F. Lovering

发表

Escape from flatland: increasing saturation as an approach to improving clinical success.

C. Humblet, F. Lovering, J. Bikker, 2009, Journal of medicinal chemistry.

Synthesis and SAR of bis-statine based peptides as BACE 1 inhibitors.

K. Fan, R. Chopra, J. Ellingboe, 2004, Bioorganic & medicinal chemistry letters.

Acylguanidines as small-molecule beta-secretase inhibitors.

M. Malamas, K. Fan, B. Harrison, 2006, Journal of medicinal chemistry.

Novel pyrrolyl 2-aminopyridines as potent and selective human beta-secretase (BACE1) inhibitors.

Rajiv Chopra, Peter Reinhart, Jim Turner, 2010, Bioorganic & medicinal chemistry letters.

Identification of Type‐II Inhibitors Using Kinase Structures

R. Kurumbail, Yogesh Sabnis, Chris Phillips, 2012, Chemical biology & drug design.

Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design.

David R. Anderson, S. Wright, V. Rao, 2017, Journal of medicinal chemistry.

Design and synthesis of 3,3-piperidine hydroxamate analogs as selective TACE inhibitors.

D. Joseph-McCarthy, J. Levin, E. Feyfant, 2007, Bioorganic & medicinal chemistry letters.

A conformationally constrained competitive inhibitor of the sodium-dependent glutamate transporter in forebrain synaptosomes: l-anti-endo-3,4-methanopyrrolidine dicarboxylate

C. Cotman, R. Bridges, F. Lovering, 1994, Neuroscience Letters.

Conformationally restricted inhibitors of the high affinity L-glutamate transporter

R. Bridges, F. Lovering, M. Stanley, 1993 .

Structure–activity relationships of indole cytosolic phospholipase A2α inhibitors: substrate mimetics

J. Alvarez, D. Joseph-McCarthy, J. D. Clark, 2003 .

Fluorine in Drug Design: A Case Study with Fluoroanisoles

M. Bunnage, R. Denny, A. Narayanan, 2015, ChemMedChem.

Escape from Flatland 2: complexity and promiscuity

F. Lovering, Frank Lovering, 2013 .

Inhibition of Cytosolic Phospholipase A 2 a: Hit to Lead Optimization

John C. McKew, S. Khor, J. D. Clark, 2006 .

Assembly of 3a-Arylperhydroindoles by the Intramolecular Cycloaddition of 2-Azaallyl Anions with Alkenes. Total Syntheses of (±)-Crinine, (±)-6-Epicrinine, (−)-Amabiline, and (−)-Augustamine

F. Lovering, W. H. Pearson, 1998 .

Short, Efficient Syntheses of the Amaryllidaceae Alkaloids (-)-Amabiline and (-)-Augustamine via Intramolecular 2-Azaallyl Anion Cycloadditions

F. Lovering, W. H. Pearson, 1995 .

Application of the 2-azaallyl anion cycloaddition method to syntheses of (±)-crinine and (±)-6-epicrinine

F. Lovering, W. H. Pearson, 1994 .

Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1.

Stephen J. Wright, Hong Wang, K. Parris, 2021, Journal of medicinal chemistry.

Acylguanidines as Small-Molecule β-Secretase Inhibitors

Rajiv Chopra, Yun Hu, Eric S. Manas, 2006 .

Millisecond dynamics of BTK reveal kinome-wide conformational plasticity within the apo kinase domain

Mohammad M. Sultan, V. Pande, R. Denny, 2017, bioRxiv.

Identification and SAR of squarate inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2).

K. Parris, J. Telliez, F. Lovering, 2009, Bioorganic & medicinal chemistry.

Rational approach to highly potent and selective apoptosis signal-regulating kinase 1 (ASK1) inhibitors.

R. Kurumbail, D. Hepworth, J. Guzova, 2017, European journal of medicinal chemistry.

Discovery of Ecopladib, an Indole Inhibitor of Cytosolic Phospholipase Α2α

S. Khor, J. D. Clark, J. McKew, 2007 .

Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay

D. Lin, Hong Wang, J. Culp, 2017, PloS one.

Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha.

S. Khor, J. McKew, M. S. Ku, 2007, Journal of medicinal chemistry.

Development of a polyvalent assay system for lead identification.

F. Lovering, Yan-ling Zhang, K. Bridges, 2004, Bioorganic & medicinal chemistry letters.

Use of structure-based drug design approaches to obtain novel anthranilic acid acyl carrier protein synthase inhibitors.

Dominick Quagliato, Diane Joseph-McCarthy, Elena Severina, 2005, Journal of medicinal chemistry.

Imidazotriazines: Spleen Tyrosine Kinase (Syk) Inhibitors Identified by Free‐Energy Perturbation (FEP)

Atli Thorarensen, Joseph McDonald, A. Moretto, 2016, ChemMedChem.

Identification of potent and selective TACE inhibitors via the S1 pocket.

Diane Joseph-McCarthy, Linhong Sun, D. Joseph-McCarthy, 2007, Bioorganic & medicinal chemistry letters.

A Selective Photoaffinity Ligand for the Kainate Class of Excitatory Amino Acid Receptor

R. Bridges, F. Lovering, C. L. Willis, 1997 .

Identification of potent and selective MMP-13 inhibitors.

T. Rush, E. Collins, J. Levin, 2005, Bioorganic & medicinal chemistry letters.

Inhibition of cytosolic phospholipase A2alpha: hit to lead optimization.

S. Khor, J. McKew, A. Mahadevan, 2006, Journal of medicinal chemistry.

Synthesis and activity of quinolinylmethyl P1' alpha-sulfone piperidine hydroxamate inhibitors of TACE.

J. Levin, Linhong Sun, Weixin Xu, 2009, Bioorganic & medicinal chemistry letters.

A novel approach to identifying β-secretase inhibitors: Bis-statine peptide mimetics discovered using structure and spot synthesis

T. Akopian, W. Somers, R. Kriz, 2006, Peptides.

Therapeutic potential of TACE inhibitors in stroke.

F. Lovering, F Lovering, Y Zhang, 2005, Current drug targets. CNS and neurological disorders.

Imidazotriazines: Spleen Tyrosine Kinase (Syk) Inhibitors Identified by Free‐Energy Perturbation (FEP)

A. Moretto, L. Fitz, A. Thorarensen, 2016, ChemMedChem.

Structure-based design of TACE selective inhibitors: manipulations in the S1'-S3' pocket.

Diane Joseph-McCarthy, Linhong Sun, D. Joseph-McCarthy, 2007, Bioorganic & medicinal chemistry.

Identification of potent and selective MMP-13 inhibitors.

T. Rush, E. Collins, J. Levin, 2005, Bioorganic & medicinal chemistry letters.