W. Klee

发表

Helix-coil transition of the isolated amino terminus of ribonuclease.

J. E. Brown, W. Klee, J. E. Brown, 1971, Biochemistry.

Opioid activities and structures of alpha-casein-derived exorphins.

W. Klee, S. Loukas, D. Varoucha, 1983, Biochemistry.

The interaction of -lactalbumin and the A protein of lactose synthetase.

C. Klee, W. Klee, 1972, Journal of Biological Chemistry.

Use of specific antibodies to quantitate the guanine nucleotide-binding protein Go in brain.

G. Milligan, M. Pines, P. Gierschik, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Agonist regulation of the expression of the delta opioid receptor in NG108‐15 cells

W. Klee, H. Chin, H. Chin, 1995, FEBS letters.

Studies on the conformation of ribonuclease S-peptide.

W. Klee, 1968, Biochemistry.

Antibodies against the carboxyl-terminal 5-kDa peptide of the alpha subunit of transducin crossreact with the 40-kDa but not the 39-kDa guanine nucleotide binding protein from brain.

G. Milligan, M. Pines, P. Gierschik, 1985, Proceedings of the National Academy of Sciences of the United States of America.

The relationship between enkephalin degradation and opiate receptor occupancy.

M. Knight, W. Klee, 1978, The Journal of biological chemistry.

Probes for narcotic receptor mediated phenomena 8. Tritiation of irreversible mu or delta specific opioid receptor affinity ligands to high specific activity

W. Simonds, T. Burke, K. Rice, 1984 .

Enkephalin generating activity of rat brain endopeptidases.

M. Knight, W. Klee, 1979, The Journal of biological chemistry.

Endorphin from pituitary inhibits cyclic AMP formation in homogenates of neuroblastoma × glioma hybrid cells

M. Nirenberg, A. Goldstein, W. Klee, 1977, Nature.

Mode of action of endogenous opiate peptides

M. Nirenberg, W. Klee, 1976, Nature.

A Neuroblastoma × Glioma Hybrid Cell Line with Morphine Receptors

M. Nirenberg, W. Klee, 1974 .

Opioid peptides as modulators of cyclic AMP levels.

W. Klee, 1979, Advances in experimental medicine and biology.

N-(2,4,5-TRIHYDROXYPHENETHYL)NORMETAZOCINE, A POTENTIAL IRREVERSIBLE INHIBITOR OF THE NARCOTIC RECEPTOR

K. Rice, W. Klee, A. E. Jacobson, 1977 .

N-(2,4,5-Trihydroxyphenehtyl)normetazocine, a potential irreversible inhibitor of the narcotic receptor.

K. Rice, W. Klee, A. E. Jacobson, 1977, Journal of medicinal chemistry.

Opiate-dependent modulation of adenylate cyclase.

M. Nirenberg, S. Sharma, W. Klee, 1977, Proceedings of the National Academy of Sciences of the United States of America.

Tolerance and dependence evoked by an endogenous opiate peptide.

M. Nirenberg, W. Klee, A. Lampert, 1976, Proceedings of the National Academy of Sciences of the United States of America.

Opiates inhibit adenylate cyclase by stimulating GTP hydrolysis.

G. Koski, W. Klee, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Developmental expression of G proteins that differentially modulate adenylyl cyclase activity in mouse brain

Y. Loh, W. Klee, R. Streaty, 1991, FEBS letters.

The synthesis of methionine by enzymic transmethylation. IX. Formation of subunits of thetin-homocys-teine methylpherase by reaction with sodium dodecyl sulfate.

W. Klee, 1962, Biochimica et biophysica acta.

Direct spectrophotometric measurement of the rate of reduction of disulfide bonds. The reactivity of the disulfide bonds of bovine -lactalbumin.

K. S. Iyer, W. Klee, 1973, The Journal of biological chemistry.

Guanine nucleotides inhibit binding of agonists and antagonists to soluble opiate receptors.

G. Koski, W. Simonds, W. Klee, 1981, The Journal of biological chemistry.

Photolabile ligands for opiate receptors.

W. Klee, S. Loukas, D. Varoucha, 1982, Life sciences.

Modulation of sodium-sensitive GTPase by partial opiate agonists. An explanation for the dual requirement for Na+ and GTP in inhibitory regulation of adenylate cyclase.

G. Koski, W. Klee, R. Streaty, 1982, The Journal of biological chemistry.

Development of opiate receptors and GTP-binding regulatory proteins in neonatal rat brain.

G. Milligan, P. Gierschik, A. Spiegel, 1987, The Journal of biological chemistry.

The inhibitory guanine nucleotide-binding protein (Ni) purified from bovine brain is a high affinity GTPase.

G. Milligan, W. Klee, 1985, The Journal of biological chemistry.

The reaction of O-methylisourea with bovine pancreatic ribonuclease.

F. Richards, W. Klee, 1957, The Journal of biological chemistry.

Probes for narcotic receptor mediated phenomena. 7. Synthesis and pharmacological properties of irreversible ligands specific for mu or delta opiate receptors.

T. Burke, K. Rice, W. Klee, 1984, Journal of medicinal chemistry.

Entry of opioid peptides into the central nervous system.

K. Pettigrew, S. Rapoport, W. Klee, 1980, Science.

Deoxymorphines: role of the phenolic hydroxyl in antinociception and opiate receptor interactions.

A. Brossi, K. Rice, M. Reich, 1979, Journal of medicinal chemistry.

Morphine receptors as regulators of adenylate cyclase activity.

M. Nirenberg, S. Sharma, W. Klee, 1975, Proceedings of the National Academy of Sciences of the United States of America.

Stereospecific and nonstereospecific effects of (+)- and (-)-morphine: evidence for a new class of receptors?

K. Rice, W. Klee, I. Iijima, 1977, Science.

Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance.

M. Nirenberg, W. Klee, S. Sharma, 1975, Proceedings of the National Academy of Sciences of the United States of America.

The synthesis of methionine by enzymic transmethylation. VI. Studies of the homogeneity, shape properties and monomer functionality of thetin-homocysteine methylpherase.

G. Cantoni, W. Klee, 1960, Biochimica et biophysica acta.

Fourier ‐ transform infrared ‐ spectrometric investigation of blends of terephthalic polyesters with polycarbonate

W. Klee, D. Hummel, 1991 .

Solubilization of active opiate receptors.

G. Koski, W. Simonds, W. Klee, 1980, Proceedings of the National Academy of Sciences of the United States of America.

The role of α-lactalbumin in lactose synthetase

C. Klee, W. Klee, Werner A. Klee, 1970 .

Guanine nucleotide dependent and independent reconstitution of G‐proteins with adenylate cyclase: stimulation or attenuation of the enzyme by Gi α subunits

D. Newton, W. Klee, 1990, FEBS letters.

Irreversible ligands with high selectivity toward delta and mu opiate receptors.

T R Burke, T. Burke, K. Rice, 1983, Science.

MULTIPLE ETORPHINE BINDING PROTEINS FROM BRAIN

W. Byrne, W. Klee, 1981 .

β-endrophin: modulation of acute tolerance and antagonism by endogenous brain systems

D. Smyth, W. Klee, Y. Jacquet, 1978, Brain Research.

Peptides of the central nervous system.

W. Klee, 1979, Advances in protein chemistry.

Regional expression and chromosomal localization of the delta opiate receptor gene.

C. Kozak, H. Jung, T. Bzdȩga, 1993, Proceedings of the National Academy of Sciences of the United States of America.

The possible actions of peptides with opioid activity derived from pepsin hydrolysates of wheat gluten and of other constituents of gluten in the function of the central nervous system

W. Klee, C. Zioudrou, 1980 .

Opioid peptides derived from food proteins. The exorphins.

W. Klee, C. Zioudrou, R. Streaty, 1979, The Journal of biological chemistry.

A new class of nonionic detergents with a gluconamide polar group.

J. C. Osborne, W. Klee, L. Hjelmeland, 1983, Analytical biochemistry.

Purification of the opiate receptor of NG108-15 neuroblastoma-glioma hybrid cells.

W. Simonds, T. Burke, K. Rice, 1985, Proceedings of the National Academy of Sciences of the United States of America.

STUDIES IN THE (+)-MORPHINAN SERIES. 5. SYNTHESIS AND BIOLOGICAL PROPERTIES OF (+)-NALOXONE

A. Brossi, K. Rice, W. Klee, 1978 .

Narcotic Receptor Sites in Morphine-dependent Rats

W. Klee, R. Streaty, 1974, Nature.

Identification of a M r 58 000 glycoprotein subunit of the opiate receptor

W. Simonds, T. Burke, K. Rice, 1982, FEBS letters.

Opioid-dependent dual regulation of adenylate cyclase in a cell-free system.

W. Klee, R. Streaty, 1981, Advances in cyclic nucleotide research.

Conformational studies of a series of overlapping peptides from ribonuclease and their relationship to the protein structure.

W. Klee, J. E. Brown, 1969, Biochemistry.

Effect of dehydration on the endogenous opiate content of the rat neuro-intermediate lobe.

H. Gainer, W. Klee, M. Mata, 1977, Life sciences.

Synthesis of leucine enkephalin derivatives: structure-function studies.

M. Nirenberg, V. Hruby, W. Klee, 1977, Biochemical and biophysical research communications.

The GTP-binding regulatory proteins of neuroblastoma x glioma, NG108-15, and glioma, C6, cells. Immunochemical evidence of a pertussis toxin substrate that is neither Ni nor No.

G. Milligan, P. Gierschik, A. Spiegel, 1986, FEBS letters.

OPIATES AND CYCLIC AMP

W. Klee, 1977 .

Bradykinin-activated transmembrane signals are coupled via No or Ni to production of inositol 1,4,5-trisphosphate, a second messenger in NG108-15 neuroblastoma-glioma hybrid cells.

M. Nirenberg, H. Higashida, W. Klee, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Probes for narcotic receptor mediated phenomena. 12. cis-(+)-3-Methylfentanyl isothiocyanate, a potent site-directed acylating agent for delta opioid receptors. Synthesis, absolute configuration, and receptor enantioselectivity.

W. Simonds, T. Burke, K. Rice, 1986, Journal of medicinal chemistry.

RIBONUCLEASE E, AN INTERMEDIATE IN THE DEGRADATION OF RIBONUCLEASE BY PORCINE ELASTASE.

W. Klee, 1965, The Journal of biological chemistry.

Intermediate stages in the thermally induced transconformation reactions of bovine pancreatic ribonuclease A.

W. Klee, 1967, Biochemistry.

Paradoxical effects of N-cyanoalkyl substituents upon the activities of several classes of opioids.

A. Brossi, K. Rice, W. Klee, 1979, Journal of medicinal chemistry.

Opiate receptors as regulators of adenylate cyclase.

M. Nirenberg, W. Klee, S. Sharma, 1975, Life sciences.

DEOXYMORPHINES: ROLE OF THE PHENOLIC HYDROXYL IN ANTINOCICEPTION AND OPIATE RECEPTOR INTERACTIONS

A. Brossi, K. Rice, W. Klee, 1979 .

Studies on the conformation and proteolytic susceptibility of rat and bovine pancreatic ribonucleases.

W. Klee, R. Streaty, 1970, The Journal of biological chemistry.

Endogenous Opiate Peptides

W. Klee, 1977 .

Anatagonist potency and receptor binding.

W. Klee, F. Ionescu, R. Katz, 1975, Life sciences.

Probes for narcotic receptor mediated phenomena. 13. Potential irreversible narcotic antagonist-based ligands derived from 6,14-endo-ethenotetrahydronororipavine with 7-(methoxyfumaroyl)amino, (bromoacetyl)amino, or isothiocyanate electrophiles: chemistry, biochemistry, and pharmacology.

K. Rice, M. Aceto, L. Harris, 1986, Journal of medicinal chemistry.

Relationships between opiate receptor binding and analgetic properties of prodine-type compounds.

W. Klee, M. A. Iorio, 1977, Journal of medicinal chemistry.

RELATIONS BETWEEN OPIATE RECEPTOR BINDING AND ANALGETIC PROPERTIES OF PRODINE-TYPE COMPOUNDS

W. Klee, M. A. Iorio, 1977 .

Potential long acting opiate antagonists: preparation, pharmacological activity, and opiate-receptor binding of N-substituted 2'-hydroxy-5-methyl-9 alpha-propyl-6,7-benzomorphans.

K. Rice, M. Aceto, W. Klee, 1977, Journal of pharmaceutical sciences.

Probes for narcotic receptor mediated phenomena. 15. (3S,4S)-(+)-trans-3-methylfentanyl isothiocyanate, a potent site-directed acylating agent for the delta opioid receptors in vitro.

J. B. Long, C. George, K. Rice, 1989, Journal of medicinal chemistry.

PROBES FOR NARCOTIC RECEPTOR MEDIATED PHENOMENA. 7. SYNTHESIS AND PHARMACOLOGICAL PROPERTIES OF IRREVERSIBLE LIGANDS SPECIFIC FOR μ OR Δ OPIATE RECEPTORS

T. Burke, K. Rice, W. Klee, 1985 .

Studies in the (+)-morphinan series. 5. Synthesis and biological properties of (+)-naloxone.

A. Brossi, K. Rice, W. Klee, 1978, Journal of medicinal chemistry.

Exorphins: peptides with opioid activity isolated from wheat gluten, and their possible role in the etiology of schizophrenia

W. Klee, C. Zioudrou, R. Streaty, 1979 .

A neuroblastoma times glioma hybrid cell line with morphine receptors.

M. Nirenberg, W. Klee, 1974, Proceedings of the National Academy of Sciences of the United States of America.

The synthesis of methionine by enzymic transmethylation. VII. Existence of two separate homocysteine methylpherases on mammalian liver.

G. Cantoni, W. Klee, H. H. Richards, 1961, Biochimica et biophysica acta.