J. Aebi

发表

Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors.

B. Kuhn, W. Haap, M. Stahl, 2016, ACS medicinal chemistry letters.

Potent inhibitors of mammalian 2,3-oxidosqualene lanosterol cyclase are orally active cholesterol lowering agents

O. Morand, H. Lengsfeld, J. Himber, 1994 .

Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase

T. Schulz-Gasch, M. Hennig, R. Thoma, 2004, Nature.

Synthesis and structure-activity studies of novel orally active non-terpenoic 2,3-oxidosqualene cyclase inhibitors.

O. Morand, J. Himber, J. Aebi, 2003, Journal of medicinal chemistry.

Cytotoxic effects of combination of oxidosqualene cyclase inhibitors with atorvastatin in human cancer cells.

L. Juillerat-Jeanneret, H. Fischer, Davide Staedler, 2012, Journal of medicinal chemistry.

Cholesterol biosynthesis inhibitors as potent novel anti-cancer agents: suppression of hormone-dependent breast cancer by the oxidosqualene cyclase inhibitor RO 48-8071

C. Besch-Williford, X. Zou, J. Aebi, 2014, Breast Cancer Research and Treatment.

A Novel Inhibitor of Oxidosqualene:Lanosterol Cyclase Inhibits Very Low–Density Lipoprotein Apolipoprotein B100 (ApoB100) Production and Enhances Low-Density Lipoprotein ApoB100 Catabolism Through Marked Reduction in Hepatic Cholesterol Content

O. Morand, P. Barrett, J. Aebi, 2005, Arteriosclerosis, thrombosis, and vascular biology.

A fluorine scan of non-peptidic inhibitors of neprilysin: Fluorophobic and fluorophilic regions in an enzyme active site

F. Diederich, M. Kansy, M. Morgenthaler, 2008 .

Synthesis of annulated pyridines as inhibitors of aldosterone synthase (CYP11B2).

Rainer E. Martin, B. Kuhn, A. Mayweg, 2016, Organic & biomolecular chemistry.

Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys.

Rainer E. Martin, B. Kuhn, A. Kuglstatter, 2015, Journal of medicinal chemistry.

Synthesis, conformation, and immunosuppressive activities of three analogues of cyclosporin A modified in the 1-position.

D. Rich, J. Aebi, D. Guillaume, 1990, Journal of medicinal chemistry.

Synthesis, conformation, and immunosuppressive activity of a conformationally restricted cyclosporine lactam analogue.

D. Rich, J. Aebi, D. Guillaume, 1988, Journal of medicinal chemistry.

Endothelin-Converting Enzyme Inhibition Ameliorates Angiotensin II–Induced Cardiac Damage

F. Luft, H. Haller, R. Dechend, 2002, Hypertension.

Identification of New ATG4B Inhibitors Based on a Novel High-Throughput Screening Platform

B. Kuhn, M. Stahl, C. Liu, 2017, SLAS discovery : advancing life sciences R & D.

Second-Generation Inhibitors for the Metalloprotease Neprilysin Based on Bicyclic Heteroaromatic Scaffolds: Synthesis, Biological Activity, and X-ray Crystal Structure Analysis

F. Diederich, C. Oefner, G. Dale, 2005 .

A New Class of Inhibitors for the Metalloprotease Neprilysin Based on a Central Imidazole Scaffold

F. Diederich, H. Böhm, W. Schweizer, 2005 .

Structure‐Based Design, Synthesis, and in vitro Evaluation of Nonpeptidic Neprilysin Inhibitors

F. Diederich, C. Oefner, H. Böhm, 2004, Chembiochem : a European journal of chemical biology.

α‐Alkylation of Amino Acids without Racemization. Preparation of Either (S)‐ or (R)‐α‐Methyldopa from (S)‐Alanine

D. Seebach, R. Naef, J. Aebi, 1985 .

Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors.

B. Kuhn, A. Kuglstatter, S. Müller, 2020, Journal of medicinal chemistry.

Flow synthesis of annulated 5-aryl-substituted pyridines by tandem intramolecular inverse-electron-demand hetero-/retro-Diels–Alder reaction

Rainer E. Martin, Thibaut Alzieu, J. Aebi, 2013 .

Endothelin-converting enzyme-1 inhibition and growth of human glioblastoma cells.

L. Juillerat-Jeanneret, E. Kitas, J. Aebi, 2005, Journal of medicinal chemistry.

α-Alkylation of threonine

D. Seebach, J. Aebi, 1983 .

α-alkylation of serine with self-reproduction of the center of chirality

D. Seebach, J. Aebi, 1984 .

A short synthesis of enantiomerically pure (2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)-6-octenoic acid, the unusual C9 amino acid found in the immunosuppressive peptide cyclosporine

D. Rich, J. Aebi, M. Dhaon, 1987 .

Diastereoselective α‐Alkylation of β‐Hydroxycarboxylic Esters through Alkoxide Enolates: Diethyl (2S, 3R)‐( + )‐3‐Allyl‐2‐Hydroxysuccinate from Diethyl (S)‐( − )‐Malate

D. Seebach, J. Aebi, D. Wasmuth, 2003 .

Ligand channel in pharmacologically stabilized rhodopsin

Gebhard F. X. Schertler, Markus G. Rudolph, Andre Alker, 2018, Proceedings of the National Academy of Sciences.

Differential Effects of the Mitochondria-Active Tetrapeptide SS-31 (D-Arg-dimethylTyr-Lys-Phe-NH2) and Its Peptidase-Targeted Prodrugs in Experimental Acute Kidney Injury

L. Juillerat-Jeanneret, Josip Mikulić, Rajesh Kumar, 2019, Front. Pharmacol..

Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin.

O. Morand, H. Lengsfeld, J. Himber, 1997, Journal of lipid research.

Cholesterol biosynthesis inhibitor RO 48-8071 suppresses growth of hormone-dependent and castration-resistant prostate cancer cells

J. Aebi, Yayun Liang, S. Hyder, 2016, OncoTargets and therapy.

Squalene-Hopene Cyclase

G. Schulz, W. Weihofen, O. Morand, 2003 .

Binding structures and potencies of oxidosqualene cyclase inhibitors with the homologous squalene-hopene cyclase.

G. Schulz, J. Aebi, H. Dehmlow, 2003, Journal of medicinal chemistry.

Oxidosqualene cyclase from Saccharomyces cerevisiae, Trypanosoma cruzi, Pneumocystis carinii and Arabidopsis thaliana expressed in yeast: a model for the development of novel antiparasitic agents.

S. Oliaro-Bosso, F. Viola, G. Caron, 2009, Bioorganic & medicinal chemistry letters.

Oxidosqualene cyclase (OSC) inhibitors for the treatment of dyslipidemia

T. Schulz-Gasch, M. Kansy, R. Thoma, 2005 .

Targeted γ-secretase inhibition of Notch signaling activation in acute renal injury.

L. Juillerat-Jeanneret, Josip Mikulić, R. Kumar, 2018, American journal of physiology. Renal physiology.

Targeted γ-Secretase Inhibition To Control the Notch Pathway in Renal Diseases.

L. Juillerat-Jeanneret, A. Flohr, R. Kumar, 2015, Journal of medicinal chemistry.

Hydroquinone: genotoxicity and prevention of genotoxicity following ingestion.

J. Aebi, E. Barber, J. O’Donoghue, 1999, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors.

B. Kuhn, W. Haap, M. Stahl, 2016, ACS medicinal chemistry letters.

Endothelin-Converting Enzyme Inhibition Ameliorates Angiotensin II–Induced Cardiac Damage

F. Luft, H. Haller, R. Dechend, 2002, Hypertension.