I. Fleming

发表

2-Anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity.

A. Osnowski, Su-Ying Wu, M. Walkinshaw, 2004, Journal of medicinal chemistry.

The activity of the metabolic form of hepatic phosphatidate phosphohydrolase correlates with the severity of alcoholic fatty liver in human beings

M. Bennett, C. Day, I. Fleming, 1993, Hepatology.

Recommendations for measurement of tumour vascularity with positron emission tomography in early phase clinical trials

Paul Kinahan, D. Visvikis, F. Gilbert, 2012, European Radiology.

Response to trastuzumab by HER2 expressing breast tumour xenografts is accompanied by decreased Hexokinase II, glut1 and [18F]-FDG incorporation and changes in 31P-NMR-detectable phosphomonoesters

A. Thompson, M. Appleyard, K. Murray, 2013, Cancer Chemotherapy and Pharmacology.

The regulation of membrane to cytosol partitioning of signalling proteins by phosphoinositides and their soluble headgroups.

I. Batty, C. Downes, A. Gray, 2005, Biochemical Society transactions.

Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1.

A. Prescott, I. Batty, C. Downes, 2004, The Biochemical journal.

Neuronal Desynchronization as a Trigger for Seizure Generation

D. Mogul, I. Fleming, Yue Li, 2008, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

Hypoxia PET/CT and Colorectal Cancer: A Case Report

K. Kerr, G. Murray, M. Zanda, 2020 .

Determination of Interaction Sites on the Small G Protein RhoA for Phospholipase D*

C. Bae, J. Exton, I. Fleming, 1998, The Journal of Biological Chemistry.

Binding of αvβ3 Integrin-Specific Radiotracers Is Modulated by Both Integrin Expression Level and Activation Status

M. Piras, M. Zanda, I. Fleming, 2017, Molecular Imaging and Biology.

Clinical value of 3'-deoxy-3'-[18F]fluorothymidine-positron emission tomography for diagnosis, staging and assessing therapy response in lung cancer

I. Fleming, S. Dall’Angelo, Bandar Alwadani, 2021, Insights into Imaging.

Building PET research collaborations

F. Gilbert, P. Blower, I. Fleming, 2012, Nuclear medicine communications.

Widespread tissue hypoxia dysregulates cell and metabolic pathways in SMA

I. Fleming, J. M. Collinson, S. Dall’Angelo, 2020, Annals of clinical and translational neurology.

Last-Step Enzymatic [(18) F]-Fluorination of Cysteine-Tethered RGD Peptides Using Modified Barbas Linkers.

M. Zanda, D. O'Hagan, I. Fleming, 2016, Chemistry.

Synthesis and anticancer properties of RGD peptides conjugated to nitric oxide releasing functional groups and abiraterone

N. Botting, D. O'Hagan, I. Fleming, 2014 .

Detection of novel intracellular agonist responsive pools of phosphatidylinositol 3,4-bisphosphate using the TAPP1 pleckstrin homology domain in immunoelectron microscopy.

C. Downes, N. Leslie, J. Lucocq, 2004, The Biochemical journal.

High‐Affinity “Click” RGD Peptidomimetics as Radiolabeled Probes for Imaging αvβ3 Integrin

M. Mori, K. Williams, M. Piras, 2017, ChemMedChem.

Enzymatic transhalogenation of dendritic RGD peptide constructs with the fluorinase.

D. O'Hagan, I. Fleming, S. Thompson, 2016, Organic & biomolecular chemistry.

Design and Synthesis of an RGD Peptidomimetic-Paclitaxel Conjugate Targeting αvβ3 Integrin for Tumour-Directed Drug Delivery

M. Piras, M. Zanda, A. Testa, 2017, Synlett.

Subcellular distribution of N-ethylmaleimide-sensitive and -insensitive phosphatidic acid phosphohydrolase in rat brain.

I. Fleming, S. Yeaman, 1995, Biochimica et biophysica acta.

Positron emission tomography radiopharmaceutical studies in humans: a guide to regulations for academic researchers

F. Gilbert, F. Aigbirhio, I. Fleming, 2012, Nuclear medicine communications.

Muscarinic-receptor-mediated inhibition of insulin-like growth factor-1 receptor-stimulated phosphoinositide 3-kinase signalling in 1321N1 astrocytoma cells.

I. Batty, C. Downes, I. Fleming, 2004, The Biochemical journal.

Synthesis, Crystal Structure Analysis, and Pharmacological Characterization of Disila-bexarotene, a Disila-Analogue of the RXR-Selective Retinoid Agonist Bexarotene

J. Montana, H. Gronemeyer, D. Ivanova, 2005 .

Synthesis, Radiosynthesis, and in vitro Studies on Novel Hypoxia PET Tracers Incorporating [ 18 F]FDR

M. Zanda, D. O'Hagan, I. Fleming, 2021, European Journal of Organic Chemistry.

Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase C delta1.

C. Downes, G. Kular, J. Lucocq, 2002, The Biochemical journal.

Combination of sapacitabine and HDAC inhibitors stimulates cell death in AML and other tumour types

I. Fleming, S. Green, I. Fleming, 2010, British Journal of Cancer.

Regulation of the Rac1-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components.

C. Downes, A. Gray, I. Fleming, 2000, The Biochemical journal.

Ca2+/Calmodulin-dependent Protein Kinase II Regulates Tiam1 by Reversible Protein Phosphorylation*

C. Downes, J. Exton, I. Fleming, 1999, The Journal of Biological Chemistry.

Probing the PI3K/Akt/mTor pathway using 31P-NMR spectroscopy: routes to glycogen synthase kinase 3

I. Fleming, C. Tseng, Tim A D Smith, 2016, Scientific Reports.

Probing the Pi3k/akt/mtor Pathway Using P-nmr Spectroscopy: Routes to Glycogen Synthase Kinase 3 Consequently Anticancer Drugs Have Been Developed That Target This Pathway. Mda-mb-468 Breast and Hct8 Colorectal Cancer Cells Were Treated with Inhibitors including Ly294002, Mk2206, Rapamycin, Azd8055

I. Fleming, C. Tseng, Tim A D Smith, 2022 .

Synergistic Inhibition of ErbB Signaling by Combined Treatment with Seliciclib and ErbB-Targeting Agents

S. McClue, S. Green, S. Frame, 2008, Clinical Cancer Research.

Lysophosphatidic Acid Induces Threonine Phosphorylation of Tiam1 in Swiss 3T3 Fibroblasts via Activation of Protein Kinase C*

John G. Collard, J. Exton, I. Fleming, 1997, The Journal of Biological Chemistry.

Differential Translocation of Rho Family GTPases by Lysophosphatidic Acid, Endothelin-1, and Platelet-derived Growth Factor*

J. Exton, I. Fleming, C. M. Elliott, 1996, The Journal of Biological Chemistry.

NGR Tumor-Homing Peptides: Structural Requirements for Effective APN (CD13) Targeting.

M. Piras, M. Zanda, I. Fleming, 2016, Bioconjugate chemistry.

A localized tolerance in the substrate specificity of the fluorinase enzyme enables "last-step" 18F fluorination of a RGD peptide under ambient aqueous conditions.

Jan Passchier, Sharon Ashworth, David O'Hagan, 2014, Angewandte Chemie.

Enzymatic radiosynthesis of a 18F-Glu-Ureido-Lys ligand for the prostate-specific membrane antigen (PSMA).

M. Piras, M. Zanda, D. O'Hagan, 2019, Organic & biomolecular chemistry.

A two-step fluorinase enzyme mediated (18)F labelling of an RGD peptide for positron emission tomography.

J. Passchier, D. O'Hagan, I. Fleming, 2015, Chemical communications.

KEMTUB012-NI2, a novel potent tubulysin analog that selectively targets hypoxic cancer cells and is potentiated by cytochrome p450 reductase downregulation

M. Zanda, P. Lazzari, I. Fleming, 2017, Hypoxia.

A role for spinal cord hypoxia in neurodegeneration

I. Fleming, S. Parson, Elena Hernandez-Gerez, 2019, Cell Death & Disease.

Purification and characterization of N-ethylmaleimide-insensitive phosphatidic acid phosphohydrolase (PAP2) from rat liver.

I. Fleming, I. Fleming, S. Yeaman, 1995, The Biochemical journal.

Hypoxia stimulates 18F-fluorodeoxyglucose uptake in breast cancer cells via hypoxia inducible factor-1 and AMP-activated protein kinase.

M. Zanda, I. Fleming, Tim A D Smith, 2013, Nuclear medicine and biology.

Positron emission tomography oncology research in the UK: a comparison with USA and Europe

F. Gilbert, P. Marsden, L. Pike, 2012, Nuclear medicine communications.

Phosphatidic Acid Phosphohydrolase: Its Role in Cell Signalling

I. Fleming, S. Yeaman, 1995 .

Hypoxia imaging with PET: which tracers and why?

P. Blower, I. Fleming, K. Chia, 2012, Nuclear medicine communications.

Opportunities for PET to deliver clinical benefit in cancer: breast cancer as a paradigm

Fiona J. Gilbert, David Cameron, F. Gilbert, 2010, Cancer imaging : the official publication of the International Cancer Imaging Society.

KEMTUB 012-NI 2 , a novel potent tubulysin analog that selectively targets hypoxic cancer cells and is potentiated by cytochrome p 450 reductase downregulation

M. Zanda, P. Lazzari, I. Fleming, 2017 .

Changes in [18F]Fluoro-2-deoxy-d-glucose incorporation induced by doxorubicin and anti-HER antibodies by breast cancer cells modulated by co-treatment with metformin and its effects on intracellular signalling

I. Fleming, Tim A D Smith, A. Cooper, 2015, Journal of Cancer Research and Clinical Oncology.

Early changes in [18F]FDG incorporation by breast cancer cells treated with trastuzumab in normoxic conditions: role of the Akt-pathway, glucose transport and HIF-1α

I. Fleming, Tim A D Smith, Alexandra Andriu, 2014, Breast Cancer Research and Treatment.

Phospholipase C‐γ, protein kinase C and Ca2+/calmodulin‐dependent protein kinase II are involved in platelet‐derived growth factor‐induced phosphorylation of Tiam1

J. Exton, I. Fleming, C. M. Elliott, 1998, FEBS letters.

Imaging tumour hypoxia with positron emission tomography

F J Gilbert, A. Harris, F. Gilbert, 2014, British Journal of Cancer.

Efficient bioconjugation of 5-fluoro-5-deoxy-ribose (FDR) to RGD peptides for positron emission tomography (PET) imaging of α(v)β(3) integrin receptor.

M. Piras, M. Zanda, D. O'Hagan, 2013, Organic & biomolecular chemistry.

The tubulysin analogue KEMTUB10 induces apoptosis in breast cancer cells via p53, Bim and Bcl-2

M. Zanda, P. Lazzari, I. Fleming, 2015, Journal of Cancer Research and Clinical Oncology.

Tumour expression of leptin is associated with chemotherapy resistance and therapy-independent prognosis in gastro-oesophageal adenocarcinomas

H. Grabsch, P. Tan, G. Murray, 2014, British Journal of Cancer.

NGR Tumor-Homing Peptides: Structural Requirements for Effective APN (CD13) Targeting.

M. Piras, M. Zanda, I. Fleming, 2016, Bioconjugate chemistry.

Beyond 18F-fluorodeoxyglucose: making the next generation of PET radiotracers available for oncology research in the UK.

F. Gilbert, P. Marsden, I. Fleming, 2011, Nuclear medicine communications.