Phenyl tetrahydroisoquinolines as dual norepinephrine and dopamine reuptake inhibitors.

D. Kitchen, Shuang Liu, R. Olson, 2012, Bioorganic & medicinal chemistry letters.

Structure-based design of novel class II c-Met inhibitors: 1. Identification of pyrazolone-based derivatives.

K. Rex, Matthew R. Lee, C. Dominguez, 2012, Journal of medicinal chemistry.

Design, synthesis, and biological evaluation of potent c-Met inhibitors.

Yuan Cheng, K. Rex, A. Coxon, 2008, Journal of medicinal chemistry.

Glow discharge electrolysis plasma initiated preparation of temperature/pH dual sensitivity reed hemicellulose-based hydrogels.

Wenming Zhang, Xiaowei Li, Yucang Zhang, 2015, Carbohydrate polymers.

Regio-controlled synthesis of N-substituted imidazoles

A. Tasker, R. Hungate, N. Xi, 2005 .

Investigation of Major Flavonoids from Artemisia argyi as a Potential COVID-19 Drug: Molecular Docking and DFT Calculations

Bin Zhang, Ning Wang, N. Xi, 2022, Crystals.

Synthesis of novel melanocortin 4 receptor agonists and antagonists containing a succinamide core.

C. Fotsch, Markian M Stec, N. Xi, 2004, Bioorganic & medicinal chemistry letters.

Glow discharge electrolysis plasma induced synthesis of cellulose-based ionic hydrogels and their multiple response behaviors

Wenming Zhang, Yucang Zhang, N. Xi, 2015 .

Electrostatic effects on 19F NMR chemical shifts in N-phenyl γ-lactam derivatives

N. Xi, Mingming Sun, Yang Lu, 2022, Tetrahedron.

Facile synthesis of bicyclic 1-arylpyrazol-5-ones

Zhuo-rong Li, N. Xi, X. Bai, 2014 .

Selective β-Hydroxyethylation at the N-1 Position of a Pyrazolone: Synthesis of Benzyl 1-(β-Hydroxyethyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylate

R. Bürli, C. Dominguez, Longbin Liu, 2008 .

Nitrogen Heterocycles From Furans: The Aza-Achmatowicz Reaction

M. Ciufolini, Toshio Shimizu, N. Xi, 1998 .