J. Pickar

发表

A randomized, placebo- and active-controlled trial of bazedoxifene/conjugated estrogens for treatment of moderate to severe vulvar/vaginal atrophy in postmenopausal women

R. Kagan, R. Williams, K. Pan, 2010, Menopause.

Emerging hormonal treatments for menopausal symptoms

B. Komm, A. Genazzani, J. Pickar, 2015, Expert opinion on emerging drugs.

Clinical Trials in Postmenopausal Hormone Therapy

J. Pickar, C. Holinka, 2007 .

Bazedoxifene/conjugated estrogens and quality of life in postmenopausal women.

W. Utian, S. Mirkin, J. Pickar, 2009, Maturitas.

Tissue selective estrogen complex (TSEC): a review

J. Pickar, M. Boucher, D. Morgenstern, 2018, Menopause.

Coronary heart disease and menopause management: the swinging pendulum of HRT.

H. Hodis, R. Lobo, J. Pickar, 2009, Atherosclerosis.

Selective estrogen receptor modulators (SERMs): a review of clinical data.

S. Mirkin, J. Pickar, 2015, Maturitas.

Effects of different hormone replacement regimens on postmenopausal women with abnormal lipid levels. Menopause Study Group.

B. Walsh, R. Wild, R. Lobo, 1998, Climacteric : the journal of the International Menopause Society.

The endometrium – from estrogens alone to TSECs

J. Pickar, 2009, Climacteric : the journal of the International Menopause Society.

Body mass index does not influence response to treatment, nor does body weight change with lower doses of conjugated estrogens and medroxyprogesterone acetate in early postmenopausal women

W. Utian, J. Pickar, M. Gass, 2004, Menopause.

Estrogens in postmenopausal women: recent insights.

G. Constantine, J. Pickar, 2003, Current opinion in pharmacology.

Endometrial effects of lower doses of conjugated equine estrogens and medroxyprogesterone acetate: two-year substudy results.

I. Yeh, J. Wheeler, J. Pickar, 2003, Fertility and sterility.

Bone response to treatment with lower doses of conjugated estrogens with and without medroxyprogesterone acetate in early postmenopausal women

R. Lindsay, J. Gallagher, M. Kleerekoper, 2005, Osteoporosis International.

Body composition during treatment with conjugated estrogens with and without medroxyprogesterone acetate: analysis of the women's Health, Osteoporosis, Progestin, Estrogen (HOPE) trial.

R. Lindsay, J. Pickar, I. Thorneycroft, 2007, American journal of obstetrics and gynecology.

Effects of lower doses of conjugated equine estrogens and medroxyprogesterone acetate on plasma lipids and lipoproteins, coagulation factors, and carbohydrate metabolism.

T. Bush, B. Carr, R. Lobo, 2001, Fertility and sterility.

Efficacy of tissue-selective estrogen complex of bazedoxifene/conjugated estrogens for osteoporosis prevention in at-risk postmenopausal women.

R. Lindsay, J. Gallagher, G. Constantine, 2009, Fertility and sterility.

HRT and breast cancer risk: a realistic perspective

H. Hodis, R. Lobo, J. Pickar, 2011, Climacteric.

Emerging therapies for postmenopausal vaginal atrophy.

J. Pickar, 2013, Maturitas.

Estradiol and progesterone bioavailability for moderate to severe vasomotor symptom treatment and endometrial protection with the continuous-combined regimen of TX-001HR (oral estradiol and progesterone capsules)

G. Constantine, R. Lobo, F. Stanczyk, 2019, Menopause.

Pharmacokinetic studies of solubilized estradiol given vaginally in a novel softgel capsule

S. Mirkin, J. Pickar, B. Bernick, 2016, Climacteric : the journal of the International Menopause Society.

Conflicts of interest in government-funded studies

J. Pickar, 2015, Climacteric : the journal of the International Menopause Society.

Pharmacokinetics of the first combination 17β-estradiol/progesterone capsule in clinical development for menopausal hormone therapy

S. Mirkin, J. Pickar, C. Bon, 2015, Menopause.

Differential effects of menopausal therapies on the endometrium

B. Komm, H. Taylor, D. Archer, 2014, Menopause.

Bazedoxifene/conjugated estrogens for menopausal symptom treatment and osteoporosis prevention

S. Mirkin, J. Pickar, J. Pinkerton, 2012, Climacteric : the journal of the International Menopause Society.

If only WHI was done well

H. Hodis, R. Lobo, J. Pickar, 2010, BMJ : British Medical Journal.

Initial investigation into the optimal dose ratio of conjugated estrogens and bazedoxifene: a double-blind, randomized, placebo-controlled phase 2 dose-finding study

B. Komm, K. Pan, J. Pickar, 2017, Menopause.

Relief of vasomotor symptoms and vaginal atrophy with lower doses of conjugated equine estrogens and medroxyprogesterone acetate.

G. Bachmann, W. Utian, D. Shoupe, 2001, Fertility and sterility.

Management of osteoporosis and menopausal symptoms: focus on bazedoxifene/conjugated estrogen combination

S. Mirkin, J. Pickar, 2013, International journal of women's health.

The assessment of bleeding patterns in postmenopausal women during continuous combined hormone replacement therapy: a review of methodology and recommendations for reporting of the data

D. Archer, J. Pickar, 2002, Climacteric : the journal of the International Menopause Society.

Endometrial Effects of Bazedoxifene Acetate, a Novel Selective Estrogen Receptor Modulator, in Postmenopausal Women

E. Baracat, G. Constantine, D. Archer, 2005, Obstetrics and gynecology.

Bleeding Patterns in Postmenopausal Women Taking Continuous Combined or Sequential Regimens of Conjugated Estrogens With Medroxyprogesterone Acetate

D. Archer, J. Pickar, F. Bottiglioni, 1994, Obstetrics and gynecology.

Endometrial effects of lower doses of conjugated equine estrogens and medroxyprogesterone acetate.

I. Yeh, J. Wheeler, J. Pickar, 2001, Fertility and sterility.

Update on medical and regulatory issues pertaining to compounded and FDA-approved drugs, including hormone therapy

J. Pickar, J. Pinkerton, 2016, Menopause.

The REJOICE trial: a phase 3 randomized, controlled trial evaluating the safety and efficacy of a novel vaginal estradiol soft-gel capsule for symptomatic vulvar and vaginal atrophy

H. Kushner, J. Simon, G. Constantine, 2017, Menopause.

A randomized, double-blind, placebo-controlled phase 2 pilot trial evaluating a novel, vaginal softgel capsule containing solubilized estradiol

S. Mirkin, J. Pickar, B. Bernick, 2016, Menopause.

Effect of lower doses of conjugated equine estrogens with and without medroxyprogesterone acetate on bone in early postmenopausal women.

R. Lindsay, J. Gallagher, M. Kleerekoper, 2002, JAMA.

Bazedoxifene/conjugated estrogens (BZA/CE): incidence of uterine bleeding in postmenopausal women.

V. Lewis, D. Archer, B. Carr, 2009, Fertility and sterility.

Evaluation of bazedoxifene/conjugated estrogens for the treatment of menopausal symptoms and effects on metabolic parameters and overall safety profile.

G. Constantine, R. Lobo, J. Pickar, 2009, Fertility and sterility.

Physical characteristics and properties of estradiol softgel vaginal inserts

J. Simon, S. Mirkin, J. Pickar, 2019, Menopause.

Estradiol vaginal inserts (4 µg and 10 µg) for treating moderate to severe vulvar and vaginal atrophy: a review of phase 3 safety, efficacy and pharmacokinetic data

J. Simon, G. Constantine, D. Archer, 2018, Current medical research and opinion.

Relief of Vasomotor Symptoms and Vaginal Atrophy With Lower Doses of Conjugated Equine Estrogens and Medroxyprogesterone Acetate

G. Bachmann, W. Utian, D. Shoupe, 2001 .

Effects of lower doses of conjugated equine estrogens and medroxyprogesterone acetate on endometrial bleeding.

D. Schneider, V. Lewis, D. Archer, 2001, Fertility and sterility.

Effects of lower doses of conjugated equine estrogens and medroxyprogesterone acetate on endometrial bleeding.

D. Schneider, V. Lewis, D. Archer, 2001, Fertility and sterility.

Menopausal Symptoms in Older Women and the Effects of Treatment With Hormone Therapy

J. Cauley, M. Stefanick, D. Grady, 2002, Obstetrics and gynecology.

Effects of equine oestrogens on markers of vasoactive function in human coronary artery endothelial cells

E. Garr, J. Pickar, J. Stevenson, 1999, Molecular and Cellular Endocrinology.

Is bleeding a predictor of endometrial hyperplasia in postmenopausal women receiving hormone replacement therapy? Menopause Study Group (United States, Italy, Netherlands, Switzerland, Belgium, Germany, and Finland.

D. Archer, J. Pickar, 1997, American journal of obstetrics and gynecology.

Effect of desvenlafaxine on mood and climacteric symptoms in menopausal women with moderate to severe vasomotor symptoms

D. Archer, W. Bao, J. Pickar, 2012, Climacteric : the journal of the International Menopause Society.

Evaluation of Bazedoxifene/Conjugated Estrogens for the Treatment of Menopausal Symptoms and Effects on Metabolic Parameters and Overall Safety Profile

G. Constantine, R. Lobo, J. Pickar, 2010 .

Metabolic impact of adding medroxyprogesterone acetate to conjugated estrogen therapy in postmenopausal women

B. Walsh, R. Wild, R. Lobo, 1994, Obstetrics and gynecology.

Incidence of endometrial hyperplasia in postmenopausal women taking conjugated estrogens (Premarin) with medroxyprogesterone acetate or conjugated estrogens alone. The Menopause Study Group.

J. Woodruff, J. Pickar, 1994, American journal of obstetrics and gynecology.

Relief of vasomotor symptoms with the tissue-selective estrogen complex containing bazedoxifene/conjugated estrogens: a randomized, controlled trial

G. Constantine, W. Utian, J. Pickar, 2009, Menopause.

Endometrial effects of a tissue selective estrogen complex containing bazedoxifene/conjugated estrogens as a menopausal therapy.

G. Bachmann, I. Yeh, J. Pickar, 2009, Fertility and sterility.

Tissue-Selective Agents: Selective Estrogen Receptor Modulators and the Tissue-Selective Estrogen Complex

S. Mirkin, J. Pickar, 2010, Menopause international.

A vaginal estradiol softgel capsule, TX-004HR, has negligible to very low systemic absorption of estradiol: Efficacy and pharmacokinetic data review.

J. Simon, G. Constantine, D. Archer, 2017, Maturitas.

Amenorrhea frequency with continuous combined hormone replacement therapy: a retrospective analysis. Menopause Study Group.

D. Archer, J. Pickar, F. Bottiglioni, 1998, Climacteric : the journal of the International Menopause Society.

Coordinate regulation of the production and signaling of retinoic acid by estrogen in the human endometrium.

G. Stancel, R. Broaddus, G. Shipley, 2003, The Journal of clinical endocrinology and metabolism.

Back to the future: Hormone replacement therapy as part of a prevention strategy for women at the onset of menopause.

W. Mack, H. Hodis, R. Lobo, 2016, Atherosclerosis.

SERMs: progress and future perspectives.

J. Pickar, James H Pickar, Tanya MacNeil, 2010, Maturitas.

Effect of Estrogen plus Progestin on Risk for Biliary Tract Surgery in Postmenopausal Women with Coronary Artery Disease: The Heart and Estrogen/progestin Replacement Study

J. Cauley, D. Hunninghake, F. Lin, 2001, Annals of Internal Medicine.

Effects of hormone replacement therapy on the endometrium and lipid parameters: a review of randomized clinical trials, 1985 to 1995.

M. Whitehead, J. Pickar, I. Thorneycroft, 1998, American journal of obstetrics and gynecology.

Molecular clustering of endometrial carcinoma based on estrogen-induced gene expression

R. Broaddus, L. Deng, K. Lu, 2009, Cancer biology & therapy.

The Positive Predictive Value of Cervical Smears in Previously Screened Postmenopausal Women: The Heart and Estrogen/progestin Replacement Study (HERS)

K. Kerlikowske, J. Mandelblatt, D. Grady, 2000, Annals of Internal Medicine.

Selective estrogen receptor modulators and the combination therapy conjugated estrogens/bazedoxifene: A review of effects on the breast

B. Komm, J. Pickar, 2015, Post reproductive health.

Identification of a Novel Estrogen-Regulated Gene, EIG121, Induced by Hormone Replacement Therapy and Differentially Expressed in Type I and Type II Endometrial Cancer

G. Stancel, R. Broaddus, G. Shipley, 2005, Clinical Cancer Research.

Uterine bleeding with hormone therapies in menopausal women: a systematic review

R. Kagan, D. Archer, S. Mirkin, 2020, Climacteric : the journal of the International Menopause Society.

Conjugated estrogens for the treatment of menopausal symptoms: a review of safety data

B. Komm, S. Mirkin, J. Pickar, 2014, Expert opinion on drug safety.

The Tissue-Selective Estrogen Complex (TSEC): A Promising New Therapy for Menopausal Symptoms and Postmenopausal Osteoporosis

S. Mirkin, J. Pickar, 2012, Current Obstetrics and Gynecology Reports.

Clinical experience with trimegestone as a new progestin in HRT

G. Constantine, J. Pickar, G. Grubb, 2003, Steroids.

Healthy Postmenopausal Women Receiving HRT Are Not at Risk for Early Coronary Events: Results from 2 Large Clinical Trials

E. Trott, G. Constantine, J. Pickar, 2002 .

Hormone Replacement Therapy: Effect of Progestin Dose and Time Since Menopause on Endometrial Bleeding

D. Archer, J. Pickar, JAMES H. PICKAR, 2000, Obstetrics and gynecology.

Endometrial safety and bleeding profile of a 17β-estradiol/progesterone oral softgel capsule (TX-001HR)∗

D. Archer, S. Mirkin, J. Pickar, 2020, Menopause.

A 17β-Estradiol-Progesterone Oral Capsule for Vasomotor Symptoms in Postmenopausal Women: A Randomized Controlled Trial.

G. Constantine, R. Kagan, D. Archer, 2018, Obstetrics and gynecology.

Safety and benefit considerations for menopausal hormone therapy

H. Taylor, R. Kagan, D. Archer, 2017, Expert opinion on drug safety.

Estrogen activity and novel tissue selectivity of delta8,9-dehydroestrone sulfate in postmenopausal women.

E. Baracat, J. Pickar, F. López, 1999, The Journal of clinical endocrinology and metabolism.

Menopausal hormone therapy for primary prevention: why the USPSTF is wrong

R. Langer, P. Sarrel, A. Pines, 2017, Menopause.

Menopausal hormone therapy for primary prevention: why the USPSTF is wrong

R. Langer, P. Sarrel, A. Pines, 2017, Climacteric : the journal of the International Menopause Society.

Clinical implications for the endometrium of hormone replacement therapy

J. Pickar, 2020, Progress in the Management of the Menopause.

Desvenlafaxine for the treatment of vasomotor symptoms associated with menopause: a double-blind, randomized, placebo-controlled trial of efficacy and safety.

G. Constantine, D. Archer, J. Pickar, 2009, American journal of obstetrics and gynecology.

A double-blind, randomly assigned, placebo-controlled study of desvenlafaxine efficacy and safety for the treatment of vasomotor symptoms associated with menopause.

G. Constantine, D. Archer, J. Pickar, 2009, American journal of obstetrics and gynecology.

Progesterone

J. Pickar, 2018, Reactions Weekly.

Transdermal estradiol gel for the treatment of symptomatic postmenopausal women

D. Archer, M. Warren, J. Pickar, 2012, Menopause.

The response to ospemifene in normal human breast tissue cultures.

J. Pickar, 2016, Menopause.

Consistency of Effect with a Low-Dose, Estradiol Vaginal Capsule (TX-004HR): Evaluating Improvement in Vaginal Physiology and Moderate-to-Severe Dyspareunia in Subgroups of Postmenopausal Women

G. Constantine, D. Archer, C. Bouchard, 2017, Journal of women's health.

Patient considerations in the management of menopausal symptoms: role of conjugated estrogens with bazedoxifene

B. Komm, R. Kagan, J. Pickar, 2016, Therapeutics and clinical risk management.

Efficacy of tissue-selective estrogen complex of bazedoxifene/conjugated estrogens for osteoporosis prevention in at-risk postmenopausal women.

R. Lindsay, J. Gallagher, G. Constantine, 2009, Fertility and sterility.

Gynecologic Safety of Conjugated Estrogens Plus Bazedoxifene: Pooled Analysis of Five Phase 3 Trials.

B. Komm, R. Kagan, D. Archer, 2016, Journal of women's health.

Recent insights into the varying activity of estrogens.

C. Lyttle, J. Pickar, M. Dey, 2000, Maturitas.

Evaluation of Cardiovascular‐Event Rates With Hormone Replacement Therapy in Healthy Postmenopausal Women

R. Lobo, J. Pickar, 2003 .

17β-Estradiol and natural progesterone for menopausal hormone therapy: REPLENISH phase 3 study design of a combination capsule and evidence review.

D. Archer, S. Mirkin, J. Pickar, 2015, Maturitas.

Recent advances help understand and improve the safety of menopausal therapies

B. Komm, D. Archer, S. Mirkin, 2015, Menopause.

Conjugated Estrogen/Bazedoxifene Tablets for the Treatment of Moderate-to-Severe Vasomotor Symptoms Associated with Menopause

B. Komm, S. Mirkin, J. Pickar, 2014, Women's health.

O-206: Bazedoxifene combined with conjugated estrogens: A novel alternative to traditional hormone therapies

G. Constantine, J. Pickar, S. Ronkin, 2006 .

TX-001HR is associated with a clinically meaningful effect on severity of moderate to severe vasomotor symptoms in the REPLENISH trial

D. Revicki, J. Simon, G. Constantine, 2020, Menopause.

Declarations of interest and the removal of the public funding exemption

J. Pickar, 2017, Climacteric : the journal of the International Menopause Society.

Conflicts of interest in government-funded studies. A reply to red herrings

J. Pickar, 2015, Climacteric : the journal of the International Menopause Society.

Independent conclusions?

J. Pickar, 2023, Climacteric : the journal of the International Menopause Society.

Conjugated estrogens and bazedoxifene in minority populations: pooled analysis of four phase 3 trials

B. Komm, K. Ryan, S. Mirkin, 2016, Menopause.

Updated Ims Recommendations on Postmenopausal Hormone Therapy and Preventive Strategies for Midlife Health Pines on Behalf of the International Menopause Society Writing Group

J. Pickar, N. Panay, M. Gambacciani, 2022 .