C. Garland

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Evidence for expression and function of phosphodiesterase type 5 (PDE‐V) in rat resistance arteries

L. J. Sampson, J. Hinton, C. Garland, 2001, British journal of pharmacology.

An indirect influence of phenylephrine on the release of endothelium‐derived vasodilators in rat small mesenteric artery

J. Hinton, C. Garland, K. Dora, 2000, British journal of pharmacology.

Spreading dilatation in rat mesenteric arteries associated with calcium‐independent endothelial cell hyperpolarization

C. Garland, Kim A Dora, K. Dora, 2004, The Journal of physiology.

Contribution of both nitric oxide and a change in membrane potential to acetylcholine‐induced relaxation in the rat small mesenteric artery

C. Garland, G. Waldron, Gareth J. Waldron, 1994, British journal of pharmacology.

Influence of the endothelium and alpha‐adrenoreceptor antagonists on responses to noradrenaline in the rabbit basilar artery.

C. Garland, 1989, The Journal of physiology.

A mechanosensitive cation channel in endothelial cells and its role in vasoregulation.

H. Kwan, C. Garland, X. Yao, 2003, Biorheology.

Constrictor actions of acetylcholine, 5‐hydroxytryptamine and histamine on bovine coronary artery inner and outer muscle

W. Keatinge, C. Garland, W. R. Keatinge, 1982, The Journal of physiology.

Scaffolding Builds to Reduce Blood Pressure

C. Garland, P. Bagher, 2014, Science Signaling.

Linking Hyperpolarization to Endothelial Cell Calcium Events in Arterioles

C. Garland, K. Dora, 2013, Microcirculation.

Endothelium‐dependent contractile responses to 5‐hydroxytryptamine in the rabbit basilar artery

C. Garland, J. Seager, A. Clark, 1992, British journal of pharmacology.

Phospholipase A2 and protein kinase C contribute to myofilament sensitization to 5‐HT in the rabbit mesenteric artery.

S. Parsons, C. Garland, M. J. Sumner, 1996, The Journal of physiology.

Electrophysiology of cerebral blood vessels.

C. Garland, F. Plane, 1992, Pharmacology & therapeutics.

K+ is an endothelium-derived hyperpolarizing factor in rat arteries

C. Garland, G. Edwards, A. Weston, 1998, Nature.

Spreading vasodilatation in resistance arteries.

C. Garland, K. Dora, H. Takano, 2005, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.

Evidence for Involvement of Both IKCa and SKCa Channels in Hyperpolarizing Responses of the Rat Middle Cerebral Artery

S. Sandow, C. Garland, C. Neylon, 2006, Stroke.

Vascular hyperpolarization to β‐adrenoceptor agonists evokes spreading dilatation in rat isolated mesenteric arteries

C. Garland, F. Jiménez-Altayó, P. Yarova, 2011, British journal of pharmacology.

Endothelium-dependent hyperpolarization: a role in the control of vascular tone.

C. Garland, T. Cocks, F. Plane, 1995, Trends in pharmacological sciences.

Smooth muscle hyperpolarization and relaxation to acetylcholine in the rabbit basilar artery.

C. Garland, F. Plane, 1994, Journal of the autonomic nervous system.

VEGF‐A inhibits agonist‐mediated Ca2+ responses and activation of IKCa channels in mouse resistance artery endothelial cells

C. Garland, P. Bagher, K. Dora, 2018, The Journal of physiology.

Spatial separation of endothelial small‐ and intermediate‐conductance calcium‐activated potassium channels (KCa) and connexins: possible relationship to vasodilator function?

S. Sandow, C. Garland, C. Neylon, 2006, Journal of anatomy.

Small‐ and Intermediate‐Conductance Calcium‐Activated K+ Channels Provide Different Facets of Endothelium‐Dependent Hyperpolarization in Rat Mesenteric Artery

C. Garland, G. J. Crane, K. Dora, 2003, The Journal of physiology.

Enhanced spontaneous Ca2+ events in endothelial cells reflect signalling through myoendothelial gap junctions in pressurized mesenteric arteries.

C. Garland, K. Dora, Yasuo Kansui, 2008, Cell calcium.

Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca2+ events, and IKCa channels, reducing arteriolar tone

C. Garland, P. Bagher, K. Dora, 2012, Proceedings of the National Academy of Sciences.

Rapid Endothelial Cell–Selective Loading of Connexin 40 Antibody Blocks Endothelium-Derived Hyperpolarizing Factor Dilation in Rat Small Mesenteric Arteries

S. Sandow, C. Garland, K. Dora, 2005, Circulation research.

Selective block of intracellular calcium release and EDHF dilatation in rat isolated resistance arteries

C. Garland, K. Dora, S. Mather, 2004 .

A technique to incorporate cell impermeant compounds into the endothelium of pressurized mesenteric arteries

C. Garland, K. Dora, S. Mather, 2004 .

Possible Role for K+ in Endothelium-Derived Hyperpolarizing Factor–Linked Dilatation in Rat Middle Cerebral Artery

C. Garland, K. Dora, A. McNeish, 2005, Stroke.

NO and KATP channels underlie endotoxin‐induced smooth muscle hyperpolarization in rat mesenteric resistance arteries

C. Garland, S. J. Chen, C. Wu, 2004, British journal of pharmacology.

The influence of phenylephrine outward potassium currents in single smooth muscle cells from the rabbit mesenteric artery.

C. Garland, D. Mistry, 1999, General pharmacology.

Nitric oxide (NO)-induced activation of large conductance Ca 2+ -dependent K + channels (BK Ca ) in smooth muscle cells isolated from the rat mesenteric artery

C. Garland, D. Mistry, 1998 .

Differential effects of acetylcholine, nitric oxide and levcromakalim on smooth muscle membrane potential and tone in the rabbit basilar artery

C. Garland, Trances Plane, 1993, British journal of pharmacology.

Ca2+ channel antagonists and inhibition of protein kinase C each block contraction but not depolarization to 5-hydroxytryptamine in the rabbit basilar artery.

C. Garland, A. Clark, 1993, European journal of pharmacology.

The role of membrane depolarization in the contractile response of the rabbit basilar artery to 5‐hydroxytryptamine.

C. Garland, 1987, The Journal of physiology.

K(Ca) channel blockers reveal hyperpolarization and relaxation to K+ in rat isolated mesenteric artery.

C. Garland, K. Dora, N. T. Ings, 2002, American journal of physiology. Heart and circulatory physiology.

Relaxation to authentic nitric oxide and SIN‐1 in rat isolated mesenteric arteries: variable role for smooth muscle hyperpolarization

L. J. Sampson, C. Garland, F. Plane, 2001, British journal of pharmacology.

Evidence that different mechanisms underlie smooth muscle relaxation to nitric oxide and nitric oxide donors in the rabbit isolated carotid artery

R. Cohen, C. Garland, F. Plane, 1998, British journal of pharmacology.

Evidence that potassium channels make a major contribution to SIN‐1‐evoked relaxation of rat isolated mesenteric artery

C. Garland, F. Plane, J. Jeremy, 1996, British journal of pharmacology.

Intrinsic regulation of microvascular tone by myoendothelial feedback circuits.

C. Garland, K. Dora, Hamish A L Lemmey, 2020, Current topics in membranes.

EDH: endothelium‐dependent hyperpolarization and microvascular signalling

C. Garland, K. Dora, 2017, Acta physiologica.

Thromboxane receptor stimulation associated with loss of SKCa activity and reduced EDHF responses in the rat isolated mesenteric artery

C. Garland, G. J. Crane, 2004, British journal of pharmacology.

5‐Hydroxytryptamine‐stimulated accumulation of 1,2‐diacylglycerol in the rabbit basilar artery: a role for protein kinase C in smooth muscle contraction

C. Garland, A. Clark, Angela H. Clark, 1991, British journal of pharmacology.

Signalling Pathways Activated by 5-HT1B/5-HT1D Receptors in Native Smooth Muscle and Primary Cultures of Rabbit Renal Artery Smooth Muscle Cells

P. B. Hill, J. Hinton, C. Garland, 2000, Journal of Vascular Research.

Endothelium-dependent hyperpolarizing factor:a significant influence on vascular dilatation in health and disease

C. Garland, 2004 .

Characterisation of inositol 1,4,5-trisphosphate binding sites in rabbit aortic smooth muscle.

L. Broad, T. Murphy, C. Garland, 1995, European journal of pharmacology.

Influence of contractile agonists on the mechanism of endothelium‐dependent relaxation in rat isolated mesenteric artery

C. Garland, F. Plane, 1996, British journal of pharmacology.

Spatial association of K-Ca and gap junction connexins in rat mesenteric artery

S. Sandow, C. Garland, 2006 .

Compromised vascular endothelial cell SKCa activity: a fundamental aspect of hypertension?

C. Garland, 2010, British journal of pharmacology.

Signaling and structures underpinning conducted vasodilation in human and porcine intramyocardial coronary arteries

C. Garland, R. Ascione, L. Borysova, 2022, Frontiers in Cardiovascular Medicine.

Hyperglycaemia disrupts conducted vasodilation in the resistance vasculature of db/db mice

C. Triggle, H. Ding, C. Garland, 2018, Vascular pharmacology.

Role of Endothelial Cell Ion Channels in the Resistance Artery Function

C. Garland, 2003, Neurophysiology.

Interactions between endothelium‐derived relaxing factors in the rat hepatic artery: focus on regulation of EDHF

P. Zygmunt, E. Högestätt, C. Garland, 1998, British journal of pharmacology.

Endothelial cell protein kinase G inhibits release of EDHF through a PKG-sensitive cation channel.

H. Kwan, C. Garland, X. Yao, 2001, American journal of physiology. Heart and circulatory physiology.

β1‐Adrenoceptor stimulation suppresses endothelial IKCa‐channel hyperpolarization and associated dilatation in resistance arteries

S. Smirnov, C. Garland, P. Yarova, 2013, British journal of pharmacology.

A novel role for HNO in local and spreading vasodilatation in rat mesenteric resistance arteries.

C. Garland, P. Yarova, K. Dora, 2011, Antioxidants & redox signaling.

Activation of endothelial cell IKCa with 1‐ethyl‐2‐benzimidazolinone evokes smooth muscle hyperpolarization in rat isolated mesenteric artery

C. Garland, G. J. Crane, K. Dora, 2001, British journal of pharmacology.

Depletion of intracellular Ca2+ stores enhances flow‐induced vascular dilatation in rat small mesenteric artery

C. Garland, Yu Huang, X. Yao, 2006, British journal of pharmacology.

Vasorelaxation to the Nitroxyl Donor Isopropylamine NONOate in Resistance Arteries Does Not Require Perivascular Calcitonin Gene–Related Peptide

C. Garland, K. Dora, Hamish A L Lemmey, 2017, Hypertension.

TRPM4 inhibitor 9‐phenanthrol activates endothelial cell intermediate conductance calcium‐activated potassium channels in rat isolated mesenteric artery

S. Smirnov, C. Garland, P. Bagher, 2015, British journal of pharmacology.

Effect of the Na-K-2Cl cotransporter NKCC1 on systemic blood pressure and smooth muscle tone.

W. C. O'Neill, S. Wall, C. Garland, 2007, American journal of physiology. Heart and circulatory physiology.

Alpha adrenoceptor antagonists selectively reduce thrombin-stimulated contraction in rabbit arteries.

J. Bevan, C. Garland, 1986, The Journal of pharmacology and experimental therapeutics.

Importance of inositol (1,4,5)‐trisphosphate, intracellular Ca2+ release and myofilament Ca2+ sensitization in 5‐hydroxytryptamine‐evoked contraction of rabbit mesenteric artery

T. Murphy, C. Garland, J. Seager, 1994, British journal of pharmacology.

Thromboxane A2 inhibition of SKCa after NO synthase block in rat middle cerebral artery

C. Garland, A. McNeish, 2007, British journal of pharmacology.

Thromboxane A 2 inhibition of SKCa after NO synthase block in rat middle cerebral artery

C. Garland, A. McNeish, 2007 .

Lack of endothelin ETB receptor-mediated smooth muscle hyperpolarization in rat mesenteric resistance arteries.

A. Roach, C. Garland, G. Waldron, 1996, European journal of pharmacology.

The relative importance of nitric oxide and nitric oxide‐independent mechanisms in acetylcholine‐evoked dilatation of the rat mesenteric bed

S. Parsons, C. Garland, G. Waldron, 1994, British journal of pharmacology.

The involvement of intracellular Ca2+ in 5‐HT1B/1D receptor‐mediated contraction of the rabbit isolated renal artery

P. B. Hill, A. Hughes, C. Garland, 2000, British journal of pharmacology.

Evidence that anandamide and EDHF act via different mechanisms in rat isolated mesenteric arteries

C. Garland, J. Boyle, F. Plane, 1997, British journal of pharmacology.

Characterization of muscarinic receptors mediating contractions of circular and longitudinal muscle of human isolated colon

C. Garland, P. Kerr, K. Hillier, 1995, British journal of pharmacology.

Extracellular ATP facilitates flow-induced vasodilatation in rat small mesenteric arteries.

C. Garland, Yu Huang, X. Yao, 2004, American journal of physiology. Heart and circulatory physiology.

Application for Membership of the ESM

Thomas Binder, Gerold Porenta, Yasuhiro Ono, 2000, Journal of Vascular Research.

Evidence against C‐type natriuretic peptide as an arterial ‘EDHF’

C. Garland, K. Dora, 2008, British journal of pharmacology.

EFFECT OF CALCIUM ON THE UPTAKE AND TOXICITY OF LEAD IN HORDEUM VULGARE L. AND FESTUCA OVINA L.

D. Wilkins, C. Garland, 1981 .

The PPARβ/δAgonist GW0742 Relaxes Pulmonary Vessels and Limits Right Heart Hypertrophy in Rats with Hypoxia-Induced Pulmonary Hypertension

J. Mitchell, L. Moreno, L. S. Harrington, 2010, PloS one.

Nitric oxide (NO)‐induced activation of large conductance Ca2+‐dependent K+ channels (BKCa) in smooth muscle cells isolated from the rat mesenteric artery

C. Garland, D. Mistry, Christopher J. Garland, 1998 .

Recent developments in vascular endothelial cell transient receptor potential channels.

C. Garland, X. Yao, 2005, Circulation research.

5‐Hydroxytryptamine stimulation of phospholipase D activity in the rabbit isolated mesenteric artery

J. Hinton, C. Garland, D. Adams, 1999, British journal of pharmacology.

EDHF: spreading the influence of the endothelium

C. Garland, C. Hiley, K. Dora, 2011, British journal of pharmacology.

Nitric oxide is the mediator of both endothelium-dependent relaxation and hyperpolarization of the rabbit carotid artery.

R. Cohen, T. Malinski, C. Garland, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Endothelium‐dependent relaxation to acetylcholine in the rabbit basilar artery: importance of membrane hyperpolarization

C. Garland, V E Rand, C J Garland, 1992, British journal of pharmacology.

Voltage-dependent Ca2+ entry into smooth muscle during contraction promotes endothelium-mediated feedback vasodilation in arterioles

C. Garland, P. Bagher, L. Borysova, 2017, Science Signaling.

Phospholemman Phosphorylation Regulates Vascular Tone, Blood Pressure, and Hypertension in Mice and Humans

M. Caulfield, A. Doney, C. Palmer, 2020, Circulation.

Modulation of Endothelial Cell KCa3.1 Channels During Endothelium-Derived Hyperpolarizing Factor Signaling in Mesenteric Resistance Arteries

C. Garland, K. Dora, A. McNeish, 2008, Circulation research.

Myoendothelial Gap Junctions May Provide the Pathway for EDHF in Mouse Mesenteric Artery

C. Hill, S. Sandow, C. Garland, 2003, Journal of Vascular Research.

Evidence for a Differential Cellular Distribution of Inward Rectifier K Channels in the Rat Isolated Mesenteric Artery

C. Garland, G. J. Crane, K. Dora, 2003, Journal of Vascular Research.

Characteristics of Single, Large-Conductance Calcium-Dependent Potassium Channels (BKCa) from Smooth Muscle Cells Isolated from the Rabbit Mesenteric Artery

C. Garland, D. Mistry, 1998, The Journal of Membrane Biology.

Evidence that nitric oxide does not mediate the hyperpolarization and relaxation to acetylcholine in the rat small mesenteric artery

C. Garland, G. Mcpherson, 1992, British journal of pharmacology.

Evidence both L-type and non-L-type voltage-dependent calcium channels contribute to cerebral artery vasospasm following loss of NO in the rat

C. Garland, A. McNeish, Francesc Jiménez Altayó, 2010, Vascular pharmacology.

Nitric Oxide Suppresses Cerebral Vasomotion by sGC-Independent Effects on Ryanodine Receptors and Voltage-Gated Calcium Channels

C. Garland, K. Dora, K. Yuill, 2009, Journal of Vascular Research.

Properties of smooth muscle hyperpolarization and relaxation to K+ in the rat isolated mesenteric artery.

C. Garland, K. Dora, 2001, American journal of physiology. Heart and circulatory physiology.

Endothelial Nitric Oxide Suppresses Action-Potential-Like Transient Spikes and Vasospasm in Small Resistance Arteries

C. Garland, C. Hiley, L. Borysova, 2020, Hypertension.

EDHF to EDH: the evolution of myoendothelial microdomains.

C. Garland, K. Dora, 2021, Journal of cardiovascular pharmacology.

Specific accumulation of inositol 1,4,5-trisphosphate in rabbit basilar artery in response to noradrenaline but not 5-hydroxytryptamine.

T. Murphy, C. Garland, 1995, European journal of pharmacology.

Elucidation of the temporal relationship between endothelial-derived NO and EDHF in mesenteric vessels.

J. Mitchell, L. S. Harrington, M. Carrier, 2007, American Journal of Physiology. Heart and Circulatory Physiology.

Hyperpolarization and the endothelium

C. Garland, K. Dora, 2023, Current Opinion in Physiology.

Smooth muscle gap-junctions allow propagation of intercellular Ca2+ waves and vasoconstriction due to Ca2+ based action potentials in rat mesenteric resistance arteries

C. Garland, T. Burdyga, L. Borysova, 2018, Cell calcium.

Role of heterocellular Gap junctional communication in endothelium-dependent smooth muscle hyperpolarization: inhibition by a connexin-mimetic peptide.

C. Garland, T. Griffith, P. Martin, 1999, Biochemical and biophysical research communications.

Statins and Selective Inhibition of Rho Kinase Protect Small Conductance Calcium-Activated Potassium Channel Function (KCa2.3) in Cerebral Arteries

G. Cottrell, C. Garland, F. Jiménez-Altayó, 2012, PloS one.

Endothelial cells and the electrical and mechanical responses of the rabbit coronary artery to 5-hydroxytryptamine.

C. Garland, 1985, Journal of Pharmacology and Experimental Therapeutics.

Phorbol esters impair endothelium-dependent and independent relaxation in rat aortic rings.

T. Murphy, C. Garland, K. Cross, 1994, General pharmacology.

How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?

W Suter, M Pirmohamed, M. Pirmohamed, 2011, British journal of pharmacology.

EDHF-like responses in rat cremaster muscle arterioles

J. Falck, W. Campbell, M. Hill, 2005 .

The changing natural history of spinal muscular atrophy type 1

G. Levy, D. Vivo, P. Kaufmann, 2007, Neurology.

through a PKG-sensitive cation channel Endothelial cell protein kinase G inhibits release of EDHF

H. Kwan, C. Garland, X. Yao, 2016 .

Involvement of cyclic GMP and potassium channels in relaxation evoked by the nitric oxide donor, diethylamine NONOate, in the rat small isolated mesenteric artery

C. Garland, F. Plane, Laura J. Sampson, 2001, Naunyn-Schmiedeberg's Archives of Pharmacology.

Nitric oxide (NO)-induced activation of large conductance Ca2+-dependent K+ channels (BK(Ca)) in smooth muscle cells isolated from the rat mesenteric artery.

C. Garland, D. Mistry, 1998, British journal of pharmacology.

The Pharmacology of Vascular Smooth Muscle

J. Angus, C. Garland, 1996 .