F. Perrino

发表

The TREX1 Double-stranded DNA Degradation Activity Is Defective in Dominant Mutations Associated with Autoimmune Disease*

T. Hollis, Duane A Lehtinen, S. Harvey, 2008, Journal of Biological Chemistry.

Synonymous Mutations in RNASEH2A Create Cryptic Splice Sites Impairing RNase H2 Enzyme Function in Aicardi–Goutières Syndrome

Martin A. M. Reijns, L. Lagae, B. Gener, 2013, Human mutation.

Sequence specificity of pausing by DNA polymerases.

L. Loeb, F. Perrino, D. Dube, 1989, Biochemical and biophysical research communications.

Targeting Bcl6 in the TREX1 D18N murine model ameliorates autoimmunity by modulating T‐follicular helper cells and germinal center B cells

Nan Yan, S. Harvey, F. Perrino, 2022, European journal of immunology.

TREX1 - Apex predator of cytosolic DNA metabolism.

F. Perrino, Sean R. Simpson, Wayne O. Hemphill, 2020, DNA repair.

TREX1 D18N mice fail to process erythroblast DNA resulting in inflammation and dysfunctional erythropoiesis

S. Harvey, F. Perrino, J. Grayson, 2018, Autoimmunity.

The TREX1 C-terminal Region Controls Cellular Localization through Ubiquitination*

Clinton D. Orebaugh, T. Hollis, S. Harvey, 2013, The Journal of Biological Chemistry.

Dysfunctional proofreading in the Escherichia coli DNA polymerase III core.

Duane A Lehtinen, F. Perrino, 2004, The Biochemical journal.

TREX1’s Homodimer Structure Has Evolved for Double-Stranded DNA Degradation

F. Salsbury, T. Hollis, F. Perrino, 2022 .

The Effects of Cytosine Arabinoside on RNA-primed DNA Synthesis by DNA Polymerase α-Primase (*)

F. Perrino, Cindy Harrington, 1995, The Journal of Biological Chemistry.

Mammalian DNA polymerases alpha, beta, gamma, delta, and epsilon incorporate fialuridine (FIAU) monophosphate into DNA and are inhibited competitively by FIAU Triphosphate.

J. Simpson, J. Colacino, F. Perrino, 1994, Biochemistry.

Towards a New Model for the TREX1 Exonuclease

F. Salsbury, F. Perrino, Wayne O. Hemphill, 2022 .

Genotype-Phenotype Correlation and Functional Insights for Two Monoallelic TREX1 Missense Variants Affecting the Catalytic Core

M. Severino, M. Zedde, R. Pascarella, 2022, Genes.

DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice.

Nan Yan, Yong-soo Kim, Chen-feng Qi, 2017, Journal of autoimmunity.

The Arg-62 Residues of the TREX1 Exonuclease Act Across the Dimer Interface Contributing to Catalysis in the Opposing Protomers*

Clinton D. Orebaugh, T. Hollis, F. Perrino, 2014, The Journal of Biological Chemistry.

The TREX1 Exonuclease R114H Mutation in Aicardi-Goutières Syndrome and Lupus Reveals Dimeric Structure Requirements for DNA Degradation Activity*♦

Clinton D. Orebaugh, T. Hollis, S. Harvey, 2011, The Journal of Biological Chemistry.

Dominant Mutations of the TREX1 Exonuclease Gene in Lupus and Aicardi-Goutières Syndrome*

Clinton D. Orebaugh, T. Hollis, F. Perrino, 2011, The Journal of Biological Chemistry.

Cooperative DNA Binding and Communication across the Dimer Interface in the TREX2 3′ → 5′-Exonuclease*

Edward E. Pryor, T. Hollis, S. Harvey, 2008, Journal of Biological Chemistry.

The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death.

J. Lieberman, Pengcheng Zhu, J. Sung, 2006, Molecular cell.

The SAMHD1 dNTP Triphosphohydrolase Is Controlled by a Redox Switch.

R. Harris, L. Daniel, C. Furdui, 2017, Antioxidants & redox signaling.

Proof-reading 3'-->5' exonucleases isolated from rat liver nuclei.

I. Shevelev, F. Perrino, S. Naryzhny, 1993, European journal of biochemistry.

Sequence variants in the 3'-->5' deoxyribonuclease TREX2: identification in a genetic screen and effects on catalysis by the recombinant proteins.

Jianfeng Xu, W. Isaacs, S. Zheng, 2004, Advances in enzyme regulation.

The Crystal Structure of TREX1 Explains the 3′ Nucleotide Specificity and Reveals a Polyproline II Helix for Protein Partnering*

S. Bailey, T. Hollis, S. Harvey, 2007, Journal of Biological Chemistry.

Functional Consequences of the RNase H2A Subunit Mutations That Cause Aicardi-Goutières Syndrome*

T. Hollis, F. Perrino, Stephanie R. Coffin, 2011, The Journal of Biological Chemistry.

The multidimensional nature of antiviral innate immunity.

R. Harris, F. Perrino, N. Shaban, 2015, Cell host & microbe.

Model for the catalytic domain of the proofreading epsilon subunit of Escherichia coli DNA polymerase III based on NMR structural data.

T. Darden, R. Schaaper, Dawei Li, 2002, Biochemistry.

Hydrolysis of 3'-terminal mispairs in vitro by the 3'----5' exonuclease of DNA polymerase delta permits subsequent extension by DNA polymerase alpha.

L. Loeb, F. Perrino, 1990, Biochemistry.

Exonucleases and the incorporation of aranucleotides into DNA

Dan J. Mazur, S. Harvey, F. Perrino, 2007, Cell Biochemistry and Biophysics.

Incorporation of cytosine arabinoside monophosphate into DNA at internucleotide linkages by human DNA polymerase alpha.

F. Perrino, H. Mekosh, 1992, The Journal of biological chemistry.

Polymerization past the N2-isopropylguanine and the N6-isopropyladenine DNA lesions with the translesion synthesis DNA polymerases eta and iota and the replicative DNA polymerase alpha.

Stacy L. Gelhaus, W. LaCourse, S. Harvey, 2005, Chemical research in toxicology.

Crystal structure of RNA-DNA duplex provides insight into conformational changes induced by RNase H binding

Ryan R Davis, T. Hollis, F. Perrino, 2015, Cell cycle.

Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune disease.

S. Bailey, T. Hollis, S. Harvey, 2012, DNA repair.

The Structure of the Mammalian RNase H2 Complex Provides Insight into RNA·DNA Hybrid Processing to Prevent Immune Dysfunction*

T. Hollis, S. Harvey, F. Perrino, 2009, The Journal of Biological Chemistry.

Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosus

J. Lieberman, J. Kere, A. Dominiczak, 2007, Nature Genetics.

Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome.

D. Barnes, Y. Crow, W. Newman, 2007, American journal of human genetics.

Extension of mismatched 3' termini of DNA is a major determinant of the infidelity of human immunodeficiency virus type 1 reverse transcriptase.

L. Loeb, B. Preston, F. Perrino, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Differential extension of 3' mispairs is a major contribution to the high fidelity of calf thymus DNA polymerase-alpha.

L. Loeb, F. Perrino, 1989, The Journal of biological chemistry.

Fialuridine and its metabolites inhibit DNA polymerase gamma at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts.

E. Levine, K. Watanabe, K. O. Tankersley, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Identification and Expression of the TREX1 and TREX2 cDNA Sequences Encoding Mammalian 3′→5′ Exonucleases*

Dan J. Mazur, F. Perrino, 1999, The Journal of Biological Chemistry.

Mutagenesis by exocyclic alkylamino purine adducts in Escherichia coli.

S. Akman, F. Perrino, J. Fishbein, 2006, Mutation research.

Bypass of N²-ethylguanine by human DNA polymerase κ.

F. Perrino, J. Fishbein, M. G. Pence, 2011, DNA repair.

Aicardi-Goutières Syndrome Gene and HIV-1 Restriction Factor SAMHD1 Is a dGTP-regulated Deoxynucleotide Triphosphohydrolase*♦

Thomas Hollis, T. Hollis, F. Perrino, 2011, The Journal of Biological Chemistry.

Variability in the nucleic acid binding site size and the amount of single‐stranded DNA‐binding protein in Escherichia coli

F. Perrino, A. Bobst, D. Rein, 1985, FEBS letters.

Animal cell DNA polymerases in DNA repair.

L. Loeb, F. Perrino, 1990, Mutation research.

Identification of a 3'-->5'-exonuclease that removes cytosine arabinoside monophosphate from 3' termini of DNA.

H. Miller, F. Perrino, K. A. Ealey, 1994, The Journal of biological chemistry.

CONTRIBUTION OF 3'5' EXONUCLEASES FROM RAT LIVER NUCLEI TO THE FIDELITY OFDNA SYNTHESIS CATALYZED BY MAMMALIAN DNA POLYMERASES ALPHA

I. Shevelev, F. Perrino, O. Legina, 1993 .

Hydrolysis of 3'-terminal mispairs in vitro by the 3' ⇒ 5' exonuclease of DNA polymerase δ permits subsequent extension by DNA polymerase α

L. Loeb, F. Perrino, 1990 .

Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort

C D Langefeld, L A Criswell, P. Gaffney, 2011, Genes and Immunity.

T Cells Produce IFN-α in the TREX1 D18N Model of Lupus-like Autoimmunity

S. Harvey, F. Perrino, Mingyong Liu, 2019, The Journal of Immunology.

A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus

J. Lieberman, M. Gahr, N. Hubner, 2007, Journal of Molecular Medicine.

A DNA Polymerase-α·Primase Cofactor with Homology to Replication Protein A-32 Regulates DNA Replication in Mammalian Cells*

G. Boss, Shunhui Zhuang, R. Pilz, 2009, Journal of Biological Chemistry.

Excision of 3′ Termini by the Trex1 and TREX2 3′→5′ Exonucleases

Dan J. Mazur, F. Perrino, 2001, The Journal of Biological Chemistry.

WRN exonuclease activity is blocked by DNA termini harboring 3′ obstructive groups

Jinshui Fan, J. Momand, V. Bohr, 2007, Mechanisms of Ageing and Development.

Structure and Expression of the TREX1 and TREX2 3′→5′ Exonuclease Genes*

Dan J. Mazur, F. Perrino, 2001, The Journal of Biological Chemistry.

Identification of Inhibitors of the dNTP Triphosphohydrolase SAMHD1 Using a Novel and Direct High-Throughput Assay.

T. Hollis, F. Perrino, Christopher H Mauney, 2018, Biochemistry.

Lesion Bypass of N2-Ethylguanine by Human DNA Polymerase ι*

T. Hollis, F. Perrino, J. Fishbein, 2009, Journal of Biological Chemistry.

The N2-ethylguanine and the O6-ethyl- and O6-methylguanine lesions in DNA: contrasting responses from the "bypass" DNA polymerase eta and the replicative DNA polymerase alpha.

Stacy L. Gelhaus, S. Akman, W. LaCourse, 2003, Chemical research in toxicology.

Solid-State Nanopore Analysis of Diverse DNA Base Modifications Using a Modular Enzymatic Labeling Process.

A. Hall, R. Kohli, D. Parsonage, 2017, Nano letters.

Measuring TREX1 and TREX2 exonuclease activities.

F. Perrino, Wayne O. Hemphill, 2019, Methods in enzymology.

Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease

T. Hollis, S. Harvey, F. Perrino, 2015, Proceedings of the National Academy of Sciences.

TREX1 as a Novel Immunotherapeutic Target

F. Salsbury, T. Hollis, F. Perrino, 2021, Frontiers in Immunology.

TREX 1 Dominant Mutations in Lupus and Aicardi-Goutieres Syndrome

Clinton D. Orebaugh, T. Hollis, F. Perrino, 2011 .

RNaseH2 mutants that cause Aicardi–Goutieres syndrome are active nucleases

T. Hollis, S. Harvey, F. Perrino, 2008, Journal of Molecular Medicine.

The Exonuclease Trex2 Shapes Psoriatic Phenotype.

F. Ciruela, T. Vavouri, M. Ferran, 2016, The Journal of investigative dermatology.

Interaction of a folded chromosome-associated protein with single-stranded DNA-binding protein of Escherichia coli, identified by affinity chromatography.

F. Perrino, A. Bobst, D. Rein, 1988, The Journal of biological chemistry.

The Human TREX2 3′ → 5′-Exonuclease Structure Suggests a Mechanism for Efficient Nonprocessive DNA Catalysis*

T. Hollis, S. Harvey, F. Perrino, 2005, Journal of Biological Chemistry.

The relative rate of synthesis and levels of single-stranded DNA binding protein during induction of SOS repair in Escherichia coli

F. Perrino, A. Bobst, D. Rein, 1987, Molecular and General Genetics MGG.

Replication of N2-ethyldeoxyguanosine DNA adducts in the human embryonic kidney cell line 293.

S. Akman, F. Perrino, J. Fishbein, 2006, Chemical research in toxicology.

Structure of the Escherichia coli DNA Polymerase III ϵ-HOT Proofreading Complex*

R. Schaaper, L. Pedersen, A. Chikova, 2006, Journal of Biological Chemistry.

Two Functional Domains of the ε Subunit of DNA Polymerase III

F. Perrino, A. Harvey, S. M. McNeill, 1999 .

Kinetic mechanism of the 3'-->5' proofreading exonuclease of DNA polymerase III. Analysis by steady state and pre-steady state methods.

F. Perrino, H. Miller, 1996, Biochemistry.

Proofreading by the epsilon subunit of Escherichia coli DNA polymerase III increases the fidelity of calf thymus DNA polymerase alpha.

L. Loeb, F. Perrino, Lawrence A. Loeb, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Multifaceted role of TREX2 in the skin defense against UV-induced skin carcinogenesis

L. Eckhart, J. García-Pedrero, J. Rodrigo, 2015, Oncotarget.

Elucidation of the epsilon-theta subunit interface of Escherichia coli DNA polymerase III by NMR spectroscopy.

T. Darden, R. Schaaper, R. London, 2003, Biochemistry.

DNA binding induces active site conformational change in the human TREX2 3′-exonuclease

T. Hollis, F. Perrino, U. de Silva, 2009, Nucleic acids research.

A preliminary CD and NMR study of the Escherichia coli DNA polymerase III Θ subunit

R. London, S. Harvey, F. Perrino, 1999, Proteins.

Eucaryotic DNA primase does not prefer to synthesize primers at pyrimidine rich DNA sequences when nucleoside triphosphates are present at concentrations found in whole cells.

R. Kuchta, F. Perrino, B. Kirk, 1997, Biochemistry.

Factor D is a selective single-stranded oligodeoxythymidine binding protein

M. Fry, F.W. Perrino, A. Levy, 1988, Nucleic Acids Res..

Primer RNA chain termination induced by 9-beta-D-arabinofuranosyl-2-fluoroadenine 5'-triphosphate. A mechanism of DNA synthesis inhibition.

C. Catapano, F. Perrino, D. Fernandes, 1993, The Journal of biological chemistry.

Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort

P. Gaffney, M. Petri, C. Langefeld, 2011, Genes and Immunity.

The TREX1 C-terminal Region Controls Cellular Localization through Ubiquitination*

Clinton D. Orebaugh, T. Hollis, S. Harvey, 2013, The Journal of Biological Chemistry.

The TREX1 Double-stranded DNA Degradation Activity Is Defective in Dominant Mutations Associated with Autoimmune Disease*

T. Hollis, Duane A Lehtinen, S. Harvey, 2008, Journal of Biological Chemistry.

A TREX1 model reveals double-strand DNA preference and inter-protomer regulation

F. Salsbury, T. Hollis, F. Perrino, 2023, bioRxiv.

Severe toxicity of fialuridine (FIAU)

F. Perrino, W. Lewis, 1996, The New England journal of medicine.