Hong C Shen

发表

Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors.

B. Kuhn, W. Haap, M. Stahl, 2016, ACS medicinal chemistry letters.

The discovery of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors.

Michael E. Lassman, Shirly Pinto, M. Garcia-Calvo, 2012, Bioorganic & medicinal chemistry letters.

Discovery of benzimidazole pyrrolidinyl amides as prolylcarboxypeptidase inhibitors.

Michael E. Lassman, Shirly Pinto, M. Garcia-Calvo, 2011, Bioorganic & medicinal chemistry letters.

Soluble epoxide hydrolase inhibitors: a patent review

Hong C Shen, 2010, Expert opinion on therapeutic patents.

Discovery of spirocyclic secondary amine-derived tertiary ureas as highly potent, selective and bioavailable soluble epoxide hydrolase inhibitors.

J. Berger, Gaochao Zhou, Sanjeev Kumar, 2009, Bioorganic & medicinal chemistry letters.

Discovery of orally bioavailable and novel urea agonists of the high affinity niacin receptor GPR109A.

Kenneth K. Wu, Q. Deng, Hong C Shen, 2007, Bioorganic & medicinal chemistry letters.

Discovery of biaryl anthranilides as full agonists for the high affinity niacin receptor.

M. Forrest, Kenneth K. Wu, Q. Deng, 2007, Journal of medicinal chemistry.

Discovery of pyrazolopyrimidines as the first class of allosteric agonists for the high affinity nicotinic acid receptor GPR109A.

Hong C Shen, J. Tata, S. Colletti, 2008, Bioorganic & medicinal chemistry letters.

Tetrahydro anthranilic acid as a surrogate for anthranilic acid: application to the discovery of potent niacin receptor agonists.

Hong C Shen, J. Tata, S. Colletti, 2008, Bioorganic & medicinal chemistry letters.

Discovery of novel tricyclic full agonists for the G-protein-coupled niacin receptor 109A with minimized flushing in rats.

Kenneth K. Wu, Q. Deng, Hong C Shen, 2009, Journal of medicinal chemistry.

Novel patent publications on high-affinity nicotinic acid receptor agonists

Hong C Shen, S. Colletti, 2009, Expert Opinion on Therapeutic Patents.

Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate.

M. Forrest, Kenneth K. Wu, Q. Deng, 2010, Journal of medicinal chemistry.

Small Molecule Approaches to Treat Autoimmune and Inflammatory Diseases (Part II): Nucleic Acid Sensing Antagonists and Inhibitors.

Xingchun Han, Hong C Shen, Wei Zhu, 2021, Bioorganic & medicinal chemistry letters.

Small molecule approaches to treat autoimmune and inflammatory diseases (Part I): kinase inhibitors.

Hong C Shen, Jiamin Zheng, Ge Zou, 2021, Bioorganic & medicinal chemistry letters.

Syntheses of seven-membered rings: ruthenium-catalyzed intramolecular [5+2] cycloadditions.

B. Trost, Hong C Shen, F. Toste, 2005, Chemistry.

Synthesis and biological evaluation of platensimycin analogs.

M. Maccoss, Hong C Shen, S. Soisson, 2009, Bioorganic & medicinal chemistry letters.

Discovery of inhibitors of soluble epoxide hydrolase: a target with multiple potential therapeutic indications.

B. Hammock, Hong C Shen, 2012, Journal of medicinal chemistry.

Discovery of imidazopyridine derivatives as highly potent respiratory syncytial virus fusion inhibitors.

Lisha Wang, Hong C Shen, Lu Gao, 2015, ACS medicinal chemistry letters.

Discovery of pyrazolyl propionyl cyclohexenamide derivatives as full agonists for the high affinity niacin receptor GPR109A.

Hong C Shen, X. Tong, Qing Chen, 2010, Bioorganic & medicinal chemistry letters.

Novelpatentpublicationson high-affinitynicotinicacid receptoragonists

Hong C Shen, S. Colletti, 2009 .

Discovery of Piperazinylquinoline Derivatives as Novel Respiratory Syncytial Virus Fusion Inhibitors.

Lisha Wang, Hong C Shen, Lu Gao, 2016, ACS medicinal chemistry letters.

An Enantioselective Multicomponent Carbonyl Allylation of Aldehydes with Dienes and Alkynyl Bromides Enabled by Chiral Palladium Phosphate

Hong C Shen, Pu-Sheng Wang, L. Gong, 2017 .

High-Affinity Niacin Receptor GPR109A Agonists

Hong C Shen, S. Colletti, 2010 .

Anthranilic acid replacements in a niacin receptor agonist.

D. Blom, Hong C Shen, J. Tata, 2010, Bioorganic & medicinal chemistry letters.

Discovery of novel oxazolidinedione derivatives as potent and selective mineralocorticoid receptor antagonists.

J. Lisnock, A. Crespo, Gaochao Zhou, 2013, Bioorganic & medicinal chemistry letters.

Identification of New ATG4B Inhibitors Based on a Novel High-Throughput Screening Platform

B. Kuhn, M. Stahl, C. Liu, 2017, SLAS discovery : advancing life sciences R & D.

Efficient Synthesis of Substituted Morpholine Derivatives via an Indium(III)-catalyzed Reductive Etherification Reaction

L. Fu, L. Ya-fei, Hong C Shen, 2020 .

Synthesis of Bridged Bicyclic Morpholine Amino Acids as Compact Modules for Medicinal Chemistry

Jie Wu, Taishan Hu, Hong C Shen, 2017 .

Synthesis of novel and conformationally constrained bridged amino acids as compact modules for drug discovery

Guozhi Tang, Li Haixia, Hong C Shen, 2016 .

A strategy of employing aminoheterocycles as amide mimics to identify novel, potent and bioavailable soluble epoxide hydrolase inhibitors.

J. Berger, Gaochao Zhou, Bei B. Zhang, 2009, Bioorganic & medicinal chemistry letters.

Discovery of 3,3-disubstituted piperidine-derived trisubstituted ureas as highly potent soluble epoxide hydrolase inhibitors.

J. Berger, Gaochao Zhou, Bei B. Zhang, 2009, Bioorganic & medicinal chemistry letters.

Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling.

Christian N. Cunningham, P. Beroza, Rohit Reja, 2020, Cell reports.

A New Approach of Mitigating CYP3A4 Induction Led to the Discovery of Potent Hepatitis B Virus (HBV) Capsid Inhibitor with Optimal ADMET Profiles.

Zheng Zhou, Sheng Zhong, Jianxun Xie, 2019, Journal of medicinal chemistry.

Zinc triflate-mediated cyclopropanation of oxindoles with vinyl diphenyl sulfonium triflate: a mild reaction with broad functional group compatibility

Yufang Xu, X. Qian, Hu Yimin, 2017 .

Access to chiral tetrahydrofluorenes through a palladium-catalyzed enantioselective tandem intramolecular Heck/Tsuji-Trost reaction.

Hong C Shen, Xiang Wu, Zhi-Yong Han, 2019, Chemical communications.

Discovery of a highly potent, selective, and bioavailable soluble epoxide hydrolase inhibitor with excellent ex vivo target engagement.

J. Berger, Gaochao Zhou, Sanjeev Kumar, 2009, Journal of medicinal chemistry.

De novo synthesis, structural assignment and biological evaluation of pseudopaline, a metallophore produced by Pseudomonas aeruginosa† †Electronic supplementary information (ESI) available. CCDC 1850196 and 1863986. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039

Xiaoguang Lei, Hong C Shen, Rongwen Yang, 2019, Chemical science.

Pd(II)-Catalyzed Asymmetric Oxidative Annulation of N-Alkoxyheteroaryl Amides and 1,3-Dienes.

Hong C Shen, L. Gong, Zhi-Yong Han, 2019, Organic letters.

Discovery of RG7834: The First-in-Class Selective and Orally Available Small Molecule Hepatitis B Virus Expression Inhibitor with Novel Mechanism of Action.

Xingchun Han, Min Jiang, Chengang Zhou, 2018, Journal of medicinal chemistry.

Gold-catalyzed 6-exo-dig cycloisomerization: a versatile approach to functionalized phenanthrenes.

Hong C Shen, L. Ye, Chao Shu, 2014, Chemistry, an Asian journal.

Gold-catalyzed formation of heterocycles - an enabling new technology for medicinal chemistry.

Hong C Shen, T. Graham, 2013, Drug discovery today. Technologies.

Recent advances in syntheses of carbocycles and heterocycles via homogeneous gold catalysis. Part 2: Cyclizations and cycloadditions

Hong C Shen, 2008 .

Recent advances in syntheses of heterocycles and carbocycles via homogeneous gold catalysis. Part 1: Heteroatom addition and hydroarylation reactions of alkynes, allenes, and alkenes

Hong C Shen, 2008 .

Discovery of (aza)indole derivatives as novel respiratory syncytial virus fusion inhibitors.

Lisha Wang, Weixing Zhang, Hong C Shen, 2019, MedChemComm.

Discovery of Ziresovir as a Potent, Selective and Orally Bioavailable Respiratory Syncytial Virus Fusion Protein Inhibitor.

J. Wu, Bo Zhang, Lisha Wang, 2019, Journal of medicinal chemistry.

Discovery of Benzoazepinequinoline (BAQ) Derivatives as Novel, Potent, Orally Bioavailable Respiratory Syncytial Virus Fusion Inhibitors.

J. Wu, Lisha Wang, Li Chen, 2018, Journal of medicinal chemistry.

Asymmetric synthesis of chiral chromans

Hong C Shen, 2009 .

Selected Applications of Transition Metal‐Catalyzed Carbon–Carbon Cross‐Coupling Reactions in the Pharmaceutical Industry

Hong C Shen, 2012 .

Eaton’s reagent-mediated metal-free and efficient synthesis of NH-sulfoximines

W. Jianping, Hong C Shen, Weili Zhao, 2017 .

Facile synthesis of fluoroalkylated quinolones using fluoroalk-2-ynoates as fluorinated building blocks

Liping Song, W. Cao, Jie Chen, 2019, Journal of Fluorine Chemistry.

Potassium Iodide-Promoted One-Pot Synthesis of Fluoroalkylated Quinoxalines via a Tandem Michael Addition/Azidation/Cycloamination Approach.

Liping Song, W. Cao, Jie Chen, 2018, The Journal of organic chemistry.

Alpha-heteroarylation of esters, lactones, amides, and lactams by nucleophilic aromatic substitution.

Hong C Shen, S. Colletti, F. Ding, 2006, Organic letters.

Enantioselective Addition of Cyclic Ketones to Unactivated Alkenes Enabled by Amine/Pd(II) Cooperative Catalysis

Yundong Wu, Ying Zhang, Jiajie Feng, 2019, ACS Catalysis.

Chapter Seventeen – Novel Therapeutics in Discovery and Development for Treatment of Chronic HBV Infection

J. Wu, A. Mayweg, Guozhi Tang, 2013 .

Divergent copper-mediated dimerization and hydroxylation of benzamides involving C-H bond functionalization.

Mingliang Wang, Hong C Shen, Yimin Hu, 2016, Organic & biomolecular chemistry.

One-pot synthesis of useful heterocycles in medicinal chemistry using a cascade strategy

Hong C Shen, Yong Huang, Weiyu Yin, 2012 .

Palladium-Catalyzed Asymmetric Aminohydroxylation of 1,3-Dienes.

Ying Zhang, Hong C Shen, L. Gong, 2018, Angewandte Chemie.

Synthesis and UV Studies of A Small Library of 6-Aryl-4-hydroxy-2-pyrones. A Relevant Structural Feature for the Inhibitory Property of Arisugacin Against Acetylcholinesterase

R. Hsung, G. Golding, Hong C Shen, 1999 .

A Formal [3 + 3] Cycloaddition Reaction. Improved Reactivity Using α,β-Unsaturated Iminium Salts and Evidence for Reversibility of 6π-Electron Electrocyclic Ring Closure of 1-Oxatrienes

R. Hsung, J. Liu, Hong C Shen, 2003 .

Sequential 1,2-Addition−Electrocyclic Ring Closures Involving Acyclic α,β-Unsaturated Iminiums: A Formal [3 + 3] Cycloaddition Strategy to Unique Pyranyl Spirocycles

R. Hsung, Hong C Shen, C. Douglas, 1999 .

Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors.

B. Kuhn, A. Kuglstatter, S. Müller, 2020, Journal of medicinal chemistry.

Efficient synthesis of perfluoroalkylated quinolines via a metal-free cascade Michael addition/intramolecular rearrangement cyclization process

Liping Song, W. Cao, Jie Chen, 2020 .

Sequential 1,2‐Addition—Electrocyclic Ring Closures Involving Acyclic α,β‐Unsaturated Iminiums: A Formal [3 + 3] Cycloaddition Strategy to Unique Pyranyl Spirocycles.

R. Hsung, Hong C Shen, C. Douglas, 1999 .

Sequential 1,2-Addition-Electrocyclic Ring Closures Involving Acyclic alpha,beta-Unsaturated Iminiums: A Formal [3 + 3] Cycloaddition Strategy to Unique Pyranyl Spirocycles.

R. Hsung, Hong C Shen, C. Douglas, 1999, The Journal of organic chemistry.

Biomimetic enantioselective total synthesis of (-)-siccanin via the Pd-catalyzed asymmetric allylic alkylation (AAA) and sequential radical cyclizations.

B. Trost, Hong C Shen, J. Surivet, 2004, Journal of the American Chemical Society.

Chiral cycloalkylidene α,β-unsaturated iminium approach to stereoselective formal [3+3] cycloaddition reaction in spiroheterocycle synthesis

R. Hsung, Hong C Shen, M. McLaughlin, 2001 .

Catalytic Enantioselective Assembly of Homoallylic Alcohols from Dienes, Aryldiazonium Salts, and Aldehydes.

Hong C Shen, L. Gong, Zhi-Yong Han, 2016, Angewandte Chemie.

One-Pot Synthesis of Useful Heterocycles in Medicinal Chemistry Using a Cascade Strategy.

Hong C Shen, Yong Huang, Weiyu Yin, 2012 .

Unusual effects in the pd-catalyzed asymmetric allylic alkylations: synthesis of chiral chromans.

B. Trost, Hong C Shen, Li Dong, 2003, Journal of the American Chemical Society.

Gold(I)-catalyzed regioselective cyclizations of silyl ketene amides and carbamates with alkynes.

Hong C Shen, F. Toste, S. Colletti, 2007, The Journal of organic chemistry.

A multicomponent formal [1+2+1+2]-cycloaddition for the synthesis of dihydropyridines.

A. Whiting, Hong C Shen, A. Batsanov, 2012, Chemical communications.

Unusual effects in the pd-catalyzed asymmetric allylic alkylations: synthesis of chiral chromans.

B. Trost, Hong C Shen, Li Dong, 2003, Journal of the American Chemical Society.

Palladium-catalyzed Suzuki-Miyaura coupling of pyridyl-2-boronic esters with aryl halides using highly active and air-stable phosphine chloride and oxide ligands.

Hong C Shen, S. Colletti, M. Song, 2009, Organic letters.

Dearomative Arylcyanation of Indoles via C-CN Bond Activation Enabled by Ni/Lewis Acid Cooperative Catalysis.

Hong C Shen, L. Gong, Wen-Qian Zhang, 2022, Organic letters.

Efficient Synthesis of Fluoroalkylated Imidazoles via a Metal-Free Cascade Michael Addition/Azidation/Cycloamination Process

Liping Song, W. Cao, Jie Chen, 2018, European Journal of Organic Chemistry.

Palladium-Catalyzed Asymmetric Dihydroxylation of 1,3-Dienes with Catechols

Hong C Shen, L. Gong, Zhi-Yong Han, 2019, Chinese Journal of Chemistry.

Synthesis of chiral chromans by the Pd-catalyzed asymmetric allylic alkylation (AAA): scope, mechanism, and applications.

B. Trost, Hong C Shen, Li Dong, 2004, Journal of the American Chemical Society.

Asymmetric Synthesis and Application of Homologous Pyrroline‐2‐alkylboronic Acids: Identification of the B–N Distance for Eliciting Bifunctional Catalysis of an Asymmetric Aldol Reaction.

A. Whiting, Hong C Shen, A. Batsanov, 2014 .

Synthesis of NH-Sulfoximines Using Recyclable Hypervalent Iodine (III) Reagents under Aqueous Micellar Conditions.

Hong C Shen, H. Tan, Weichun Chen, 2020, ChemSusChem.

Ruthenium-Catalyzed Intramolecular [5 + 2] Cycloadditions

B. Trost, Hong C Shen, and F. Dean Toste, 2000 .

Alternative tandem cyclisation pathways in the reaction between imines and enones

A. Whiting, Hong C Shen, A. Batsanov, 2016 .

On the diastereoselectivity of ru-catalyzed [5 + 2] cycloadditions.

B. Trost, T. Schulz, Hong C Shen, 2003, Organic letters.

Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms

F. García-Alcalde, J. Young, Zhiheng Xu, 2017, Scientific Reports.

Discovery and Pre-Clinical Characterization of Third-Generation 4-H Heteroaryldihydropyrimidine (HAP) Analogues as Hepatitis B Virus (HBV) Capsid Inhibitors.

J. Wu, J. Young, Zheng Zhou, 2017, Journal of medicinal chemistry.

Design and Synthesis of Orally Bioavailable 4-Methyl Heteroaryldihydropyrimidine Based Hepatitis B Virus (HBV) Capsid Inhibitors.

J. Wu, Min Jiang, Zheng Zhou, 2016, Journal of medicinal chemistry.

Discovery of Small Molecule Therapeutics for Treatment of Chronic HBV Infection.

J. Young, Xingchun Han, Song Yang, 2018, ACS infectious diseases.

Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP-TEAD Protein-Protein Interaction.

J. Wong, Zheng Zhou, Zhiheng Xu, 2014, ACS medicinal chemistry letters.

Palladium-Catalyzed Suzuki—Miyaura Coupling of Pyridyl-2-boronic Esters with Aryl Halides Using Highly Active and Air-Stable Phosphine Chloride and Oxide Ligands.

Hong C Shen, S. Colletti, M. Song, 2009 .

Discovery of methylsulfonyl indazoles as potent and orally active respiratory syncytial Virus(RSV) fusion inhibitors.

Hong C Shen, Lu Gao, Chao Li, 2017, European journal of medicinal chemistry.

Discovery of Pyrido[2,3-b]indole Derivatives with Gram-negative Activity Targeting Both DNA Gyrase and Topoisomerase IV.

Chengang Zhou, Zheng Zhou, Zhiheng Xu, 2020, Journal of medicinal chemistry.

Discovery of benzimidazole oxazolidinediones as novel and selective nonsteroidal mineralocorticoid receptor antagonists.

J. Lisnock, A. Crespo, Gaochao Zhou, 2015, ACS medicinal chemistry letters.

Efficient cyclopropanation of aryl/heteroaryl acetates and acetonitriles with vinyl diphenyl sulfonium triflate

X. Qian, Hu Yimin, Hong C Shen, 2018 .

Efficient synthesis of functionalized chromones via a two-base mediated formal [3+3] cycloaddition

M. Jiang, Hong C Shen, Qian Dong, 2016 .

Small Molecule Approaches to Treat Autoimmune and Inflammatory Diseases (Part III): Targeting Cytokines and Cytokine Receptor Complexes.

Xiao Ding, Hong C Shen, Xuefei Tan, 2021, Bioorganic & medicinal chemistry letters.

An enantioselective biomimetic total synthesis of (-)-siccanin.

B. Trost, Hong C Shen, J. Surivet, 2003, Angewandte Chemie.

An Enantioselective Biomimetic Total Synthesis of (‐)‐Siccanin.

B. Trost, Hong C Shen, J. Surivet, 2003 .

Constructing Tricyclic Compounds Containing a Seven-Membered Ring by Ruthenium-Catalyzed Intramolecular [5+2] Cycloaddition.

B. Trost, Hong C Shen, 2001, Angewandte Chemie.

A synthesis of trisubstituted alkenes by a Ru-catalyzed addition.

B. Trost, A. Pinkerton, Hong C Shen, 2002, Chemistry.

A Synthesis of Trisubstituted Alkenes by a Ru‐Catalyzed Addition.

B. Trost, A. Pinkerton, Hong C Shen, 2002 .

Acyl hydroxypyrazoles as novel agonists for high-affinity nicotinic acid receptor GPR109A: WO2008051403

Hong C Shen, 2009, Expert opinion on therapeutic patents.

Discovery of benzodihydroisofurans as novel, potent, bioavailable and brain-penetrant prolylcarboxypeptidase inhibitors.

Michael E. Lassman, Shirly Pinto, M. Garcia-Calvo, 2012, Bioorganic & medicinal chemistry letters.

Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors.

B. Kuhn, W. Haap, M. Stahl, 2016, ACS medicinal chemistry letters.

Mineralocorticoid receptor antagonists: identification of heterocyclic amide replacements in the oxazolidinedione series.

J. Lisnock, A. Crespo, Gaochao Zhou, 2014, Bioorganic & medicinal chemistry letters.

C-H Bond Functionalization of Tetrahydropyridopyrimidines and Other Related Hetereocycles.

Song Yang, Sheng Zhong, Hong C Shen, 2017, The Journal of organic chemistry.

Palladium-Catalyzed Difluoromethylation of Aryl Chlorides and Triflates and Its Applications in the Preparation of Difluoromethylated Derivatives of Drug/Agrochemical Molecules.

Yucheng Gu, Q. Shen, Taishan Hu, 2018, The Journal of organic chemistry.

Iridium-Catalyzed Asymmetric Difunctionalization of C–C σ-Bonds Enabled by Ring-Strained Boronate Complexes

R. Paton, Hong C Shen, V. Aggarwal, 2023, Journal of the American Chemical Society.

Biomimetic enantioselective total synthesis of (-)-siccanin via the Pd-catalyzed asymmetric allylic alkylation (AAA) and sequential radical cyclizations.

B. Trost, Hong C Shen, Jean-Philippe Surivet, 2004, Journal of the American Chemical Society.

Discovery of imidazopyridine derivatives as highly potent respiratory syncytial virus fusion inhibitors.

Lisha Wang, Hong C Shen, Lu Gao, 2015, ACS medicinal chemistry letters.

Gold-catalyzed 6-exo-dig cycloisomerization: a versatile approach to functionalized phenanthrenes.

Hong C Shen, L. Ye, Chao Shu, 2014, Chemistry, an Asian journal.

Intramolecular N-Me and N-H aminoetherification for the synthesis of N-unprotected 3-amino-O-heterocycles.

J. Falck, Mingliang Wang, J. Siitonen, 2021, Organic & biomolecular chemistry.

Nickel/Enamine Cooperative Catalysis Enables Highly Enantioselective Allylic Alkylation of α-Branched Aldehydes

Hong C Shen, Wen-Qian Zhang, 2021, ACS Catalysis.

Palladium-Catalyzed Asymmetric Aminohydroxylation of 1,3-Dienes.

Ying Zhang, Hong C Shen, L. Gong, 2018, Angewandte Chemie.

Discovery of pyrazolyl propionyl cyclohexenamide derivatives as full agonists for the high affinity niacin receptor GPR109A.

Hong C Shen, X. Tong, Qing Chen, 2010, Bioorganic & medicinal chemistry letters.